Q97WC9 - SULSO - GREMLIN Contacts

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Q97WC9 - Cobalamin biosynthesis precorrin-3 methylase, putative (CbiF)

UniProt:	Q97WC9	Sequences: MIGKVVFIGSGPGDPELITIKAKKYIETADVIVYAGSLVNPEILKWSRKDAEVYNSSSLTLNEIVEIMVKKASEGKLVARLKSGDSSIYGALFEEMWALEAAGIPFEVIPGITAAIAAASVIPIELTVPKLSQTVIITRASLRVPMQGSIKDFAKMVKIGATMVIYTGIHIIDRVVNDLKEGGLTDDTPVIVVYRATWPEQKIIKGTLADIVSKVREAKIYRDSVIIVGLSADPQQIKNMVRSSVYDPKHNHSYRPWKVEED	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	262 (225)
Sequences:	12432 (8067)
Seq/√Len:	537.8

ECOLI - CYSG RSMI
BACSU - NASF SUMT RSMI
HALSA - Q9HPN2 Q9HPM9 Q9HMY4 Q9HPN0 Q9HPM0 Q9HPN3
SULSO - Q97WC9 Q97WC5 Q97W12 Q97UT5 Q97WD1 Q97WC8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_E	24_K	3.653	1.00
23_K	27_E	3.158	1.00
186_D	209_A	2.563	1.00
6_V	25_Y	2.506	1.00
206_G	210_D	2.497	1.00
71_K	76_K	2.471	1.00
4_K	107_E	2.417	1.00
194_Y	202_K	2.399	1.00
29_A	79_A	2.341	1.00
40_N	81_L	2.334	1.00
121_V	201_Q	2.303	1.00
4_K	105_P	2.275	1.00
73_S	102_A	2.262	1.00
24_K	28_T	2.178	1.00
8_I	79_A	2.151	1.00
114_A	166_Y	2.142	1.00
6_V	77_L	2.030	1.00
20_I	23_K	2.021	1.00
52_E	71_K	1.990	1.00
118_A	196_A	1.950	1.00
206_G	214_K	1.934	1.00
207_T	210_D	1.925	1.00
193_V	196_A	1.907	1.00
195_R	200_E	1.886	1.00
190_V	211_I	1.859	1.00
71_K	74_E	1.850	1.00
98_A	102_A	1.850	1.00
8_I	22_A	1.844	1.00
30_D	77_L	1.783	1.00
189_P	229_G	1.782	1.00
69_V	102_A	1.744	1.00
9_G	109_I	1.737	1.00
98_A	101_A	1.713	1.00
152_D	155_K	1.658	1.00
30_D	76_K	1.646	1.00
31_V	71_K	1.642	1.00
193_V	203_I	1.611	1.00
4_K	77_L	1.606	1.00
24_K	27_E	1.580	1.00
70_K	74_E	1.570	1.00
41_P	45_K	1.555	1.00
6_V	107_E	1.548	1.00
210_D	214_K	1.539	1.00
178_D	181_E	1.520	1.00
25_Y	109_I	1.520	1.00
173_D	216_R	1.509	1.00
206_G	211_I	1.502	1.00
16_E	21_K	1.500	1.00
176_V	180_K	1.465	1.00
121_V	203_I	1.456	1.00
214_K	218_A	1.444	1.00
115_A	166_Y	1.429	1.00
195_R	198_W	1.427	1.00
179_L	208_L	1.418	1.00
184_L	188_T	1.418	1.00
187_D	209_A	1.404	1.00
113_T	116_I	1.391	1.00
213_S	217_E	1.377	1.00
149_S	178_D	1.364	1.00
28_T	77_L	1.355	1.00
32_I	47_S	1.352	1.00
73_S	104_I	1.347	1.00
18_I	23_K	1.335	1.00
14_D	21_K	1.334	1.00
67_I	71_K	1.323	1.00
