GREMLIN Database
Q97WE3 - NADH oxidase
UniProt: Q97WE3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 441 (400)
Sequences: 17855 (11879)
Seq/√Len: 594.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_A227_V4.4491.00
258_D262_R3.9471.00
34_S80_K3.7691.00
146_R169_K3.3301.00
171_V203_K3.0761.00
248_K256_W2.9161.00
169_K201_E2.8691.00
381_A396_M2.8501.00
193_T197_E2.7581.00
114_R241_D2.5711.00
90_I101_K2.5541.00
344_K374_D2.5421.00
395_M414_T2.4681.00
3_R28_H2.3911.00
104_F107_L2.3821.00
16_A108_L2.3781.00
121_E210_S2.3671.00
114_R239_N2.3581.00
116_K237_E2.3531.00
89_R267_N2.3481.00
344_K373_A2.3191.00
372_E375_T2.2831.00
143_S168_K2.2641.00
92_V101_K2.1961.00
5_I102_Y2.1741.00
376_M407_E2.1651.00
106_Y267_N2.1611.00
148_A173_I2.1601.00
32_F102_Y2.1471.00
4_L20_V2.0841.00
94_R99_K2.0801.00
250_G254_A2.0741.00
377_R403_G2.0631.00
30_T76_K2.0611.00
12_A271_A2.0391.00
301_A305_I2.0381.00
186_E336_N2.0271.00
146_R228_D2.0261.00
92_V99_K2.0161.00
346_V373_A2.0121.00
5_I91_V2.0081.00
5_I32_F1.9781.00
333_V338_A1.9591.00
177_R205_N1.9341.00
157_I172_L1.8991.00
399_V404_F1.8921.00
130_H133_E1.8791.00
85_D88_S1.8721.00
90_I103_E1.8711.00
383_I389_V1.8581.00
175_R207_S1.8261.00
114_R237_E1.8081.00
242_L245_D1.8031.00
333_V341_Y1.7941.00
262_R266_E1.7831.00
248_K264_S1.7271.00
164_R169_K1.7071.00
3_R105_D1.7011.00
108_L305_I1.6831.00
209_V218_V1.6761.00
147_I168_K1.6741.00
345_T370_I1.6681.00
133_E136_Y1.6391.00
203_K206_E1.6231.00
206_E221_D1.6011.00
171_V201_E1.5991.00
82_E92_V1.5941.00
335_E339_K1.5931.00
369_L381_A1.5931.00
269_Y304_N1.5881.00
210_S218_V1.5851.00
195_K198_S1.5851.00
85_D90_I1.5661.00
336_N340_R1.5641.00
111_T274_S1.5581.00
5_I104_F1.5571.00
164_R200_I1.5491.00
5_I30_T1.5401.00
327_I390_L1.5381.00
147_I163_L1.5281.00
178_Y189_G1.5231.00
30_T102_Y1.5071.00
28_H74_N1.4921.00
4_L27_M1.4811.00
108_L271_A1.4801.00
216_R226_D1.4691.00
405_T408_D1.4681.00
185_D368_K1.4661.00
95_E100_R1.4611.00
63_T67_F1.4451.00
262_R267_N1.4371.00
109_F274_S1.4351.00
186_E190_K1.4231.00
131_P134_A1.4071.00
260_H304_N1.3851.00
19_W303_N1.3841.00
157_I324_E1.3731.00
106_Y305_I1.3731.00
261_M275_T1.3711.00
207_S220_T1.3601.00
335_E368_K1.3581.00
129_H137_I1.3561.00
126_F129_H1.3371.00
145_N228_D1.3331.00
191_I384_V1.3331.00
203_K223_G1.3291.00
12_A294_A1.3291.00
338_A345_T1.3191.00
62_Y66_Y1.3181.00
265_V268_V1.3181.00
129_H133_E1.3181.00
131_P135_S1.3161.00
212_I218_V1.3151.00
343_I379_I1.3081.00
66_Y70_K1.3071.00
259_N311_T1.3051.00
