GREMLIN Database
Q97WD5 - Protein kinase, putative
UniProt: Q97WD5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 554 (444)
Sequences: 926 (891)
Seq/√Len: 42.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
379_A424_L7.2081.00
346_E423_K7.0691.00
365_W525_P4.9541.00
393_V472_T4.5221.00
261_V268_Y4.4591.00
391_L460_A3.4831.00
399_Y425_G3.2491.00
314_L343_I3.2021.00
466_I535_M3.0441.00
377_A549_I3.0341.00
372_L422_V3.0141.00
373_I473_A2.9991.00
394_K441_T2.9911.00
518_L521_I2.9381.00
393_V424_L2.8761.00
395_P444_Y2.8341.00
477_L528_L2.8041.00
384_H546_Y2.7891.00
466_I546_Y2.7681.00
539_R542_A2.7641.00
531_L549_I2.6541.00
258_I269_A2.6191.00
534_D544_A2.6091.00
32_M35_I2.5951.00
261_V270_M2.5501.00
253_G258_I2.4911.00
380_L469_L2.4601.00
354_L396_Q2.4131.00
32_M36_A2.3011.00
308_T382_V2.2991.00
544_A549_I2.2131.00
394_K426_D2.1951.00
440_F482_V2.1530.99
184_K187_P2.1150.99
530_N552_N2.0980.99
530_N534_D2.0930.99
253_G269_A2.0810.99
138_Q142_W2.0770.99
169_K172_T2.0570.99
548_T551_Y1.9940.99
160_L165_N1.9590.99
33_Y41_S1.9460.99
193_N196_E1.9110.99
166_I172_T1.9090.99
471_A482_V1.9070.99
440_F445_C1.8900.99
473_A531_L1.8620.99
248_D260_K1.8400.98
162_W169_K1.8180.98
139_L142_W1.8160.98
186_N189_F1.8110.98
274_K393_V1.8080.98
400_F422_V1.8060.98
442_E449_Q1.7990.98
460_A464_M1.7990.98
164_I168_G1.7690.98
184_K196_E1.7620.98
442_E445_C1.7600.98
97_T100_L1.7570.98
159_N163_N1.7540.98
93_Y101_S1.7170.97
517_V521_I1.7060.97
463_S545_I1.7040.97
380_L393_V1.6940.97
304_V375_D1.6830.97
34_G42_S1.6200.96
110_Y113_F1.6150.96
188_S191_V1.6140.96
244_Y316_A1.6030.96
35_I41_S1.6010.96
138_Q141_A1.5980.96
143_R146_S1.5970.96
253_G392_D1.5880.96
537_L542_A1.5730.96
64_P68_S1.5670.96
208_G211_S1.5610.96
251_A258_I1.5420.95
203_P206_T1.5420.95
92_K95_I1.5270.95
156_L161_K1.5240.95
398_I424_L1.5240.95
42_S50_G1.5150.95
166_I170_N1.5060.95
31_V43_I1.4980.94
52_L60_P1.4880.94
169_K173_F1.4840.94
202_L205_P1.4670.94
162_W165_N1.4650.94
37_L44_G1.4650.94
373_I469_L1.4550.93
445_C451_E1.4400.93
249_L252_I1.4310.93
158_D164_I1.4280.93
470_G535_M1.4050.92
34_G38_G1.3920.92
251_A269_A1.3900.92
162_W171_Y1.3890.92
116_E124_I1.3840.92
224_R231_W1.3780.91
40_L43_I1.3740.91
198_Y204_K1.3650.91
191_V194_V1.3640.91
392_D426_D1.3570.91
318_S474_Y1.3490.91
93_Y98_V1.3440.90
43_I48_L1.3390.90
81_L87_C1.3320.90
38_G45_Y1.3310.90
377_A469_L1.3170.89
467_F552_N1.3130.89
32_M40_L1.3120.89
190_Y201_Y1.3100.89
39_S49_A1.3090.89
32_M37_L1.3050.89
35_I38_G1.3000.89
91_R103_S1.2850.88
47_T57_L1.2810.88
352_N429_S1.2780.88
142_W146_S1.2760.88
45_Y55_F1.2710.88
445_C483_Y1.2670.88
474_Y483_Y1.2620.87
162_W166_I1.2550.87
78_S85_F1.2500.87
228_I231_W1.2500.87
535_M549_I1.2480.87
381_D385_S1.2450.87
469_L549_I1.2440.87
445_C482_V1.2350.86