113_T	166_Y	1.316	1.00
67_I	70_K	1.313	1.00
230_L	233_D	1.306	1.00
21_K	107_E	1.301	1.00
165_I	228_V	1.275	1.00
9_G	85_D	1.271	1.00
176_V	212_V	1.266	1.00
69_V	73_S	1.266	1.00
66_E	70_K	1.257	1.00
87_S	92_L	1.254	1.00
118_A	193_V	1.253	1.00
154_A	181_E	1.242	1.00
214_K	217_E	1.226	1.00
192_V	224_S	1.201	1.00
63_E	66_E	1.186	1.00
34_Y	53_V	1.182	1.00
122_I	191_I	1.178	1.00
72_A	104_I	1.176	1.00
180_K	186_D	1.175	1.00
177_N	181_E	1.169	1.00
5_V	99_L	1.166	1.00
173_D	177_N	1.164	1.00
108_V	120_S	1.160	1.00
204_I	214_K	1.153	1.00
5_V	72_A	1.149	1.00
19_T	112_I	1.146	1.00
65_V	98_A	1.135	1.00
172_I	215_V	1.131	1.00
69_V	98_A	1.127	1.00
52_E	76_K	1.124	1.00
164_V	227_I	1.115	1.00
25_Y	79_A	1.106	1.00
191_I	203_I	1.099	1.00
18_I	22_A	1.099	1.00
85_D	120_S	1.098	1.00
99_L	104_I	1.088	1.00
33_V	68_M	1.083	1.00
179_L	228_V	1.076	1.00
33_V	78_V	1.069	1.00
190_V	208_L	1.053	1.00
23_K	46_W	1.050	1.00
154_A	178_D	1.048	1.00
42_E	45_K	1.047	1.00
31_V	78_V	1.046	1.00
64_I	67_I	1.045	1.00
29_A	77_L	1.039	1.00
202_K	218_A	1.036	1.00
131_L	161_A	1.029	1.00
155_K	158_K	1.020	1.00
57_S	60_T	1.016	1.00
154_A	182_G	1.011	1.00
191_I	205_K	1.011	1.00
180_K	209_A	1.006	1.00
17_L	21_K	1.006	1.00
150_I	178_D	1.000	1.00
174_R	177_N	0.996	1.00
100_E	205_K	0.988	1.00
136_I	161_A	0.987	1.00
93_F	128_V	0.986	1.00
6_V	109_I	0.982	1.00
165_I	168_G	0.981	1.00
172_I	211_I	0.978	1.00
61_L	94_E	0.972	1.00
180_K	208_L	0.972	1.00
154_A	157_V	0.970	1.00
136_I	160_G	0.965	1.00
172_I	226_I	0.965	1.00
192_V	215_V	0.963	1.00
171_I	174_R	0.963	1.00
220_I	224_S	0.961	1.00
31_V	76_K	0.959	1.00
97_W	101_A	0.956	1.00
179_L	184_L	0.955	1.00
33_V	71_K	0.954	1.00
173_D	212_V	0.954	1.00
154_A	158_K	0.938	1.00
194_Y	221_Y	0.936	1.00
33_V	54_Y	0.926	1.00
176_V	208_L	0.926	1.00
133_Q	161_A	0.925	1.00
108_V	203_I	0.918	1.00
174_R	178_D	0.916	1.00
129_P	133_Q	0.916	1.00
80_R	95_E	0.913	1.00
16_E	20_I	0.912	1.00
96_M	106_F	0.904	1.00
51_A	54_Y	0.903	1.00
194_Y	224_S	0.896	1.00
180_K	212_V	0.894	1.00
136_I	152_D	0.893	1.00
185_T	188_T	0.884	1.00
33_V	67_I	0.876	1.00
20_I	24_K	0.870	1.00
164_V	225_V	0.861	1.00
177_N	212_V	0.859	1.00
124_I	191_I	0.857	1.00
167_T	171_I	0.852	1.00
47_S	51_A	0.852	1.00
