GREMLIN Database
Q97WD4 - Amino acid transporter, putative
UniProt: Q97WD4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 512 (425)
Sequences: 24834 (16372)
Seq/√Len: 794.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_V387_L4.3591.00
369_K381_Y4.2791.00
427_I431_K3.4641.00
59_L287_G3.2111.00
273_R277_L3.1031.00
372_Q381_Y3.1021.00
419_L450_Y2.9291.00
19_S270_R2.8971.00
83_Y363_D2.8771.00
269_Y274_V2.7681.00
99_A360_L2.7021.00
204_M296_E2.6411.00
361_S371_S2.6191.00
374_N380_V2.6171.00
329_I333_I2.5731.00
165_A391_L2.5571.00
437_M440_A2.5291.00
71_I429_G2.4781.00
267_S362_F2.4731.00
24_V281_L2.4691.00
202_I206_I2.4661.00
20_L281_L2.3961.00
369_K372_Q2.3571.00
384_V388_T2.3431.00
268_E355_R2.2641.00
87_S95_G2.1981.00
172_V383_H2.1721.00
20_L274_V2.1501.00
173_L177_L2.1171.00
23_A269_Y2.1171.00
422_G449_V2.1081.00
20_L24_V2.1041.00
447_Y451_L2.0901.00
358_F362_F2.0871.00
180_K184_K2.0631.00
90_L427_I2.0421.00
165_A394_L2.0301.00
176_I380_V2.0291.00
169_A391_L2.0081.00
486_V490_I1.9911.00
164_S394_L1.9711.00
103_L386_D1.9641.00
68_V422_G1.9611.00
87_S92_G1.9531.00
42_S51_L1.9501.00
14_L373_L1.9461.00
60_F64_P1.9341.00
364_R368_E1.9291.00
277_L281_L1.9041.00
19_S22_D1.8931.00
370_F385_F1.8761.00
191_M195_L1.8541.00
175_N347_S1.8101.00
280_F284_L1.8041.00
90_L423_I1.7961.00
100_V484_G1.7901.00
374_N378_S1.7901.00
86_I98_F1.7281.00
22_D187_T1.7251.00
302_G305_F1.7241.00
470_N473_T1.7141.00
480_S484_G1.7111.00
271_G274_V1.6931.00
491_T495_N1.6891.00
50_V244_T1.6831.00
441_G445_T1.6781.00
27_N282_S1.6771.00
195_L199_L1.6691.00
478_L482_I1.6561.00
320_V323_A1.6561.00
451_L455_A1.6551.00
114_S346_L1.6511.00
427_I430_R1.6451.00
169_A387_L1.6431.00
110_Y390_T1.6421.00
98_F420_A1.6371.00
316_N320_V1.6351.00
444_M448_F1.6251.00
18_V22_D1.6241.00
176_I384_V1.6221.00
439_I442_I1.6201.00
168_F390_T1.6151.00
305_F324_L1.6021.00
91_D94_I1.5911.00
121_V163_I1.5901.00
24_V285_I1.5871.00
284_L288_I1.5821.00
214_L217_P1.5531.00
194_M198_I1.5431.00
381_Y385_F1.5251.00
271_G277_L1.5231.00
114_S168_F1.5221.00
213_S216_L1.5161.00
205_A296_E1.5061.00
196_T337_G1.4951.00
265_V351_L1.4861.00
54_A247_L1.4631.00
479_G483_A1.4631.00
117_S339_I1.4621.00
237_Y240_S1.4621.00
168_F387_L1.4571.00
433_R436_L1.4561.00
79_T267_S1.4521.00
90_L94_I1.4421.00
432_I435_G1.4171.00
58_G252_A1.4151.00
353_F386_D1.4131.00
14_L358_F1.3991.00
358_F373_L1.3961.00
15_I377_G1.3941.00
423_I427_I1.3921.00
447_Y458_N1.3911.00
357_V382_A1.3801.00
66_A283_L1.3761.00
217_P220_K1.3621.00
455_A459_P1.3561.00
22_D183_Y1.3531.00
482_I486_V1.3511.00
332_W336_L1.3501.00
423_I450_Y1.3361.00
490_I494_V1.3331.00
117_S167_A1.3331.00
468_G471_V1.3321.00
165_A169_A1.3291.00
