GREMLIN Database
Q97WC8 - Cobalamin biosynthesis precorrin-2 methyltransferase, putative (CbiL)
UniProt: Q97WC8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (208)
Sequences: 9029 (5488)
Seq/√Len: 380.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_A25_K3.7461.00
14_E22_K3.4351.00
130_K196_E3.2101.00
4_Y23_I2.9481.00
189_R197_K2.6221.00
27_V89_A2.6051.00
200_N204_E2.5381.00
127_C191_C2.4731.00
56_K83_E2.4371.00
188_A191_C2.4291.00
200_N208_D2.3721.00
4_Y87_D2.3381.00
190_R195_D2.1951.00
6_V89_A2.1271.00
201_M204_E2.0871.00
14_E19_R2.0241.00
19_R116_E1.9541.00
154_A181_K1.9381.00
123_S166_L1.9211.00
176_A180_S1.9071.00
131_A186_I1.8711.00
4_Y116_E1.8651.00
28_R87_D1.8131.00
12_D19_R1.8061.00
23_I118_V1.7911.00
30_I51_A1.7731.00
81_C111_C1.7561.00
22_K25_K1.7541.00
78_E82_S1.7351.00
108_K111_C1.7321.00
22_K26_E1.7261.00
152_T155_K1.6801.00
21_A50_Y1.6691.00
18_L21_A1.6681.00
176_A206_I1.6461.00
200_N205_I1.6191.00
34_Y63_P1.6131.00
26_E87_D1.5901.00
97_T102_F1.5661.00
190_R193_M1.5371.00
143_S160_F1.5191.00
178_I181_K1.5101.00
82_S85_E1.5011.00
164_I216_I1.4681.00
204_E208_D1.4661.00
29_T83_E1.4511.00
122_S125_T1.4501.00
154_A178_I1.4341.00
6_V20_G1.4331.00
32_I57_L1.4131.00
143_S161_E1.4131.00
174_E177_D1.3881.00
5_V102_F1.3791.00
122_S166_L1.3671.00
127_C188_A1.3611.00
75_K78_E1.3591.00
144_I166_L1.3501.00
79_K83_E1.3481.00
124_I166_L1.3481.00
16_I20_G1.3481.00
7_G96_P1.3451.00
155_K158_E1.3431.00
171_N174_E1.3361.00
154_A182_K1.3251.00
17_T121_V1.2991.00
165_V217_A1.2891.00
81_C108_K1.2451.00
189_R210_D1.2431.00
97_T117_I1.2431.00
3_L109_L1.2421.00
173_K207_N1.2371.00
23_I89_A1.2131.00
177_D181_K1.2071.00
20_G118_V1.1951.00
155_K159_V1.1901.00
31_F83_E1.1871.00
165_V168_A1.1821.00
4_Y118_V1.1751.00
154_A158_E1.1731.00
172_I205_I1.1701.00
19_R118_V1.1331.00
68_V71_N1.1321.00
106_K115_V1.1321.00
130_K192_F1.1121.00
84_S111_C1.1111.00
81_C84_S1.1061.00
176_A202_E1.1051.00
126_A192_F1.1011.00
187_Y213_S1.0921.00
185_L205_I1.0891.00
19_R22_K1.0791.00
15_L19_R1.0781.00
16_I47_V1.0751.00
187_Y209_K1.0721.00
64_M170_E1.0711.00
110_P132_M1.0661.00
34_Y59_L1.0661.00
10_P15_L1.0661.00
141_S161_E1.0651.00
23_I116_E1.0601.00
178_I182_K1.0531.00
163_I179_L1.0511.00
6_V118_V1.0511.00
79_K82_S1.0491.00
199_V208_D1.0491.00
90_F105_I1.0391.00
173_K177_D1.0371.00
188_A198_L1.0371.00
164_I214_M1.0281.00
172_I209_K1.0261.00
98_L125_T1.0161.00
174_E178_I1.0161.00
103_F137_N1.0111.00
13_D46_I1.0101.00
128_A216_I0.9911.00
18_L50_Y0.9901.00
77_G81_C0.9841.00
133_I186_I0.9831.00
84_S113_I0.9801.00
31_F60_L0.9681.00
150_L174_E0.9671.00
51_A55_S0.9671.00
25_K50_Y0.9641.00
58_V79_K0.9611.00
71_N75_K0.9591.00
77_G80_I0.9571.00
172_I215_I0.9501.00
46_I49_K0.9461.00
128_A135_L0.9441.00
169_N213_S0.9331.00
130_K198_L0.9321.00
102_F106_K0.9301.00
28_R52_D0.9281.00
51_A57_L0.9211.00
31_F80_I0.9071.00
127_C214_M0.9061.00
117_I129_S0.9041.00
64_M67_D0.9011.00
107_N137_N0.9011.00
110_P115_V0.9001.00
52_D55_S0.8981.00
58_V83_E0.8941.00
76_L80_I0.8931.00
71_N79_K0.8931.00
31_F58_V0.8931.00
13_D49_K0.8921.00
19_R23_I0.8861.00
153_I175_I0.8821.00
96_P100_S0.8781.00
173_K206_I0.8731.00
92_T100_S0.8721.00
31_F79_K0.8701.00
67_D71_N0.8671.00
14_E18_L0.8651.00
165_V175_I0.8601.00
31_F88_S0.8581.00
179_L217_A0.8481.00
43_A46_I0.8471.00
78_E81_C0.8371.00
23_I87_D0.8351.00
20_G47_V0.8321.00
47_V91_V0.8321.00
187_Y205_I0.8311.00
