Q97WD6 - SULSO - GREMLIN Contacts

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Q97WD6 - Exodeoxyribonuclease

UniProt:	Q97WD6	Sequences: MKIVSWNINGLRSALKKNLVNFLESNTFDIVMFQETRGDIVPLDFIMMGYEVISFPARRKGYSGVMTLTKIKPIKVIKGLQIKEFDDEGRTVSLELKDFYLINAYFPRAGDNLERLDFKLKFNNGIENFLLKLREVKPVILCGDFNIAHQSIDAAFSDPKIPGLTPQERAWFTHLLSLGFIDTFRYLHPNVRKYSWWSYMGNAREKNLGLRLDYCIVSEELKDSIKMADILTDVQGSDHAPIILELT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	247 (243)
Sequences:	5730 (3433)
Seq/√Len:	220.2

ECOLI - EX3
BACSU - EXOA
SULSO - Q97WD6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
67_T	94_L	3.842	1.00
2_K	245_E	3.378	1.00
32_M	142_C	3.280	1.00
202_N	205_E	3.264	1.00
229_D	243_I	2.977	1.00
183_T	217_V	2.731	1.00
124_N	171_W	2.632	1.00
4_V	243_I	2.504	1.00
51_E	72_K	2.499	1.00
166_P	170_A	2.257	1.00
231_L	243_I	2.229	1.00
183_T	225_I	2.146	1.00
138_P	220_E	2.143	1.00
127_E	174_H	2.117	1.00
58_R	87_D	2.083	1.00
5_S	242_I	2.076	1.00
149_H	173_T	2.047	1.00
176_L	216_I	2.028	1.00
186_Y	222_K	1.978	1.00
219_E	222_K	1.959	1.00
32_M	101_L	1.947	1.00
95_E	137_K	1.936	1.00
134_R	220_E	1.930	1.00
159_P	166_P	1.898	1.00
22_F	26_N	1.893	1.00
227_M	245_E	1.882	1.00
193_K	232_T	1.867	1.00
33_F	36_T	1.865	1.00
181_I	219_E	1.862	1.00
172_F	216_I	1.854	1.00
195_S	242_I	1.837	1.00
74_I	97_K	1.822	1.00
139_V	180_F	1.816	1.00
11_L	38_G	1.796	1.00
121_K	125_G	1.771	1.00
215_C	244_L	1.754	1.00
187_L	225_I	1.701	1.00
184_F	193_K	1.677	1.00
84_E	121_K	1.663	1.00
18_N	21_N	1.614	1.00
28_F	31_V	1.606	1.00
226_K	245_E	1.568	1.00
188_H	191_V	1.566	1.00
142_C	215_C	1.513	1.00
170_A	174_H	1.505	1.00
181_I	186_Y	1.504	1.00
217_V	225_I	1.502	1.00
129_F	133_L	1.479	1.00
80_L	91_T	1.467	1.00
75_K	95_E	1.463	1.00
39_D	42_P	1.463	1.00
181_I	222_K	1.460	1.00
202_N	206_K	1.449	1.00
111_D	200_M	1.447	1.00
73_P	96_L	1.444	1.00
39_D	60_K	1.439	1.00
225_I	244_L	1.429	1.00
138_P	224_S	1.424	1.00
95_E	100_Y	1.420	1.00
51_E	71_I	1.419	1.00
21_N	24_E	1.413	1.00
149_H	214_Y	1.411	1.00
23_L	31_V	1.408	1.00
131_L	178_L	1.393	1.00
8_I	33_F	1.385	1.00
188_H	193_K	1.374	1.00
24_E	48_M	1.373	1.00
38_G	43_L	1.369	1.00
173_T	177_S	1.363	1.00
130_L	141_L	1.356	1.00
30_I	101_L	1.348	1.00
172_F	214_Y	1.346	1.00
218_S	221_L	1.341	1.00
127_E	131_L	1.330	1.00
20_V	24_E	1.319	1.00
32_M	103_N	1.314	1.00
