GREMLIN Database
Q97WD1 - Cobalamin biosynthesis precorrin-6B methylase, putative (CbiE)
UniProt: Q97WD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (211)
Sequences: 14310 (9312)
Seq/√Len: 641.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_E27_K3.8781.00
26_Y30_R3.4551.00
123_R197_E2.9931.00
32_S79_A2.9041.00
190_E198_K2.7341.00
9_Y28_A2.6501.00
7_T109_N2.6261.00
203_D207_S2.5251.00
7_T107_K2.4061.00
27_K31_D2.3861.00
23_L26_Y2.3481.00
11_V79_A2.2721.00
33_V77_N2.2561.00
42_L81_L2.2511.00
191_K196_D2.1831.00
204_N207_S2.1611.00
120_A192_L2.1561.00
33_V76_E2.1511.00
189_F192_L2.1371.00
185_R224_F2.1361.00
9_Y77_N2.1331.00
11_V25_G2.1241.00
116_S162_I2.0211.00
73_G104_K1.7851.00
12_G111_I1.7691.00
27_K30_R1.7311.00
19_E24_K1.7291.00
132_G157_R1.7221.00
148_D151_N1.7111.00
9_Y109_N1.6971.00
28_A111_I1.6971.00
186_I208_L1.6861.00
7_T77_N1.6751.00
189_F199_R1.6721.00
100_I104_K1.6661.00
100_I103_S1.6191.00
70_I104_K1.5971.00
124_L187_V1.5811.00
31_D77_N1.5691.00
145_F176_F1.5231.00
120_A189_F1.5181.00
187_V202_Y1.4881.00
203_D208_L1.4681.00
87_S94_V1.4591.00
123_R199_R1.4501.00
115_S118_N1.4291.00
24_K109_N1.4221.00
71_E74_K1.4121.00
176_F179_D1.4021.00
67_E71_E1.4011.00
174_A178_Y1.3901.00
35_V49_L1.3651.00
17_D24_K1.3551.00
43_E47_P1.3461.00
183_N206_V1.3281.00
12_G85_D1.3261.00
68_E71_E1.3231.00
174_A209_M1.3151.00
21_L26_Y1.3001.00
171_Q175_K1.2871.00
110_I122_S1.2831.00
10_I94_V1.2701.00
186_I205_L1.2701.00
169_G172_K1.2541.00
64_E67_E1.2491.00
28_A79_A1.2371.00
70_I73_G1.2291.00
191_K194_Y1.2261.00
117_L162_I1.2221.00
130_F134_V1.2211.00
151_N155_M1.2071.00
36_A78_V1.1901.00
178_Y206_V1.1791.00
9_Y111_I1.1751.00
26_Y48_I1.1651.00
66_L100_I1.1581.00
188_V219_T1.1521.00
73_G106_V1.1491.00
12_G86_P1.1461.00
115_S162_I1.1371.00
25_G111_I1.1351.00
187_V199_R1.1351.00
36_A55_V1.1301.00
37_G54_T1.1271.00
65_T68_E1.1271.00
8_V101_A1.1271.00
150_L180_N1.1211.00
161_V223_I1.1161.00
177_L205_L1.0981.00
175_K179_D1.0961.00
176_F180_N1.0891.00
200_R203_D1.0821.00
36_A69_V1.0781.00
21_L25_G1.0721.00
190_E216_S1.0721.00
199_R202_Y1.0701.00
62_E66_L1.0691.00
61_N64_E1.0681.00
98_K108_V1.0671.00
19_E23_L1.0581.00
23_L27_K1.0561.00
32_S77_N1.0551.00
80_I97_I1.0551.00
41_V44_R1.0551.00
146_L176_F1.0481.00
121_L128_I1.0461.00
53_R76_E1.0431.00
8_V72_I1.0401.00
95_E99_N1.0351.00
177_L223_I1.0351.00
160_I222_V1.0341.00
70_I100_I1.0301.00
34_V76_E1.0231.00
119_I193_S1.0161.00
15_P20_Y1.0151.00
72_I106_V1.0051.00
20_Y24_K1.0041.00
34_V78_V0.9981.00
171_Q211_E0.9941.00
9_Y32_S0.9931.00
85_D122_S0.9881.00
178_Y209_M0.9851.00
172_K175_K0.9791.00
131_I135_T0.9781.00
172_K176_F0.9711.00
62_E96_K0.9701.00
150_L176_F0.9571.00
34_V55_V0.9521.00
175_K209_M0.9491.00
36_A68_E0.9411.00
87_S110_I0.9411.00
37_G42_L0.9401.00
11_V28_A0.9371.00
28_A31_D0.9311.00
131_I136_L0.9301.00
102_A202_Y0.9251.00
198_K213_N0.9231.00
185_R202_Y0.9181.00
28_A109_N0.9091.00
66_L70_I0.9051.00
22_T114_V0.8991.00
132_G155_M0.8961.00
151_N154_R0.8941.00
86_P90_D0.8931.00
117_L133_F0.8931.00
170_P221_M0.8901.00
101_A106_V0.8901.00
177_L181_N0.8761.00
178_Y205_L0.8751.00
174_A205_L0.8711.00
67_E100_I0.8631.00
171_Q209_M0.8621.00
126_L187_V0.8601.00
49_L52_K0.8561.00
137_H148_D0.8551.00
102_A125_G0.8491.00
11_V111_I0.8421.00
110_I199_R0.8371.00
215_F219_T0.8351.00
44_R47_P0.8321.00
39_K56_V0.8211.00
150_L179_D0.8171.00
170_P208_L0.8171.00
35_V52_K0.8061.00
135_T138_V0.8051.00
