Q97WD0 - SULSO - GREMLIN Contacts

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Q97WD0 - Cobalamin biosynthesis protein G homolog, putative (CbiG-like)

UniProt:	Q97WD0	Sequences: MESGGRLTMIENLWRGICIISASEDAFSAGETIKEKLKSFEIPVVHYRYKDAEIETIWKCYDAIVFVMALEGATRIVCKYAKSKTEDPAIVCIDDKINYVIPLLGGHWGANDIARELSVILNSTPIITTAAEIKGKLSIERIANILIAKIINPENIVKINAALLRDESICIDGIDVNVNFPENIKVNSEECSYIISLRGDKEYKDKIVVWLKPLKISIGIGSKKDVKMEEIRDGIYKVLERLNLKRERIGIIASIREEVKKIADEFNVRFRLVNEEEINNFMNPCLTPPSKTLIEVGLKGVAEISALIAGGRNSKLILRKIAISRNSTIAVATYEGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	337 (313)
Sequences:	1082 (881)
Seq/√Len:	49.8

HALSA - Q9HPN1
SULSO - Q97WD0 Q980Y9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
254_S	270_F	4.620	1.00
99_Y	124_T	4.363	1.00
91_V	100_V	3.611	1.00
224_K	258_E	3.368	1.00
255_I	296_V	3.277	1.00
300_G	304_I	3.109	1.00
70_L	103_L	3.010	1.00
274_N	277_E	3.006	1.00
216_I	244_L	2.998	1.00
63_A	113_I	2.961	1.00
231_I	262_I	2.960	1.00
199_G	333_T	2.816	1.00
306_A	332_A	2.748	1.00
232_R	265_E	2.747	1.00
254_S	272_L	2.698	1.00
253_A	309_A	2.676	1.00
85_T	153_P	2.643	1.00
102_P	114_A	2.546	1.00
212_K	245_K	2.527	1.00
234_G	327_S	2.360	1.00
310_G	314_S	2.328	1.00
218_I	235_I	2.313	1.00
239_L	249_I	2.310	1.00
235_I	262_I	2.222	1.00
218_I	249_I	2.191	1.00
278_I	305_S	2.137	1.00
287_T	319_R	2.128	1.00
151_I	212_K	2.113	1.00
290_S	293_L	2.026	1.00
68_M	73_A	1.998	1.00
288_P	299_K	1.906	0.99
20_I	64_I	1.888	0.99
232_R	266_F	1.882	0.99
277_E	308_I	1.882	0.99
223_K	326_N	1.882	0.99
255_I	275_E	1.880	0.99
212_K	248_R	1.854	0.99
81_A	104_L	1.844	0.99
281_F	308_I	1.822	0.99
159_I	169_I	1.810	0.99
238_V	318_L	1.809	0.99
66_F	73_A	1.808	0.99
216_I	331_V	1.797	0.99
83_S	153_P	1.761	0.99
199_G	215_K	1.757	0.99
238_V	329_I	1.747	0.99
293_L	299_K	1.732	0.99
148_A	211_L	1.704	0.98
72_G	76_I	1.701	0.98
99_Y	126_I	1.697	0.98
33_I	117_L	1.688	0.98
117_L	121_L	1.686	0.98
91_V	113_I	1.678	0.98
111_N	129_T	1.677	0.98
93_I	100_V	1.650	0.98
291_K	295_E	1.644	0.98
257_E	272_L	1.638	0.98
262_I	266_F	1.618	0.98
18_C	61_Y	1.605	0.98
234_G	323_I	1.592	0.98
252_I	263_A	1.585	0.98
131_A	160_N	1.560	0.97
234_G	329_I	1.537	0.97
93_I	121_L	1.536	0.97
218_I	252_I	1.534	0.97
85_T	108_W	1.516	0.97
217_S	251_I	1.502	0.97
318_L	331_V	1.493	0.96
310_G	332_A	1.470	0.96
238_V	242_L	1.463	0.96
307_L	332_A	1.460	0.96
102_P	125_P	1.440	0.96
29_A	67_V	1.438	0.96