48_R	51_A	0.849	1.00
18_I	43_I	0.843	1.00
93_F	97_W	0.839	1.00
60_T	63_E	0.838	1.00
66_E	98_A	0.836	1.00
136_I	153_F	0.836	1.00
22_A	109_I	0.835	1.00
125_E	128_V	0.828	1.00
87_S	108_V	0.827	1.00
100_E	106_F	0.826	1.00
118_A	227_I	0.824	1.00
8_I	109_I	0.823	1.00
88_I	135_V	0.819	1.00
117_A	197_T	0.815	1.00
100_E	123_P	0.813	1.00
108_V	121_V	0.812	1.00
88_I	116_I	0.809	1.00
6_V	29_A	0.808	1.00
188_T	230_L	0.808	1.00
212_V	216_R	0.808	1.00
187_D	207_T	0.807	1.00
9_G	86_S	0.803	1.00
88_I	126_L	0.799	1.00
7_F	92_L	0.798	1.00
146_M	150_I	0.796	1.00
54_Y	71_K	0.796	1.00
32_I	51_A	0.795	1.00
166_Y	225_V	0.784	1.00
189_P	207_T	0.779	1.00
86_S	90_G	0.778	1.00
25_Y	28_T	0.776	1.00
39_V	42_E	0.776	1.00
175_V	226_I	0.775	1.00
15_P	42_E	0.774	1.00
25_Y	77_L	0.769	1.00
9_G	117_A	0.768	1.00
8_I	25_Y	0.765	1.00
72_A	78_V	0.764	1.00
151_K	154_A	0.764	1.00
192_V	211_I	0.764	1.00
65_V	69_V	0.761	1.00
143_R	146_M	0.760	1.00
85_D	108_V	0.756	1.00
93_F	125_E	0.755	1.00
61_L	65_V	0.752	1.00
191_I	227_I	0.751	1.00
178_D	182_G	0.746	1.00
153_F	175_V	0.745	1.00
173_D	213_S	0.740	1.00
133_Q	152_D	0.737	1.00
134_T	161_A	0.737	1.00
54_Y	67_I	0.734	1.00
160_G	184_L	0.734	1.00
31_V	54_Y	0.733	1.00
54_Y	64_I	0.731	1.00
25_Y	107_E	0.729	1.00
14_D	17_L	0.724	1.00
155_K	159_I	0.724	1.00
119_A	126_L	0.723	1.00
204_I	215_V	0.721	1.00
169_I	224_S	0.716	1.00
215_V	220_I	0.715	1.00
163_M	228_V	0.712	1.00
131_L	159_I	0.712	1.00
117_A	196_A	0.712	1.00
147_Q	151_K	0.710	1.00
89_Y	132_S	0.710	1.00
204_I	211_I	0.710	1.00
213_S	216_R	0.708	1.00
21_K	24_K	0.708	1.00
30_D	48_R	0.705	1.00
163_M	179_L	0.704	1.00
70_K	73_S	0.704	1.00
121_V	197_T	0.703	1.00
26_I	32_I	0.702	1.00
6_V	79_A	0.701	1.00
40_N	44_L	0.700	1.00
21_K	109_I	0.700	1.00
204_I	220_I	0.692	1.00
29_A	32_I	0.687	1.00
25_Y	29_A	0.683	1.00
62_N	98_A	0.682	1.00
155_K	160_G	0.682	1.00
7_F	96_M	0.679	1.00
96_M	100_E	0.675	1.00
150_I	174_R	0.671	1.00
150_I	154_A	0.670	1.00
177_N	216_R	0.670	1.00
99_L	106_F	0.667	1.00
43_I	46_W	0.665	1.00
210_D	213_S	0.663	1.00
47_S	53_V	0.662	1.00
169_I	220_I	0.659	1.00
204_I	218_A	0.657	1.00
56_S	61_L	0.656	1.00
145_P	148_G	0.653	1.00
62_N	66_E	0.651	1.00
87_S	120_S	0.649	1.00
21_K	25_Y	0.649	1.00
