CBID - SULSO - GREMLIN Contacts

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CBID - Cobalt-precorrin-5B C(1)-methyltransferase

UniProt:	Q97WC6	Sequences: MIINSLKRFGITTGAAASAAAKAAVIGLLNKEKRSTVVIPTPIGLRLEIPVEKVEIDSEISCAEVKKFSGDNPDILDGLVIRCCAKLNENNEIVIIGERGVGKVTRSGLKATMGEMAISPTVREMIINAIREVTDKGIQITIEVPNGETIAEKTLNKMVGIVGGISILGTTGIETPVSDDDYLEHIRCELNVIRQSYDYVVIAPGNSAAKYAAELFDSNCIIKVGDRIGDSIKLASNLFKKVILAGLPAKLLKVYAGIFNTHYSQGDARLESLTHASVLAGLPYGTLTKISNALSVEEAFTYMTKEQRRKVMNIVAEKILSRIKSFNDNINFCVIIFDYDGESLSRVGC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	349 (341)
Sequences:	1239 (924)
Seq/√Len:	50.0

SULSO - CBID

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
144_V	167_I	5.156	1.00
15_A	39_I	4.093	1.00
86_K	139_Q	3.995	1.00
83_C	142_I	3.992	1.00
144_V	165_I	3.921	1.00
198_D	240_K	3.788	1.00
146_N	149_T	3.695	1.00
21_A	83_C	3.366	1.00
62_C	84_C	3.170	1.00
277_S	290_I	3.090	1.00
96_I	103_K	2.958	1.00
99_R	148_E	2.928	1.00
79_L	150_I	2.925	1.00
22_K	132_E	2.889	1.00
149_T	152_E	2.870	1.00
96_I	139_Q	2.866	1.00
127_I	131_R	2.772	1.00
86_K	141_T	2.715	1.00
194_R	239_F	2.691	1.00
69_S	77_D	2.676	1.00
130_I	140_I	2.627	1.00
101_V	144_V	2.591	1.00
96_I	116_M	2.565	1.00
52_E	66_K	2.461	1.00
23_A	51_V	2.413	1.00
66_K	80_V	2.396	1.00
94_V	139_Q	2.265	1.00
85_A	140_I	2.237	1.00
57_D	60_I	2.229	1.00
191_N	238_L	2.197	1.00
241_K	331_N	2.194	1.00
224_V	228_I	2.164	1.00
202_I	231_S	2.158	1.00
274_T	287_L	2.135	1.00
258_I	266_G	2.124	1.00
190_L	200_V	2.110	1.00
38_V	46_R	2.092	1.00
183_L	230_D	2.075	1.00
75_I	150_I	2.061	1.00
190_L	239_F	2.029	1.00
256_A	272_S	2.017	1.00
96_I	141_T	2.014	1.00
124_E	128_N	2.000	1.00
286_T	302_Y	1.982	1.00
103_K	116_M	1.970	0.99
54_V	61_S	1.958	0.99
233_K	326_F	1.957	0.99
338_D	342_E	1.950	0.99
270_L	299_A	1.928	0.99
277_S	282_L	1.928	0.99
110_K	120_P	1.922	0.99
199_Y	243_I	1.910	0.99
20_A	65_V	1.813	0.99
87_L	138_I	1.804	0.99
8_R	68_F	1.744	0.99
186_I	231_S	1.687	0.98
64_E	80_V	1.672	0.98
278_V	284_Y	1.661	0.98
51_V	65_V	1.653	0.98
79_L	144_V	1.640	0.98
38_V	48_E	1.637	0.98
232_I	242_V	1.615	0.98
134_T	138_I	1.597	0.98
97_G	103_K	1.594	0.98
11_I	16_A	1.594	0.98
97_G	116_M	1.586	0.98
126_I	140_I	1.578	0.97
22_K	129_A	1.554	0.97
320_L	334_V	1.549	0.97
199_Y	241_K	1.547	0.97
129_A	132_E	1.532	0.97
21_A	130_I	1.531	0.97
286_T	306_E	1.523	0.97
41_T	45_L	1.516	0.97
276_A	314_I	1.508	0.97
21_A	25_V	1.502	0.97
256_A	269_R	1.489	0.96
289_K	305_K	1.466	0.96
190_L	238_L	1.451	0.96
320_L	324_K	1.439	0.96
22_K	26_I	1.434	0.96
278_V	287_L	1.424	0.95
111_A	120_P	1.411	0.95
