GREMLIN Database
Q97WC9 - Cobalamin biosynthesis precorrin-3 methylase, putative (CbiF)
UniProt: Q97WC9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (225)
Sequences: 12432 (8067)
Seq/√Len: 537.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_E24_K3.6531.00
23_K27_E3.1581.00
186_D209_A2.5631.00
6_V25_Y2.5061.00
206_G210_D2.4971.00
71_K76_K2.4711.00
4_K107_E2.4171.00
194_Y202_K2.3991.00
29_A79_A2.3411.00
40_N81_L2.3341.00
121_V201_Q2.3031.00
4_K105_P2.2751.00
73_S102_A2.2621.00
24_K28_T2.1781.00
8_I79_A2.1511.00
114_A166_Y2.1421.00
6_V77_L2.0301.00
20_I23_K2.0211.00
52_E71_K1.9901.00
118_A196_A1.9501.00
206_G214_K1.9341.00
207_T210_D1.9251.00
193_V196_A1.9071.00
195_R200_E1.8861.00
190_V211_I1.8591.00
71_K74_E1.8501.00
98_A102_A1.8501.00
8_I22_A1.8441.00
30_D77_L1.7831.00
189_P229_G1.7821.00
69_V102_A1.7441.00
9_G109_I1.7371.00
98_A101_A1.7131.00
152_D155_K1.6581.00
30_D76_K1.6461.00
31_V71_K1.6421.00
193_V203_I1.6111.00
4_K77_L1.6061.00
24_K27_E1.5801.00
70_K74_E1.5701.00
41_P45_K1.5551.00
6_V107_E1.5481.00
210_D214_K1.5391.00
178_D181_E1.5201.00
25_Y109_I1.5201.00
173_D216_R1.5091.00
206_G211_I1.5021.00
16_E21_K1.5001.00
176_V180_K1.4651.00
121_V203_I1.4561.00
214_K218_A1.4441.00
115_A166_Y1.4291.00
195_R198_W1.4271.00
179_L208_L1.4181.00
184_L188_T1.4181.00
187_D209_A1.4041.00
113_T116_I1.3911.00
213_S217_E1.3771.00
149_S178_D1.3641.00
28_T77_L1.3551.00
32_I47_S1.3521.00
73_S104_I1.3471.00
18_I23_K1.3351.00
14_D21_K1.3341.00
67_I71_K1.3231.00
113_T166_Y1.3161.00
67_I70_K1.3131.00
230_L233_D1.3061.00
21_K107_E1.3011.00
165_I228_V1.2751.00
9_G85_D1.2711.00
176_V212_V1.2661.00
69_V73_S1.2661.00
66_E70_K1.2571.00
87_S92_L1.2541.00
118_A193_V1.2531.00
154_A181_E1.2421.00
214_K217_E1.2261.00
192_V224_S1.2011.00
63_E66_E1.1861.00
34_Y53_V1.1821.00
122_I191_I1.1781.00
72_A104_I1.1761.00
180_K186_D1.1751.00
177_N181_E1.1691.00
5_V99_L1.1661.00
173_D177_N1.1641.00
108_V120_S1.1601.00
204_I214_K1.1531.00
5_V72_A1.1491.00
19_T112_I1.1461.00
65_V98_A1.1351.00
172_I215_V1.1311.00
69_V98_A1.1271.00
52_E76_K1.1241.00
164_V227_I1.1151.00
25_Y79_A1.1061.00
191_I203_I1.0991.00
18_I22_A1.0991.00
85_D120_S1.0981.00
99_L104_I1.0881.00
33_V68_M1.0831.00
179_L228_V1.0761.00
33_V78_V1.0691.00
190_V208_L1.0531.00
23_K46_W1.0501.00
154_A178_D1.0481.00
42_E45_K1.0471.00
31_V78_V1.0461.00
64_I67_I1.0451.00
29_A77_L1.0391.00
202_K218_A1.0361.00
131_L161_A1.0291.00
