GREMLIN Database
CBID - Cobalt-precorrin-5B C(1)-methyltransferase
UniProt: Q97WC6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (341)
Sequences: 1239 (924)
Seq/√Len: 50.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_V167_I5.1561.00
15_A39_I4.0931.00
86_K139_Q3.9951.00
83_C142_I3.9921.00
144_V165_I3.9211.00
198_D240_K3.7881.00
146_N149_T3.6951.00
21_A83_C3.3661.00
62_C84_C3.1701.00
277_S290_I3.0901.00
96_I103_K2.9581.00
99_R148_E2.9281.00
79_L150_I2.9251.00
22_K132_E2.8891.00
149_T152_E2.8701.00
96_I139_Q2.8661.00
127_I131_R2.7721.00
86_K141_T2.7151.00
194_R239_F2.6911.00
69_S77_D2.6761.00
130_I140_I2.6271.00
101_V144_V2.5911.00
96_I116_M2.5651.00
52_E66_K2.4611.00
23_A51_V2.4131.00
66_K80_V2.3961.00
94_V139_Q2.2651.00
85_A140_I2.2371.00
57_D60_I2.2291.00
191_N238_L2.1971.00
241_K331_N2.1941.00
224_V228_I2.1641.00
202_I231_S2.1581.00
274_T287_L2.1351.00
258_I266_G2.1241.00
190_L200_V2.1101.00
38_V46_R2.0921.00
183_L230_D2.0751.00
75_I150_I2.0611.00
190_L239_F2.0291.00
256_A272_S2.0171.00
96_I141_T2.0141.00
124_E128_N2.0001.00
286_T302_Y1.9821.00
103_K116_M1.9700.99
54_V61_S1.9580.99
233_K326_F1.9570.99
338_D342_E1.9500.99
270_L299_A1.9280.99
277_S282_L1.9280.99
110_K120_P1.9220.99
199_Y243_I1.9100.99
20_A65_V1.8130.99
87_L138_I1.8040.99
8_R68_F1.7440.99
186_I231_S1.6870.98
64_E80_V1.6720.98
278_V284_Y1.6610.98
51_V65_V1.6530.98
79_L144_V1.6400.98
38_V48_E1.6370.98
232_I242_V1.6150.98
134_T138_I1.5970.98
97_G103_K1.5940.98
11_I16_A1.5940.98
97_G116_M1.5860.98
126_I140_I1.5780.97
22_K129_A1.5540.97
320_L334_V1.5490.97
199_Y241_K1.5470.97
129_A132_E1.5320.97
21_A130_I1.5310.97
286_T306_E1.5230.97
41_T45_L1.5160.97
276_A314_I1.5080.97
21_A25_V1.5020.97
256_A269_R1.4890.96
289_K305_K1.4660.96
190_L238_L1.4510.96
320_L324_K1.4390.96
22_K26_I1.4340.96
278_V287_L1.4240.95
111_A120_P1.4110.95
20_A83_C1.4040.95
115_E123_R1.3900.95
202_I235_A1.3660.94
241_K333_C1.3610.94
273_L299_A1.3510.94
201_V212_A1.3510.94
21_A129_A1.3500.94
200_V239_F1.3360.93
212_A245_A1.3300.93
53_K64_E1.3280.93
324_K332_F1.3190.93
234_L237_N1.3190.93
52_E80_V1.3060.93
259_F322_R1.3040.93
314_I318_K1.2990.92
152_E157_K1.2950.92
25_V130_I1.2850.92
79_L146_N1.2820.92
82_R145_P1.2770.92
25_V134_T1.2760.92
88_N137_G1.2740.92
53_K80_V1.2740.92
21_A126_I1.2730.92
25_V138_I1.2590.91
187_R234_L1.2570.91
268_A272_S1.2470.91
36_T48_E1.2340.90
55_E62_C1.2310.90
288_T292_N1.2060.89
40_P46_R1.1980.89
60_I84_C1.1980.89
180_D184_E1.1920.89
27_G33_K1.1900.89
95_I123_R1.1860.89
82_R143_E1.1830.88
280_A314_I1.1720.88
84_C141_T1.1650.88
283_P306_E1.1630.88
157_K162_V1.1590.87
210_K213_A1.1520.87
244_L251_L1.1490.87
251_L336_I1.1420.87
293_A299_A1.1340.86
64_E82_R1.1270.86