18_V183_Y1.3261.00
354_S383_H1.3221.00
449_V453_Y1.3181.00
368_E372_Q1.3181.00
453_Y456_A1.3161.00
172_V384_V1.3081.00
18_V23_A1.3051.00
368_E371_S1.2921.00
454_E458_N1.2891.00
303_Y306_N1.2871.00
357_V366_F1.2821.00
86_I420_A1.2811.00
323_A331_E1.2731.00
65_Q422_G1.2681.00
491_T494_V1.2681.00
93_A491_T1.2611.00
61_L452_T1.2531.00
66_A279_V1.2521.00
240_S243_A1.2501.00
89_N424_S1.2491.00
372_Q380_V1.2471.00
456_A459_P1.2461.00
60_F448_F1.2441.00
20_L277_L1.2431.00
67_L280_F1.2401.00
52_W295_L1.2391.00
201_M292_I1.2271.00
274_V277_L1.2261.00
113_I345_V1.2091.00
490_I493_Y1.2081.00
84_V88_R1.2031.00
76_I88_R1.1911.00
208_A299_L1.1901.00
471_V474_L1.1871.00
373_L377_G1.1871.00
37_L116_F1.1861.00
171_I346_L1.1851.00
31_M286_T1.1781.00
64_P448_F1.1781.00
288_I292_I1.1751.00
28_I285_I1.1751.00
43_P51_L1.1671.00
23_A278_N1.1651.00
21_T25_M1.1651.00
404_A409_G1.1581.00
78_R84_V1.1551.00
487_I491_T1.1541.00
469_V472_T1.1531.00
162_G166_F1.1521.00
200_A204_M1.1501.00
174_I185_L1.1471.00
489_N493_Y1.1451.00
485_I489_N1.1361.00
492_R495_N1.1321.00
204_M300_I1.1301.00
103_L357_V1.1271.00
477_V481_F1.1271.00
176_I378_S1.1251.00
215_V220_K1.1201.00
205_A209_K1.1171.00
27_N262_G1.1161.00
404_A407_L1.1161.00
161_Y165_A1.1151.00
381_Y384_V1.1151.00
186_V347_S1.1141.00
455_A458_N1.1141.00
69_Y82_D1.1081.00
487_I490_I1.0981.00
320_V324_L1.0961.00
270_R274_V1.0951.00
215_V218_L1.0901.00
166_F170_I1.0891.00
83_Y359_A1.0851.00
450_Y454_E1.0771.00
185_L189_L1.0761.00
73_N85_W1.0761.00
199_L203_V1.0741.00
71_I74_R1.0721.00
388_T392_L1.0721.00
96_T100_V1.0691.00
362_F371_S1.0671.00
26_L265_V1.0641.00
474_L477_V1.0631.00
430_R433_R1.0621.00
172_V176_I1.0551.00
176_I374_N1.0521.00
86_I94_I1.0501.00
118_A164_S1.0451.00
444_M447_Y1.0291.00
198_I202_I1.0271.00
118_A163_I1.0251.00
184_K188_G1.0241.00
419_L454_E1.0231.00
216_L219_L1.0181.00
471_V475_S1.0171.00
257_P414_G1.0131.00
442_I446_V1.0071.00
214_L218_L1.0061.00
445_T449_V0.9971.00
88_R432_I0.9931.00
17_H270_R0.9931.00
316_N322_M0.9921.00
75_K435_G0.9881.00
426_I447_Y0.9791.00
443_L447_Y0.9791.00
266_S275_S0.9761.00
169_A173_L0.9761.00
438_K441_G0.9761.00
59_L256_Y0.9721.00
121_V125_L0.9691.00
213_S217_P0.9691.00
479_G482_I0.9681.00
446_V460_L0.9671.00
68_V446_V0.9651.00
475_S479_G0.9641.00
446_V449_V0.9561.00
350_V387_L0.9551.00
56_L291_T0.9511.00
121_V339_I0.9441.00
260_N264_A0.9431.00
215_V219_L0.9421.00
194_M289_F0.9391.00
444_M458_N0.9391.00
429_G433_R0.9381.00
323_A328_P0.9281.00
171_I347_S0.9251.00
179_S351_L0.9201.00
443_L446_V0.9181.00
170_I343_Y0.9171.00
474_L478_L0.9141.00
271_G276_K0.9081.00
473_T477_V0.9051.00
75_K433_R0.9051.00
189_L344_Y0.9041.00
118_A160_F0.9021.00