155_K158_K1.0201.00
57_S60_T1.0161.00
154_A182_G1.0111.00
191_I205_K1.0111.00
180_K209_A1.0061.00
17_L21_K1.0061.00
150_I178_D1.0001.00
174_R177_N0.9961.00
100_E205_K0.9881.00
136_I161_A0.9871.00
93_F128_V0.9861.00
6_V109_I0.9821.00
165_I168_G0.9811.00
172_I211_I0.9781.00
61_L94_E0.9721.00
180_K208_L0.9721.00
154_A157_V0.9701.00
136_I160_G0.9651.00
172_I226_I0.9651.00
192_V215_V0.9631.00
171_I174_R0.9631.00
220_I224_S0.9611.00
31_V76_K0.9591.00
97_W101_A0.9561.00
179_L184_L0.9551.00
33_V71_K0.9541.00
173_D212_V0.9541.00
154_A158_K0.9381.00
194_Y221_Y0.9361.00
33_V54_Y0.9261.00
176_V208_L0.9261.00
133_Q161_A0.9251.00
108_V203_I0.9181.00
174_R178_D0.9161.00
129_P133_Q0.9161.00
80_R95_E0.9131.00
16_E20_I0.9121.00
96_M106_F0.9041.00
51_A54_Y0.9031.00
194_Y224_S0.8961.00
180_K212_V0.8941.00
136_I152_D0.8931.00
185_T188_T0.8841.00
33_V67_I0.8761.00
20_I24_K0.8701.00
164_V225_V0.8611.00
177_N212_V0.8591.00
124_I191_I0.8571.00
167_T171_I0.8521.00
47_S51_A0.8521.00
48_R51_A0.8491.00
18_I43_I0.8431.00
93_F97_W0.8391.00
60_T63_E0.8381.00
66_E98_A0.8361.00
136_I153_F0.8361.00
22_A109_I0.8351.00
125_E128_V0.8281.00
87_S108_V0.8271.00
100_E106_F0.8261.00
118_A227_I0.8241.00
8_I109_I0.8231.00
88_I135_V0.8191.00
117_A197_T0.8151.00
100_E123_P0.8131.00
108_V121_V0.8121.00
88_I116_I0.8091.00
6_V29_A0.8081.00
188_T230_L0.8081.00
212_V216_R0.8081.00
187_D207_T0.8071.00
9_G86_S0.8031.00
88_I126_L0.7991.00
7_F92_L0.7981.00
146_M150_I0.7961.00
54_Y71_K0.7961.00
32_I51_A0.7951.00
166_Y225_V0.7841.00
189_P207_T0.7791.00
86_S90_G0.7781.00
25_Y28_T0.7761.00
39_V42_E0.7761.00
175_V226_I0.7751.00
15_P42_E0.7741.00
25_Y77_L0.7691.00
9_G117_A0.7681.00
8_I25_Y0.7651.00
72_A78_V0.7641.00
151_K154_A0.7641.00
192_V211_I0.7641.00
65_V69_V0.7611.00
143_R146_M0.7601.00
85_D108_V0.7561.00
93_F125_E0.7551.00
61_L65_V0.7521.00
191_I227_I0.7511.00
178_D182_G0.7461.00
153_F175_V0.7451.00
173_D213_S0.7401.00
133_Q152_D0.7371.00
134_T161_A0.7371.00
54_Y67_I0.7341.00
160_G184_L0.7341.00
31_V54_Y0.7331.00
54_Y64_I0.7311.00
25_Y107_E0.7291.00
14_D17_L0.7241.00
155_K159_I0.7241.00
119_A126_L0.7231.00
204_I215_V0.7211.00
169_I224_S0.7161.00
215_V220_I0.7151.00
163_M228_V0.7121.00
131_L159_I0.7121.00
117_A196_A0.7121.00
147_Q151_K0.7101.00
89_Y132_S0.7101.00
204_I211_I0.7101.00
213_S216_R0.7081.00
21_K24_K0.7081.00
30_D48_R0.7051.00
163_M179_L0.7041.00
70_K73_S0.7041.00
121_V197_T0.7031.00
26_I32_I0.7021.00
