Q97WD1 - SULSO - GREMLIN Contacts

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Q97WD1 - Cobalamin biosynthesis precorrin-6B methylase, putative (CbiE)

UniProt:	Q97WD1	Sequences: MRVSKITVYIVGVGPGDPEYLTLKGYKAIRDSVVVAGWKSVLERFSPILEGKRTVVLTYKNESETLEEVIEIGKTENVAILDHGDPSVSDWQFVEKIKNIAASKGVKVNIISGVSSLNIALSRLGLDINFIGFVTLHVRGDISKFLNDILNILRMGRVAIVIPEPHKDGPQKVAKFLYDNNLNCRIVVFEKLSYDDEKRRVYDNLVSLMNEKNDFSDLTMMVIFPKF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	227 (211)
Sequences:	14310 (9312)
Seq/√Len:	641.1

ECOLI - CYSG RSMI
BACSU - SUMT NASF RSMI
HALSA - Q9HPM0 Q9HMY4 Q9HPN2 Q9HPN0 Q9HPM9 Q9HPN3
SULSO - Q97WD1 Q97WC5 Q97W12 Q97WC9 Q97UT5 Q97WC8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_E	27_K	3.878	1.00
26_Y	30_R	3.455	1.00
123_R	197_E	2.993	1.00
32_S	79_A	2.904	1.00
190_E	198_K	2.734	1.00
9_Y	28_A	2.650	1.00
7_T	109_N	2.626	1.00
203_D	207_S	2.525	1.00
7_T	107_K	2.406	1.00
27_K	31_D	2.386	1.00
23_L	26_Y	2.348	1.00
11_V	79_A	2.272	1.00
33_V	77_N	2.256	1.00
42_L	81_L	2.251	1.00
191_K	196_D	2.183	1.00
204_N	207_S	2.161	1.00
120_A	192_L	2.156	1.00
33_V	76_E	2.151	1.00
189_F	192_L	2.137	1.00
185_R	224_F	2.136	1.00
9_Y	77_N	2.133	1.00
11_V	25_G	2.124	1.00
116_S	162_I	2.021	1.00
73_G	104_K	1.785	1.00
12_G	111_I	1.769	1.00
27_K	30_R	1.731	1.00
19_E	24_K	1.729	1.00
132_G	157_R	1.722	1.00
148_D	151_N	1.711	1.00
9_Y	109_N	1.697	1.00
28_A	111_I	1.697	1.00
186_I	208_L	1.686	1.00
7_T	77_N	1.675	1.00
189_F	199_R	1.672	1.00
100_I	104_K	1.666	1.00
100_I	103_S	1.619	1.00
70_I	104_K	1.597	1.00
124_L	187_V	1.581	1.00
31_D	77_N	1.569	1.00
145_F	176_F	1.523	1.00
120_A	189_F	1.518	1.00
187_V	202_Y	1.488	1.00
203_D	208_L	1.468	1.00
87_S	94_V	1.459	1.00
123_R	199_R	1.450	1.00
115_S	118_N	1.429	1.00
24_K	109_N	1.422	1.00
71_E	74_K	1.412	1.00
176_F	179_D	1.402	1.00
67_E	71_E	1.401	1.00
174_A	178_Y	1.390	1.00
35_V	49_L	1.365	1.00
17_D	24_K	1.355	1.00
43_E	47_P	1.346	1.00
183_N	206_V	1.328	1.00
12_G	85_D	1.326	1.00
68_E	71_E	1.323	1.00
174_A	209_M	1.315	1.00
21_L	26_Y	1.300	1.00
171_Q	175_K	1.287	1.00
110_I	122_S	1.283	1.00
10_I	94_V	1.270	1.00
186_I	205_L	1.270	1.00
169_G	172_K	1.254	1.00
64_E	67_E	1.249	1.00
28_A	79_A	1.237	1.00
70_I	73_G	1.229	1.00
191_K	194_Y	1.226	1.00
117_L	162_I	1.222	1.00
130_F	134_V	1.221	1.00
151_N	155_M	1.207	1.00
36_A	78_V	1.190	1.00
178_Y	206_V	1.179	1.00
9_Y	111_I	1.175	1.00
26_Y	48_I	1.165	1.00
66_L	100_I	1.158	1.00
188_V	219_T	1.152	1.00
73_G	106_V	1.149	1.00
12_G	86_P	1.146	1.00
115_S	162_I	1.137	1.00
25_G	111_I	1.135	1.00
187_V	199_R	1.135	1.00
36_A	55_V	1.130	1.00
37_G	54_T	1.127	1.00
65_T	68_E	1.127	1.00
8_V	101_A	1.127	1.00
150_L	180_N	1.121	1.00
161_V	223_I	1.116	1.00
177_L	205_L	1.098	1.00
175_K	179_D	1.096	1.00
176_F	180_N	1.089	1.00
200_R	203_D	1.082	1.00
