GREMLIN Database
SYC - Cysteine--tRNA ligase
UniProt: Q97WE6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 470 (422)
Sequences: 20023 (11401)
Seq/√Len: 555.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_L62_Y5.3401.00
128_Q132_D3.8761.00
355_N372_Y3.6871.00
60_R357_H3.6801.00
147_D150_T3.3361.00
87_D90_E3.2451.00
129_R132_D3.0931.00
38_Y98_D3.0661.00
283_K306_E3.0321.00
25_L63_T2.8951.00
52_A294_L2.8921.00
265_E271_L2.8671.00
434_Q438_M2.7871.00
133_K244_A2.7451.00
80_K83_E2.7371.00
401_K405_E2.7251.00
182_A185_K2.5331.00
135_H150_T2.5311.00
104_S109_K2.5301.00
84_I94_Y2.5051.00
129_R133_K2.4901.00
147_D176_K2.4191.00
354_N358_T2.4121.00
358_T363_D2.3501.00
98_D101_D2.3101.00
56_Y60_R2.2651.00
89_N93_D2.2181.00
365_D368_T2.1921.00
97_K101_D2.1781.00
125_D129_R2.1741.00
193_Y196_S2.1141.00
54_S58_R2.0661.00
100_L104_S2.0181.00
86_K94_Y2.0041.00
372_Y375_E1.9971.00
57_L60_R1.9961.00
141_S175_K1.9901.00
222_D251_V1.9451.00
195_E200_K1.9261.00
189_P192_P1.9221.00
86_K90_E1.8871.00
126_F245_L1.8831.00
105_Q282_K1.8801.00
143_S175_K1.8321.00
348_E379_L1.8291.00
279_E282_K1.8281.00
191_E194_W1.7961.00
54_S64_V1.7761.00
188_K191_E1.7621.00
192_P195_E1.7601.00
138_V177_H1.7521.00
430_D434_Q1.7511.00
359_A368_T1.7451.00
93_D97_K1.7441.00
175_K187_W1.7401.00
50_F225_G1.7361.00
101_D105_Q1.7261.00
351_N355_N1.7201.00
122_E215_R1.7041.00
359_A372_Y1.6761.00
427_A431_I1.6691.00
357_H362_N1.6651.00
130_L244_A1.6641.00
190_G194_W1.6511.00
219_E242_T1.6341.00
348_E351_N1.6271.00
189_P194_W1.6191.00
398_E402_Q1.6191.00
190_G193_Y1.6111.00
188_K192_P1.5881.00
352_N376_I1.5841.00
97_K100_L1.5691.00
189_P193_Y1.5651.00
278_N282_K1.5631.00
53_I364_F1.5611.00
86_K91_I1.5601.00
426_D430_D1.5511.00
58_R109_K1.5411.00
427_A430_D1.4961.00
280_A289_L1.4931.00
56_Y357_H1.4931.00
205_W208_E1.4401.00
412_E415_Y1.4331.00
421_M424_I1.4291.00
208_E211_T1.4211.00
349_I402_Q1.4191.00
397_F401_K1.4141.00
214_T217_L1.4141.00
407_F415_Y1.4121.00
347_R351_N1.4081.00
190_G195_E1.4061.00
306_E310_E1.4051.00
107_K413_E1.4051.00
181_F184_W1.4041.00
22_E25_L1.4001.00
191_E195_E1.4001.00
57_L362_N1.3841.00
276_P279_E1.3831.00
388_R391_L1.3791.00
191_E196_S1.3771.00
288_V313_K1.3721.00
406_V409_V1.3701.00
47_F103_L1.3691.00
252_T364_F1.3691.00
78_I82_Q1.3631.00
184_W187_W1.3611.00
190_G197_P1.3441.00
100_L113_H1.3401.00
33_P36_Y1.3401.00
112_I118_Q1.3321.00
211_T215_R1.3311.00
355_N358_T1.3301.00
209_C213_S1.3261.00
262_I305_S1.3221.00
353_L357_H1.3201.00
22_E27_K1.3201.00
170_E173_K1.3151.00
208_E213_S1.3021.00
166_N174_E1.2991.00
90_E94_Y1.2981.00
433_N437_Q1.2931.00
181_F186_A1.2771.00
279_E283_K1.2681.00
176_K180_D1.2631.00