55_V68_E0.7981.00
88_V118_N0.7971.00
24_K27_K0.7961.00
133_F162_I0.7871.00
150_L153_L0.7831.00
99_N103_S0.7801.00
134_V148_D0.7781.00
200_R213_N0.7781.00
132_G156_G0.7741.00
185_R204_N0.7721.00
17_D20_Y0.7681.00
88_V131_I0.7681.00
146_L179_D0.7651.00
62_E65_T0.7591.00
63_S100_I0.7591.00
82_D90_D0.7541.00
119_I192_L0.7531.00
94_V98_K0.7491.00
117_L160_I0.7441.00
63_S67_E0.7441.00
29_I35_V0.7421.00
9_Y79_A0.7401.00
38_W41_V0.7391.00
29_I79_A0.7371.00
17_D193_S0.7371.00
190_E219_T0.7331.00
18_P44_R0.7321.00
82_D93_F0.7301.00
130_F157_R0.7281.00
183_N204_N0.7271.00
95_E129_N0.7261.00
28_A77_N0.7241.00
120_A222_V0.7231.00
187_V222_V0.7221.00
129_N135_T0.7181.00
120_A220_M0.7151.00
95_E127_D0.7111.00
102_A108_V0.7111.00
200_R208_L0.7091.00
170_P219_T0.7081.00
42_L46_S0.7061.00
161_V164_E0.6991.00
137_H149_I0.6991.00
147_N150_L0.6951.00
70_I101_A0.6931.00
150_L154_R0.6921.00
138_V148_D0.6911.00
85_D110_I0.6851.00
58_T61_N0.6821.00
72_I78_V0.6801.00
123_R193_S0.6791.00
64_E68_E0.6791.00
24_K111_I0.6701.00
46_S49_L0.6691.00
148_D152_I0.6691.00
165_P215_F0.6691.00
32_S35_V0.6651.00
110_I123_R0.6601.00
42_L45_F0.6501.00
163_P169_G0.6491.00
36_A57_L0.6461.00
21_L45_F0.6451.00
132_G138_V0.6381.00
12_G119_I0.6361.00
60_K64_E0.6341.00
209_M212_K0.6341.00
24_K28_A0.6301.00
134_V157_R0.6301.00
200_R215_F0.6301.00
173_V221_M0.6281.00
88_V128_I0.6271.00
22_T25_G0.6261.00
170_P174_A0.6251.00
63_S66_L0.6251.00
28_A32_S0.6241.00
60_K68_E0.6231.00
30_R48_I0.6231.00
129_N138_V0.6231.00
190_E200_R0.6211.00
87_S122_S0.6211.00
131_I137_H0.6211.00
59_Y62_E0.6211.00
12_G114_V0.6181.00
55_V65_T0.6161.00
119_I123_R0.6141.00
90_D93_F0.6131.00
165_P168_D0.6131.00
124_L199_R0.6121.00
52_K55_V0.6081.00
152_I155_M0.6061.00
25_G79_A0.6001.00
54_T57_L0.6001.00
34_V53_R0.5991.00
191_K216_S0.5991.00
164_E168_D0.5981.00
35_V79_A0.5961.00
121_L222_V0.5951.00
160_I220_M0.5941.00
207_S210_N0.5921.00
188_V208_L0.5871.00
23_L30_R0.5851.00
141_D146_L0.5851.00
162_I220_M0.5841.00
49_L54_T0.5821.00
133_F136_L0.5811.00
10_I98_K0.5801.00
89_S133_F0.5801.00
45_F49_L0.5781.00
188_V203_D0.5771.00
189_F222_V0.5761.00
98_K102_A0.5721.00
174_A208_L0.5671.00
134_V152_I0.5581.00
184_C223_I0.5561.00
8_V80_I0.5561.00
165_P219_T0.5541.00
151_N156_G0.5531.00
124_L189_F0.5531.00
134_V159_A0.5531.00
170_P215_F0.5501.00
153_L180_N0.5481.00
46_S54_T0.5451.00
18_P47_P0.5411.00
114_V119_I0.5401.00
63_S96_K0.5401.00
191_K218_L0.5391.00
152_I159_A0.5380.99
149_I173_V0.5370.99
128_I160_I0.5370.99
47_P51_G0.5340.99
18_P48_I0.5330.99
118_N128_I0.5330.99
43_E54_T0.5310.99
33_V50_E0.5310.99
11_V29_I0.5300.99
130_F136_L0.5290.99
16_G20_Y0.5270.99
53_R68_E0.5260.99
8_V69_V0.5260.99
12_G123_R0.5250.99
42_L49_L0.5240.99
146_L150_L0.5220.99
159_A223_I0.5170.99
10_I82_D0.5170.99
134_V161_V0.5160.99
37_G41_V0.5150.99
134_V138_V0.5130.99
56_V59_Y0.5100.99
86_P110_I0.5060.99
173_V176_F0.5010.99
61_N65_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ndcA 2 0.9692 100 0.217 Contact Map
2yboA 2 0.9648 100 0.218 Contact Map
1cbfA 2 0.9736 100 0.219 Contact Map
3kwpA 2 0.9604 100 0.222 Contact Map
1s4dA 4 0.9648 100 0.227 Contact Map
4e16A 2 0.9427 100 0.227 Contact Map
1wyzA 2 0.9207 100 0.235 Contact Map
2e0nA 2 0.9075 100 0.238 Contact Map
1pjqA 2 0.9648 100 0.239 Contact Map
1ve2A 2 0.9075 100 0.245 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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