396_Q439_E1.2340.86
466_I545_I1.2180.85
207_Y211_S1.2160.85
39_S44_G1.2150.85
401_N421_T1.2010.85
249_L259_L1.1970.84
167_D172_T1.1900.84
93_Y135_N1.1860.84
113_F120_E1.1850.84
531_L544_A1.1820.84
137_V141_A1.1780.83
206_T210_I1.1770.83
474_Y482_V1.1750.83
134_G137_V1.1720.83
246_V261_V1.1720.83
190_Y194_V1.1690.83
220_T223_S1.1670.83
348_M423_K1.1640.83
40_L47_T1.1620.83
170_N174_T1.1610.82
195_L199_N1.1530.82
33_Y43_I1.1520.82
165_N168_G1.1490.82
178_V209_I1.1450.82
204_K208_G1.1430.81
397_N426_D1.1400.81
96_I100_L1.1390.81
160_L163_N1.1360.81
155_G159_N1.1310.81
444_Y481_Y1.1310.81
167_D171_Y1.1300.81
156_L159_N1.1270.81
377_A546_Y1.1270.81
31_V34_G1.1240.80
181_K192_G1.1190.80
259_L318_S1.1180.80
253_G426_D1.1160.80
275_I321_D1.1140.80
259_L272_I1.1090.79
439_E460_A1.1090.79
109_T114_I1.1080.79
171_Y177_Q1.1060.79
43_I47_T1.1040.79
162_W167_D1.1010.79
187_P190_Y1.1000.79
92_K96_I1.0980.79
198_Y202_L1.0950.79
41_S50_G1.0950.79
135_N139_L1.0910.78
164_I167_D1.0880.78
273_P429_S1.0880.78
56_T64_P1.0860.78
535_M546_Y1.0830.78
445_C471_A1.0780.77
384_H391_L1.0770.77
494_A497_D1.0700.77
185_K188_S1.0690.77
135_N146_S1.0680.77
157_P168_G1.0660.77
269_A426_D1.0640.77
129_G137_V1.0630.76
316_A472_T1.0530.76
39_S42_S1.0520.76
515_Y521_I1.0470.75
76_L79_I1.0370.75
345_M440_F1.0360.75
168_G172_T1.0340.74
294_L440_F1.0310.74
294_L445_C1.0310.74
130_F133_I1.0310.74
494_A499_Q1.0290.74
37_L40_L1.0280.74
36_A40_L1.0270.74
117_L121_S1.0260.74
546_Y549_I1.0250.74
50_G53_Y1.0230.74
314_L483_Y1.0230.74
184_K188_S1.0220.74
191_V202_L1.0210.74
133_I137_V1.0190.73
143_R147_R1.0190.73
118_I125_W1.0180.73
443_F481_Y1.0140.73
94_G98_V1.0090.73
188_S199_N1.0080.73
425_G464_M1.0080.73
467_F536_L1.0080.73
88_K91_R1.0050.72
429_S450_I1.0020.72
193_N199_N0.9980.72
36_A39_S0.9930.71
133_I146_S0.9890.71
119_Q124_I0.9810.70
118_I121_S0.9800.70
259_L429_S0.9800.70
393_V429_S0.9800.70
178_V192_G0.9790.70
157_P170_N0.9730.70
106_V109_T0.9730.70
391_L439_E0.9720.70
33_Y36_A0.9700.70
35_I43_I0.9580.69
375_D421_T0.9560.68
275_I439_E0.9550.68
312_V345_M0.9540.68
297_E392_D0.9530.68
496_E499_Q0.9490.68
40_L51_I0.9490.68
354_L430_A0.9490.68
57_L65_P0.9480.68
167_D170_N0.9450.68
31_V35_I0.9440.67
531_L535_M0.9430.67
116_E119_Q0.9420.67
279_A396_Q0.9410.67
157_P160_L0.9390.67
185_K191_V0.9390.67
159_N162_W0.9390.67
137_V145_G0.9350.67
35_I40_L0.9310.66
48_L56_T0.9300.66
97_T101_S0.9280.66
311_V427_L0.9280.66
395_P479_D0.9270.66
90_V100_L0.9260.66
380_L425_G0.9250.66
164_I169_K0.9210.66
35_I45_Y0.9180.65
260_K347_L0.9170.65
393_V462_P0.9170.65
264_G546_Y0.9150.65
535_M544_A0.9140.65
368_I400_F0.9100.65
255_S273_P0.9100.65
381_D547_T0.9090.65
187_P191_V0.9070.64
203_P207_Y0.9070.64
240_K244_Y0.9000.64
125_W184_K0.8980.64
301_L343_I0.8950.63
