GREMLIN Database
Q97WD6 - Exodeoxyribonuclease
UniProt: Q97WD6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (243)
Sequences: 5730 (3433)
Seq/√Len: 220.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_T94_L3.8421.00
2_K245_E3.3781.00
32_M142_C3.2801.00
202_N205_E3.2641.00
229_D243_I2.9771.00
183_T217_V2.7311.00
124_N171_W2.6321.00
4_V243_I2.5041.00
51_E72_K2.4991.00
166_P170_A2.2571.00
231_L243_I2.2291.00
183_T225_I2.1461.00
138_P220_E2.1431.00
127_E174_H2.1171.00
58_R87_D2.0831.00
5_S242_I2.0761.00
149_H173_T2.0471.00
176_L216_I2.0281.00
186_Y222_K1.9781.00
219_E222_K1.9591.00
32_M101_L1.9471.00
95_E137_K1.9361.00
134_R220_E1.9301.00
159_P166_P1.8981.00
22_F26_N1.8931.00
227_M245_E1.8821.00
193_K232_T1.8671.00
33_F36_T1.8651.00
181_I219_E1.8621.00
172_F216_I1.8541.00
195_S242_I1.8371.00
74_I97_K1.8221.00
139_V180_F1.8161.00
11_L38_G1.7961.00
121_K125_G1.7711.00
215_C244_L1.7541.00
187_L225_I1.7011.00
184_F193_K1.6771.00
84_E121_K1.6631.00
18_N21_N1.6141.00
28_F31_V1.6061.00
226_K245_E1.5681.00
188_H191_V1.5661.00
142_C215_C1.5131.00
170_A174_H1.5051.00
181_I186_Y1.5041.00
217_V225_I1.5021.00
129_F133_L1.4791.00
80_L91_T1.4671.00
75_K95_E1.4631.00
39_D42_P1.4631.00
181_I222_K1.4601.00
202_N206_K1.4491.00
111_D200_M1.4471.00
73_P96_L1.4441.00
39_D60_K1.4391.00
225_I244_L1.4291.00
138_P224_S1.4241.00
95_E100_Y1.4201.00
51_E71_I1.4191.00
21_N24_E1.4131.00
149_H214_Y1.4111.00
23_L31_V1.4081.00
131_L178_L1.3931.00
8_I33_F1.3851.00
188_H193_K1.3741.00
24_E48_M1.3731.00
38_G43_L1.3691.00
173_T177_S1.3631.00
130_L141_L1.3561.00
30_I101_L1.3481.00
172_F214_Y1.3461.00
218_S221_L1.3411.00
127_E131_L1.3301.00
20_V24_E1.3191.00
32_M103_N1.3141.00
12_R42_P1.3121.00
102_I130_L1.2931.00
150_Q173_T1.2931.00
36_T40_I1.2911.00
104_A141_L1.2811.00
3_I140_I1.2791.00
67_T103_N1.2781.00
155_A208_L1.2691.00
32_M67_T1.2571.00
126_I141_L1.2461.00
124_N174_H1.2301.00
186_Y225_I1.2111.00
3_I101_L1.2101.00
201_G208_L1.1901.00
203_A208_L1.1771.00
120_L167_Q1.1761.00
27_T70_K1.1751.00
81_Q86_D1.1691.00
110_G114_E1.1611.00
123_N147_I1.1601.00
171_W174_H1.1571.00
3_I30_I1.1451.00
127_E178_L1.1431.00
148_A154_A1.1421.00
130_L180_F1.1401.00
111_D114_E1.1251.00
217_V222_K1.1221.00
140_I215_C1.1141.00
195_S230_I1.1121.00
38_G42_P1.0991.00
85_F125_G1.0911.00
29_D70_K1.0891.00
124_N128_N1.0821.00
187_L227_M1.0791.00
231_L234_V1.0741.00
148_A164_L1.0741.00
40_I54_S1.0721.00
106_F123_N1.0691.00
228_A244_L1.0651.00
104_A145_F1.0601.00
141_L145_F1.0561.00
151_S159_P1.0551.00
121_K124_N1.0521.00
100_Y137_K1.0461.00
117_D121_K1.0451.00
73_P76_V1.0441.00
