CBIT - SULSO - GREMLIN Contacts

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CBIT - Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)

UniProt:	Q97WC7	Sequences: MEWNYVIPGIPDNLFERDEEIPMTKEEIRALALSKLRIKKGDKVLDIGCGTGSITVEASLLVGNSGRVYGIDKEEKAINLTRRNAEKFGVLNNIVLIKGEAPAILSTINEKFDRIFIGGGSEKIKEIISASWEIINKGGRIVIDAILLETVNNALSAMEKIGFVNLEITEVIIAKGMKTKVGTAMMARNPIFIISGEKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	199 (181)
Sequences:	1948 (1335)
Seq/√Len:	99.2

HALSA - CBIT
SULSO - CBIT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_A	144_D	5.265	1.00
27_E	175_K	3.461	1.00
49_C	70_G	3.233	1.00
49_C	81_T	3.116	1.00
43_K	69_Y	2.869	1.00
99_G	104_I	2.838	1.00
115_I	131_S	2.752	1.00
16_E	83_R	2.683	1.00
128_I	157_A	2.631	1.00
149_E	183_T	2.416	1.00
31_L	171_V	2.244	1.00
145_A	150_T	2.222	1.00
135_I	139_G	2.189	1.00
73_K	100_E	2.116	1.00
44_V	58_A	2.066	1.00
78_I	96_L	2.031	1.00
71_I	108_I	2.019	1.00
85_A	94_I	2.018	1.00
45_L	112_F	1.965	1.00
177_M	186_M	1.853	1.00
143_I	154_A	1.847	1.00
75_E	98_K	1.846	1.00
59_S	94_I	1.816	1.00
26_E	35_K	1.757	1.00
49_C	55_T	1.755	1.00
79_N	83_R	1.743	1.00
125_K	160_K	1.739	1.00
38_I	58_A	1.725	1.00
62_V	66_G	1.711	1.00
78_I	98_K	1.707	1.00
23_M	51_T	1.633	1.00
144_D	193_I	1.631	1.00
43_K	67_R	1.619	1.00
184_A	189_N	1.600	1.00
82_R	98_K	1.599	1.00
42_D	114_R	1.591	1.00
17_R	23_M	1.584	1.00
49_C	72_D	1.580	1.00
55_T	94_I	1.554	1.00
83_R	86_E	1.536	1.00
47_I	101_A	1.526	1.00
82_R	86_E	1.513	1.00
113_D	136_N	1.511	1.00
141_I	196_G	1.510	1.00
67_R	95_V	1.482	1.00
70_G	81_T	1.472	1.00
54_I	116_F	1.455	1.00
71_I	104_I	1.425	1.00
121_S	150_T	1.418	1.00
157_A	161_I	1.405	1.00
27_E	35_K	1.378	0.99
102_P	105_L	1.374	0.99
132_W	196_G	1.336	0.99
110_E	134_I	1.334	0.99
39_K	42_D	1.309	0.99
132_W	163_F	1.300	0.99
114_R	140_R	1.278	0.99
131_S	139_G	1.277	0.99
185_M	192_F	1.275	0.99
179_T	189_N	1.273	0.99
73_K	121_S	1.246	0.99
32_A	193_I	1.228	0.99
176_G	185_M	1.217	0.99
47_I	71_I	1.209	0.99
59_S	93_N	1.207	0.99
12_D	23_M	1.202	0.99
51_T	80_L	1.201	0.98
147_L	182_G	1.192	0.98
110_E	136_N	1.174	0.98
186_M	189_N	1.163	0.98
10_I	88_F	1.160	0.98
81_T	96_L	1.155	0.98
156_S	160_K	1.152	0.98
176_G	183_T	1.143	0.98
9_G	57_E	1.134	0.98
175_K	188_R	1.114	0.98
11_P	14_L	1.098	0.97
72_D	81_T	1.097	0.97
174_A	190_P	1.093	0.97
85_A	90_V	1.061	0.97
27_E	31_L	1.053	0.97