187_D349_I1.3031.00
3_R30_T1.3021.00
174_H204_L1.2931.00
55_D59_F1.2861.00
194_D197_E1.2751.00
145_N169_K1.2571.00
178_Y186_E1.2561.00
47_Y50_E1.2451.00
298_G302_G1.2381.00
338_A370_I1.2361.00
209_V220_T1.2341.00
64_P67_F1.2341.00
4_L108_L1.2291.00
337_E340_R1.2241.00
83_E92_V1.2231.00
129_H134_A1.2221.00
68_I71_R1.2061.00
76_K100_R1.2001.00
63_T66_Y1.2001.00
344_K372_E1.1931.00
193_T202_L1.1931.00
152_G179_L1.1911.00
150_I230_T1.1901.00
255_I274_S1.1841.00
65_E69_E1.1821.00
218_V224_K1.1811.00
7_I109_F1.1661.00
89_R93_V1.1651.00
193_T204_L1.1591.00
132_A135_S1.1581.00
32_F93_V1.1511.00
146_R226_D1.1481.00
106_Y269_Y1.1441.00
369_L396_M1.1421.00
80_K94_R1.1401.00
125_I128_V1.1381.00
23_L303_N1.1361.00
211_V230_T1.1341.00
6_I17_A1.1321.00
76_K102_Y1.1321.00
302_G306_G1.1301.00
402_K408_D1.1231.00
173_I225_Y1.1231.00
115_P118_I1.1221.00
147_I229_A1.1171.00
125_I133_E1.1131.00
46_P49_T1.1111.00
146_R171_V1.1071.00
134_A137_I1.1061.00
261_M301_A1.1051.00
206_E220_T1.1041.00
352_H385_G1.0961.00
93_V102_Y1.0951.00
328_I384_V1.0951.00
347_S370_I1.0941.00
203_K225_Y1.0921.00
7_I81_V1.0841.00
135_S138_R1.0821.00
219_I223_G1.0801.00
184_L320_I1.0801.00
219_I222_K1.0791.00
188_M366_I1.0771.00
247_L265_V1.0771.00
188_M384_V1.0761.00
55_D58_L1.0751.00
194_D198_S1.0731.00
335_E345_T1.0731.00
190_K193_T1.0701.00
184_L330_K1.0691.00
125_I129_H1.0591.00
150_I232_V1.0591.00
128_V131_P1.0571.00
372_E377_R1.0531.00
349_I366_I1.0511.00
303_N308_K1.0471.00
335_E347_S1.0451.00
388_E391_G1.0441.00
82_E85_D1.0401.00
320_I330_K1.0391.00
396_M424_W1.0371.00
32_F81_V1.0361.00
119_N122_G1.0301.00
128_V211_V1.0281.00
129_H229_A1.0281.00
187_D368_K1.0261.00
197_E201_E1.0261.00
212_I216_R1.0251.00
257_A270_A1.0241.00
123_D128_V1.0191.00
83_E245_D1.0181.00
32_F76_K1.0141.00
157_I196_V1.0131.00
367_V423_V1.0131.00
394_N416_Y1.0131.00
271_A301_A1.0091.00
124_R129_H1.0081.00
259_N312_F1.0051.00
152_G174_H1.0031.00
172_L202_L1.0021.00
198_S364_D1.0011.00
65_E77_T0.9951.00
123_D126_F0.9941.00
329_G393_L0.9931.00
23_L306_G0.9881.00
262_R304_N0.9871.00
247_L255_I0.9871.00
178_Y193_T0.9871.00
134_A138_R0.9861.00
148_A225_Y0.9831.00
20_V302_G0.9811.00
95_E99_K0.9751.00
321_T416_Y0.9741.00
130_H135_S0.9741.00
54_D58_L0.9711.00
67_F71_R0.9701.00
19_W23_L0.9681.00
301_A304_N0.9661.00
404_F408_D0.9661.00
124_R128_V0.9621.00
376_M406_A0.9581.00
132_A136_Y0.9561.00
192_V384_V0.9551.00
64_P68_I0.9541.00
251_Q256_W0.9541.00
192_V328_I0.9521.00
339_K345_T0.9471.00
76_K81_V0.9461.00
16_A301_A0.9431.00