20_A	83_C	1.404	0.95
115_E	123_R	1.390	0.95
202_I	235_A	1.366	0.94
241_K	333_C	1.361	0.94
273_L	299_A	1.351	0.94
201_V	212_A	1.351	0.94
21_A	129_A	1.350	0.94
200_V	239_F	1.336	0.93
212_A	245_A	1.330	0.93
53_K	64_E	1.328	0.93
324_K	332_F	1.319	0.93
234_L	237_N	1.319	0.93
52_E	80_V	1.306	0.93
259_F	322_R	1.304	0.93
314_I	318_K	1.299	0.92
152_E	157_K	1.295	0.92
25_V	130_I	1.285	0.92
79_L	146_N	1.282	0.92
82_R	145_P	1.277	0.92
25_V	134_T	1.276	0.92
88_N	137_G	1.274	0.92
53_K	80_V	1.274	0.92
21_A	126_I	1.273	0.92
25_V	138_I	1.259	0.91
187_R	234_L	1.257	0.91
268_A	272_S	1.247	0.91
36_T	48_E	1.234	0.90
55_E	62_C	1.231	0.90
288_T	292_N	1.206	0.89
40_P	46_R	1.198	0.89
60_I	84_C	1.198	0.89
180_D	184_E	1.192	0.89
27_G	33_K	1.190	0.89
95_I	123_R	1.186	0.89
82_R	143_E	1.183	0.88
280_A	314_I	1.172	0.88
84_C	141_T	1.165	0.88
283_P	306_E	1.163	0.88
157_K	162_V	1.159	0.87
210_K	213_A	1.152	0.87
244_L	251_L	1.149	0.87
251_L	336_I	1.142	0.87
293_A	299_A	1.134	0.86
64_E	82_R	1.127	0.86
101_V	142_I	1.118	0.85
26_I	133_V	1.118	0.85
276_A	318_K	1.115	0.85
56_I	61_S	1.115	0.85
335_I	343_S	1.114	0.85
18_S	126_I	1.111	0.85
107_S	113_M	1.098	0.84
271_E	291_S	1.095	0.84
95_I	126_I	1.090	0.84
11_I	49_I	1.087	0.84
229_G	259_F	1.087	0.84
95_I	116_M	1.078	0.83
69_S	75_I	1.074	0.83
208_A	247_L	1.073	0.83
112_T	115_E	1.059	0.82
318_K	321_S	1.057	0.82
148_E	163_G	1.053	0.82
228_I	254_V	1.048	0.81
207_S	247_L	1.043	0.81
19_A	65_V	1.038	0.81
81_I	144_V	1.036	0.81
9_F	175_T	1.036	0.81
27_G	61_S	1.035	0.81
99_R	146_N	1.030	0.80
283_P	286_T	1.023	0.80
15_A	49_I	1.023	0.80
204_P	226_D	1.022	0.80
217_D	220_C	1.016	0.79
279_L	291_S	1.012	0.79
259_F	326_F	1.002	0.78
320_L	333_C	1.002	0.78
183_L	234_L	1.000	0.78
125_M	173_I	0.999	0.78
31_K	56_I	0.988	0.77
277_S	281_G	0.986	0.77
116_M	141_T	0.982	0.77
183_L	187_R	0.982	0.77
72_N	174_E	0.981	0.77
92_E	137_G	0.977	0.77
168_L	295_S	0.976	0.77
320_L	332_F	0.975	0.77
16_A	65_V	0.974	0.76
210_K	214_E	0.972	0.76
248_P	300_F	0.972	0.76
106_R	219_N	0.969	0.76
158_M	209_A	0.966	0.76
52_E	64_E	0.965	0.76
282_L	286_T	0.965	0.76
274_T	291_S	0.964	0.76
23_A	63_A	0.958	0.75
260_N	263_Y	0.957	0.75
240_K	331_N	0.956	0.75
49_I	65_V	0.955	0.75
150_I	165_I	0.952	0.75
298_E	301_T	0.940	0.74
177_V	225_G	0.933	0.73
313_N	317_E	0.932	0.73
79_L	101_V	0.926	0.73
42_P	121_T	0.924	0.73
204_P	208_A	0.921	0.72
272_S	276_A	0.918	0.72
24_A	63_A	0.917	0.72
230_D	234_L	0.914	0.72
323_I	332_F	0.914	0.72
40_P	132_E	0.913	0.72
84_C	143_E	0.900	0.71
90_N	137_G	0.895	0.70
68_F	77_D	0.889	0.70
275_H	291_S	0.888	0.70
69_S	150_I	0.884	0.69
