GREMLIN Database
Q97WD0 - Cobalamin biosynthesis protein G homolog, putative (CbiG-like)
UniProt: Q97WD0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (313)
Sequences: 1082 (881)
Seq/√Len: 49.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
254_S270_F4.6201.00
99_Y124_T4.3631.00
91_V100_V3.6111.00
224_K258_E3.3681.00
255_I296_V3.2771.00
300_G304_I3.1091.00
70_L103_L3.0101.00
274_N277_E3.0061.00
216_I244_L2.9981.00
63_A113_I2.9611.00
231_I262_I2.9601.00
199_G333_T2.8161.00
306_A332_A2.7481.00
232_R265_E2.7471.00
254_S272_L2.6981.00
253_A309_A2.6761.00
85_T153_P2.6431.00
102_P114_A2.5461.00
212_K245_K2.5271.00
234_G327_S2.3601.00
310_G314_S2.3281.00
218_I235_I2.3131.00
239_L249_I2.3101.00
235_I262_I2.2221.00
218_I249_I2.1911.00
278_I305_S2.1371.00
287_T319_R2.1281.00
151_I212_K2.1131.00
290_S293_L2.0261.00
68_M73_A1.9981.00
288_P299_K1.9060.99
20_I64_I1.8880.99
232_R266_F1.8820.99
277_E308_I1.8820.99
223_K326_N1.8820.99
255_I275_E1.8800.99
212_K248_R1.8540.99
81_A104_L1.8440.99
281_F308_I1.8220.99
159_I169_I1.8100.99
238_V318_L1.8090.99
66_F73_A1.8080.99
216_I331_V1.7970.99
83_S153_P1.7610.99
199_G215_K1.7570.99
238_V329_I1.7470.99
293_L299_K1.7320.99
148_A211_L1.7040.98
72_G76_I1.7010.98
99_Y126_I1.6970.98
33_I117_L1.6880.98
117_L121_L1.6860.98
91_V113_I1.6780.98
111_N129_T1.6770.98
93_I100_V1.6500.98
291_K295_E1.6440.98
257_E272_L1.6380.98
262_I266_F1.6180.98
18_C61_Y1.6050.98
234_G323_I1.5920.98
252_I263_A1.5850.98
131_A160_N1.5600.97
234_G329_I1.5370.97
93_I121_L1.5360.97
218_I252_I1.5340.97
85_T108_W1.5160.97
217_S251_I1.5020.97
318_L331_V1.4930.96
310_G332_A1.4700.96
238_V242_L1.4630.96
307_L332_A1.4600.96
102_P125_P1.4400.96
29_A67_V1.4380.96
228_M265_E1.4370.96
54_I66_F1.4350.96
55_E80_Y1.4310.95
237_K241_R1.4240.95
251_I271_R1.4160.95
129_T132_E1.4150.95
181_P184_I1.4080.95
149_K214_L1.4020.95
230_E326_N1.3930.95
307_L316_L1.3920.95
231_I327_S1.3920.95
316_L332_A1.3850.95
235_I329_I1.3810.94
242_L318_L1.3540.94
261_K264_D1.3510.94
17_I63_A1.3210.93
21_S27_F1.3200.93
275_E296_V1.3190.93
100_V117_L1.3160.93
65_V91_V1.3130.93
82_K86_E1.3090.93
102_P117_L1.3050.93
273_V309_A1.3050.93
315_K333_T1.3030.93
236_Y266_F1.3030.93
112_D145_I1.3010.92
232_R236_Y1.3010.92
152_N156_I1.3000.92
29_A97_I1.2970.92
105_G108_W1.2870.92
131_A211_L1.2850.92
111_N132_E1.2720.92
63_A91_V1.2560.91
83_S86_E1.2550.91
228_M261_K1.2470.91
100_V123_S1.2320.90
92_C101_I1.2190.90
236_Y246_R1.2130.90
223_K291_K1.2050.89
241_R321_I1.2020.89