101_V142_I1.1180.85
26_I133_V1.1180.85
276_A318_K1.1150.85
56_I61_S1.1150.85
335_I343_S1.1140.85
18_S126_I1.1110.85
107_S113_M1.0980.84
271_E291_S1.0950.84
95_I126_I1.0900.84
11_I49_I1.0870.84
229_G259_F1.0870.84
95_I116_M1.0780.83
69_S75_I1.0740.83
208_A247_L1.0730.83
112_T115_E1.0590.82
318_K321_S1.0570.82
148_E163_G1.0530.82
228_I254_V1.0480.81
207_S247_L1.0430.81
19_A65_V1.0380.81
81_I144_V1.0360.81
9_F175_T1.0360.81
27_G61_S1.0350.81
99_R146_N1.0300.80
283_P286_T1.0230.80
15_A49_I1.0230.80
204_P226_D1.0220.80
217_D220_C1.0160.79
279_L291_S1.0120.79
259_F326_F1.0020.78
320_L333_C1.0020.78
183_L234_L1.0000.78
125_M173_I0.9990.78
31_K56_I0.9880.77
277_S281_G0.9860.77
116_M141_T0.9820.77
183_L187_R0.9820.77
72_N174_E0.9810.77
92_E137_G0.9770.77
168_L295_S0.9760.77
320_L332_F0.9750.77
16_A65_V0.9740.76
210_K214_E0.9720.76
248_P300_F0.9720.76
106_R219_N0.9690.76
158_M209_A0.9660.76
52_E64_E0.9650.76
282_L286_T0.9650.76
274_T291_S0.9640.76
23_A63_A0.9580.75
260_N263_Y0.9570.75
240_K331_N0.9560.75
49_I65_V0.9550.75
150_I165_I0.9520.75
298_E301_T0.9400.74
177_V225_G0.9330.73
313_N317_E0.9320.73
79_L101_V0.9260.73
42_P121_T0.9240.73
204_P208_A0.9210.72
272_S276_A0.9180.72
24_A63_A0.9170.72
230_D234_L0.9140.72
323_I332_F0.9140.72
40_P132_E0.9130.72
84_C143_E0.9000.71
90_N137_G0.8950.70
68_F77_D0.8890.70
275_H291_S0.8880.70
69_S150_I0.8840.69
97_G126_I0.8820.69
190_L235_A0.8790.69
104_V111_A0.8790.69
313_N345_S0.8780.69
235_A242_V0.8750.68
88_N139_Q0.8730.68
72_N122_V0.8690.68
119_S122_V0.8660.68
204_P247_L0.8580.67
234_L238_L0.8540.67
246_G251_L0.8530.66
120_P124_E0.8510.66
27_G34_R0.8500.66
69_S174_E0.8480.66
174_E181_D0.8480.66
194_R198_D0.8460.66
81_I167_I0.8430.66
107_S195_Q0.8410.65
215_L335_I0.8380.65
225_G247_L0.8370.65
261_T297_E0.8370.65
290_I299_A0.8350.65
247_L297_E0.8330.65
93_I138_I0.8270.64
72_N76_L0.8270.64
284_Y287_L0.8270.64
279_L318_K0.8250.64
92_E131_R0.8200.63
229_G246_G0.8170.63
281_G287_L0.8140.63
235_A239_F0.8130.63
208_A226_D0.8110.62
34_R54_V0.8070.62
231_S242_V0.8030.62
20_A24_A0.8030.62
19_A37_V0.8000.61
191_N195_Q0.8000.61
131_R135_D0.7990.61
252_L255_Y0.7980.61
27_G54_V0.7960.61
187_R230_D0.7950.61
155_L182_Y0.7940.61
40_P128_N0.7920.61
293_A302_Y0.7890.60
203_A249_A0.7850.60
248_P296_V0.7840.60
226_D263_Y0.7790.59
18_S39_I0.7770.59
197_Y220_C0.7760.59
83_C140_I0.7730.59
177_V208_A0.7730.59
69_S78_G0.7720.59
259_F263_Y0.7710.59
316_A336_I0.7710.59
289_K298_E0.7630.58
102_G161_I0.7620.58
260_N265_Q0.7600.57
59_E87_L0.7600.57
275_H279_L0.7590.57
337_F343_S0.7580.57
312_M345_S0.7570.57
282_L290_I0.7560.57
129_A133_V0.7550.57
67_K119_S0.7520.57
98_E141_T0.7520.57
105_T160_G0.7500.56
317_E321_S0.7500.56