165_N169_K0.8950.63
253_G428_G0.8940.63
126_I133_I0.8890.63
260_K267_F0.8880.63
225_L229_N0.8880.63
185_K194_V0.8870.63
194_V200_I0.8840.62
449_Q460_A0.8830.62
33_Y40_L0.8820.62
395_P425_G0.8820.62
442_E482_V0.8820.62
31_V38_G0.8750.62
352_N399_Y0.8750.62
274_K302_Q0.8690.61
193_N197_G0.8680.61
64_P67_L0.8620.60
56_T59_S0.8620.60
97_T103_S0.8610.60
352_N438_R0.8570.60
352_N443_F0.8550.60
52_L56_T0.8540.60
158_D162_W0.8520.59
87_C91_R0.8500.59
310_N390_H0.8490.59
516_A521_I0.8450.59
194_V204_K0.8440.59
488_Y491_V0.8440.59
50_G56_T0.8430.59
135_N138_Q0.8410.58
244_Y270_M0.8380.58
35_I51_I0.8360.58
490_I494_A0.8360.58
89_T97_T0.8360.58
425_G429_S0.8350.58
426_D441_T0.8340.58
157_P163_N0.8300.57
192_G196_E0.8290.57
70_S73_S0.8290.57
439_E475_K0.8280.57
163_N172_T0.8270.57
398_I422_V0.8260.57
354_L425_G0.8260.57
389_V475_K0.8240.57
324_N441_T0.8230.57
300_N377_A0.8230.57
125_W129_G0.8230.57
104_Y119_Q0.8220.57
468_A475_K0.8220.57
161_K165_N0.8220.57
118_I145_G0.8190.56
445_C549_I0.8180.56
49_A52_L0.8170.56
225_L231_W0.8150.56
498_F538_Q0.8120.56
316_A370_G0.8090.55
161_K164_I0.8070.55
52_L112_F0.8060.55
142_W145_G0.8060.55
380_L546_Y0.8040.55
94_G100_L0.8040.55
42_S45_Y0.8030.55
113_F121_S0.8010.55
139_L146_S0.8010.55
32_M43_I0.8000.55
387_G462_P0.7980.54
352_N355_Q0.7980.54
127_L130_F0.7980.54
103_S118_I0.7980.54
92_K101_S0.7970.54
114_I117_L0.7970.54
139_L143_R0.7960.54
95_I99_L0.7950.54
46_S51_I0.7950.54
55_F58_Y0.7920.54
95_I98_V0.7920.54
159_N164_I0.7900.54
467_F479_D0.7890.54
122_I139_L0.7880.54
273_P354_L0.7880.54
155_G158_D0.7880.54
347_L420_V0.7820.53
104_Y124_I0.7820.53
537_L544_A0.7780.53
140_L145_G0.7770.52
40_L44_G0.7760.52
388_Y479_D0.7760.52
256_S356_L0.7760.52
62_L71_A0.7760.52
467_F483_Y0.7760.52
357_L368_I0.7740.52
249_L257_Y0.7730.52
40_L46_S0.7700.52
422_V467_F0.7690.52
36_A44_G0.7680.52
156_L160_L0.7680.52
136_I139_L0.7670.52
429_S464_M0.7650.51
439_E471_A0.7650.51
39_S61_F0.7640.51
36_A50_G0.7620.51
83_K87_C0.7600.51
318_S395_P0.7600.51
133_I141_A0.7600.51
194_V198_Y0.7600.51
266_M323_N0.7600.51
516_A520_K0.7590.51
183_R187_P0.7570.51
253_G256_S0.7570.51
106_V112_F0.7550.50
442_E484_P0.7540.50
197_G201_Y0.7540.50
120_E130_F0.7530.50
168_G178_V0.7530.50
53_Y56_T0.7520.50
31_V41_S0.7510.50
137_V140_L0.7510.50
296_K472_T0.7500.50
168_G171_Y0.7490.50
224_R228_I0.7480.50
124_I145_G0.7470.50
244_Y425_G0.7460.50
307_K313_Q0.7430.49
156_L168_G0.7430.49
87_C92_K0.7410.49
79_I82_Y0.7400.49
347_L401_N0.7370.49
111_N115_A0.7360.49
312_V422_V0.7360.49
275_I278_S0.7340.48
161_K170_N0.7340.48
120_E124_I0.7310.48
144_T147_R0.7300.48
135_N147_R0.7290.48
108_Y111_N0.7280.48
107_L120_E0.7270.48
86_K94_G0.7270.48
390_H472_T0.7250.48
293_D431_R0.7220.47
390_H545_I0.7210.47
75_L81_L0.7190.47
158_D163_N0.7190.47