35_T45_I0.9411.00
300_V304_N0.9411.00
262_R265_V0.9361.00
173_I206_E0.9351.00
161_E165_A0.9301.00
257_A275_T0.9271.00
78_N81_V0.9251.00
27_M105_D0.9221.00
68_I73_I0.9221.00
128_V134_A0.9211.00
250_G276_E0.9201.00
137_I229_A0.9191.00
16_A298_G0.9151.00
46_P50_E0.9141.00
220_T223_G0.9121.00
346_V376_M0.9111.00
131_P138_R0.9051.00
252_T276_E0.9041.00
134_A163_L0.9031.00
333_V337_E0.9021.00
367_V383_I0.9001.00
191_I195_K0.8981.00
249_I256_W0.8951.00
19_W22_R0.8911.00
256_W264_S0.8911.00
240_I249_I0.8911.00
394_N421_N0.8901.00
349_I368_K0.8901.00
176_G181_N0.8901.00
177_R186_E0.8861.00
317_G400_I0.8841.00
116_K234_I0.8841.00
63_T68_I0.8841.00
9_G31_V0.8801.00
150_I208_L0.8751.00
81_V85_D0.8741.00
338_A343_I0.8741.00
174_H181_N0.8721.00
250_G256_W0.8721.00
188_M382_Q0.8701.00
321_T390_L0.8701.00
238_P254_A0.8671.00
334_T337_E0.8661.00
85_D89_R0.8651.00
156_G174_H0.8611.00
127_Y229_A0.8611.00
146_R168_K0.8561.00
260_H309_D0.8541.00
329_G389_V0.8541.00
27_M306_G0.8531.00
38_V75_V0.8531.00
149_I156_G0.8531.00
206_E223_G0.8521.00
179_L204_L0.8491.00
255_I270_A0.8481.00
243_V247_L0.8481.00
14_M31_V0.8471.00
270_A274_S0.8411.00
262_R269_Y0.8381.00
241_D244_K0.8361.00
190_K194_D0.8331.00
148_A217_V0.8331.00
129_H132_A0.8321.00
107_L268_V0.8291.00
108_L301_A0.8271.00
191_I194_D0.8261.00
45_I132_A0.8231.00
261_M304_N0.8211.00
337_E341_Y0.8181.00
30_T74_N0.8161.00
195_K364_D0.8151.00
113_A236_V0.8141.00
160_A172_L0.8141.00
146_R227_V0.8141.00
147_I231_V0.8131.00
179_L202_L0.8131.00
343_I372_E0.8131.00
150_I234_I0.8121.00
82_E94_R0.8111.00
173_I203_K0.8081.00
335_E370_I0.8071.00
178_Y336_N0.8041.00
331_T400_I0.8041.00
179_L193_T0.8021.00
119_N123_D0.8021.00
216_R224_K0.8001.00
395_M398_A0.7991.00
5_I107_L0.7981.00
18_S71_R0.7971.00
296_K299_F0.7961.00
263_T270_A0.7831.00
378_I396_M0.7801.00
257_A261_M0.7791.00
118_I232_V0.7791.00
16_A302_G0.7791.00
27_M305_I0.7791.00
348_A427_V0.7791.00
63_T71_R0.7781.00
19_W302_G0.7771.00
52_L58_L0.7711.00
20_V305_I0.7711.00
372_E379_I0.7691.00
195_K384_V0.7681.00
149_I231_V0.7681.00
27_M106_Y0.7641.00
300_V313_P0.7631.00
68_I75_V0.7621.00
206_E219_I0.7581.00
116_K119_N0.7561.00
212_I224_K0.7551.00
15_T295_N0.7531.00
247_L264_S0.7531.00
171_V227_V0.7491.00
399_V409_L0.7491.00
83_E107_L0.7481.00
62_Y65_E0.7481.00
88_S101_K0.7481.00
3_R27_M0.7471.00
144_F168_K0.7451.00
21_R73_I0.7441.00
66_Y69_E0.7431.00
24_K27_M0.7401.00
9_G33_E0.7381.00
9_G38_V0.7381.00
343_I370_I0.7361.00
381_A400_I0.7351.00
327_I388_E0.7351.00
