GREMLIN Database
PGMI - Bifunctional phosphoglucose/phosphomannose isomerase
UniProt: Q97WE5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (266)
Sequences: 5555 (3459)
Seq/√Len: 212.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_D60_E5.4551.00
90_I101_A4.6351.00
79_E100_L4.0491.00
117_T120_A3.3931.00
30_F40_G3.3221.00
149_V153_K3.0451.00
82_V102_K2.9271.00
186_F261_A2.9191.00
65_V128_L2.8331.00
165_E271_K2.7501.00
80_N83_K2.6301.00
25_N62_L2.5891.00
153_K156_I2.5281.00
64_A78_V2.5061.00
40_G65_V2.4571.00
78_V97_L2.4261.00
43_A128_L2.3571.00
121_F182_I2.3561.00
270_K276_P2.2141.00
26_D58_G2.1931.00
187_K198_A2.1741.00
168_I271_K2.0781.00
184_K200_Y2.0701.00
148_G155_Q2.0701.00
66_S97_L2.0521.00
80_N84_A2.0191.00
107_K123_Y1.9801.00
37_G41_E1.9671.00
166_L239_N1.9341.00
70_T96_I1.9311.00
58_G61_S1.9161.00
27_N49_E1.9081.00
29_V61_S1.8871.00
148_G153_K1.8861.00
227_S250_D1.8631.00
57_T86_S1.8441.00
137_G142_E1.8361.00
92_T98_E1.7551.00
267_E271_K1.7391.00
245_P257_L1.7261.00
191_N199_F1.7251.00
87_E103_E1.6891.00
49_E54_R1.6801.00
62_L89_I1.6761.00
98_E104_K1.6541.00
28_I62_L1.6431.00
121_F258_L1.6421.00
46_L129_I1.6381.00
146_K153_K1.6301.00
158_A161_T1.6131.00
76_N79_E1.5901.00
151_E154_E1.5781.00
35_G117_T1.5701.00
156_I259_A1.5691.00
134_K138_I1.5661.00
64_A88_V1.5661.00
147_E150_I1.5611.00
275_K278_K1.5231.00
161_T267_E1.5211.00
233_I238_L1.5151.00
52_F202_E1.4751.00
223_V261_A1.4671.00
133_T136_R1.4171.00
159_D162_R1.3991.00
49_E53_K1.3991.00
28_I63_I1.3901.00
30_F63_I1.3901.00
151_E155_Q1.3881.00
154_E157_K1.3871.00
27_N61_S1.3841.00
72_S76_N1.3751.00
41_E184_K1.3731.00
152_A156_I1.3721.00
150_I153_K1.3631.00
263_V267_E1.3601.00
161_T165_E1.3591.00
64_A74_T1.3571.00
167_L264_T1.3561.00
134_K137_G1.3321.00
229_E232_K1.3301.00
182_I258_L1.3161.00
225_V257_L1.3111.00
94_G98_E1.3041.00
78_V88_V1.3011.00
148_G151_E1.2961.00
90_I97_L1.2901.00
185_R189_E1.2811.00
126_T255_S1.2761.00
147_E151_E1.2701.00
228_S250_D1.2601.00
144_E249_S1.2581.00
21_H87_E1.2481.00
27_N58_G1.2441.00
224_I230_I1.2351.00
26_D61_S1.2321.00
153_K157_K1.2151.00
144_E148_G1.2091.00
47_G54_R1.2001.00
61_S86_S1.1831.00
88_V101_A1.1771.00
171_I217_G1.1761.00
176_S206_I1.1751.00
221_V264_T1.1641.00
47_G53_K1.1561.00
81_A86_S1.1561.00
142_E146_K1.1551.00
172_P197_P1.1451.00
269_A274_E1.1431.00
163_L241_I1.1241.00
180_L253_N1.1121.00
214_Y238_L1.1081.00
79_E83_K1.1071.00
226_E230_I1.1051.00
264_T268_M1.1041.00
94_G99_K1.0961.00
64_A81_A1.0761.00
31_S77_D1.0721.00
223_V257_L1.0691.00
105_S127_P1.0641.00
24_K60_E1.0521.00
173_V196_H1.0511.00
171_I215_V1.0441.00
214_Y220_L1.0381.00
44_N49_E1.0361.00
43_A132_T1.0331.00
87_E102_K1.0321.00
146_K150_I1.0291.00
171_I272_L1.0191.00
201_G210_E1.0151.00
149_V152_A1.0151.00
91_I127_P1.0111.00
82_V100_L1.0111.00
133_T145_L1.0081.00
90_I104_K0.9981.00
107_K124_L0.9941.00