183_T228_A1.0361.00
173_T176_L1.0351.00
88_E115_R1.0311.00
204_R235_Q1.0311.00
217_V246_L1.0301.00
15_L20_V1.0291.00
69_T94_L1.0231.00
55_F78_K1.0181.00
187_L228_A1.0171.00
55_F79_G1.0161.00
53_I76_V1.0031.00
141_L216_I1.0001.00
131_L134_R0.9981.00
82_I125_G0.9971.00
120_L171_W0.9951.00
133_L139_V0.9901.00
151_S164_L0.9881.00
21_N25_S0.9871.00
69_T73_P0.9861.00
116_L165_T0.9851.00
100_Y136_V0.9851.00
184_F228_A0.9841.00
6_W19_L0.9671.00
69_T72_K0.9571.00
93_S100_Y0.9491.00
112_N117_D0.9421.00
20_V48_M0.9421.00
22_F231_L0.9411.00
113_L117_D0.9381.00
127_E175_L0.9321.00
98_D224_S0.9311.00
30_I96_L0.9230.99
207_N232_T0.9230.99
75_K100_Y0.9220.99
4_V26_N0.9210.99
30_I99_F0.9200.99
140_I217_V0.9200.99
1_M245_E0.9180.99
104_A126_I0.9170.99
123_N171_W0.9140.99
26_N231_L0.9040.99
47_M52_V0.9010.99
98_D138_P0.8980.99
23_L28_F0.8950.99
156_F208_L0.8940.99
132_K135_E0.8910.99
158_D161_I0.8850.99
53_I78_K0.8800.99
195_S228_A0.8720.99
197_W240_A0.8660.99
46_I51_E0.8640.99
19_L45_F0.8630.99
193_K230_I0.8580.99
36_T66_M0.8560.99
138_P218_S0.8550.99
101_L215_C0.8480.99
10_G13_S0.8440.99
131_L180_F0.8420.99
230_I240_A0.8420.99
154_A210_L0.8320.99
4_V28_F0.8300.99
33_F68_L0.8240.99
91_T102_I0.8230.99
184_F195_S0.8220.99
128_N132_K0.8220.99
204_R236_G0.8210.99
152_I191_V0.8170.99
69_T96_L0.8120.99
78_K92_V0.8100.99
5_S228_A0.8090.99
163_G210_L0.8080.99
53_I73_P0.8070.99
19_L31_V0.8010.99
59_R62_Y0.8010.99
170_A173_T0.8000.99
2_K26_N0.7980.98
84_E125_G0.7980.98
129_F132_K0.7950.98
103_N142_C0.7920.98
93_S102_I0.7890.98
222_K225_I0.7890.98
53_I69_T0.7840.98
231_L236_G0.7820.98
74_I95_E0.7810.98
234_V240_A0.7800.98
71_I97_K0.7790.98
184_F191_V0.7780.98
85_F118_F0.7710.98
184_F230_I0.7690.98
30_I71_I0.7690.98
93_S129_F0.7670.98
138_P221_L0.7590.98
197_W207_N0.7560.98
193_K229_D0.7510.98
91_T129_F0.7470.98
106_F122_F0.7450.98
5_S34_Q0.7450.98
165_T168_E0.7450.98
73_P94_L0.7450.98
25_S233_D0.7440.98
80_L129_F0.7420.98
77_I129_F0.7390.98
47_M68_L0.7310.97
52_V68_L0.7270.97
231_L235_Q0.7250.97
91_T126_I0.7230.97
128_N131_L0.7160.97
215_C242_I0.7140.97
67_T92_V0.7120.97
67_T101_L0.7120.97
106_F145_F0.7010.97
217_V244_L0.7000.97
188_H227_M0.6950.96
217_V221_L0.6950.96
34_Q103_N0.6930.96
53_I92_V0.6930.96
158_D164_L0.6930.96
109_A116_L0.6900.96
189_P192_R0.6890.96
59_R63_S0.6820.96
102_I139_V0.6820.96
205_E236_G0.6740.96
120_L124_N0.6730.96
114_E117_D0.6730.96
201_G206_K0.6730.96
83_K87_D0.6700.96
91_T104_A0.6700.96
125_G128_N0.6700.96
127_E171_W0.6690.96
12_R38_G0.6690.96
15_L43_L0.6680.96
160_K166_P0.6670.95
190_N193_K0.6660.95