12_R	42_P	1.312	1.00
102_I	130_L	1.293	1.00
150_Q	173_T	1.293	1.00
36_T	40_I	1.291	1.00
104_A	141_L	1.281	1.00
3_I	140_I	1.279	1.00
67_T	103_N	1.278	1.00
155_A	208_L	1.269	1.00
32_M	67_T	1.257	1.00
126_I	141_L	1.246	1.00
124_N	174_H	1.230	1.00
186_Y	225_I	1.211	1.00
3_I	101_L	1.210	1.00
201_G	208_L	1.190	1.00
203_A	208_L	1.177	1.00
120_L	167_Q	1.176	1.00
27_T	70_K	1.175	1.00
81_Q	86_D	1.169	1.00
110_G	114_E	1.161	1.00
123_N	147_I	1.160	1.00
171_W	174_H	1.157	1.00
3_I	30_I	1.145	1.00
127_E	178_L	1.143	1.00
148_A	154_A	1.142	1.00
130_L	180_F	1.140	1.00
111_D	114_E	1.125	1.00
217_V	222_K	1.122	1.00
140_I	215_C	1.114	1.00
195_S	230_I	1.112	1.00
38_G	42_P	1.099	1.00
85_F	125_G	1.091	1.00
29_D	70_K	1.089	1.00
124_N	128_N	1.082	1.00
187_L	227_M	1.079	1.00
231_L	234_V	1.074	1.00
148_A	164_L	1.074	1.00
40_I	54_S	1.072	1.00
106_F	123_N	1.069	1.00
228_A	244_L	1.065	1.00
104_A	145_F	1.060	1.00
141_L	145_F	1.056	1.00
151_S	159_P	1.055	1.00
121_K	124_N	1.052	1.00
100_Y	137_K	1.046	1.00
117_D	121_K	1.045	1.00
73_P	76_V	1.044	1.00
183_T	228_A	1.036	1.00
173_T	176_L	1.035	1.00
88_E	115_R	1.031	1.00
204_R	235_Q	1.031	1.00
217_V	246_L	1.030	1.00
15_L	20_V	1.029	1.00
69_T	94_L	1.023	1.00
55_F	78_K	1.018	1.00
187_L	228_A	1.017	1.00
55_F	79_G	1.016	1.00
53_I	76_V	1.003	1.00
141_L	216_I	1.000	1.00
131_L	134_R	0.998	1.00
82_I	125_G	0.997	1.00
120_L	171_W	0.995	1.00
133_L	139_V	0.990	1.00
151_S	164_L	0.988	1.00
21_N	25_S	0.987	1.00
69_T	73_P	0.986	1.00
116_L	165_T	0.985	1.00
100_Y	136_V	0.985	1.00
184_F	228_A	0.984	1.00
6_W	19_L	0.967	1.00
69_T	72_K	0.957	1.00
93_S	100_Y	0.949	1.00
112_N	117_D	0.942	1.00
20_V	48_M	0.942	1.00
22_F	231_L	0.941	1.00
113_L	117_D	0.938	1.00
127_E	175_L	0.932	1.00
98_D	224_S	0.931	1.00
30_I	96_L	0.923	0.99
207_N	232_T	0.923	0.99
75_K	100_Y	0.922	0.99
4_V	26_N	0.921	0.99
30_I	99_F	0.920	0.99
140_I	217_V	0.920	0.99
1_M	245_E	0.918	0.99
104_A	126_I	0.917	0.99
123_N	171_W	0.914	0.99
26_N	231_L	0.904	0.99
47_M	52_V	0.901	0.99
98_D	138_P	0.898	0.99
23_L	28_F	0.895	0.99
156_F	208_L	0.894	0.99
132_K	135_E	0.891	0.99
158_D	161_I	0.885	0.99
53_I	78_K	0.880	0.99
195_S	228_A	0.872	0.99
197_W	240_A	0.866	0.99
46_I	51_E	0.864	0.99
19_L	45_F	0.863	0.99
193_K	230_I	0.858	0.99
36_T	66_M	0.856	0.99
138_P	218_S	0.855	0.99
101_L	215_C	0.848	0.99
10_G	13_S	0.844	0.99