123_D127_Y0.7341.00
21_R29_V0.7331.00
16_A271_A0.7291.00
219_I225_Y0.7281.00
314_G401_Q0.7271.00
130_H134_A0.7261.00
178_Y190_K0.7231.00
93_V100_R0.7231.00
331_T381_A0.7231.00
312_F315_V0.7221.00
20_V27_M0.7221.00
184_L328_I0.7211.00
196_V200_I0.7201.00
107_L267_N0.7191.00
160_A200_I0.7181.00
179_L189_G0.7171.00
404_F409_L0.7161.00
74_N100_R0.7151.00
196_V202_L0.7121.00
117_K232_V0.7121.00
346_V371_A0.7111.00
278_I318_T0.7101.00
377_R405_T0.7091.00
175_R181_N0.7071.00
18_S22_R0.7031.00
17_A73_I0.7021.00
52_L55_D0.7001.00
20_V306_G0.6981.00
90_I93_V0.6961.00
120_A208_L0.6951.00
254_A289_P0.6941.00
51_G54_D0.6941.00
207_S218_V0.6941.00
81_V84_V0.6921.00
62_Y67_F0.6891.00
369_L427_V0.6881.00
378_I400_I0.6871.00
154_I322_K0.6841.00
254_A276_E0.6841.00
355_R359_Y0.6831.00
31_V68_I0.6831.00
246_Q265_V0.6821.00
23_L308_K0.6811.00
356_A359_Y0.6811.00
34_S239_N0.6801.00
19_W299_F0.6771.00
3_R102_Y0.6761.00
271_A298_G0.6761.00
406_A410_F0.6741.00
42_P47_Y0.6731.00
125_I211_V0.6721.00
137_I163_L0.6711.00
50_E159_M0.6711.00
13_G17_A0.6701.00
185_D382_Q0.6691.00
139_Q229_A0.6671.00
401_Q411_F0.6631.00
334_T382_Q0.6601.00
331_T397_A0.6581.00
398_A404_F0.6581.00
36_K78_N0.6571.00
132_A137_I0.6561.00
52_L56_E0.6541.00
6_I16_A0.6521.00
163_L168_K0.6501.00
398_A402_K0.6491.00
240_I274_S0.6481.00
162_A166_R0.6471.00
355_R358_Y0.6461.00
408_D411_F0.6461.00
117_K130_H0.6451.00
396_M400_I0.6421.00
78_N93_V0.6411.00
218_V222_K0.6411.00
110_S271_A0.6401.00
77_T81_V0.6391.00
192_V324_E0.6371.00
375_T403_G0.6341.00
6_I13_G0.6341.00
303_N307_G0.6341.00
157_I179_L0.6311.00
214_E226_D0.6301.00
338_A379_I0.6291.00
191_I366_I0.6281.00
398_A409_L0.6271.00
351_H354_T0.6271.00
78_N82_E0.6251.00
89_R103_E0.6251.00
363_K386_E0.6251.00
124_R127_Y0.6241.00
165_A325_E0.6231.00
180_L192_V0.6221.00
397_A401_Q0.6221.00
20_V29_V0.6211.00
68_I72_K0.6211.00
249_I253_G0.6211.00
45_I49_T0.6181.00
417_V422_R0.6151.00
261_M300_V0.6151.00
173_I219_I0.6151.00
211_V232_V0.6111.00
383_I392_R0.6111.00
132_A138_R0.6111.00
47_Y52_L0.6071.00
369_L378_I0.6051.00
128_V135_S0.6051.00
44_G47_Y0.6021.00
259_N277_S0.6021.00
293_V318_T0.6011.00
188_M191_I0.6011.00
352_H423_V0.6001.00
345_T379_I0.5991.00
4_L302_G0.5991.00
157_I202_L0.5981.00
188_M328_I0.5961.00
240_I254_A0.5941.00
218_V223_G0.5931.00
348_A371_A0.5921.00
89_R265_V0.5911.00
125_I130_H0.5901.00
385_G389_V0.5881.00
80_K83_E0.5871.00
128_V133_E0.5861.00
104_F265_V0.5851.00
50_E54_D0.5851.00
131_P137_I0.5831.00
371_A406_A0.5821.00