239_L246_R1.1810.88
228_M262_I1.1810.88
65_V93_I1.1800.88
244_L331_V1.1740.88
215_K333_T1.1710.88
220_I259_V1.1690.88
96_K133_I1.1680.88
223_K226_V1.1670.88
37_L116_E1.1660.88
302_A330_A1.1500.87
54_I77_V1.1430.87
56_T60_C1.1430.87
205_D208_V1.1370.86
260_K272_L1.1350.86
273_V278_I1.1230.86
218_I331_V1.1220.86
167_E192_S1.1200.85
279_N299_K1.1150.85
53_E57_I1.1090.85
232_R262_I1.1090.85
63_A89_A1.1080.85
16_G62_D1.1060.85
22_A68_M1.1060.85
222_S226_V1.1050.85
279_N293_L1.1020.84
153_P156_I1.1020.84
21_S30_G1.0960.84
279_N298_L1.0880.84
136_K163_L1.0830.83
49_Y52_A1.0820.83
151_I247_E1.0790.83
252_I268_V1.0660.82
303_E320_K1.0640.82
143_A209_V1.0620.82
24_E165_R1.0550.82
220_I235_I1.0520.82
67_V93_I1.0430.81
299_K304_I1.0420.81
226_V231_I1.0410.81
210_W245_K1.0410.81
218_I329_I1.0380.81
245_K248_R1.0360.81
89_A110_A1.0340.80
156_I160_N1.0330.80
139_I156_I1.0330.80
193_Y196_S1.0290.80
283_N304_I1.0190.79
217_S253_A1.0140.79
278_I304_I1.0130.79
36_K120_I1.0020.78
251_I309_A0.9980.78
306_A310_G0.9960.78
291_K326_N0.9840.77
193_Y197_L0.9720.76
275_E278_I0.9620.75
54_I80_Y0.9590.75
254_S263_A0.9510.75
139_I160_N0.9420.74
198_R210_W0.9420.74
162_A167_E0.9420.74
231_I235_I0.9410.74
114_A125_P0.9390.74
108_W153_P0.9380.74
25_D134_K0.9350.73
65_V279_N0.9330.73
230_E323_I0.9320.73
141_R145_I0.9280.73
131_A164_L0.9260.73
298_L304_I0.9230.72
263_A270_F0.9180.72
20_I57_I0.9160.72
152_N210_W0.9030.71
249_I268_V0.8920.70
263_A268_V0.8910.70
303_E330_A0.8910.70
278_I300_G0.8900.70
98_N124_T0.8890.69
225_D228_M0.8840.69
259_V270_F0.8830.69
94_D98_N0.8830.69
92_C102_P0.8830.69
39_S42_I0.8820.69
131_A157_V0.8790.69
215_K248_R0.8750.68
18_C57_I0.8750.68
253_A273_V0.8730.68
72_G143_A0.8640.67
132_E140_E0.8580.67
21_S26_A0.8570.67
156_I164_L0.8560.67
262_I268_V0.8530.66
273_V308_I0.8500.66
222_S259_V0.8430.65
220_I231_I0.8410.65
230_E234_G0.8360.65
235_I249_I0.8310.64
67_V253_A0.8270.64
27_F31_E0.8250.64
77_V81_A0.8200.63
218_I239_L0.8190.63
288_P291_K0.8190.63
151_I245_K0.8190.63
237_K323_I0.8180.63
33_I325_R0.8160.63
242_L329_I0.8150.63
137_L304_I0.8090.62
226_V230_E0.8080.62
92_C128_T0.8060.62
58_W111_N0.8050.62
150_I156_I0.7950.61
239_L331_V0.7930.61
250_G269_R0.7930.61
229_E261_K0.7920.60
284_P287_T0.7910.60
57_I64_I0.7870.60
292_T297_G0.7850.60
283_N300_G0.7850.60
102_P127_I0.7830.60
284_P304_I0.7790.59
249_I331_V0.7780.59
291_K294_I0.7780.59
222_S231_I0.7770.59
220_I252_I0.7700.58
299_K302_A0.7670.58
143_A211_L0.7620.58
307_L330_A0.7610.57