228_M	265_E	1.437	0.96
54_I	66_F	1.435	0.96
55_E	80_Y	1.431	0.95
237_K	241_R	1.424	0.95
251_I	271_R	1.416	0.95
129_T	132_E	1.415	0.95
181_P	184_I	1.408	0.95
149_K	214_L	1.402	0.95
230_E	326_N	1.393	0.95
307_L	316_L	1.392	0.95
231_I	327_S	1.392	0.95
316_L	332_A	1.385	0.95
235_I	329_I	1.381	0.94
242_L	318_L	1.354	0.94
261_K	264_D	1.351	0.94
17_I	63_A	1.321	0.93
21_S	27_F	1.320	0.93
275_E	296_V	1.319	0.93
100_V	117_L	1.316	0.93
65_V	91_V	1.313	0.93
82_K	86_E	1.309	0.93
102_P	117_L	1.305	0.93
273_V	309_A	1.305	0.93
315_K	333_T	1.303	0.93
236_Y	266_F	1.303	0.93
112_D	145_I	1.301	0.92
232_R	236_Y	1.301	0.92
152_N	156_I	1.300	0.92
29_A	97_I	1.297	0.92
105_G	108_W	1.287	0.92
131_A	211_L	1.285	0.92
111_N	132_E	1.272	0.92
63_A	91_V	1.256	0.91
83_S	86_E	1.255	0.91
228_M	261_K	1.247	0.91
100_V	123_S	1.232	0.90
92_C	101_I	1.219	0.90
236_Y	246_R	1.213	0.90
223_K	291_K	1.205	0.89
241_R	321_I	1.202	0.89
239_L	246_R	1.181	0.88
228_M	262_I	1.181	0.88
65_V	93_I	1.180	0.88
244_L	331_V	1.174	0.88
215_K	333_T	1.171	0.88
220_I	259_V	1.169	0.88
96_K	133_I	1.168	0.88
223_K	226_V	1.167	0.88
37_L	116_E	1.166	0.88
302_A	330_A	1.150	0.87
54_I	77_V	1.143	0.87
56_T	60_C	1.143	0.87
205_D	208_V	1.137	0.86
260_K	272_L	1.135	0.86
273_V	278_I	1.123	0.86
218_I	331_V	1.122	0.86
167_E	192_S	1.120	0.85
279_N	299_K	1.115	0.85
53_E	57_I	1.109	0.85
232_R	262_I	1.109	0.85
63_A	89_A	1.108	0.85
16_G	62_D	1.106	0.85
22_A	68_M	1.106	0.85
222_S	226_V	1.105	0.85
279_N	293_L	1.102	0.84
153_P	156_I	1.102	0.84
21_S	30_G	1.096	0.84
279_N	298_L	1.088	0.84
136_K	163_L	1.083	0.83
49_Y	52_A	1.082	0.83
151_I	247_E	1.079	0.83
252_I	268_V	1.066	0.82
303_E	320_K	1.064	0.82
143_A	209_V	1.062	0.82
24_E	165_R	1.055	0.82
220_I	235_I	1.052	0.82
67_V	93_I	1.043	0.81
299_K	304_I	1.042	0.81
226_V	231_I	1.041	0.81
210_W	245_K	1.041	0.81
218_I	329_I	1.038	0.81
245_K	248_R	1.036	0.81
89_A	110_A	1.034	0.80
156_I	160_N	1.033	0.80
139_I	156_I	1.033	0.80
193_Y	196_S	1.029	0.80
283_N	304_I	1.019	0.79
217_S	253_A	1.014	0.79
278_I	304_I	1.013	0.79
36_K	120_I	1.002	0.78
251_I	309_A	0.998	0.78
306_A	310_G	0.996	0.78
291_K	326_N	0.984	0.77
193_Y	197_L	0.972	0.76
275_E	278_I	0.962	0.75
54_I	80_Y	0.959	0.75
254_S	263_A	0.951	0.75
139_I	160_N	0.942	0.74
198_R	210_W	0.942	0.74
162_A	167_E	0.942	0.74
231_I	235_I	0.941	0.74
114_A	125_P	0.939	0.74
108_W	153_P	0.938	0.74
25_D	134_K	0.935	0.73
