GREMLIN Database
CBIT - Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)
UniProt: Q97WC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (181)
Sequences: 1948 (1335)
Seq/√Len: 99.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_A144_D5.2651.00
27_E175_K3.4611.00
49_C70_G3.2331.00
49_C81_T3.1161.00
43_K69_Y2.8691.00
99_G104_I2.8381.00
115_I131_S2.7521.00
16_E83_R2.6831.00
128_I157_A2.6311.00
149_E183_T2.4161.00
31_L171_V2.2441.00
145_A150_T2.2221.00
135_I139_G2.1891.00
73_K100_E2.1161.00
44_V58_A2.0661.00
78_I96_L2.0311.00
71_I108_I2.0191.00
85_A94_I2.0181.00
45_L112_F1.9651.00
177_M186_M1.8531.00
143_I154_A1.8471.00
75_E98_K1.8461.00
59_S94_I1.8161.00
26_E35_K1.7571.00
49_C55_T1.7551.00
79_N83_R1.7431.00
125_K160_K1.7391.00
38_I58_A1.7251.00
62_V66_G1.7111.00
78_I98_K1.7071.00
23_M51_T1.6331.00
144_D193_I1.6311.00
43_K67_R1.6191.00
184_A189_N1.6001.00
82_R98_K1.5991.00
42_D114_R1.5911.00
17_R23_M1.5841.00
49_C72_D1.5801.00
55_T94_I1.5541.00
83_R86_E1.5361.00
47_I101_A1.5261.00
82_R86_E1.5131.00
113_D136_N1.5111.00
141_I196_G1.5101.00
67_R95_V1.4821.00
70_G81_T1.4721.00
54_I116_F1.4551.00
71_I104_I1.4251.00
121_S150_T1.4181.00
157_A161_I1.4051.00
27_E35_K1.3780.99
102_P105_L1.3740.99
132_W196_G1.3360.99
110_E134_I1.3340.99
39_K42_D1.3090.99
132_W163_F1.3000.99
114_R140_R1.2780.99
131_S139_G1.2770.99
185_M192_F1.2750.99
179_T189_N1.2730.99
73_K121_S1.2460.99
32_A193_I1.2280.99
176_G185_M1.2170.99
47_I71_I1.2090.99
59_S93_N1.2070.99
12_D23_M1.2020.99
51_T80_L1.2010.98
147_L182_G1.1920.98
110_E136_N1.1740.98
186_M189_N1.1630.98
10_I88_F1.1600.98
81_T96_L1.1550.98
156_S160_K1.1520.98
176_G183_T1.1430.98
9_G57_E1.1340.98
175_K188_R1.1140.98
11_P14_L1.0980.97
72_D81_T1.0970.97
174_A190_P1.0930.97
85_A90_V1.0610.97
27_E31_L1.0530.97
127_I131_S1.0480.96
117_I143_I1.0420.96
126_E129_S1.0350.96
14_L88_F1.0290.96
35_K167_E1.0290.96
31_L173_I1.0230.96
79_N82_R1.0210.96
59_S68_V1.0170.96
10_I60_L1.0130.96
78_I82_R1.0080.96
151_V192_F1.0010.95
62_V65_S0.9880.95
158_M196_G0.9880.95
121_S143_I0.9830.95
38_I62_V0.9720.95
10_I14_L0.9670.94
41_G66_G0.9650.94
15_F56_V0.9630.94
55_T68_V0.9600.94
16_E80_L0.9580.94
47_I131_S0.9510.94
38_I44_V0.9360.93
140_R195_S0.9360.93
129_S161_I0.9190.93
47_I102_P0.9170.93
130_A134_I0.9150.93
85_A96_L0.9150.93
22_P80_L0.9100.92
56_V88_F0.9020.92
30_A34_S0.9020.92
112_F115_I0.9000.92
36_L116_F0.8920.92
36_L44_V0.8900.92
40_K65_S0.8880.91
35_K193_I0.8750.91
152_N156_S0.8710.91
100_E103_A0.8660.90
168_I176_G0.8620.90
31_L34_S0.8600.90
22_P51_T0.8580.90
142_V193_I0.8540.90
149_E182_G0.8520.90
125_K156_S0.8410.89
17_R22_P0.8400.89
123_K126_E0.8300.88
31_L35_K0.8270.88
44_V62_V0.8250.88
154_A194_I0.8210.88
32_A116_F0.8170.88
105_L130_A0.8100.87
14_L60_L0.8090.87
42_D66_G0.8060.87
69_Y97_I0.8060.87
170_E192_F0.8030.87
129_S133_E0.8030.87
156_S159_E0.8030.87
143_I150_T0.8010.87
82_R85_A0.7960.86
21_I77_A0.7930.86
129_S160_K0.7900.86
169_T173_I0.7860.86
23_M53_S0.7840.85