36_A	69_V	1.078	1.00
21_L	25_G	1.072	1.00
190_E	216_S	1.072	1.00
199_R	202_Y	1.070	1.00
62_E	66_L	1.069	1.00
61_N	64_E	1.068	1.00
98_K	108_V	1.067	1.00
19_E	23_L	1.058	1.00
23_L	27_K	1.056	1.00
32_S	77_N	1.055	1.00
80_I	97_I	1.055	1.00
41_V	44_R	1.055	1.00
146_L	176_F	1.048	1.00
121_L	128_I	1.046	1.00
53_R	76_E	1.043	1.00
8_V	72_I	1.040	1.00
95_E	99_N	1.035	1.00
177_L	223_I	1.035	1.00
160_I	222_V	1.034	1.00
70_I	100_I	1.030	1.00
34_V	76_E	1.023	1.00
119_I	193_S	1.016	1.00
15_P	20_Y	1.015	1.00
72_I	106_V	1.005	1.00
20_Y	24_K	1.004	1.00
34_V	78_V	0.998	1.00
171_Q	211_E	0.994	1.00
9_Y	32_S	0.993	1.00
85_D	122_S	0.988	1.00
178_Y	209_M	0.985	1.00
172_K	175_K	0.979	1.00
131_I	135_T	0.978	1.00
172_K	176_F	0.971	1.00
62_E	96_K	0.970	1.00
150_L	176_F	0.957	1.00
34_V	55_V	0.952	1.00
175_K	209_M	0.949	1.00
36_A	68_E	0.941	1.00
87_S	110_I	0.941	1.00
37_G	42_L	0.940	1.00
11_V	28_A	0.937	1.00
28_A	31_D	0.931	1.00
131_I	136_L	0.930	1.00
102_A	202_Y	0.925	1.00
198_K	213_N	0.923	1.00
185_R	202_Y	0.918	1.00
28_A	109_N	0.909	1.00
66_L	70_I	0.905	1.00
22_T	114_V	0.899	1.00
132_G	155_M	0.896	1.00
151_N	154_R	0.894	1.00
86_P	90_D	0.893	1.00
117_L	133_F	0.893	1.00
170_P	221_M	0.890	1.00
101_A	106_V	0.890	1.00
177_L	181_N	0.876	1.00
178_Y	205_L	0.875	1.00
174_A	205_L	0.871	1.00
67_E	100_I	0.863	1.00
171_Q	209_M	0.862	1.00
126_L	187_V	0.860	1.00
49_L	52_K	0.856	1.00
137_H	148_D	0.855	1.00
102_A	125_G	0.849	1.00
11_V	111_I	0.842	1.00
110_I	199_R	0.837	1.00
215_F	219_T	0.835	1.00
44_R	47_P	0.832	1.00
39_K	56_V	0.821	1.00
150_L	179_D	0.817	1.00
170_P	208_L	0.817	1.00
35_V	52_K	0.806	1.00
135_T	138_V	0.805	1.00
55_V	68_E	0.798	1.00
88_V	118_N	0.797	1.00
24_K	27_K	0.796	1.00
133_F	162_I	0.787	1.00
150_L	153_L	0.783	1.00
99_N	103_S	0.780	1.00
134_V	148_D	0.778	1.00
200_R	213_N	0.778	1.00
132_G	156_G	0.774	1.00
185_R	204_N	0.772	1.00
17_D	20_Y	0.768	1.00
88_V	131_I	0.768	1.00
146_L	179_D	0.765	1.00
62_E	65_T	0.759	1.00
63_S	100_I	0.759	1.00
82_D	90_D	0.754	1.00
119_I	192_L	0.753	1.00
94_V	98_K	0.749	1.00
117_L	160_I	0.744	1.00
63_S	67_E	0.744	1.00
29_I	35_V	0.742	1.00
9_Y	79_A	0.740	1.00
38_W	41_V	0.739	1.00
29_I	79_A	0.737	1.00
17_D	193_S	0.737	1.00
190_E	219_T	0.733	1.00
18_P	44_R	0.732	1.00
82_D	93_F	0.730	1.00
130_F	157_R	0.728	1.00
183_N	204_N	0.727	1.00
95_E	129_N	0.726	1.00
28_A	77_N	0.724	1.00
120_A	222_V	0.723	1.00
187_V	222_V	0.722	1.00
129_N	135_T	0.718	1.00
120_A	220_M	0.715	1.00
95_E	127_D	0.711	1.00
102_A	108_V	0.711	1.00
200_R	208_L	0.709	1.00
170_P	219_T	0.708	1.00
42_L	46_S	0.706	1.00
161_V	164_E	0.699	1.00
137_H	149_I	0.699	1.00
147_N	150_L	0.695	1.00
70_I	101_A	0.693	1.00
150_L	154_R	0.692	1.00
138_V	148_D	0.691	1.00
85_D	110_I	0.685	1.00
58_T	61_N	0.682	1.00
72_I	78_V	0.680	1.00