65_V	279_N	0.933	0.73
230_E	323_I	0.932	0.73
141_R	145_I	0.928	0.73
131_A	164_L	0.926	0.73
298_L	304_I	0.923	0.72
263_A	270_F	0.918	0.72
20_I	57_I	0.916	0.72
152_N	210_W	0.903	0.71
249_I	268_V	0.892	0.70
263_A	268_V	0.891	0.70
303_E	330_A	0.891	0.70
278_I	300_G	0.890	0.70
98_N	124_T	0.889	0.69
225_D	228_M	0.884	0.69
259_V	270_F	0.883	0.69
94_D	98_N	0.883	0.69
92_C	102_P	0.883	0.69
39_S	42_I	0.882	0.69
131_A	157_V	0.879	0.69
215_K	248_R	0.875	0.68
18_C	57_I	0.875	0.68
253_A	273_V	0.873	0.68
72_G	143_A	0.864	0.67
132_E	140_E	0.858	0.67
21_S	26_A	0.857	0.67
156_I	164_L	0.856	0.67
262_I	268_V	0.853	0.66
273_V	308_I	0.850	0.66
222_S	259_V	0.843	0.65
220_I	231_I	0.841	0.65
230_E	234_G	0.836	0.65
235_I	249_I	0.831	0.64
67_V	253_A	0.827	0.64
27_F	31_E	0.825	0.64
77_V	81_A	0.820	0.63
218_I	239_L	0.819	0.63
288_P	291_K	0.819	0.63
151_I	245_K	0.819	0.63
237_K	323_I	0.818	0.63
33_I	325_R	0.816	0.63
242_L	329_I	0.815	0.63
137_L	304_I	0.809	0.62
226_V	230_E	0.808	0.62
92_C	128_T	0.806	0.62
58_W	111_N	0.805	0.62
150_I	156_I	0.795	0.61
239_L	331_V	0.793	0.61
250_G	269_R	0.793	0.61
229_E	261_K	0.792	0.60
284_P	287_T	0.791	0.60
57_I	64_I	0.787	0.60
292_T	297_G	0.785	0.60
283_N	300_G	0.785	0.60
102_P	127_I	0.783	0.60
284_P	304_I	0.779	0.59
249_I	331_V	0.778	0.59
291_K	294_I	0.778	0.59
222_S	231_I	0.777	0.59
220_I	252_I	0.770	0.58
299_K	302_A	0.767	0.58
143_A	211_L	0.762	0.58
307_L	330_A	0.761	0.57
193_Y	198_R	0.760	0.57
287_T	299_K	0.759	0.57
157_V	161_A	0.758	0.57
38_K	41_E	0.746	0.56
72_G	223_K	0.745	0.56
224_K	272_L	0.745	0.56
159_I	193_Y	0.745	0.56
223_K	295_E	0.745	0.56
318_L	321_I	0.743	0.56
229_E	241_R	0.741	0.55
238_V	331_V	0.741	0.55
161_A	165_R	0.740	0.55
234_G	238_V	0.739	0.55
68_M	72_G	0.738	0.55
275_E	305_S	0.738	0.55
206_K	276_E	0.738	0.55
100_V	121_L	0.736	0.55
271_R	331_V	0.736	0.55
220_I	329_I	0.735	0.55
170_C	191_C	0.735	0.55
81_A	155_N	0.733	0.55
236_Y	240_E	0.730	0.54
216_I	333_T	0.729	0.54
19_I	67_V	0.726	0.54
69_A	72_G	0.726	0.54
112_D	115_R	0.724	0.54
31_E	35_E	0.721	0.53
111_N	127_I	0.720	0.53
19_I	33_I	0.716	0.53
36_K	276_E	0.716	0.53
316_L	330_A	0.715	0.53
139_I	171_I	0.715	0.53
97_I	123_S	0.715	0.53
289_P	292_T	0.714	0.53
34_K	42_I	0.711	0.52
76_I	80_Y	0.710	0.52
95_D	133_I	0.708	0.52
95_D	134_K	0.706	0.52
19_I	30_G	0.706	0.52
101_I	128_T	0.706	0.52
141_R	161_A	0.705	0.52
22_A	304_I	0.705	0.52
162_A	193_Y	0.705	0.52