284_Y288_T0.7470.56
53_K82_R0.7470.56
31_K34_R0.7460.56
278_V291_S0.7460.56
321_S325_S0.7450.56
302_Y305_K0.7440.56
207_S297_E0.7430.56
314_I317_E0.7420.56
254_V339_Y0.7390.55
18_S25_V0.7390.55
191_N234_L0.7370.55
252_L296_V0.7360.55
204_P207_S0.7330.55
67_K72_N0.7330.55
19_A49_I0.7320.55
206_N263_Y0.7310.55
142_I165_I0.7300.54
69_S181_D0.7260.54
28_L61_S0.7180.53
204_P269_R0.7090.52
277_S280_A0.7090.52
303_M311_V0.7070.52
203_A245_A0.7040.52
88_N94_V0.7030.52
27_G53_K0.7020.52
91_N137_G0.7010.51
69_S79_L0.7010.51
71_D176_P0.7010.51
123_R127_I0.6980.51
80_V146_N0.6950.51
272_S275_H0.6950.51
103_K141_T0.6950.51
72_N119_S0.6930.51
285_G288_T0.6930.51
104_V109_L0.6890.50
310_K313_N0.6890.50
155_L226_D0.6880.50
146_N150_I0.6880.50
72_N181_D0.6860.50
304_T308_R0.6840.50
130_I138_I0.6810.49
33_K56_I0.6800.49
17_A95_I0.6780.49
62_C143_E0.6760.49
33_K54_V0.6740.49
177_V247_L0.6720.49
276_A279_L0.6690.48
280_A311_V0.6680.48
294_L298_E0.6660.48
124_E142_I0.6650.48
76_L174_E0.6640.48
88_N91_N0.6640.48
26_I30_N0.6550.47
279_L284_Y0.6550.47
148_E162_V0.6520.46
26_I37_V0.6520.46
258_I268_A0.6490.46
120_P294_L0.6480.46
252_L315_V0.6460.46
243_I335_I0.6460.46
182_Y260_N0.6460.46
201_V221_I0.6450.46
338_D341_G0.6450.46
206_N247_L0.6450.46
233_K318_K0.6440.46
179_D225_G0.6440.46
194_R238_L0.6430.46
202_I242_V0.6420.45
208_A225_G0.6420.45
88_N92_E0.6420.45
94_V290_I0.6410.45
290_I303_M0.6400.45
208_A297_E0.6400.45
22_K133_V0.6390.45
289_K302_Y0.6380.45
271_E275_H0.6380.45
287_L298_E0.6330.45
25_V133_V0.6320.44
256_A268_A0.6320.44
242_V330_I0.6320.44
286_T289_K0.6290.44
300_F304_T0.6280.44
96_I115_E0.6270.44
148_E152_E0.6260.44
273_L308_R0.6210.43
12_T17_A0.6210.43
182_Y227_R0.6190.43
300_F312_M0.6170.43
256_A267_D0.6160.43
97_G165_I0.6150.43
40_P129_A0.6140.43
31_K59_E0.6130.43
11_I47_L0.6120.42
268_A296_V0.6100.42
7_K179_D0.6100.42
25_V29_L0.6100.42
177_V206_N0.6080.42
127_I152_E0.6060.42
43_I171_T0.6040.42
58_S136_K0.6040.42
229_G263_Y0.6030.42
18_S22_K0.6020.41
92_E285_G0.6010.41
122_V159_V0.6010.41
15_A47_L0.6010.41
228_I246_G0.6000.41
175_T191_N0.6000.41
278_V281_G0.6000.41
93_I140_I0.5990.41
270_L293_A0.5990.41
246_G319_I0.5980.41
11_I223_K0.5980.41
75_I315_V0.5970.41
122_V181_D0.5970.41
258_I272_S0.5970.41
207_S269_R0.5970.41
39_I157_K0.5960.41
270_L273_L0.5960.41
316_A322_R0.5960.41
256_A275_H0.5950.41
202_I224_V0.5940.41
282_L287_L0.5930.41
26_I34_R0.5930.41
207_S225_G0.5910.40
247_L269_R0.5900.40
327_N332_F0.5890.40
252_L256_A0.5880.40
224_V231_S0.5850.40
177_V269_R0.5850.40
211_Y263_Y0.5830.40
244_L254_V0.5830.40
208_A269_R0.5830.40
276_A291_S0.5820.39
8_R71_D0.5810.39
110_K168_L0.5810.39
254_V263_Y0.5810.39
207_S337_F0.5800.39
206_N223_K0.5790.39