209_C212_M1.2631.00
105_Q281_I1.2581.00
409_V412_E1.2551.00
194_W197_P1.2541.00
202_R205_W1.2531.00
350_L353_L1.2501.00
101_D104_S1.2481.00
211_T214_T1.2451.00
193_Y197_P1.2391.00
79_K83_E1.2361.00
360_M410_M1.2321.00
166_N169_E1.2311.00
190_G196_S1.2251.00
80_K84_I1.2241.00
353_L402_Q1.2201.00
307_E310_E1.2161.00
192_P196_S1.2151.00
382_S386_Y1.2111.00
128_Q131_I1.2091.00
342_D383_T1.2061.00
360_M369_A1.2031.00
149_D177_H1.2001.00
219_E248_E1.1941.00
189_P195_E1.1941.00
135_H186_A1.1921.00
210_S213_S1.1901.00
70_I96_T1.1871.00
430_D433_N1.1861.00
318_R377_V1.1861.00
262_I307_E1.1861.00
48_V293_Y1.1791.00
207_I210_S1.1761.00
115_R118_Q1.1751.00
213_S216_Y1.1681.00
183_L187_W1.1671.00
404_N410_M1.1621.00
394_M398_E1.1541.00
323_M400_L1.1481.00
70_I100_L1.1481.00
101_D278_N1.1451.00
56_Y360_M1.1451.00
180_D184_W1.1441.00
189_P197_P1.1401.00
28_M54_S1.1371.00
47_F108_V1.1361.00
105_Q278_N1.1351.00
154_Y157_L1.1351.00
348_E352_N1.1341.00
129_R245_L1.1271.00
161_K164_E1.1221.00
180_D186_A1.1201.00
91_I95_F1.1181.00
100_L115_R1.1171.00
340_D343_I1.1151.00
192_P197_P1.1121.00
153_N156_E1.1041.00
94_Y98_D1.1031.00
202_R210_S1.1001.00
339_K342_D1.0991.00
349_I353_L1.0981.00
409_V415_Y1.0971.00
182_A186_A1.0951.00
210_S214_T1.0941.00
206_H209_C1.0911.00
423_K426_D1.0901.00
397_F400_L1.0901.00
418_Y421_M1.0871.00
212_M215_R1.0841.00
102_M278_N1.0821.00
176_K179_Y1.0811.00
423_K427_A1.0781.00
394_M397_F1.0761.00
356_F369_A1.0661.00
180_D183_L1.0611.00
44_G106_L1.0591.00
283_K310_E1.0591.00
218_G222_D1.0591.00
155_G158_S1.0561.00
192_P199_G1.0551.00
408_G415_Y1.0541.00
352_N372_Y1.0541.00
343_I347_R1.0531.00
46_T257_S1.0531.00
175_K181_F1.0501.00
307_E311_Q1.0481.00
422_Y426_D1.0461.00
177_H180_D1.0421.00
405_E408_G1.0421.00
26_V62_Y1.0411.00
24_N62_Y1.0401.00
19_G113_H1.0381.00
212_M216_Y1.0371.00
188_K194_W1.0361.00
119_H216_Y1.0321.00
235_H253_Y1.0311.00
39_V43_H1.0281.00
356_F360_M1.0261.00
287_S320_K1.0251.00
183_L186_A1.0221.00
201_G205_W1.0211.00
209_C216_Y1.0141.00
434_Q437_Q1.0121.00
404_N409_V1.0111.00
211_T216_Y1.0091.00
38_Y278_N1.0061.00
428_V431_I1.0051.00
178_S181_F1.0001.00
191_E197_P0.9991.00
411_D414_F0.9951.00
404_N415_Y0.9911.00
369_A410_M0.9901.00
188_K195_E0.9891.00
264_K303_D0.9891.00
402_Q405_E0.9891.00
125_D128_Q0.9861.00
90_E93_D0.9861.00
135_H244_A0.9851.00
349_I376_I0.9791.00
322_S377_V0.9751.00
59_L408_G0.9701.00
122_E125_D0.9681.00
404_N411_D0.9671.00
58_R111_D0.9651.00
53_I57_L0.9581.00
111_D114_P0.9581.00
313_K317_Q0.9571.00
141_S177_H0.9551.00
402_Q406_V0.9551.00
368_T371_S0.9541.00
322_S380_V0.9541.00
29_Y32_G0.9491.00
37_D43_H0.9461.00
202_R206_H0.9451.00
371_S375_E0.9441.00