54_I	76_I	0.704	0.52
93_I	117_L	0.702	0.51
252_I	262_I	0.701	0.51
33_I	100_V	0.699	0.51
95_D	130_A	0.699	0.51
25_D	96_K	0.696	0.51
307_L	314_S	0.696	0.51
94_D	99_Y	0.695	0.51
231_I	259_V	0.693	0.51
131_A	143_A	0.692	0.50
69_A	129_T	0.690	0.50
153_P	161_A	0.690	0.50
22_A	73_A	0.688	0.50
50_K	53_E	0.686	0.50
73_A	92_C	0.686	0.50
57_I	61_Y	0.682	0.49
195_I	211_L	0.682	0.49
260_K	270_F	0.679	0.49
304_I	326_N	0.678	0.49
284_P	288_P	0.677	0.49
28_S	167_E	0.672	0.48
159_I	195_I	0.671	0.48
246_R	266_F	0.669	0.48
169_I	183_N	0.669	0.48
25_D	95_D	0.668	0.48
164_L	304_I	0.666	0.48
25_D	276_E	0.663	0.47
84_K	107_H	0.663	0.47
141_R	171_I	0.662	0.47
288_P	295_E	0.660	0.47
254_S	325_R	0.659	0.47
102_P	126_I	0.657	0.47
228_M	231_I	0.656	0.47
172_D	175_D	0.656	0.47
172_D	176_V	0.656	0.47
51_D	76_I	0.654	0.47
156_I	161_A	0.654	0.47
194_I	208_V	0.653	0.46
212_K	247_E	0.652	0.46
142_I	304_I	0.651	0.46
98_N	133_I	0.650	0.46
280_N	308_I	0.649	0.46
146_L	209_V	0.647	0.46
243_N	246_R	0.645	0.46
28_S	32_T	0.642	0.45
100_V	118_S	0.641	0.45
33_I	93_I	0.641	0.45
284_P	298_L	0.640	0.45
230_E	325_R	0.640	0.45
54_I	72_G	0.639	0.45
288_P	304_I	0.639	0.45
199_G	248_R	0.636	0.45
29_A	93_I	0.635	0.45
132_E	289_P	0.634	0.44
23_S	26_A	0.633	0.44
155_N	209_V	0.633	0.44
281_F	300_G	0.632	0.44
63_A	117_L	0.631	0.44
99_Y	133_I	0.630	0.44
107_H	221_G	0.628	0.44
152_N	155_N	0.627	0.44
196_S	200_D	0.624	0.43
169_I	199_G	0.622	0.43
216_I	318_L	0.622	0.43
180_F	183_N	0.620	0.43
32_T	60_C	0.618	0.43
238_V	321_I	0.616	0.43
287_T	303_E	0.614	0.42
288_P	300_G	0.614	0.42
163_L	169_I	0.614	0.42
154_E	158_K	0.614	0.42
162_A	207_I	0.613	0.42
27_F	30_G	0.612	0.42
138_S	222_S	0.610	0.42
142_I	146_L	0.610	0.42
201_K	243_N	0.608	0.42
278_I	298_L	0.607	0.42
157_V	164_L	0.604	0.41
87_D	94_D	0.603	0.41
160_N	164_L	0.603	0.41
88_P	248_R	0.599	0.41
191_C	194_I	0.599	0.41
284_P	299_K	0.598	0.41
198_R	247_E	0.597	0.41
240_E	277_E	0.596	0.41
142_I	160_N	0.596	0.41
105_G	302_A	0.595	0.41
26_A	130_A	0.591	0.40
167_E	191_C	0.591	0.40
74_T	92_C	0.586	0.40
229_E	265_E	0.586	0.40
25_D	28_S	0.583	0.39
137_L	142_I	0.583	0.39
70_L	73_A	0.582	0.39
50_K	76_I	0.581	0.39
160_N	211_L	0.580	0.39
253_A	270_F	0.575	0.39
221_G	328_T	0.573	0.38
73_A	137_L	0.571	0.38
99_Y	127_I	0.569	0.38
306_A	314_S	0.567	0.38
278_I	288_P	0.566	0.38
118_S	123_S	0.565	0.38
162_A	194_I	0.565	0.38
221_G	256_R	0.563	0.37
143_A	148_A	0.562	0.37