14_L355_R0.8991.00
488_W492_R0.8951.00
112_I254_Y0.8941.00
425_A446_V0.8931.00
326_L330_I0.8921.00
483_A486_V0.8901.00
412_I477_V0.8901.00
217_P221_D0.8891.00
446_V458_N0.8861.00
17_H180_K0.8861.00
449_V456_A0.8851.00
78_R88_R0.8851.00
80_G84_V0.8831.00
372_Q375_A0.8811.00
212_D216_L0.8811.00
28_I286_T0.8801.00
56_L60_F0.8791.00
232_K236_P0.8761.00
201_M296_E0.8731.00
168_F394_L0.8721.00
317_F320_V0.8701.00
193_S341_W0.8691.00
437_M441_G0.8691.00
276_K279_V0.8661.00
287_G291_T0.8661.00
442_I445_T0.8661.00
366_F370_F0.8651.00
216_L220_K0.8631.00
328_P332_W0.8631.00
483_A487_I0.8621.00
404_A408_Y0.8561.00
22_D184_K0.8531.00
209_K213_S0.8531.00
406_S409_G0.8521.00
456_A460_L0.8511.00
470_N474_L0.8511.00
445_T459_P0.8501.00
93_A485_I0.8491.00
52_W298_D0.8481.00
437_M442_I0.8461.00
419_L423_I0.8431.00
213_S220_K0.8401.00
14_L268_E0.8391.00
302_G324_L0.8381.00
87_S363_D0.8381.00
439_I443_L0.8381.00
472_T475_S0.8371.00
441_G444_M0.8361.00
173_L176_I0.8341.00
484_G487_I0.8341.00
117_S342_N0.8331.00
370_F381_Y0.8321.00
86_I424_S0.8301.00
295_L299_L0.8271.00
472_T476_F0.8271.00
213_S218_L0.8261.00
380_V384_V0.8251.00
261_A352_V0.8241.00
25_M187_T0.8231.00
201_M205_A0.8211.00
53_I244_T0.8201.00
161_Y394_L0.8161.00
450_Y458_N0.8121.00
100_V366_F0.8111.00
63_L280_F0.8101.00
212_D215_V0.8081.00
20_L278_N0.8081.00
316_N319_T0.8081.00
117_S343_Y0.8071.00
21_T187_T0.8041.00
317_F322_M0.8011.00
387_L391_L0.8011.00
163_I166_F0.8011.00
327_N330_I0.8001.00
91_D492_R0.8001.00
479_G486_V0.7971.00
241_I244_T0.7921.00
50_V237_Y0.7891.00
318_W322_M0.7891.00
305_F308_N0.7841.00
208_A296_E0.7821.00
449_V452_T0.7811.00
476_F479_G0.7791.00
64_P68_V0.7751.00
24_V278_N0.7721.00
452_T456_A0.7691.00
309_A320_V0.7681.00
275_S279_V0.7681.00
94_I420_A0.7681.00
475_S478_L0.7651.00
484_G488_W0.7651.00
218_L221_D0.7631.00
206_I209_K0.7631.00
257_P418_F0.7621.00
35_I293_G0.7531.00
93_A97_I0.7521.00
102_Y106_S0.7491.00
424_S428_F0.7481.00
243_A246_F0.7471.00
479_G484_G0.7471.00
281_L285_I0.7461.00
175_N383_H0.7441.00
445_T452_T0.7441.00
80_G83_Y0.7421.00
107_T389_L0.7411.00
446_V452_T0.7411.00
171_I350_V0.7381.00
453_Y460_L0.7381.00
17_H179_S0.7361.00
469_V474_L0.7361.00
29_A190_G0.7331.00
63_L67_L0.7321.00
177_L181_W0.7311.00
214_L220_K0.7301.00
413_V417_Y0.7291.00
374_N377_G0.7281.00
263_P279_V0.7281.00
439_I446_V0.7251.00
350_V354_S0.7231.00
53_I56_L0.7231.00
426_I430_R0.7221.00
53_I57_I0.7211.00
83_Y87_S0.7161.00
453_Y458_N0.7141.00
101_A417_Y0.7141.00
235_L238_S0.7141.00
31_M282_S0.7131.00
437_M443_L0.7131.00
52_W291_T0.7131.00
32_S290_V0.7121.00
109_F410_A0.7121.00
232_K235_L0.7121.00
183_Y347_S0.7071.00
213_S219_L0.7061.00
357_V385_F0.7051.00