97_G	126_I	0.882	0.69
190_L	235_A	0.879	0.69
104_V	111_A	0.879	0.69
313_N	345_S	0.878	0.69
235_A	242_V	0.875	0.68
88_N	139_Q	0.873	0.68
72_N	122_V	0.869	0.68
119_S	122_V	0.866	0.68
204_P	247_L	0.858	0.67
234_L	238_L	0.854	0.67
246_G	251_L	0.853	0.66
120_P	124_E	0.851	0.66
27_G	34_R	0.850	0.66
69_S	174_E	0.848	0.66
174_E	181_D	0.848	0.66
194_R	198_D	0.846	0.66
81_I	167_I	0.843	0.66
107_S	195_Q	0.841	0.65
215_L	335_I	0.838	0.65
225_G	247_L	0.837	0.65
261_T	297_E	0.837	0.65
290_I	299_A	0.835	0.65
247_L	297_E	0.833	0.65
93_I	138_I	0.827	0.64
72_N	76_L	0.827	0.64
284_Y	287_L	0.827	0.64
279_L	318_K	0.825	0.64
92_E	131_R	0.820	0.63
229_G	246_G	0.817	0.63
281_G	287_L	0.814	0.63
235_A	239_F	0.813	0.63
208_A	226_D	0.811	0.62
34_R	54_V	0.807	0.62
231_S	242_V	0.803	0.62
20_A	24_A	0.803	0.62
19_A	37_V	0.800	0.61
191_N	195_Q	0.800	0.61
131_R	135_D	0.799	0.61
252_L	255_Y	0.798	0.61
27_G	54_V	0.796	0.61
187_R	230_D	0.795	0.61
155_L	182_Y	0.794	0.61
40_P	128_N	0.792	0.61
293_A	302_Y	0.789	0.60
203_A	249_A	0.785	0.60
248_P	296_V	0.784	0.60
226_D	263_Y	0.779	0.59
18_S	39_I	0.777	0.59
197_Y	220_C	0.776	0.59
83_C	140_I	0.773	0.59
177_V	208_A	0.773	0.59
69_S	78_G	0.772	0.59
259_F	263_Y	0.771	0.59
316_A	336_I	0.771	0.59
289_K	298_E	0.763	0.58
102_G	161_I	0.762	0.58
260_N	265_Q	0.760	0.57
59_E	87_L	0.760	0.57
275_H	279_L	0.759	0.57
337_F	343_S	0.758	0.57
312_M	345_S	0.757	0.57
282_L	290_I	0.756	0.57
129_A	133_V	0.755	0.57
67_K	119_S	0.752	0.57
98_E	141_T	0.752	0.57
105_T	160_G	0.750	0.56
317_E	321_S	0.750	0.56
284_Y	288_T	0.747	0.56
53_K	82_R	0.747	0.56
31_K	34_R	0.746	0.56
278_V	291_S	0.746	0.56
321_S	325_S	0.745	0.56
302_Y	305_K	0.744	0.56
207_S	297_E	0.743	0.56
314_I	317_E	0.742	0.56
254_V	339_Y	0.739	0.55
18_S	25_V	0.739	0.55
191_N	234_L	0.737	0.55
252_L	296_V	0.736	0.55
204_P	207_S	0.733	0.55
67_K	72_N	0.733	0.55
19_A	49_I	0.732	0.55
206_N	263_Y	0.731	0.55
142_I	165_I	0.730	0.54
69_S	181_D	0.726	0.54
28_L	61_S	0.718	0.53
204_P	269_R	0.709	0.52
277_S	280_A	0.709	0.52
303_M	311_V	0.707	0.52
203_A	245_A	0.704	0.52
88_N	94_V	0.703	0.52
27_G	53_K	0.702	0.52
91_N	137_G	0.701	0.51
69_S	79_L	0.701	0.51
71_D	176_P	0.701	0.51
123_R	127_I	0.698	0.51
80_V	146_N	0.695	0.51
272_S	275_H	0.695	0.51
103_K	141_T	0.695	0.51
72_N	119_S	0.693	0.51
285_G	288_T	0.693	0.51
104_V	109_L	0.689	0.50
310_K	313_N	0.689	0.50
155_L	226_D	0.688	0.50
146_N	150_I	0.688	0.50
72_N	181_D	0.686	0.50
304_T	308_R	0.684	0.50
130_I	138_I	0.681	0.49
33_K	56_I	0.680	0.49
17_A	95_I	0.678	0.49
62_C	143_E	0.676	0.49
33_K	54_V	0.674	0.49
177_V	247_L	0.672	0.49