143_S173_K0.9411.00
292_W308_A0.9371.00
160_T165_W0.9371.00
345_V399_T0.9341.00
431_I435_L0.9311.00
96_T100_L0.9221.00
189_P196_S0.9221.00
209_C217_L0.9171.00
261_T303_D0.9171.00
208_E212_M0.9111.00
355_N359_A0.9091.00
401_K404_N0.9051.00
52_A360_M0.9011.00
188_K193_Y0.9011.00
209_C215_R0.8971.00
121_R125_D0.8941.00
114_P118_Q0.8941.00
205_W216_Y0.8931.00
422_Y433_N0.8911.00
176_K181_F0.8901.00
178_S186_A0.8891.00
59_L405_E0.8881.00
417_T420_K0.8871.00
346_Y398_E0.8851.00
201_G204_G0.8811.00
351_N354_N0.8741.00
181_F185_K0.8721.00
196_S199_G0.8711.00
179_Y183_L0.8671.00
399_T402_Q0.8671.00
356_F373_I0.8661.00
181_F187_W0.8661.00
231_I255_V0.8651.00
130_L241_Q0.8641.00
200_K206_H0.8641.00
77_I88_W0.8621.00
84_I91_I0.8611.00
171_F174_E0.8611.00
407_F411_D0.8581.00
356_F372_Y0.8571.00
377_V403_F0.8561.00
175_K178_S0.8551.00
162_K165_W0.8541.00
210_S215_R0.8531.00
398_E401_K0.8521.00
267_M273_N0.8441.00
405_E409_V0.8431.00
201_G206_H0.8431.00
344_K348_E0.8421.00
54_S109_K0.8421.00
178_S182_A0.8391.00
204_G207_I0.8351.00
176_K184_W0.8331.00
205_W209_C0.8321.00
315_A374_H0.8311.00
119_H201_G0.8281.00
248_E251_V0.8281.00
180_D185_K0.8281.00
163_E170_E0.8241.00
359_A363_D0.8141.00
201_G207_I0.8141.00
179_Y184_W0.8111.00
147_D167_Q0.8111.00
346_Y350_L0.8111.00
37_D80_K0.8111.00
375_E379_L0.8101.00
130_L133_K0.8081.00
175_K179_Y0.8061.00
281_I286_P0.8051.00
51_D55_R0.8031.00
424_I440_L0.8031.00
207_I211_T0.8001.00
435_L439_K0.7991.00
437_Q441_Y0.7971.00
419_D422_Y0.7971.00
193_Y199_G0.7921.00
60_R362_N0.7901.00
359_A369_A0.7891.00
212_M217_L0.7871.00
426_D433_N0.7871.00
420_K423_K0.7871.00
203_P206_H0.7861.00
353_L406_V0.7851.00
316_L411_D0.7831.00
56_Y362_N0.7821.00
350_L354_N0.7801.00
94_Y97_K0.7791.00
48_V108_V0.7781.00
45_R302_I0.7761.00
95_F98_D0.7761.00
435_L438_M0.7751.00
194_W198_W0.7751.00
380_V399_T0.7741.00
355_N375_E0.7721.00
121_R124_I0.7711.00
193_Y198_W0.7701.00
30_V225_G0.7701.00
55_R412_E0.7691.00
310_E314_S0.7681.00
416_P419_D0.7681.00
50_F66_R0.7681.00
65_I112_I0.7671.00
209_C214_T0.7671.00
175_K184_W0.7661.00
349_I399_T0.7661.00
160_T163_E0.7641.00
285_G288_V0.7641.00
330_I397_F0.7621.00
204_G208_E0.7621.00
409_V413_E0.7571.00
352_N356_F0.7551.00
422_Y425_I0.7541.00
429_V433_N0.7531.00
402_Q409_V0.7521.00
418_Y422_Y0.7501.00
249_K252_T0.7471.00
355_N368_T0.7431.00
411_D415_Y0.7401.00
399_T403_F0.7361.00
192_P198_W0.7361.00
38_Y95_F0.7361.00
190_G199_G0.7351.00
432_R436_R0.7311.00
202_R216_Y0.7311.00
205_W213_S0.7301.00
204_G209_C0.7291.00
204_G210_S0.7291.00
200_K205_W0.7261.00
199_G203_P0.7261.00
201_G208_E0.7251.00
433_N436_R0.7241.00
319_I377_V0.7231.00
96_T117_T0.7181.00