205_A292_I0.7041.00
469_V473_T0.7041.00
292_I296_E0.7021.00
480_S487_I0.6991.00
445_T448_F0.6981.00
488_W495_N0.6941.00
478_L481_F0.6931.00
72_F425_A0.6931.00
69_Y421_V0.6881.00
448_F459_P0.6871.00
448_F452_T0.6861.00
126_L129_G0.6841.00
354_S382_A0.6841.00
118_A121_V0.6831.00
89_N427_I0.6791.00
409_G413_V0.6791.00
179_S265_V0.6771.00
300_I321_A0.6761.00
125_L129_G0.6751.00
468_G474_L0.6751.00
21_T184_K0.6741.00
175_N351_L0.6731.00
490_I495_N0.6731.00
485_I488_W0.6731.00
233_T236_P0.6731.00
369_K385_F0.6731.00
440_A444_M0.6721.00
51_L294_F0.6721.00
473_T476_F0.6721.00
388_T391_L0.6701.00
303_Y307_L0.6681.00
375_A380_V0.6671.00
183_Y187_T0.6671.00
243_A247_L0.6661.00
322_M325_S0.6661.00
441_G446_V0.6651.00
471_V484_G0.6621.00
329_I332_W0.6621.00
446_V453_Y0.6611.00
105_E414_G0.6601.00
293_G318_W0.6591.00
237_Y244_T0.6571.00
176_I383_H0.6561.00
39_Q294_F0.6551.00
79_T358_F0.6551.00
125_L128_I0.6551.00
90_L424_S0.6531.00
290_V294_F0.6511.00
184_K187_T0.6501.00
241_I245_L0.6501.00
457_R460_L0.6501.00
121_V167_A0.6481.00
83_Y95_G0.6461.00
451_L454_E0.6461.00
487_I493_Y0.6461.00
471_V477_V0.6431.00
281_L284_L0.6431.00
470_N477_V0.6401.00
62_A259_M0.6401.00
425_A429_G0.6401.00
109_F112_I0.6401.00
293_G297_M0.6381.00
212_D218_L0.6381.00
161_Y164_S0.6371.00
64_P445_T0.6371.00
234_I237_Y0.6371.00
52_W56_L0.6361.00
109_F113_I0.6351.00
285_I289_F0.6351.00
395_L398_V0.6311.00
479_G490_I0.6301.00
72_F85_W0.6301.00
111_A393_F0.6281.00
24_V27_N0.6281.00
304_Y308_N0.6271.00
488_W494_V0.6271.00
245_L455_A0.6261.00
370_F382_A0.6261.00
376_N380_V0.6251.00
201_M293_G0.6251.00
488_W491_T0.6251.00
355_R358_F0.6241.00
426_I446_V0.6231.00
127_T130_Y0.6231.00
405_V408_Y0.6221.00
422_G450_Y0.6211.00
350_V383_H0.6181.00
124_V336_L0.6181.00
430_R443_L0.6181.00
165_A395_L0.6171.00
181_W184_K0.6141.00
82_D264_A0.6141.00
285_I288_I0.6141.00
341_W344_Y0.6141.00
306_N309_A0.6131.00
486_V489_N0.6121.00
28_I190_G0.6111.00
72_F89_N0.6111.00
472_T477_V0.6101.00
120_S338_L0.6101.00
480_S483_A0.6081.00
441_G447_Y0.6081.00
257_P260_N0.6081.00
71_I75_K0.6071.00
267_S358_F0.6061.00
450_Y459_P0.6051.00
470_N476_F0.6051.00
455_A460_L0.6051.00
115_F406_S0.6051.00
123_S335_G0.6041.00
167_A346_L0.6031.00
319_T323_A0.6021.00
438_K442_I0.6011.00
66_A259_M0.6001.00
273_R276_K0.5991.00
481_F484_G0.5981.00
106_S349_G0.5971.00
476_F480_S0.5971.00
89_N428_F0.5971.00
83_Y99_A0.5951.00
446_V456_A0.5951.00
428_F432_I0.5931.00
82_D260_N0.5931.00
234_I240_S0.5921.00
48_G298_D0.5911.00
322_M326_L0.5911.00
264_A352_V0.5901.00
419_L453_Y0.5881.00
245_L249_P0.5881.00
452_T458_N0.5871.00
181_W185_L0.5871.00
473_T480_S0.5861.00
37_L40_S0.5851.00
203_V207_N0.5851.00