31_S64_A0.9911.00
149_V155_Q0.9911.00
47_G50_L0.9901.00
148_G249_S0.9891.00
21_H24_K0.9841.00
162_R165_E0.9811.00
33_I71_T0.9731.00
78_V101_A0.9701.00
25_N87_E0.9691.00
108_L111_I0.9691.00
25_N61_S0.9661.00
30_F50_L0.9641.00
146_K149_V0.9551.00
180_L257_L0.9531.00
98_E106_L0.9440.99
48_V51_S0.9410.99
49_E52_F0.9390.99
164_A264_T0.9350.99
192_E208_H0.9310.99
75_I79_E0.9310.99
76_N80_N0.9310.99
110_K119_Y0.9260.99
249_S252_K0.9240.99
174_I218_P0.9170.99
266_L270_K0.9160.99
39_V128_L0.9140.99
122_P255_S0.9120.99
47_G52_F0.9090.99
248_N256_S0.9050.99
125_F255_S0.9040.99
176_S222_S0.9040.99
220_L238_L0.9040.99
195_K280_Y0.9040.99
175_Y190_I0.9030.99
155_Q256_S0.8950.99
145_L149_V0.8940.99
186_F223_V0.8840.99
132_T136_R0.8750.99
75_I96_I0.8720.99
48_V54_R0.8720.99
234_T240_S0.8710.99
121_F181_A0.8680.99
35_G189_E0.8640.99
47_G51_S0.8600.99
122_P262_G0.8590.99
48_V53_K0.8530.99
186_F258_L0.8520.99
35_G188_Q0.8490.99
96_I100_L0.8380.99
63_I89_I0.8360.99
30_F43_A0.8300.99
35_G185_R0.8290.99
143_M146_K0.8250.99
137_G141_N0.8220.99
215_V280_Y0.8220.99
155_Q248_N0.8160.99
144_E147_E0.8090.98
91_I128_L0.8070.98
117_T212_E0.8040.98
46_L132_T0.7890.98
268_M272_L0.7870.98
22_E25_N0.7840.98
31_S81_A0.7830.98
136_R140_I0.7830.98
36_S92_T0.7810.98
146_K155_Q0.7810.98
51_S54_R0.7810.98
95_G98_E0.7810.98
188_Q209_N0.7710.98
112_P118_R0.7680.98
116_Q193_N0.7610.98
248_N252_K0.7550.98
46_L179_Y0.7540.98
234_T237_V0.7530.97
130_K133_T0.7480.97
32_G36_S0.7470.97
88_V102_K0.7440.97
189_E212_E0.7380.97
67_Y117_T0.7370.97
183_A223_V0.7360.97
196_H272_L0.7320.97
131_M135_R0.7300.97
173_V190_I0.7280.97
133_T139_K0.7270.97
124_L128_L0.7150.97
94_G106_L0.7150.97
207_N211_I0.7120.97
133_T141_N0.7110.96
160_A263_V0.7110.96
167_L173_V0.7100.96
196_H268_M0.7100.96
189_E262_G0.7080.96
112_P119_Y0.7070.96
24_K87_E0.7060.96
152_A255_S0.7060.96
161_T271_K0.7040.96
160_A260_L0.7020.96
150_I154_E0.6990.96
148_G152_A0.6990.96
180_L223_V0.6980.96
194_A274_E0.6950.96
25_N60_E0.6930.96
82_V88_V0.6870.96
206_I211_I0.6790.95
143_M151_E0.6760.95
137_G140_I0.6760.95
233_I240_S0.6740.95
176_S233_I0.6720.95
33_I205_E0.6720.95
67_Y93_S0.6640.95
163_L264_T0.6630.95
185_R262_G0.6630.95
67_Y119_Y0.6620.95
48_V52_F0.6580.95
185_R188_Q0.6550.94
172_P218_P0.6550.94
279_L282_I0.6540.94
267_E270_K0.6540.94
161_T270_K0.6520.94
175_Y221_V0.6480.94
189_E279_L0.6470.94
73_E204_P0.6470.94
136_R141_N0.6460.94
67_Y112_P0.6450.94
29_V58_G0.6450.94
57_T61_S0.6450.94
42_I182_I0.6440.94
30_F48_V0.6430.94
160_A264_T0.6390.94
227_S230_I0.6390.94
145_L249_S0.6360.94
41_E181_A0.6360.94
21_H25_N0.6350.94
113_S278_K0.6350.94
159_D163_L0.6260.93
38_I185_R0.6220.93
64_A101_A0.6190.93
115_F277_D0.6190.93
116_Q119_Y0.6180.93
189_E277_D0.6180.93
35_G212_E0.6180.93
256_S259_A0.6110.92
118_R189_E0.6080.92
33_I73_E0.6060.92
97_L101_A0.6050.92