276_A	279_L	0.669	0.48
280_A	311_V	0.668	0.48
294_L	298_E	0.666	0.48
124_E	142_I	0.665	0.48
76_L	174_E	0.664	0.48
88_N	91_N	0.664	0.48
26_I	30_N	0.655	0.47
279_L	284_Y	0.655	0.47
148_E	162_V	0.652	0.46
26_I	37_V	0.652	0.46
258_I	268_A	0.649	0.46
120_P	294_L	0.648	0.46
252_L	315_V	0.646	0.46
243_I	335_I	0.646	0.46
182_Y	260_N	0.646	0.46
201_V	221_I	0.645	0.46
338_D	341_G	0.645	0.46
206_N	247_L	0.645	0.46
233_K	318_K	0.644	0.46
179_D	225_G	0.644	0.46
194_R	238_L	0.643	0.46
202_I	242_V	0.642	0.45
208_A	225_G	0.642	0.45
88_N	92_E	0.642	0.45
94_V	290_I	0.641	0.45
290_I	303_M	0.640	0.45
208_A	297_E	0.640	0.45
22_K	133_V	0.639	0.45
289_K	302_Y	0.638	0.45
271_E	275_H	0.638	0.45
287_L	298_E	0.633	0.45
25_V	133_V	0.632	0.44
256_A	268_A	0.632	0.44
242_V	330_I	0.632	0.44
286_T	289_K	0.629	0.44
300_F	304_T	0.628	0.44
96_I	115_E	0.627	0.44
148_E	152_E	0.626	0.44
273_L	308_R	0.621	0.43
12_T	17_A	0.621	0.43
182_Y	227_R	0.619	0.43
300_F	312_M	0.617	0.43
256_A	267_D	0.616	0.43
97_G	165_I	0.615	0.43
40_P	129_A	0.614	0.43
31_K	59_E	0.613	0.43
11_I	47_L	0.612	0.42
268_A	296_V	0.610	0.42
7_K	179_D	0.610	0.42
25_V	29_L	0.610	0.42
177_V	206_N	0.608	0.42
127_I	152_E	0.606	0.42
43_I	171_T	0.604	0.42
58_S	136_K	0.604	0.42
229_G	263_Y	0.603	0.42
18_S	22_K	0.602	0.41
92_E	285_G	0.601	0.41
122_V	159_V	0.601	0.41
15_A	47_L	0.601	0.41
228_I	246_G	0.600	0.41
175_T	191_N	0.600	0.41
278_V	281_G	0.600	0.41
93_I	140_I	0.599	0.41
270_L	293_A	0.599	0.41
246_G	319_I	0.598	0.41
11_I	223_K	0.598	0.41
75_I	315_V	0.597	0.41
122_V	181_D	0.597	0.41
258_I	272_S	0.597	0.41
207_S	269_R	0.597	0.41
39_I	157_K	0.596	0.41
270_L	273_L	0.596	0.41
316_A	322_R	0.596	0.41
256_A	275_H	0.595	0.41
202_I	224_V	0.594	0.41
282_L	287_L	0.593	0.41
26_I	34_R	0.593	0.41
207_S	225_G	0.591	0.40
247_L	269_R	0.590	0.40
327_N	332_F	0.589	0.40
252_L	256_A	0.588	0.40
224_V	231_S	0.585	0.40
177_V	269_R	0.585	0.40
211_Y	263_Y	0.583	0.40
244_L	254_V	0.583	0.40
208_A	269_R	0.583	0.40
276_A	291_S	0.582	0.39
8_R	71_D	0.581	0.39
110_K	168_L	0.581	0.39
254_V	263_Y	0.581	0.39
207_S	337_F	0.580	0.39
206_N	223_K	0.579	0.39
277_S	345_S	0.579	0.39
243_I	333_C	0.578	0.39
322_R	326_F	0.574	0.39
175_T	266_G	0.574	0.39
41_T	47_L	0.573	0.39
258_I	267_D	0.572	0.38
211_Y	337_F	0.570	0.38
203_A	211_Y	0.569	0.38
72_N	185_H	0.569	0.38
259_F	297_E	0.568	0.38
25_V	126_I	0.568	0.38
25_V	85_A	0.567	0.38
155_L	267_D	0.565	0.38
209_A	223_K	0.564	0.38
117_A	176_P	0.564	0.38
207_S	339_Y	0.562	0.37
28_L	87_L	0.562	0.37
193_I	200_V	0.561	0.37
255_Y	276_A	0.561	0.37
67_K	117_A	0.561	0.37