441_G458_N0.5841.00
55_S255_T0.5831.00
113_I346_L0.5821.00
268_E379_P0.5821.00
483_A491_T0.5801.00
171_I343_Y0.5791.00
23_A274_V0.5761.00
296_E299_L0.5761.00
449_V460_L0.5751.00
168_F391_L0.5741.00
70_T74_R0.5741.00
200_A322_M0.5741.00
170_I174_I0.5731.00
73_N263_P0.5731.00
36_A197_V0.5731.00
451_L458_N0.5731.00
450_Y460_L0.5721.00
208_A300_I0.5711.00
203_V322_M0.5711.00
192_F196_T0.5701.00
307_L310_F0.5681.00
448_F451_L0.5681.00
36_A193_S0.5681.00
445_T458_N0.5671.00
91_D95_G0.5661.00
66_A70_T0.5661.00
73_N275_S0.5651.00
212_D217_P0.5631.00
443_L460_L0.5621.00
65_Q453_Y0.5601.00
111_A390_T0.5601.00
442_I447_Y0.5591.00
355_R379_P0.5591.00
477_V482_I0.5581.00
169_A384_V0.5581.00
177_L376_N0.5571.00
489_N492_R0.5571.00
414_G417_Y0.5561.00
169_A172_V0.5561.00
47_R50_V0.5551.00
215_V299_L0.5541.00
317_F321_A0.5531.00
471_V478_L0.5531.00
187_T191_M0.5531.00
379_P382_A0.5521.00
242_P246_F0.5511.00
392_L395_L0.5511.00
23_A265_V0.5511.00
361_S370_F0.5511.00
30_N261_A0.5511.00
166_F169_A0.5491.00
272_D277_L0.5481.00
71_I437_M0.5481.00
182_G351_L0.5481.00
214_L219_L0.5471.00
17_H21_T0.5451.00
453_Y457_R0.5451.00
203_V327_N0.5451.00
446_V450_Y0.5431.00
446_V459_P0.5431.00
440_A443_L0.5431.00
70_T276_K0.5411.00
353_F357_V0.5411.00
192_F337_G0.5391.00
385_F389_L0.5371.00
468_G472_T0.5371.00
27_N278_N0.5371.00
322_M327_N0.5351.00
81_G263_P0.5341.00
468_G473_T0.5331.00
441_G460_L0.5321.00
447_Y450_Y0.5321.00
257_P410_A0.5311.00
449_V459_P0.5311.00
262_G275_S0.5281.00
317_F325_S0.5271.00
65_Q260_N0.5261.00
236_P240_S0.5261.00
269_Y275_S0.5231.00
172_V350_V0.5221.00
471_V479_G0.5211.00
58_G256_Y0.5211.00
70_T279_V0.5191.00
57_I248_L0.5151.00
209_K215_V0.5151.00
268_E373_L0.5151.00
452_T455_A0.5151.00
21_T24_V0.5141.00
101_A105_E0.5141.00
27_N31_M0.5141.00
186_V344_Y0.5141.00
336_L340_M0.5141.00
178_H181_W0.5121.00
452_T459_P0.5111.00
63_L284_L0.5111.00
448_F458_N0.5111.00
190_G193_S0.5111.00
209_K214_L0.5091.00
43_P47_R0.5081.00
426_I443_L0.5071.00
482_I485_I0.5051.00
19_S180_K0.5041.00
487_I494_V0.5041.00
355_R373_L0.5031.00
34_G254_Y0.5021.00
114_S118_A0.5011.00
204_M208_A0.5011.00
428_F433_R0.5011.00
14_L79_T0.5001.00
55_S294_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8164 100 0.383 Contact Map
3giaA 1 0.832 100 0.423 Contact Map
4djkA 2 0.834 100 0.433 Contact Map
3dh4A 3 0.8633 99 0.863 Contact Map
2xq2A 2 0.8652 99 0.863 Contact Map
2jlnA 1 0.8184 98.7 0.877 Contact Map
4xp4A 1 0.9219 98.5 0.885 Contact Map
2a65A 2 0.8926 98.5 0.886 Contact Map
4wgvA 2 0.7305 98.1 0.898 Contact Map
4us3A 1 0.8027 97.9 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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