291_K	302_A	0.562	0.37
220_I	262_I	0.559	0.37
67_V	263_A	0.559	0.37
68_M	95_D	0.558	0.37
92_C	126_I	0.556	0.37
35_E	243_N	0.555	0.37
169_I	188_S	0.555	0.37
227_K	230_E	0.554	0.37
133_I	302_A	0.554	0.37
194_I	200_D	0.554	0.37
106_G	132_E	0.553	0.37
292_T	296_V	0.551	0.36
165_R	300_G	0.551	0.36
291_K	300_G	0.550	0.36
189_E	192_S	0.550	0.36
125_P	300_G	0.550	0.36
170_C	194_I	0.549	0.36
303_E	316_L	0.548	0.36
203_Y	261_K	0.547	0.36
254_S	273_V	0.545	0.36
311_G	332_A	0.545	0.36
139_I	163_L	0.544	0.36
23_S	220_I	0.544	0.36
156_I	210_W	0.541	0.35
239_L	244_L	0.540	0.35
250_G	317_I	0.539	0.35
173_G	176_V	0.538	0.35
87_D	140_E	0.538	0.35
298_L	326_N	0.535	0.35
24_E	167_E	0.535	0.35
33_I	121_L	0.533	0.35
148_A	209_V	0.533	0.35
181_P	197_L	0.532	0.35
57_I	90_I	0.532	0.35
138_S	145_I	0.532	0.35
155_N	158_K	0.530	0.34
270_F	290_S	0.530	0.34
26_A	91_V	0.529	0.34
295_E	298_L	0.527	0.34
37_L	120_I	0.525	0.34
58_W	64_I	0.525	0.34
271_R	309_A	0.525	0.34
179_N	184_I	0.523	0.34
114_A	123_S	0.522	0.34
305_S	330_A	0.520	0.33
105_G	160_N	0.519	0.33
162_A	321_I	0.518	0.33
135_G	188_S	0.518	0.33
38_K	42_I	0.518	0.33
130_A	163_L	0.518	0.33
96_K	134_K	0.518	0.33
287_T	304_I	0.517	0.33
67_V	72_G	0.516	0.33
148_A	302_A	0.516	0.33
131_A	156_I	0.516	0.33
78_C	106_G	0.515	0.33
92_C	325_R	0.515	0.33
72_G	132_E	0.513	0.33
223_K	298_L	0.513	0.33
20_I	54_I	0.512	0.33
292_T	295_E	0.512	0.33
235_I	238_V	0.510	0.33
68_M	137_L	0.510	0.33
47_Y	53_E	0.509	0.32
131_A	291_K	0.509	0.32
101_I	228_M	0.509	0.32
221_G	301_V	0.507	0.32
58_W	114_A	0.507	0.32
89_A	306_A	0.507	0.32
189_E	195_I	0.507	0.32
68_M	142_I	0.506	0.32
235_I	239_L	0.506	0.32
108_W	144_N	0.506	0.32
213_P	231_I	0.506	0.32
129_T	164_L	0.504	0.32
214_L	223_K	0.503	0.32
236_Y	265_E	0.503	0.32
19_I	23_S	0.503	0.32
111_N	125_P	0.503	0.32
32_T	36_K	0.502	0.32
77_V	90_I	0.502	0.32
204_K	208_V	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3eeqA	2	0.9258	100	0.152	Contact Map
2w6kA	1	0.3917	100	0.69	Contact Map
3by5A	2	0.3501	100	0.702	Contact Map
4iciA	1	0.3769	86.1	0.955	Contact Map
2wc1A	1	0.4481	85.4	0.956	Contact Map
3d7nA	4	0.4065	85.4	0.956	Contact Map
2fz5A	1	0.3798	80.4	0.958	Contact Map
3f6rA	1	0.3828	77.5	0.96	Contact Map
4heqA	2	0.3798	77.1	0.96	Contact Map
1yobA	1	0.4392	74.1	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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