127_I	131_S	1.048	0.96
117_I	143_I	1.042	0.96
126_E	129_S	1.035	0.96
14_L	88_F	1.029	0.96
35_K	167_E	1.029	0.96
31_L	173_I	1.023	0.96
79_N	82_R	1.021	0.96
59_S	68_V	1.017	0.96
10_I	60_L	1.013	0.96
78_I	82_R	1.008	0.96
151_V	192_F	1.001	0.95
62_V	65_S	0.988	0.95
158_M	196_G	0.988	0.95
121_S	143_I	0.983	0.95
38_I	62_V	0.972	0.95
10_I	14_L	0.967	0.94
41_G	66_G	0.965	0.94
15_F	56_V	0.963	0.94
55_T	68_V	0.960	0.94
16_E	80_L	0.958	0.94
47_I	131_S	0.951	0.94
38_I	44_V	0.936	0.93
140_R	195_S	0.936	0.93
129_S	161_I	0.919	0.93
47_I	102_P	0.917	0.93
130_A	134_I	0.915	0.93
85_A	96_L	0.915	0.93
22_P	80_L	0.910	0.92
56_V	88_F	0.902	0.92
30_A	34_S	0.902	0.92
112_F	115_I	0.900	0.92
36_L	116_F	0.892	0.92
36_L	44_V	0.890	0.92
40_K	65_S	0.888	0.91
35_K	193_I	0.875	0.91
152_N	156_S	0.871	0.91
100_E	103_A	0.866	0.90
168_I	176_G	0.862	0.90
31_L	34_S	0.860	0.90
22_P	51_T	0.858	0.90
142_V	193_I	0.854	0.90
149_E	182_G	0.852	0.90
125_K	156_S	0.841	0.89
17_R	22_P	0.840	0.89
123_K	126_E	0.830	0.88
31_L	35_K	0.827	0.88
44_V	62_V	0.825	0.88
154_A	194_I	0.821	0.88
32_A	116_F	0.817	0.88
105_L	130_A	0.810	0.87
14_L	60_L	0.809	0.87
42_D	66_G	0.806	0.87
69_Y	97_I	0.806	0.87
170_E	192_F	0.803	0.87
129_S	133_E	0.803	0.87
156_S	159_E	0.803	0.87
143_I	150_T	0.801	0.87
82_R	85_A	0.796	0.86
21_I	77_A	0.793	0.86
129_S	160_K	0.790	0.86
169_T	173_I	0.786	0.86
23_M	53_S	0.784	0.85
69_Y	109_N	0.778	0.85
72_D	77_A	0.760	0.84
38_I	42_D	0.752	0.83
48_G	119_G	0.749	0.83
77_A	80_L	0.749	0.83
18_D	77_A	0.746	0.83
174_A	187_A	0.746	0.83
75_E	79_N	0.744	0.82
125_K	153_N	0.741	0.82
120_G	124_I	0.741	0.82
130_A	133_E	0.739	0.82
146_I	186_M	0.737	0.82
21_I	80_L	0.730	0.81
128_I	141_I	0.726	0.81
123_K	182_G	0.725	0.81
26_E	34_S	0.721	0.80
61_L	66_G	0.714	0.80
49_C	96_L	0.711	0.79
18_D	21_I	0.710	0.79
169_T	195_S	0.709	0.79
97_I	104_I	0.690	0.77
45_L	115_I	0.688	0.77
153_N	157_A	0.684	0.77
145_A	194_I	0.675	0.76
99_G	103_A	0.675	0.76
170_E	174_A	0.675	0.76
36_L	140_R	0.674	0.76
35_K	195_S	0.667	0.75
132_W	157_A	0.666	0.75
22_P	77_A	0.665	0.75
103_A	106_S	0.665	0.75
36_L	54_I	0.664	0.75
24_T	48_G	0.658	0.74
71_I	101_A	0.656	0.74
53_S	56_V	0.654	0.73
143_I	158_M	0.653	0.73
61_L	64_N	0.648	0.73
31_L	144_D	0.646	0.73
27_E	173_I	0.646	0.73
124_I	150_T	0.646	0.73
54_I	58_A	0.643	0.72
17_R	51_T	0.642	0.72
81_T	85_A	0.642	0.72
151_V	185_M	0.640	0.72
82_R	95_V	0.640	0.72