270_M344_V0.7170.47
171_Y174_T0.7170.47
365_W528_L0.7150.47
157_P164_I0.7140.47
268_Y296_K0.7120.46
189_F194_V0.7100.46
78_S103_S0.7100.46
293_D443_F0.7080.46
130_F142_W0.7030.46
203_P209_I0.7020.45
254_G396_Q0.7020.45
528_L535_M0.7020.45
193_N212_S0.7000.45
525_P552_N0.7000.45
203_P210_I0.6990.45
124_I128_I0.6980.45
143_R166_I0.6980.45
134_G144_T0.6980.45
481_Y494_A0.6970.45
298_F384_H0.6960.45
80_F96_I0.6950.45
351_G538_Q0.6950.45
185_K203_P0.6950.45
343_I473_A0.6940.45
465_D543_R0.6920.45
157_P165_N0.6920.45
294_L318_S0.6910.44
79_I102_I0.6880.44
485_K490_I0.6870.44
140_L143_R0.6870.44
50_G59_S0.6860.44
124_I127_L0.6810.43
374_R550_E0.6800.43
276_N347_L0.6780.43
157_P161_K0.6780.43
377_A550_E0.6770.43
472_T536_L0.6770.43
359_A389_V0.6770.43
72_I81_L0.6740.43
440_F443_F0.6740.43
290_I293_D0.6730.43
42_S47_T0.6730.43
107_L127_L0.6710.43
54_T57_L0.6700.42
399_Y467_F0.6690.42
50_G55_F0.6690.42
80_F137_V0.6680.42
241_I318_S0.6680.42
56_T62_L0.6680.42
439_E443_F0.6670.42
192_G195_L0.6660.42
73_S79_I0.6650.42
32_M42_S0.6650.42
524_I528_L0.6630.42
107_L133_I0.6630.42
102_I177_Q0.6610.42
438_R441_T0.6600.42
132_E139_L0.6590.41
156_L163_N0.6590.41
133_I138_Q0.6590.41
469_L535_M0.6560.41
141_A146_S0.6560.41
165_N177_Q0.6550.41
439_E464_M0.6530.41
253_G394_K0.6520.41
194_V201_Y0.6490.41
105_V113_F0.6490.41
199_N203_P0.6490.41
69_L73_S0.6480.40
293_D391_L0.6480.40
43_I46_S0.6470.40
206_T209_I0.6460.40
375_D422_V0.6450.40
269_A399_Y0.6450.40
395_P438_R0.6420.40
445_C499_Q0.6420.40
158_D170_N0.6420.40
84_A112_F0.6420.40
254_G443_F0.6400.40
389_V431_R0.6400.40
268_Y445_C0.6390.40
301_L471_A0.6390.40
161_K166_I0.6380.40
188_S192_G0.6360.39
137_V146_S0.6360.39
392_D440_F0.6360.39
190_Y195_L0.6350.39
183_R191_V0.6350.39
102_I126_I0.6340.39
95_I102_I0.6330.39
316_A433_I0.6320.39
261_V344_V0.6310.39
390_H423_K0.6300.39
46_S50_G0.6290.39
128_I132_E0.6280.39
201_Y208_G0.6280.39
48_L51_I0.6260.38
40_L45_Y0.6250.38
481_Y485_K0.6230.38
491_V499_Q0.6220.38
348_M429_S0.6170.38
363_K437_V0.6170.38
48_L57_L0.6150.37
127_L132_E0.6150.37
145_G148_T0.6140.37
34_G43_I0.6130.37
75_L103_S0.6130.37
162_W168_G0.6090.37
42_S52_L0.6080.37
56_T68_S0.6070.37
155_G160_L0.6060.37
296_K443_F0.6050.37
111_N120_E0.6050.37
46_S49_A0.6030.36
190_Y193_N0.6020.36
310_N316_A0.6020.36
81_L86_K0.6010.36
128_I133_I0.6000.36
66_L87_C0.5980.36
270_M298_F0.5980.36
361_R378_K0.5970.36
374_R378_K0.5960.36
361_R518_L0.5950.36
469_L546_Y0.5940.36
77_A80_F0.5930.36
163_N167_D0.5930.36
58_Y66_L0.5930.36
89_T96_I0.5900.35
478_F524_I0.5890.35
230_N233_P0.5880.35
34_G39_S0.5870.35
41_S44_G0.5860.35
261_V396_Q0.5850.35
311_V379_A0.5840.35
112_F116_E0.5830.35
41_S55_F0.5830.35
95_I101_S0.5830.35
202_L206_T0.5830.35
163_N166_I0.5810.35
372_L400_F0.5790.34
269_A392_D0.5790.34