193_Y198_R0.7600.57
287_T299_K0.7590.57
157_V161_A0.7580.57
38_K41_E0.7460.56
72_G223_K0.7450.56
224_K272_L0.7450.56
159_I193_Y0.7450.56
223_K295_E0.7450.56
318_L321_I0.7430.56
229_E241_R0.7410.55
238_V331_V0.7410.55
161_A165_R0.7400.55
234_G238_V0.7390.55
68_M72_G0.7380.55
275_E305_S0.7380.55
206_K276_E0.7380.55
100_V121_L0.7360.55
271_R331_V0.7360.55
220_I329_I0.7350.55
170_C191_C0.7350.55
81_A155_N0.7330.55
236_Y240_E0.7300.54
216_I333_T0.7290.54
19_I67_V0.7260.54
69_A72_G0.7260.54
112_D115_R0.7240.54
31_E35_E0.7210.53
111_N127_I0.7200.53
19_I33_I0.7160.53
36_K276_E0.7160.53
316_L330_A0.7150.53
139_I171_I0.7150.53
97_I123_S0.7150.53
289_P292_T0.7140.53
34_K42_I0.7110.52
76_I80_Y0.7100.52
95_D133_I0.7080.52
95_D134_K0.7060.52
19_I30_G0.7060.52
101_I128_T0.7060.52
141_R161_A0.7050.52
22_A304_I0.7050.52
162_A193_Y0.7050.52
54_I76_I0.7040.52
93_I117_L0.7020.51
252_I262_I0.7010.51
33_I100_V0.6990.51
95_D130_A0.6990.51
25_D96_K0.6960.51
307_L314_S0.6960.51
94_D99_Y0.6950.51
231_I259_V0.6930.51
131_A143_A0.6920.50
69_A129_T0.6900.50
153_P161_A0.6900.50
22_A73_A0.6880.50
50_K53_E0.6860.50
73_A92_C0.6860.50
57_I61_Y0.6820.49
195_I211_L0.6820.49
260_K270_F0.6790.49
304_I326_N0.6780.49
284_P288_P0.6770.49
28_S167_E0.6720.48
159_I195_I0.6710.48
246_R266_F0.6690.48
169_I183_N0.6690.48
25_D95_D0.6680.48
164_L304_I0.6660.48
25_D276_E0.6630.47
84_K107_H0.6630.47
141_R171_I0.6620.47
288_P295_E0.6600.47
254_S325_R0.6590.47
102_P126_I0.6570.47
228_M231_I0.6560.47
172_D175_D0.6560.47
172_D176_V0.6560.47
51_D76_I0.6540.47
156_I161_A0.6540.47
194_I208_V0.6530.46
212_K247_E0.6520.46
142_I304_I0.6510.46
98_N133_I0.6500.46
280_N308_I0.6490.46
146_L209_V0.6470.46
243_N246_R0.6450.46
28_S32_T0.6420.45
100_V118_S0.6410.45
33_I93_I0.6410.45
284_P298_L0.6400.45
230_E325_R0.6400.45
54_I72_G0.6390.45
288_P304_I0.6390.45
199_G248_R0.6360.45
29_A93_I0.6350.45
132_E289_P0.6340.44
23_S26_A0.6330.44
155_N209_V0.6330.44
281_F300_G0.6320.44
63_A117_L0.6310.44
99_Y133_I0.6300.44
107_H221_G0.6280.44
152_N155_N0.6270.44
196_S200_D0.6240.43
169_I199_G0.6220.43
216_I318_L0.6220.43
180_F183_N0.6200.43
32_T60_C0.6180.43
238_V321_I0.6160.43
287_T303_E0.6140.42
288_P300_G0.6140.42
163_L169_I0.6140.42
154_E158_K0.6140.42
162_A207_I0.6130.42
27_F30_G0.6120.42
138_S222_S0.6100.42
142_I146_L0.6100.42
201_K243_N0.6080.42
278_I298_L0.6070.42
157_V164_L0.6040.41
87_D94_D0.6030.41
160_N164_L0.6030.41
88_P248_R0.5990.41
191_C194_I0.5990.41
284_P299_K0.5980.41
198_R247_E0.5970.41