45_N49_K0.8241.00
141_S146_P0.8181.00
12_D192_F0.8171.00
158_E182_K0.8081.00
23_I26_E0.8041.00
126_A191_C0.8011.00
98_L135_L0.8001.00
63_P66_K0.7991.00
16_I21_A0.7981.00
24_L30_I0.7961.00
4_Y27_V0.7931.00
34_Y64_M0.7921.00
96_P117_I0.7891.00
4_Y89_A0.7881.00
47_V51_A0.7861.00
180_S203_R0.7811.00
72_E75_K0.7791.00
73_L77_G0.7771.00
12_D15_L0.7721.00
30_I55_S0.7701.00
117_I132_M0.7691.00
153_I165_V0.7651.00
142_I146_P0.7601.00
166_L214_M0.7591.00
183_Y219_R0.7591.00
121_V126_A0.7591.00
3_L80_I0.7491.00
98_L142_I0.7481.00
141_S145_I0.7371.00
127_C216_I0.7361.00
24_L89_A0.7351.00
6_V23_I0.7351.00
24_L51_A0.7291.00
27_V30_I0.7221.00
189_R213_S0.7181.00
140_D146_P0.7171.00
74_K78_E0.7151.00
176_A205_I0.7131.00
23_I27_V0.7091.00
135_L164_I0.7041.00
152_T158_E0.6990.99
77_G108_K0.6980.99
48_K51_A0.6950.99
142_I145_I0.6910.99
18_L22_K0.6910.99
131_A198_L0.6900.99
102_F117_I0.6860.99
44_E48_K0.6800.99
27_V87_D0.6750.99
189_R199_V0.6750.99
74_K108_K0.6690.99
131_A188_A0.6680.99
29_T58_V0.6670.99
145_I156_A0.6600.99
123_S128_A0.6580.99
153_I156_A0.6580.99
20_G89_A0.6570.99
157_S179_L0.6550.99
147_A175_I0.6530.99
142_I156_A0.6520.99
169_N209_K0.6480.99
125_T135_L0.6400.99
190_R212_F0.6380.99
141_S147_A0.6370.99
185_L206_I0.6360.99
163_I217_A0.6350.99
93_L212_F0.6340.99
126_A214_M0.6320.99
74_K77_G0.6320.99
106_K110_P0.6310.99
75_K82_S0.6290.99
6_V24_L0.6250.99
56_K79_K0.6200.99
98_L144_I0.6200.99
73_L76_L0.6200.99
15_L192_F0.6160.99
177_D206_I0.6160.99
203_R206_I0.6160.99
152_T156_A0.6150.99
45_N48_K0.6130.99
205_I208_D0.6110.99
34_Y61_G0.6100.99
64_M211_Y0.6100.99
75_K79_K0.6100.99
206_I209_K0.6080.99
97_T106_K0.6040.98
145_I165_V0.6020.98
172_I176_A0.6000.98
149_R152_T0.5990.98
140_D147_A0.5990.98
92_T101_T0.5990.98
136_A142_I0.5970.98
76_L79_K0.5930.98
156_A160_F0.5900.98
140_D145_I0.5830.98
32_I59_L0.5820.98
5_V105_I0.5720.98
190_R210_D0.5710.98
73_L104_R0.5690.98
109_L115_V0.5680.98
8_L43_A0.5670.98
59_L68_V0.5630.98
199_V209_K0.5630.98
188_A216_I0.5610.98
157_S183_Y0.5610.98
64_M68_V0.5580.97
125_T166_L0.5570.97
106_K117_I0.5570.97
128_A191_C0.5560.97
44_E51_A0.5550.97
25_K53_N0.5540.97
115_V130_K0.5510.97
63_P68_V0.5510.97
62_F65_A0.5470.97
142_I147_A0.5470.97
185_L202_E0.5460.97
16_I50_Y0.5440.97
140_D150_L0.5410.97
186_I216_I0.5390.97
189_R211_Y0.5380.97
121_V125_T0.5380.97
124_I164_I0.5370.97
147_A171_N0.5350.97
106_K132_M0.5320.97
103_F136_A0.5290.97
187_Y215_I0.5240.96
10_P192_F0.5220.96
180_S206_I0.5220.96
157_S182_K0.5210.96
187_Y199_V0.5200.96
77_G111_C0.5180.96
157_S163_I0.5150.96
48_K57_L0.5150.96
204_E207_N0.5140.96
8_L47_V0.5120.96
185_L209_K0.5110.96
176_A185_L0.5100.96
104_R138_S0.5100.96
67_D72_E0.5100.96
13_D50_Y0.5090.96
124_I144_I0.5090.96
68_V72_E0.5080.96
44_E57_L0.5080.96
211_Y215_I0.5070.96
130_K188_A0.5060.96
143_S159_V0.5060.96
143_S163_I0.5050.96
7_G121_V0.5020.95
115_V132_M0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbuA 2 0.9685 100 0.277 Contact Map
2e0nA 2 0.9865 100 0.291 Contact Map
1pjqA 2 0.9505 100 0.316 Contact Map
1s4dA 4 0.9595 100 0.32 Contact Map
2yboA 2 0.9234 100 0.32 Contact Map
3ndcA 2 0.9369 100 0.338 Contact Map
1ve2A 2 0.9054 100 0.342 Contact Map
1cbfA 2 0.9369 100 0.348 Contact Map
4e16A 2 0.9279 100 0.348 Contact Map
2zvbA 2 0.9369 100 0.364 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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