6_V79_A0.7011.00
40_N44_L0.7001.00
21_K109_I0.7001.00
204_I220_I0.6921.00
29_A32_I0.6871.00
25_Y29_A0.6831.00
62_N98_A0.6821.00
155_K160_G0.6821.00
7_F96_M0.6791.00
96_M100_E0.6751.00
150_I174_R0.6711.00
150_I154_A0.6701.00
177_N216_R0.6701.00
99_L106_F0.6671.00
43_I46_W0.6651.00
210_D213_S0.6631.00
47_S53_V0.6621.00
169_I220_I0.6591.00
204_I218_A0.6571.00
56_S61_L0.6561.00
145_P148_G0.6531.00
62_N66_E0.6511.00
87_S120_S0.6491.00
21_K25_Y0.6491.00
229_G232_A0.6481.00
172_I224_S0.6481.00
92_L96_M0.6421.00
69_V99_L0.6301.00
116_I126_L0.6271.00
56_S65_V0.6241.00
40_N47_S0.6231.00
41_P44_L0.6211.00
22_A43_I0.6211.00
148_G151_K0.6181.00
97_W189_P0.6151.00
134_T156_M0.6131.00
119_A227_I0.6121.00
136_I159_I0.6111.00
143_R152_D0.6101.00
82_K90_G0.6071.00
66_E102_A0.6071.00
12_P17_L0.6071.00
42_E46_W0.6031.00
27_E46_W0.6031.00
176_V211_I0.6011.00
152_D158_K0.6001.00
9_G112_I0.6001.00
93_F127_T0.5971.00
115_A164_V0.5951.00
23_K47_S0.5941.00
156_M163_M0.5921.00
20_I27_E0.5880.99
22_A79_A0.5850.99
65_V68_M0.5840.99
193_V227_I0.5840.99
62_N94_E0.5830.99
190_V212_V0.5800.99
26_I79_A0.5760.99
195_R223_D0.5750.99
150_I181_E0.5720.99
118_A225_V0.5720.99
172_I176_V0.5700.99
117_A121_V0.5690.99
31_V52_E0.5690.99
41_P53_V0.5640.99
63_E67_I0.5580.99
14_D197_T0.5580.99
195_R222_R0.5550.99
15_P46_W0.5540.99
196_A203_I0.5520.99
175_V179_L0.5460.99
4_K72_A0.5430.99
65_V94_E0.5420.99
58_S61_L0.5400.99
149_S153_F0.5380.99
131_L230_L0.5340.99
37_S222_R0.5300.99
55_N64_I0.5290.99
59_L63_E0.5280.99
44_L47_S0.5280.99
7_F120_S0.5280.99
133_Q156_M0.5280.99
9_G121_V0.5260.99
190_V215_V0.5240.99
135_V164_V0.5240.99
205_K232_A0.5240.99
13_G198_W0.5200.99
87_S96_M0.5200.99
127_T162_T0.5200.99
205_K233_D0.5190.99
12_P197_T0.5190.99
159_I163_M0.5160.99
131_L163_M0.5160.99
5_V80_R0.5150.99
62_N65_V0.5150.99
7_F106_F0.5130.99
20_I46_W0.5120.99
131_L233_D0.5090.99
35_A91_A0.5040.98
96_M108_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s4dA 4 0.9351 100 0.22 Contact Map
1pjqA 2 0.9008 100 0.258 Contact Map
2yboA 2 0.9008 100 0.261 Contact Map
4e16A 2 0.874 100 0.274 Contact Map
1cbfA 2 0.8893 100 0.274 Contact Map
3kwpA 2 0.8664 100 0.278 Contact Map
1ve2A 2 0.8626 100 0.285 Contact Map
2zvbA 2 0.8397 100 0.304 Contact Map
3ndcA 2 0.9008 100 0.305 Contact Map
1wyzA 2 0.8168 100 0.315 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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