133_K246_I0.7171.00
344_K347_R0.7151.00
203_P210_S0.7151.00
202_R207_I0.7141.00
193_Y200_K0.7111.00
310_E313_K0.7071.00
53_I366_T0.7061.00
291_Y370_L0.7051.00
46_T256_H0.7051.00
203_P208_E0.7051.00
203_P211_T0.7041.00
213_S221_F0.7031.00
195_E198_W0.7001.00
264_K272_G0.6991.00
223_I252_T0.6991.00
39_V102_M0.6991.00
201_G210_S0.6981.00
84_I87_D0.6971.00
404_N413_E0.6971.00
124_I128_Q0.6971.00
53_I223_I0.6931.00
107_K286_P0.6911.00
347_R419_D0.6911.00
176_K182_A0.6911.00
338_V346_Y0.6901.00
54_S111_D0.6901.00
338_V395_L0.6891.00
110_I113_H0.6881.00
202_R211_T0.6871.00
265_E272_G0.6871.00
149_D169_E0.6861.00
404_N414_F0.6841.00
267_M274_I0.6841.00
178_S184_W0.6771.00
210_S217_L0.6751.00
397_F402_Q0.6751.00
262_I274_I0.6741.00
395_L398_E0.6731.00
271_L274_I0.6731.00
208_E216_Y0.6731.00
89_N118_Q0.6731.00
120_I124_I0.6721.00
352_N355_N0.6721.00
77_I92_V0.6721.00
347_R350_L0.6711.00
194_W199_G0.6701.00
38_Y102_M0.6671.00
404_N412_E0.6671.00
403_F406_V0.6661.00
205_W210_S0.6641.00
32_G36_Y0.6621.00
27_K65_I0.6621.00
359_A365_D0.6621.00
156_E159_N0.6611.00
176_K186_A0.6601.00
54_S66_R0.6591.00
396_A399_T0.6591.00
424_I428_V0.6591.00
48_V52_A0.6571.00
210_S216_Y0.6561.00
338_V343_I0.6551.00
205_W215_R0.6541.00
291_Y315_A0.6521.00
397_F404_N0.6521.00
178_S183_L0.6491.00
203_P209_C0.6481.00
131_I136_A0.6481.00
48_V294_L0.6481.00
223_I254_W0.6451.00
205_W214_T0.6441.00
202_R209_C0.6421.00
74_D78_I0.6421.00
263_R303_D0.6411.00
27_K222_D0.6401.00
205_W212_M0.6391.00
279_E306_E0.6391.00
226_G235_H0.6381.00
179_Y182_A0.6361.00
202_R213_S0.6361.00
189_P199_G0.6351.00
146_F151_Y0.6341.00
167_Q171_F0.6341.00
416_P420_K0.6331.00
417_T421_M0.6301.00
202_R208_E0.6301.00
291_Y312_A0.6291.00
103_L108_V0.6291.00
397_F412_E0.6281.00
49_V225_G0.6261.00
44_G277_L0.6251.00
422_Y430_D0.6251.00
308_A311_Q0.6231.00
358_T362_N0.6231.00
180_D187_W0.6231.00
80_K91_I0.6211.00
30_V50_F0.6211.00
41_I274_I0.6201.00
198_W202_R0.6191.00
206_H210_S0.6181.00
395_L399_T0.6171.00
213_S217_L0.6141.00
29_Y36_Y0.6141.00
38_Y276_P0.6141.00
319_I404_N0.6131.00
408_G412_E0.6111.00
142_G180_D0.6111.00
177_H181_F0.6101.00
409_V414_F0.6091.00
164_E167_Q0.6091.00
166_N173_K0.6081.00
420_K424_I0.6081.00
228_A259_F0.6051.00
325_I385_Q0.6051.00
96_T115_R0.6031.00
211_T217_L0.6031.00
385_Q388_R0.6021.00
191_E199_G0.6011.00
351_N422_Y0.6001.00
21_V252_T0.5981.00
200_K203_P0.5981.00
308_A312_A0.5971.00
201_G209_C0.5951.00
73_I120_I0.5951.00
41_I267_M0.5951.00
341_D387_S0.5941.00
257_S260_V0.5931.00
207_I213_S0.5931.00
179_Y186_A0.5921.00
144_V153_N0.5911.00
294_L370_L0.5901.00
296_S302_I0.5901.00
354_N357_H0.5891.00
102_M276_P0.5881.00
22_E63_T0.5881.00