3_I32_M0.6660.95
188_H229_D0.6660.95
189_P193_K0.6660.95
13_S16_K0.6650.95
4_V22_F0.6600.95
109_A119_K0.6590.95
115_R118_F0.6590.95
148_A210_L0.6560.95
145_F216_I0.6480.95
10_G62_Y0.6410.94
203_A206_K0.6410.94
227_M243_I0.6370.94
10_G61_G0.6330.94
152_I192_R0.6330.94
6_W236_G0.6270.94
31_V68_L0.6260.94
159_P164_L0.6240.94
119_K123_N0.6150.93
158_D210_L0.6140.93
16_K20_V0.6130.93
65_V92_V0.6120.93
174_H177_S0.6110.93
202_N232_T0.6100.93
172_F176_L0.6100.93
141_L175_L0.6090.93
167_Q170_A0.6080.93
51_E69_T0.6080.93
101_L140_I0.6080.93
24_E27_T0.6070.93
76_V92_V0.6060.93
204_R240_A0.6050.93
35_E144_D0.6020.92
154_A158_D0.5970.92
16_K21_N0.5910.92
75_K78_K0.5910.92
11_L19_L0.5900.92
22_F234_V0.5900.92
77_I93_S0.5880.91
20_V47_M0.5870.91
163_G168_E0.5870.91
105_Y144_D0.5840.91
130_L175_L0.5840.91
126_I129_F0.5830.91
119_K171_W0.5830.91
232_T235_Q0.5820.91
159_P169_R0.5820.91
48_M52_V0.5810.91
183_T244_L0.5790.91
6_W108_R0.5790.91
116_L167_Q0.5780.91
131_L174_H0.5770.91
188_H228_A0.5770.91
157_S161_I0.5720.90
55_F92_V0.5710.90
140_I246_L0.5700.90
155_A210_L0.5690.90
4_V231_L0.5680.90
36_T39_D0.5670.90
145_F214_Y0.5670.90
77_I100_Y0.5660.90
144_D238_D0.5650.90
102_I106_F0.5630.90
197_W209_G0.5600.89
96_L99_F0.5570.89
35_E146_N0.5570.89
219_E223_D0.5570.89
85_F121_K0.5550.89
7_N146_N0.5550.89
99_F221_L0.5530.89
187_L192_R0.5530.89
23_L50_Y0.5510.89
91_T122_F0.5510.89
25_S234_V0.5470.88
105_Y146_N0.5470.88
49_G71_I0.5460.88
110_G161_I0.5450.88
182_D211_R0.5440.88
168_E196_W0.5380.87
26_N234_V0.5370.87
184_F187_L0.5370.87
186_Y189_P0.5360.87
226_K229_D0.5320.87
162_P165_T0.5270.86
155_A158_D0.5270.86
54_S68_L0.5260.86
35_E105_Y0.5240.86
1_M4_V0.5240.86
14_A18_N0.5240.86
19_L33_F0.5220.86
152_I190_N0.5200.86
116_L162_P0.5180.85
183_T222_K0.5170.85
71_I96_L0.5170.85
74_I99_F0.5160.85
120_L123_N0.5110.85
9_N12_R0.5110.85
45_F48_M0.5100.85
164_L210_L0.5100.85
30_I69_T0.5100.85
77_I95_E0.5090.84
186_Y223_D0.5080.84
69_T76_V0.5080.84
140_I221_L0.5080.84
35_E238_D0.5060.84
109_A123_N0.5040.84
127_E177_S0.5010.83
30_I94_L0.5010.83
52_V55_F0.5000.83
45_F52_V0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g91A 1 1 100 0.356 Contact Map
2jc5A 1 1 100 0.356 Contact Map
2j63A 1 1 100 0.357 Contact Map
1hd7A 1 0.9514 100 0.359 Contact Map
4f1rA 1 0.996 100 0.363 Contact Map
4jg3A 1 1 100 0.366 Contact Map
2voaA 1 0.9838 100 0.379 Contact Map
2jc4A 1 0.9879 100 0.381 Contact Map
1akoA 1 0.9879 100 0.401 Contact Map
4qheA 1 1 100 0.407 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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