229_G	232_A	0.648	1.00
172_I	224_S	0.648	1.00
92_L	96_M	0.642	1.00
69_V	99_L	0.630	1.00
116_I	126_L	0.627	1.00
56_S	65_V	0.624	1.00
40_N	47_S	0.623	1.00
41_P	44_L	0.621	1.00
22_A	43_I	0.621	1.00
148_G	151_K	0.618	1.00
97_W	189_P	0.615	1.00
134_T	156_M	0.613	1.00
119_A	227_I	0.612	1.00
136_I	159_I	0.611	1.00
143_R	152_D	0.610	1.00
82_K	90_G	0.607	1.00
66_E	102_A	0.607	1.00
12_P	17_L	0.607	1.00
42_E	46_W	0.603	1.00
27_E	46_W	0.603	1.00
176_V	211_I	0.601	1.00
152_D	158_K	0.600	1.00
9_G	112_I	0.600	1.00
93_F	127_T	0.597	1.00
115_A	164_V	0.595	1.00
23_K	47_S	0.594	1.00
156_M	163_M	0.592	1.00
20_I	27_E	0.588	0.99
22_A	79_A	0.585	0.99
65_V	68_M	0.584	0.99
193_V	227_I	0.584	0.99
62_N	94_E	0.583	0.99
190_V	212_V	0.580	0.99
26_I	79_A	0.576	0.99
195_R	223_D	0.575	0.99
150_I	181_E	0.572	0.99
118_A	225_V	0.572	0.99
172_I	176_V	0.570	0.99
117_A	121_V	0.569	0.99
31_V	52_E	0.569	0.99
41_P	53_V	0.564	0.99
63_E	67_I	0.558	0.99
14_D	197_T	0.558	0.99
195_R	222_R	0.555	0.99
15_P	46_W	0.554	0.99
196_A	203_I	0.552	0.99
175_V	179_L	0.546	0.99
4_K	72_A	0.543	0.99
65_V	94_E	0.542	0.99
58_S	61_L	0.540	0.99
149_S	153_F	0.538	0.99
131_L	230_L	0.534	0.99
37_S	222_R	0.530	0.99
55_N	64_I	0.529	0.99
59_L	63_E	0.528	0.99
44_L	47_S	0.528	0.99
7_F	120_S	0.528	0.99
133_Q	156_M	0.528	0.99
9_G	121_V	0.526	0.99
190_V	215_V	0.524	0.99
135_V	164_V	0.524	0.99
205_K	232_A	0.524	0.99
13_G	198_W	0.520	0.99
87_S	96_M	0.520	0.99
127_T	162_T	0.520	0.99
205_K	233_D	0.519	0.99
12_P	197_T	0.519	0.99
159_I	163_M	0.516	0.99
131_L	163_M	0.516	0.99
5_V	80_R	0.515	0.99
62_N	65_V	0.515	0.99
7_F	106_F	0.513	0.99
20_I	46_W	0.512	0.99
131_L	233_D	0.509	0.99
35_A	91_A	0.504	0.98
96_M	108_V	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1s4dA	4	0.9351	100	0.22	Contact Map
1pjqA	2	0.9008	100	0.258	Contact Map
2yboA	2	0.9008	100	0.261	Contact Map
4e16A	2	0.874	100	0.274	Contact Map
1cbfA	2	0.8893	100	0.274	Contact Map
3kwpA	2	0.8664	100	0.278	Contact Map
1ve2A	2	0.8626	100	0.285	Contact Map
2zvbA	2	0.8397	100	0.304	Contact Map
3ndcA	2	0.9008	100	0.305	Contact Map
1wyzA	2	0.8168	100	0.315	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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