240_E277_E0.5960.41
142_I160_N0.5960.41
105_G302_A0.5950.41
26_A130_A0.5910.40
167_E191_C0.5910.40
74_T92_C0.5860.40
229_E265_E0.5860.40
25_D28_S0.5830.39
137_L142_I0.5830.39
70_L73_A0.5820.39
50_K76_I0.5810.39
160_N211_L0.5800.39
253_A270_F0.5750.39
221_G328_T0.5730.38
73_A137_L0.5710.38
99_Y127_I0.5690.38
306_A314_S0.5670.38
278_I288_P0.5660.38
118_S123_S0.5650.38
162_A194_I0.5650.38
221_G256_R0.5630.37
143_A148_A0.5620.37
291_K302_A0.5620.37
220_I262_I0.5590.37
67_V263_A0.5590.37
68_M95_D0.5580.37
92_C126_I0.5560.37
35_E243_N0.5550.37
169_I188_S0.5550.37
227_K230_E0.5540.37
133_I302_A0.5540.37
194_I200_D0.5540.37
106_G132_E0.5530.37
292_T296_V0.5510.36
165_R300_G0.5510.36
291_K300_G0.5500.36
189_E192_S0.5500.36
125_P300_G0.5500.36
170_C194_I0.5490.36
303_E316_L0.5480.36
203_Y261_K0.5470.36
254_S273_V0.5450.36
311_G332_A0.5450.36
139_I163_L0.5440.36
23_S220_I0.5440.36
156_I210_W0.5410.35
239_L244_L0.5400.35
250_G317_I0.5390.35
173_G176_V0.5380.35
87_D140_E0.5380.35
298_L326_N0.5350.35
24_E167_E0.5350.35
33_I121_L0.5330.35
148_A209_V0.5330.35
181_P197_L0.5320.35
57_I90_I0.5320.35
138_S145_I0.5320.35
155_N158_K0.5300.34
270_F290_S0.5300.34
26_A91_V0.5290.34
295_E298_L0.5270.34
37_L120_I0.5250.34
58_W64_I0.5250.34
271_R309_A0.5250.34
179_N184_I0.5230.34
114_A123_S0.5220.34
305_S330_A0.5200.33
105_G160_N0.5190.33
162_A321_I0.5180.33
135_G188_S0.5180.33
38_K42_I0.5180.33
130_A163_L0.5180.33
96_K134_K0.5180.33
287_T304_I0.5170.33
67_V72_G0.5160.33
148_A302_A0.5160.33
131_A156_I0.5160.33
78_C106_G0.5150.33
92_C325_R0.5150.33
72_G132_E0.5130.33
223_K298_L0.5130.33
20_I54_I0.5120.33
292_T295_E0.5120.33
235_I238_V0.5100.33
68_M137_L0.5100.33
47_Y53_E0.5090.32
131_A291_K0.5090.32
101_I228_M0.5090.32
221_G301_V0.5070.32
58_W114_A0.5070.32
89_A306_A0.5070.32
189_E195_I0.5070.32
68_M142_I0.5060.32
235_I239_L0.5060.32
108_W144_N0.5060.32
213_P231_I0.5060.32
129_T164_L0.5040.32
214_L223_K0.5030.32
236_Y265_E0.5030.32
19_I23_S0.5030.32
111_N125_P0.5030.32
32_T36_K0.5020.32
77_V90_I0.5020.32
204_K208_V0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eeqA 2 0.9258 100 0.152 Contact Map
2w6kA 1 0.3917 100 0.69 Contact Map
3by5A 2 0.3501 100 0.702 Contact Map
4iciA 1 0.3769 86.1 0.955 Contact Map
2wc1A 1 0.4481 85.4 0.956 Contact Map
3d7nA 4 0.4065 85.4 0.956 Contact Map
2fz5A 1 0.3798 80.4 0.958 Contact Map
3f6rA 1 0.3828 77.5 0.96 Contact Map
4heqA 2 0.3798 77.1 0.96 Contact Map
1yobA 1 0.4392 74.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.