37_L71_A0.5780.34
94_G97_T0.5780.34
268_Y344_V0.5770.34
193_N202_L0.5760.34
39_S47_T0.5760.34
132_E135_N0.5760.34
38_G58_Y0.5750.34
85_F126_I0.5750.34
391_L429_S0.5720.34
44_G56_T0.5710.34
321_D368_I0.5710.34
48_L71_A0.5700.34
47_T50_G0.5690.34
255_S296_K0.5690.34
52_L57_L0.5680.33
444_Y536_L0.5680.33
439_E481_Y0.5680.33
129_G177_Q0.5670.33
52_L63_L0.5660.33
390_H439_E0.5660.33
228_I236_W0.5660.33
172_T191_V0.5630.33
158_D165_N0.5630.33
372_L398_I0.5630.33
302_Q467_F0.5630.33
36_A52_L0.5630.33
444_Y475_K0.5620.33
110_Y124_I0.5620.33
253_G440_F0.5600.33
517_V520_K0.5600.33
394_K440_F0.5600.33
74_Y126_I0.5590.33
352_N441_T0.5580.33
104_Y109_T0.5570.33
68_S142_W0.5570.33
86_K113_F0.5540.32
31_V37_L0.5530.32
466_I544_A0.5530.32
345_M349_E0.5520.32
230_N235_L0.5520.32
36_A49_A0.5510.32
133_I140_L0.5500.32
446_P460_A0.5500.32
118_I124_I0.5480.32
318_S467_F0.5480.32
43_I58_Y0.5470.32
207_Y210_I0.5460.32
75_L86_K0.5460.32
352_N391_L0.5450.32
33_Y38_G0.5440.31
165_N174_T0.5440.31
445_C464_M0.5440.31
106_V111_N0.5430.31
167_D174_T0.5420.31
186_N194_V0.5410.31
262_R551_Y0.5410.31
272_I379_A0.5390.31
423_K428_G0.5390.31
158_D174_T0.5390.31
58_Y75_L0.5380.31
396_Q425_G0.5380.31
532_L536_L0.5370.31
101_S142_W0.5360.31
64_P117_L0.5350.31
323_N461_L0.5350.31
59_S73_S0.5350.31
247_V262_R0.5330.31
161_K168_G0.5320.30
115_A118_I0.5310.30
40_L48_L0.5310.30
223_S227_D0.5310.30
41_S45_Y0.5300.30
202_L210_I0.5300.30
106_V117_L0.5290.30
184_K207_Y0.5290.30
135_N141_A0.5280.30
189_F209_I0.5280.30
521_I524_I0.5280.30
278_S439_E0.5260.30
138_Q149_I0.5260.30
343_I444_Y0.5250.30
471_A474_Y0.5250.30
352_N450_I0.5250.30
437_V443_F0.5240.30
49_A53_Y0.5240.30
381_D446_P0.5240.30
130_F143_R0.5240.30
345_M442_E0.5230.30
107_L111_N0.5190.29
101_S120_E0.5190.29
159_N170_N0.5180.29
142_W147_R0.5170.29
83_K93_Y0.5170.29
396_Q443_F0.5170.29
318_S368_I0.5160.29
254_G439_E0.5150.29
39_S43_I0.5140.29
187_P194_V0.5140.29
101_S109_T0.5140.29
376_V424_L0.5130.29
443_F472_T0.5110.29
183_R197_G0.5100.29
105_V111_N0.5100.29
77_A128_I0.5090.29
436_D486_E0.5090.29
89_T128_I0.5080.29
122_I138_Q0.5080.29
166_I169_K0.5080.29
39_S45_Y0.5070.29
460_A485_K0.5060.28
278_S460_A0.5050.28
109_T137_V0.5030.28
368_I396_Q0.5030.28
125_W145_G0.5010.28
78_S82_Y0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gv1A 1 0.4549 100 0.432 Contact Map
4lqsA 1 0.5253 100 0.436 Contact Map
4gt4A 1 0.4549 100 0.438 Contact Map
4qoxA 1 0.4819 100 0.439 Contact Map
4bkyA 1 0.4296 100 0.44 Contact Map
4cfeA 1 0.4567 100 0.44 Contact Map
3soaA 5 0.4603 100 0.441 Contact Map
4g3fA 1 0.5162 100 0.441 Contact Map
2yabA 2 0.4801 100 0.441 Contact Map
4fr4A 1 0.4639 100 0.442 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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