410_M415_Y0.5861.00
408_G413_E0.5861.00
284_W310_E0.5851.00
202_R212_M0.5851.00
410_M414_F0.5841.00
262_I303_D0.5841.00
201_G211_T0.5831.00
382_S385_Q0.5831.00
439_K442_E0.5821.00
341_D344_K0.5811.00
214_T246_I0.5811.00
204_G213_S0.5811.00
206_H212_M0.5811.00
219_E222_D0.5801.00
155_G159_N0.5780.99
224_H238_E0.5780.99
161_K165_W0.5780.99
400_L403_F0.5770.99
205_W217_L0.5770.99
405_E412_E0.5770.99
425_I428_V0.5760.99
199_G202_R0.5740.99
424_I427_A0.5730.99
304_F309_L0.5710.99
114_P117_T0.5710.99
208_E214_T0.5700.99
208_E217_L0.5700.99
145_Y173_K0.5700.99
204_G217_L0.5690.99
435_L440_L0.5680.99
206_H216_Y0.5670.99
267_M275_I0.5670.99
84_I95_F0.5650.99
220_R252_T0.5630.99
52_A366_T0.5600.99
135_H185_K0.5600.99
324_A327_R0.5600.99
321_D325_I0.5590.99
119_H122_E0.5590.99
228_A301_P0.5590.99
154_Y158_S0.5580.99
394_M409_V0.5570.99
401_K409_V0.5560.99
345_V376_I0.5560.99
169_E173_K0.5550.99
407_F413_E0.5520.99
63_T218_G0.5520.99
131_I138_V0.5510.99
190_G198_W0.5510.99
311_Q315_A0.5480.99
346_Y395_L0.5470.99
189_P198_W0.5450.99
170_E174_E0.5440.99
182_A187_W0.5440.99
97_K104_S0.5430.99
116_V123_I0.5390.99
421_M425_I0.5380.99
379_L382_S0.5370.99
228_A231_I0.5370.99
208_E215_R0.5360.99
138_V141_S0.5350.99
275_I304_F0.5350.99
422_Y432_R0.5350.99
188_K196_S0.5350.99
137_Y182_A0.5340.99
93_D115_R0.5330.99
408_G414_F0.5320.99
397_F409_V0.5320.99
436_R441_Y0.5310.99
43_H47_F0.5310.99
223_I364_F0.5310.99
31_C36_Y0.5310.99
53_I255_V0.5300.99
207_I217_L0.5300.99
419_D423_K0.5300.99
206_H211_T0.5300.99
72_D117_T0.5290.99
25_L65_I0.5280.99
292_W312_A0.5270.99
51_D290_R0.5270.99
428_V432_R0.5250.99
202_R214_T0.5240.99
146_F244_A0.5230.99
368_T372_Y0.5210.99
145_Y159_N0.5210.99
268_S271_L0.5210.99
116_V119_H0.5210.99
424_I433_N0.5200.99
406_V411_D0.5180.99
249_K253_Y0.5180.99
204_G212_M0.5160.99
33_P46_T0.5140.99
243_E248_E0.5130.99
204_G211_T0.5130.99
79_K82_Q0.5110.99
205_W211_T0.5100.99
418_Y423_K0.5100.99
352_N379_L0.5100.99
177_H184_W0.5060.99
103_L110_I0.5060.99
407_F410_M0.5050.99
207_I212_M0.5050.99
400_L409_V0.5050.99
176_K187_W0.5040.99
250_W253_Y0.5040.99
431_I434_Q0.5020.99
203_P212_M0.5020.99
202_R217_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1li5A 1 0.8149 100 0.233 Contact Map
3tqoA 1 0.817 100 0.234 Contact Map
3sp1A 1 0.9 100 0.273 Contact Map
1rqgA 2 0.9468 100 0.294 Contact Map
1gaxA 1 0.9872 100 0.298 Contact Map
3kflA 1 0.9128 100 0.3 Contact Map
3ziuA 1 0.9553 100 0.312 Contact Map
1ffyA 1 0.9915 100 0.325 Contact Map
2x1lA 1 0.9106 100 0.33 Contact Map
2csxA 1 0.8489 100 0.332 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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