69_Y109_N0.7780.85
72_D77_A0.7600.84
38_I42_D0.7520.83
48_G119_G0.7490.83
77_A80_L0.7490.83
18_D77_A0.7460.83
174_A187_A0.7460.83
75_E79_N0.7440.82
125_K153_N0.7410.82
120_G124_I0.7410.82
130_A133_E0.7390.82
146_I186_M0.7370.82
21_I80_L0.7300.81
128_I141_I0.7260.81
123_K182_G0.7250.81
26_E34_S0.7210.80
61_L66_G0.7140.80
49_C96_L0.7110.79
18_D21_I0.7100.79
169_T195_S0.7090.79
97_I104_I0.6900.77
45_L115_I0.6880.77
153_N157_A0.6840.77
145_A194_I0.6750.76
99_G103_A0.6750.76
170_E174_A0.6750.76
36_L140_R0.6740.76
35_K195_S0.6670.75
132_W157_A0.6660.75
22_P77_A0.6650.75
103_A106_S0.6650.75
36_L54_I0.6640.75
24_T48_G0.6580.74
71_I101_A0.6560.74
53_S56_V0.6540.73
143_I158_M0.6530.73
61_L64_N0.6480.73
31_L144_D0.6460.73
27_E173_I0.6460.73
124_I150_T0.6460.73
54_I58_A0.6430.72
17_R51_T0.6420.72
81_T85_A0.6420.72
151_V185_M0.6400.72
82_R95_V0.6400.72
153_N156_S0.6390.72
59_S66_G0.6370.72
78_I81_T0.6340.71
17_R77_A0.6330.71
28_I144_D0.6320.71
70_G94_I0.6320.71
26_E188_R0.6240.70
152_N155_L0.6210.70
187_A190_P0.6160.69
11_P26_E0.6160.69
83_R87_K0.6130.69
82_R96_L0.6110.68
15_F88_F0.6090.68
150_T182_G0.6080.68
74_E77_A0.6060.68
109_N112_F0.6060.68
25_K119_G0.6050.68
170_E173_I0.6010.67
11_P37_R0.6000.67
23_M80_L0.5990.67
128_I161_I0.5980.67
55_T81_T0.5980.67
42_D62_V0.5950.66
56_V90_V0.5950.66
17_R21_I0.5920.66
80_L85_A0.5830.65
53_S80_L0.5820.65
9_G33_L0.5810.65
37_R42_D0.5800.64
96_L142_V0.5800.64
151_V184_A0.5790.64
43_K109_N0.5760.64
14_L87_K0.5750.64
100_E123_K0.5700.63
60_L88_F0.5700.63
179_T182_G0.5690.63
124_I154_A0.5660.63
129_S157_A0.5660.63
24_T118_G0.5660.63
38_I114_R0.5650.62
179_T184_A0.5640.62
135_I138_G0.5630.62
28_I191_I0.5610.62
79_N98_K0.5590.62
44_V66_G0.5580.61
41_G62_V0.5570.61
151_V168_I0.5560.61
170_E185_M0.5530.61
159_E178_K0.5510.60
8_P61_L0.5500.60
45_L109_N0.5440.59
55_T88_F0.5430.59
36_L114_R0.5420.59
71_I105_L0.5420.59
8_P37_R0.5400.59
146_I185_M0.5370.59
128_I158_M0.5320.58
29_R84_N0.5320.58
32_A192_F0.5310.58
100_E104_I0.5300.58
151_V194_I0.5270.57
171_V193_I0.5270.57
55_T59_S0.5270.57
24_T119_G0.5250.57
9_G37_R0.5210.56
35_K169_T0.5190.56
9_G34_S0.5170.56
90_V94_I0.5160.56
71_I99_G0.5160.56
18_D51_T0.5160.56
58_A66_G0.5160.56
12_D26_E0.5150.55
146_I194_I0.5150.55
21_I74_E0.5140.55
158_M183_T0.5130.55
151_V170_E0.5100.55
23_M77_A0.5070.54
41_G65_S0.5060.54
108_I112_F0.5050.54
51_T77_A0.5030.54
8_P34_S0.5010.53
56_V81_T0.5010.53
167_E195_S0.5000.53
121_S124_I0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e05A 4 0.9698 100 0.586 Contact Map
3hm2A 3 0.8693 100 0.596 Contact Map
1l3iA 5 0.9296 100 0.608 Contact Map
2yxdA 4 0.9045 100 0.614 Contact Map
3njrA 4 0.9196 99.9 0.628 Contact Map
1o54A 4 0.9698 99.8 0.7 Contact Map
3gnlA 1 0.8643 99.8 0.711 Contact Map
2pwyA 3 0.9648 99.8 0.713 Contact Map
1i9gA 3 0.9648 99.8 0.714 Contact Map
3mb5A 3 0.9598 99.8 0.715 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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