277_S345_S0.5790.39
243_I333_C0.5780.39
322_R326_F0.5740.39
175_T266_G0.5740.39
41_T47_L0.5730.39
258_I267_D0.5720.38
211_Y337_F0.5700.38
203_A211_Y0.5690.38
72_N185_H0.5690.38
259_F297_E0.5680.38
25_V126_I0.5680.38
25_V85_A0.5670.38
155_L267_D0.5650.38
209_A223_K0.5640.38
117_A176_P0.5640.38
207_S339_Y0.5620.37
28_L87_L0.5620.37
193_I200_V0.5610.37
255_Y276_A0.5610.37
67_K117_A0.5610.37
301_T340_D0.5600.37
244_L343_S0.5590.37
117_A166_S0.5590.37
87_L134_T0.5590.37
106_R246_G0.5570.37
215_L346_R0.5560.37
103_K113_M0.5550.37
110_K339_Y0.5550.37
117_A178_S0.5540.37
60_I335_I0.5540.37
95_I111_A0.5530.37
175_T337_F0.5530.37
56_I60_I0.5520.37
122_V174_E0.5510.36
103_K139_Q0.5490.36
71_D178_S0.5480.36
62_C82_R0.5480.36
40_P315_V0.5480.36
179_D247_L0.5480.36
158_M244_L0.5450.36
216_F221_I0.5450.36
203_A221_I0.5440.36
285_G289_K0.5440.36
177_V226_D0.5430.36
255_Y272_S0.5420.36
295_S303_M0.5420.36
186_I234_L0.5410.36
68_F174_E0.5400.35
140_I311_V0.5400.35
319_I334_V0.5400.35
39_I81_I0.5390.35
186_I190_L0.5390.35
311_V314_I0.5380.35
105_T122_V0.5370.35
240_K305_K0.5360.35
153_K190_L0.5360.35
318_K323_I0.5360.35
312_M315_V0.5360.35
258_I269_R0.5360.35
189_E193_I0.5360.35
177_V223_K0.5350.35
153_K177_V0.5340.35
110_K297_E0.5330.35
252_L273_L0.5330.35
138_I173_I0.5330.35
256_A266_G0.5320.35
274_T290_I0.5320.35
319_I337_F0.5300.34
111_A115_E0.5290.34
36_T51_V0.5290.34
247_L339_Y0.5280.34
186_I208_A0.5270.34
112_T149_T0.5270.34
207_S226_D0.5270.34
204_P225_G0.5260.34
190_L234_L0.5260.34
223_K341_G0.5260.34
76_L122_V0.5260.34
263_Y297_E0.5250.34
187_R191_N0.5250.34
182_Y225_G0.5250.34
142_I145_P0.5240.34
198_D292_N0.5200.34
212_A216_F0.5200.34
245_A337_F0.5190.33
267_D271_E0.5180.33
231_S234_L0.5160.33
204_P251_L0.5160.33
251_L319_I0.5150.33
324_K329_N0.5140.33
35_S310_K0.5120.33
93_I157_K0.5110.33
54_V62_C0.5110.33
67_K178_S0.5090.33
104_V108_G0.5090.33
268_A276_A0.5080.32
166_S178_S0.5070.32
183_L260_N0.5070.32
232_I280_A0.5070.32
296_V300_F0.5060.32
206_N260_N0.5050.32
130_I294_L0.5040.32
128_N131_R0.5040.32
21_A142_I0.5030.32
226_D247_L0.5030.32
118_I140_I0.5020.32
60_I86_K0.5020.32
72_N178_S0.5010.32
17_A172_G0.5010.32
32_E329_N0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sr8A 1 0.702 100 0.341 Contact Map
4ezeA 1 0.2321 56 0.972 Contact Map
4qs8A 1 0.235 50.4 0.973 Contact Map
3ojcA 4 0.4499 49.8 0.973 Contact Map
4eg2A 4 0.2264 40.9 0.974 Contact Map
3e3mA 2 0.1032 38.6 0.975 Contact Map
2zskA 2 0.4384 23.9 0.977 Contact Map
3un1A 4 0.2923 22.8 0.977 Contact Map
1ykdA 2 0.1805 20.6 0.978 Contact Map
2h5gA 2 0.1891 20.6 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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