65_E68_I0.5801.00
381_A393_L0.5801.00
370_I373_A0.5781.00
156_G233_A0.5781.00
249_I254_A0.5781.00
296_K425_D0.5771.00
159_M162_A0.5771.00
74_N77_T0.5741.00
129_H135_S0.5741.00
189_G193_T0.5731.00
391_G421_N0.5731.00
356_A360_P0.5721.00
61_T165_A0.5721.00
154_I320_I0.5701.00
67_F70_K0.5691.00
325_E386_E0.5691.00
398_A412_V0.5691.00
159_M231_V0.5681.00
171_V225_Y0.5671.00
104_F267_N0.5661.00
85_D92_V0.5641.00
297_M315_V0.5611.00
84_V109_F0.5601.00
54_D162_A0.5590.99
4_L305_I0.5590.99
50_E162_A0.5590.99
293_V297_M0.5580.99
362_S386_E0.5570.99
93_V99_K0.5570.99
209_V219_I0.5570.99
123_D129_H0.5560.99
133_E137_I0.5560.99
156_G175_R0.5550.99
269_Y305_I0.5540.99
64_P69_E0.5540.99
149_I160_A0.5530.99
327_I420_V0.5530.99
17_A31_V0.5520.99
226_D229_A0.5490.99
381_A424_W0.5440.99
88_S267_N0.5440.99
63_T70_K0.5440.99
271_A305_I0.5430.99
126_F133_E0.5430.99
255_I263_T0.5430.99
146_R164_R0.5420.99
94_R100_R0.5420.99
12_A110_S0.5400.99
252_T256_W0.5370.99
17_A29_V0.5360.99
401_Q412_V0.5360.99
4_L16_A0.5350.99
351_H364_D0.5340.99
161_E196_V0.5340.99
88_S93_V0.5330.99
351_H366_I0.5320.99
303_N311_T0.5310.99
51_G55_D0.5310.99
23_L302_G0.5290.99
184_L322_K0.5280.99
307_G312_F0.5280.99
241_D245_D0.5270.99
120_A123_D0.5270.99
106_Y262_R0.5260.99
67_F72_K0.5260.99
69_E72_K0.5260.99
395_M421_N0.5240.99
251_Q254_A0.5240.99
244_K249_I0.5230.99
273_D294_A0.5210.99
105_D267_N0.5200.99
333_V343_I0.5190.99
247_L268_V0.5190.99
147_I170_I0.5180.99
9_G39_S0.5170.99
400_I404_F0.5170.99
303_N310_V0.5150.99
295_N425_D0.5140.99
131_P136_Y0.5130.99
336_N339_K0.5130.99
127_Y130_H0.5120.99
227_V230_T0.5120.99
47_Y51_G0.5120.99
371_A376_M0.5100.99
3_R103_E0.5100.99
164_R199_E0.5090.99
407_E411_F0.5090.99
78_N94_R0.5090.99
394_N397_A0.5090.99
350_V354_T0.5090.99
146_R229_A0.5080.99
84_V92_V0.5080.99
71_R76_K0.5080.99
56_E60_M0.5070.99
372_E376_M0.5070.99
15_T298_G0.5050.99
40_H43_C0.5040.99
334_T370_I0.5040.99
36_K77_T0.5040.99
371_A378_I0.5030.99
160_A170_I0.5020.99
409_L412_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iwaA 2 0.8662 100 0.237 Contact Map
1ojtA 2 0.9524 100 0.237 Contact Map
2cduA 2 0.9955 100 0.242 Contact Map
3oc4A 2 0.9456 100 0.242 Contact Map
1xdiA 3 0.941 100 0.245 Contact Map
3ladA 2 0.9456 100 0.25 Contact Map
3ic9A 2 0.9365 100 0.251 Contact Map
3cgbA 2 0.9773 100 0.251 Contact Map
3icsA 2 0.9977 100 0.252 Contact Map
3ntdA 2 0.9955 100 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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