301_T	340_D	0.560	0.37
244_L	343_S	0.559	0.37
117_A	166_S	0.559	0.37
87_L	134_T	0.559	0.37
106_R	246_G	0.557	0.37
215_L	346_R	0.556	0.37
103_K	113_M	0.555	0.37
110_K	339_Y	0.555	0.37
117_A	178_S	0.554	0.37
60_I	335_I	0.554	0.37
95_I	111_A	0.553	0.37
175_T	337_F	0.553	0.37
56_I	60_I	0.552	0.37
122_V	174_E	0.551	0.36
103_K	139_Q	0.549	0.36
71_D	178_S	0.548	0.36
62_C	82_R	0.548	0.36
40_P	315_V	0.548	0.36
179_D	247_L	0.548	0.36
158_M	244_L	0.545	0.36
216_F	221_I	0.545	0.36
203_A	221_I	0.544	0.36
285_G	289_K	0.544	0.36
177_V	226_D	0.543	0.36
255_Y	272_S	0.542	0.36
295_S	303_M	0.542	0.36
186_I	234_L	0.541	0.36
68_F	174_E	0.540	0.35
140_I	311_V	0.540	0.35
319_I	334_V	0.540	0.35
39_I	81_I	0.539	0.35
186_I	190_L	0.539	0.35
311_V	314_I	0.538	0.35
105_T	122_V	0.537	0.35
240_K	305_K	0.536	0.35
153_K	190_L	0.536	0.35
318_K	323_I	0.536	0.35
312_M	315_V	0.536	0.35
258_I	269_R	0.536	0.35
189_E	193_I	0.536	0.35
177_V	223_K	0.535	0.35
153_K	177_V	0.534	0.35
110_K	297_E	0.533	0.35
252_L	273_L	0.533	0.35
138_I	173_I	0.533	0.35
256_A	266_G	0.532	0.35
274_T	290_I	0.532	0.35
319_I	337_F	0.530	0.34
111_A	115_E	0.529	0.34
36_T	51_V	0.529	0.34
247_L	339_Y	0.528	0.34
186_I	208_A	0.527	0.34
112_T	149_T	0.527	0.34
207_S	226_D	0.527	0.34
204_P	225_G	0.526	0.34
190_L	234_L	0.526	0.34
223_K	341_G	0.526	0.34
76_L	122_V	0.526	0.34
263_Y	297_E	0.525	0.34
187_R	191_N	0.525	0.34
182_Y	225_G	0.525	0.34
142_I	145_P	0.524	0.34
198_D	292_N	0.520	0.34
212_A	216_F	0.520	0.34
245_A	337_F	0.519	0.33
267_D	271_E	0.518	0.33
231_S	234_L	0.516	0.33
204_P	251_L	0.516	0.33
251_L	319_I	0.515	0.33
324_K	329_N	0.514	0.33
35_S	310_K	0.512	0.33
93_I	157_K	0.511	0.33
54_V	62_C	0.511	0.33
67_K	178_S	0.509	0.33
104_V	108_G	0.509	0.33
268_A	276_A	0.508	0.32
166_S	178_S	0.507	0.32
183_L	260_N	0.507	0.32
232_I	280_A	0.507	0.32
296_V	300_F	0.506	0.32
206_N	260_N	0.505	0.32
130_I	294_L	0.504	0.32
128_N	131_R	0.504	0.32
21_A	142_I	0.503	0.32
226_D	247_L	0.503	0.32
118_I	140_I	0.502	0.32
60_I	86_K	0.502	0.32
72_N	178_S	0.501	0.32
17_A	172_G	0.501	0.32
32_E	329_N	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sr8A	1	0.702	100	0.341	Contact Map
4ezeA	1	0.2321	56	0.972	Contact Map
4qs8A	1	0.235	50.4	0.973	Contact Map
3ojcA	4	0.4499	49.8	0.973	Contact Map
4eg2A	4	0.2264	40.9	0.974	Contact Map
3e3mA	2	0.1032	38.6	0.975	Contact Map
2zskA	2	0.4384	23.9	0.977	Contact Map
3un1A	4	0.2923	22.8	0.977	Contact Map
1ykdA	2	0.1805	20.6	0.978	Contact Map
2h5gA	2	0.1891	20.6	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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