131_L	180_F	0.842	0.99
230_I	240_A	0.842	0.99
154_A	210_L	0.832	0.99
4_V	28_F	0.830	0.99
33_F	68_L	0.824	0.99
91_T	102_I	0.823	0.99
184_F	195_S	0.822	0.99
128_N	132_K	0.822	0.99
204_R	236_G	0.821	0.99
152_I	191_V	0.817	0.99
69_T	96_L	0.812	0.99
78_K	92_V	0.810	0.99
5_S	228_A	0.809	0.99
163_G	210_L	0.808	0.99
53_I	73_P	0.807	0.99
19_L	31_V	0.801	0.99
59_R	62_Y	0.801	0.99
170_A	173_T	0.800	0.99
2_K	26_N	0.798	0.98
84_E	125_G	0.798	0.98
129_F	132_K	0.795	0.98
103_N	142_C	0.792	0.98
93_S	102_I	0.789	0.98
222_K	225_I	0.789	0.98
53_I	69_T	0.784	0.98
231_L	236_G	0.782	0.98
74_I	95_E	0.781	0.98
234_V	240_A	0.780	0.98
71_I	97_K	0.779	0.98
184_F	191_V	0.778	0.98
85_F	118_F	0.771	0.98
184_F	230_I	0.769	0.98
30_I	71_I	0.769	0.98
93_S	129_F	0.767	0.98
138_P	221_L	0.759	0.98
197_W	207_N	0.756	0.98
193_K	229_D	0.751	0.98
91_T	129_F	0.747	0.98
106_F	122_F	0.745	0.98
5_S	34_Q	0.745	0.98
165_T	168_E	0.745	0.98
73_P	94_L	0.745	0.98
25_S	233_D	0.744	0.98
80_L	129_F	0.742	0.98
77_I	129_F	0.739	0.98
47_M	68_L	0.731	0.97
52_V	68_L	0.727	0.97
231_L	235_Q	0.725	0.97
91_T	126_I	0.723	0.97
128_N	131_L	0.716	0.97
215_C	242_I	0.714	0.97
67_T	92_V	0.712	0.97
67_T	101_L	0.712	0.97
106_F	145_F	0.701	0.97
217_V	244_L	0.700	0.97
188_H	227_M	0.695	0.96
217_V	221_L	0.695	0.96
34_Q	103_N	0.693	0.96
53_I	92_V	0.693	0.96
158_D	164_L	0.693	0.96
109_A	116_L	0.690	0.96
189_P	192_R	0.689	0.96
59_R	63_S	0.682	0.96
102_I	139_V	0.682	0.96
205_E	236_G	0.674	0.96
120_L	124_N	0.673	0.96
114_E	117_D	0.673	0.96
201_G	206_K	0.673	0.96
83_K	87_D	0.670	0.96
91_T	104_A	0.670	0.96
125_G	128_N	0.670	0.96
127_E	171_W	0.669	0.96
12_R	38_G	0.669	0.96
15_L	43_L	0.668	0.96
160_K	166_P	0.667	0.95
190_N	193_K	0.666	0.95
3_I	32_M	0.666	0.95
188_H	229_D	0.666	0.95
189_P	193_K	0.666	0.95
13_S	16_K	0.665	0.95
4_V	22_F	0.660	0.95
109_A	119_K	0.659	0.95
115_R	118_F	0.659	0.95
148_A	210_L	0.656	0.95
145_F	216_I	0.648	0.95
10_G	62_Y	0.641	0.94
203_A	206_K	0.641	0.94
227_M	243_I	0.637	0.94
10_G	61_G	0.633	0.94
152_I	192_R	0.633	0.94
6_W	236_G	0.627	0.94
31_V	68_L	0.626	0.94
159_P	164_L	0.624	0.94
119_K	123_N	0.615	0.93
158_D	210_L	0.614	0.93
16_K	20_V	0.613	0.93
65_V	92_V	0.612	0.93
174_H	177_S	0.611	0.93
202_N	232_T	0.610	0.93
172_F	176_L	0.610	0.93
141_L	175_L	0.609	0.93
167_Q	170_A	0.608	0.93
51_E	69_T	0.608	0.93