129_I145_L0.6040.92
129_I251_E0.6030.92
20_I24_K0.6010.92
176_S183_A0.6010.92
207_N283_P0.6000.91
250_D253_N0.5990.91
126_T152_A0.5990.91
132_T135_R0.5980.91
67_Y116_Q0.5980.91
74_T77_D0.5970.91
67_Y207_N0.5960.91
42_I181_A0.5960.91
174_I206_I0.5940.91
248_N253_N0.5930.91
212_E280_Y0.5920.91
178_K229_E0.5920.91
145_L153_K0.5910.91
133_T142_E0.5900.91
180_L225_V0.5890.91
42_I254_I0.5890.91
181_A184_K0.5880.91
115_F119_Y0.5870.91
22_E135_R0.5870.91
37_G52_F0.5850.90
46_L251_E0.5820.90
206_I214_Y0.5820.90
182_I223_V0.5790.90
63_I131_M0.5780.90
185_R277_D0.5780.90
20_I23_I0.5760.90
92_T126_T0.5750.90
64_A97_L0.5750.90
227_S253_N0.5750.90
138_I141_N0.5750.90
143_M156_I0.5730.90
66_S69_G0.5730.90
150_I156_I0.5730.90
152_A155_Q0.5720.89
69_G192_E0.5720.89
38_I41_E0.5720.89
27_N52_F0.5710.89
98_E101_A0.5710.89
150_I155_Q0.5680.89
233_I236_D0.5630.89
120_A285_A0.5630.89
245_P248_N0.5630.89
121_F125_F0.5620.89
164_A271_K0.5590.88
114_G210_E0.5590.88
142_E153_K0.5580.88
158_A162_R0.5580.88
244_K247_F0.5580.88
73_E207_N0.5570.88
118_R185_R0.5560.88
38_I184_K0.5540.88
190_I194_A0.5520.88
162_R166_L0.5490.87
41_E44_N0.5490.87
123_Y126_T0.5480.87
203_I207_N0.5480.87
79_E99_K0.5470.87
207_N212_E0.5470.87
125_F129_I0.5450.87
146_K152_A0.5430.87
146_K154_E0.5420.87
164_A267_E0.5420.87
115_F282_I0.5420.87
206_I233_I0.5410.87
170_R239_N0.5410.87
91_I107_K0.5390.86
30_F128_L0.5380.86
94_G104_K0.5380.86
262_G279_L0.5370.86
163_L167_L0.5360.86
144_E159_D0.5350.86
143_M147_E0.5340.86
220_L233_I0.5340.86
138_I142_E0.5330.86
32_G40_G0.5310.86
112_P116_Q0.5300.86
81_A85_G0.5300.86
126_T130_K0.5300.86
69_G208_H0.5290.85
55_K80_N0.5290.85
104_K108_L0.5280.85
72_S285_A0.5280.85
207_N213_S0.5260.85
181_A187_K0.5250.85
168_I268_M0.5250.85
148_G248_N0.5240.85
205_E281_N0.5230.85
124_L211_I0.5220.85
146_K156_I0.5210.85
136_R142_E0.5200.84
175_Y186_F0.5200.84
36_S210_E0.5170.84
145_L148_G0.5160.84
112_P185_R0.5160.84
133_T137_G0.5160.84
216_H237_V0.5150.84
167_L268_M0.5140.84
195_K212_E0.5130.84
117_T124_L0.5130.84
35_G210_E0.5130.84
75_I100_L0.5120.84
253_N257_L0.5120.84
188_Q192_E0.5100.83
27_N47_G0.5080.83
112_P115_F0.5080.83
26_D59_K0.5080.83
67_Y185_R0.5080.83
187_K200_Y0.5070.83
67_Y110_K0.5060.83
173_V219_S0.5060.83
133_T138_I0.5040.83
144_E149_V0.5040.83
73_E195_K0.5020.82
24_K83_K0.5010.82
268_M271_K0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fj1A 2 0.9392 100 0.319 Contact Map
3hbaA 2 0.9054 100 0.319 Contact Map
2zj3A 2 0.9764 100 0.335 Contact Map
1moqA 2 0.973 100 0.339 Contact Map
3tbfA 2 0.9426 100 0.343 Contact Map
3g68A 3 0.9865 100 0.346 Contact Map
3knzA 2 0.8885 100 0.346 Contact Map
4amvA 2 0.9764 100 0.349 Contact Map
2pocA 4 0.9358 100 0.35 Contact Map
4s1wA 2 0.9324 100 0.355 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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