123_R	193_S	0.679	1.00
64_E	68_E	0.679	1.00
24_K	111_I	0.670	1.00
46_S	49_L	0.669	1.00
148_D	152_I	0.669	1.00
165_P	215_F	0.669	1.00
32_S	35_V	0.665	1.00
110_I	123_R	0.660	1.00
42_L	45_F	0.650	1.00
163_P	169_G	0.649	1.00
36_A	57_L	0.646	1.00
21_L	45_F	0.645	1.00
132_G	138_V	0.638	1.00
12_G	119_I	0.636	1.00
60_K	64_E	0.634	1.00
209_M	212_K	0.634	1.00
24_K	28_A	0.630	1.00
134_V	157_R	0.630	1.00
200_R	215_F	0.630	1.00
173_V	221_M	0.628	1.00
88_V	128_I	0.627	1.00
22_T	25_G	0.626	1.00
170_P	174_A	0.625	1.00
63_S	66_L	0.625	1.00
28_A	32_S	0.624	1.00
60_K	68_E	0.623	1.00
30_R	48_I	0.623	1.00
129_N	138_V	0.623	1.00
190_E	200_R	0.621	1.00
87_S	122_S	0.621	1.00
131_I	137_H	0.621	1.00
59_Y	62_E	0.621	1.00
12_G	114_V	0.618	1.00
55_V	65_T	0.616	1.00
119_I	123_R	0.614	1.00
90_D	93_F	0.613	1.00
165_P	168_D	0.613	1.00
124_L	199_R	0.612	1.00
52_K	55_V	0.608	1.00
152_I	155_M	0.606	1.00
25_G	79_A	0.600	1.00
54_T	57_L	0.600	1.00
34_V	53_R	0.599	1.00
191_K	216_S	0.599	1.00
164_E	168_D	0.598	1.00
35_V	79_A	0.596	1.00
121_L	222_V	0.595	1.00
160_I	220_M	0.594	1.00
207_S	210_N	0.592	1.00
188_V	208_L	0.587	1.00
23_L	30_R	0.585	1.00
141_D	146_L	0.585	1.00
162_I	220_M	0.584	1.00
49_L	54_T	0.582	1.00
133_F	136_L	0.581	1.00
10_I	98_K	0.580	1.00
89_S	133_F	0.580	1.00
45_F	49_L	0.578	1.00
188_V	203_D	0.577	1.00
189_F	222_V	0.576	1.00
98_K	102_A	0.572	1.00
174_A	208_L	0.567	1.00
134_V	152_I	0.558	1.00
184_C	223_I	0.556	1.00
8_V	80_I	0.556	1.00
165_P	219_T	0.554	1.00
151_N	156_G	0.553	1.00
124_L	189_F	0.553	1.00
134_V	159_A	0.553	1.00
170_P	215_F	0.550	1.00
153_L	180_N	0.548	1.00
46_S	54_T	0.545	1.00
18_P	47_P	0.541	1.00
114_V	119_I	0.540	1.00
63_S	96_K	0.540	1.00
191_K	218_L	0.539	1.00
152_I	159_A	0.538	0.99
149_I	173_V	0.537	0.99
128_I	160_I	0.537	0.99
47_P	51_G	0.534	0.99
18_P	48_I	0.533	0.99
118_N	128_I	0.533	0.99
43_E	54_T	0.531	0.99
33_V	50_E	0.531	0.99
11_V	29_I	0.530	0.99
130_F	136_L	0.529	0.99
16_G	20_Y	0.527	0.99
53_R	68_E	0.526	0.99
8_V	69_V	0.526	0.99
12_G	123_R	0.525	0.99
42_L	49_L	0.524	0.99
146_L	150_L	0.522	0.99
159_A	223_I	0.517	0.99
10_I	82_D	0.517	0.99
134_V	161_V	0.516	0.99
37_G	41_V	0.515	0.99
134_V	138_V	0.513	0.99
56_V	59_Y	0.510	0.99
86_P	110_I	0.506	0.99
173_V	176_F	0.501	0.99
61_N	65_T	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ndcA	2	0.9692	100	0.217	Contact Map
2yboA	2	0.9648	100	0.218	Contact Map
1cbfA	2	0.9736	100	0.219	Contact Map
3kwpA	2	0.9604	100	0.222	Contact Map
1s4dA	4	0.9648	100	0.227	Contact Map
4e16A	2	0.9427	100	0.227	Contact Map
1wyzA	2	0.9207	100	0.235	Contact Map
2e0nA	2	0.9075	100	0.238	Contact Map
1pjqA	2	0.9648	100	0.239	Contact Map
1ve2A	2	0.9075	100	0.245	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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