101_L	140_I	0.608	0.93
24_E	27_T	0.607	0.93
76_V	92_V	0.606	0.93
204_R	240_A	0.605	0.93
35_E	144_D	0.602	0.92
154_A	158_D	0.597	0.92
16_K	21_N	0.591	0.92
75_K	78_K	0.591	0.92
11_L	19_L	0.590	0.92
22_F	234_V	0.590	0.92
77_I	93_S	0.588	0.91
20_V	47_M	0.587	0.91
163_G	168_E	0.587	0.91
105_Y	144_D	0.584	0.91
130_L	175_L	0.584	0.91
126_I	129_F	0.583	0.91
119_K	171_W	0.583	0.91
232_T	235_Q	0.582	0.91
159_P	169_R	0.582	0.91
48_M	52_V	0.581	0.91
183_T	244_L	0.579	0.91
6_W	108_R	0.579	0.91
116_L	167_Q	0.578	0.91
131_L	174_H	0.577	0.91
188_H	228_A	0.577	0.91
157_S	161_I	0.572	0.90
55_F	92_V	0.571	0.90
140_I	246_L	0.570	0.90
155_A	210_L	0.569	0.90
4_V	231_L	0.568	0.90
36_T	39_D	0.567	0.90
145_F	214_Y	0.567	0.90
77_I	100_Y	0.566	0.90
144_D	238_D	0.565	0.90
102_I	106_F	0.563	0.90
197_W	209_G	0.560	0.89
96_L	99_F	0.557	0.89
35_E	146_N	0.557	0.89
219_E	223_D	0.557	0.89
85_F	121_K	0.555	0.89
7_N	146_N	0.555	0.89
99_F	221_L	0.553	0.89
187_L	192_R	0.553	0.89
23_L	50_Y	0.551	0.89
91_T	122_F	0.551	0.89
25_S	234_V	0.547	0.88
105_Y	146_N	0.547	0.88
49_G	71_I	0.546	0.88
110_G	161_I	0.545	0.88
182_D	211_R	0.544	0.88
168_E	196_W	0.538	0.87
26_N	234_V	0.537	0.87
184_F	187_L	0.537	0.87
186_Y	189_P	0.536	0.87
226_K	229_D	0.532	0.87
162_P	165_T	0.527	0.86
155_A	158_D	0.527	0.86
54_S	68_L	0.526	0.86
35_E	105_Y	0.524	0.86
1_M	4_V	0.524	0.86
14_A	18_N	0.524	0.86
19_L	33_F	0.522	0.86
152_I	190_N	0.520	0.86
116_L	162_P	0.518	0.85
183_T	222_K	0.517	0.85
71_I	96_L	0.517	0.85
74_I	99_F	0.516	0.85
120_L	123_N	0.511	0.85
9_N	12_R	0.511	0.85
45_F	48_M	0.510	0.85
164_L	210_L	0.510	0.85
30_I	69_T	0.510	0.85
77_I	95_E	0.509	0.84
186_Y	223_D	0.508	0.84
69_T	76_V	0.508	0.84
140_I	221_L	0.508	0.84
35_E	238_D	0.506	0.84
109_A	123_N	0.504	0.84
127_E	177_S	0.501	0.83
30_I	94_L	0.501	0.83
52_V	55_F	0.500	0.83
45_F	52_V	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3g91A	1	1	100	0.356	Contact Map
2jc5A	1	1	100	0.356	Contact Map
2j63A	1	1	100	0.357	Contact Map
1hd7A	1	0.9514	100	0.359	Contact Map
4f1rA	1	0.996	100	0.363	Contact Map
4jg3A	1	1	100	0.366	Contact Map
2voaA	1	0.9838	100	0.379	Contact Map
2jc4A	1	0.9879	100	0.381	Contact Map
1akoA	1	0.9879	100	0.401	Contact Map
4qheA	1	1	100	0.407	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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