153_N	156_S	0.639	0.72
59_S	66_G	0.637	0.72
78_I	81_T	0.634	0.71
17_R	77_A	0.633	0.71
28_I	144_D	0.632	0.71
70_G	94_I	0.632	0.71
26_E	188_R	0.624	0.70
152_N	155_L	0.621	0.70
187_A	190_P	0.616	0.69
11_P	26_E	0.616	0.69
83_R	87_K	0.613	0.69
82_R	96_L	0.611	0.68
15_F	88_F	0.609	0.68
150_T	182_G	0.608	0.68
74_E	77_A	0.606	0.68
109_N	112_F	0.606	0.68
25_K	119_G	0.605	0.68
170_E	173_I	0.601	0.67
11_P	37_R	0.600	0.67
23_M	80_L	0.599	0.67
128_I	161_I	0.598	0.67
55_T	81_T	0.598	0.67
42_D	62_V	0.595	0.66
56_V	90_V	0.595	0.66
17_R	21_I	0.592	0.66
80_L	85_A	0.583	0.65
53_S	80_L	0.582	0.65
9_G	33_L	0.581	0.65
37_R	42_D	0.580	0.64
96_L	142_V	0.580	0.64
151_V	184_A	0.579	0.64
43_K	109_N	0.576	0.64
14_L	87_K	0.575	0.64
100_E	123_K	0.570	0.63
60_L	88_F	0.570	0.63
179_T	182_G	0.569	0.63
124_I	154_A	0.566	0.63
129_S	157_A	0.566	0.63
24_T	118_G	0.566	0.63
38_I	114_R	0.565	0.62
179_T	184_A	0.564	0.62
135_I	138_G	0.563	0.62
28_I	191_I	0.561	0.62
79_N	98_K	0.559	0.62
44_V	66_G	0.558	0.61
41_G	62_V	0.557	0.61
151_V	168_I	0.556	0.61
170_E	185_M	0.553	0.61
159_E	178_K	0.551	0.60
8_P	61_L	0.550	0.60
45_L	109_N	0.544	0.59
55_T	88_F	0.543	0.59
36_L	114_R	0.542	0.59
71_I	105_L	0.542	0.59
8_P	37_R	0.540	0.59
146_I	185_M	0.537	0.59
128_I	158_M	0.532	0.58
29_R	84_N	0.532	0.58
32_A	192_F	0.531	0.58
100_E	104_I	0.530	0.58
151_V	194_I	0.527	0.57
171_V	193_I	0.527	0.57
55_T	59_S	0.527	0.57
24_T	119_G	0.525	0.57
9_G	37_R	0.521	0.56
35_K	169_T	0.519	0.56
9_G	34_S	0.517	0.56
90_V	94_I	0.516	0.56
71_I	99_G	0.516	0.56
18_D	51_T	0.516	0.56
58_A	66_G	0.516	0.56
12_D	26_E	0.515	0.55
146_I	194_I	0.515	0.55
21_I	74_E	0.514	0.55
158_M	183_T	0.513	0.55
151_V	170_E	0.510	0.55
23_M	77_A	0.507	0.54
41_G	65_S	0.506	0.54
108_I	112_F	0.505	0.54
51_T	77_A	0.503	0.54
8_P	34_S	0.501	0.53
56_V	81_T	0.501	0.53
167_E	195_S	0.500	0.53
121_S	124_I	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3e05A	4	0.9698	100	0.586	Contact Map
3hm2A	3	0.8693	100	0.596	Contact Map
1l3iA	5	0.9296	100	0.608	Contact Map
2yxdA	4	0.9045	100	0.614	Contact Map
3njrA	4	0.9196	99.9	0.628	Contact Map
1o54A	4	0.9698	99.8	0.7	Contact Map
3gnlA	1	0.8643	99.8	0.711	Contact Map
2pwyA	3	0.9648	99.8	0.713	Contact Map
1i9gA	3	0.9648	99.8	0.714	Contact Map
3mb5A	3	0.9598	99.8	0.715	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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