GREMLIN Database
Q97WC5 - Cobalamin biosynthesis precorrin-3 methylase, putative (CbiH)
UniProt: Q97WC5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 250 (220)
Sequences: 13011 (8438)
Seq/√Len: 568.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_E25_E4.0041.00
24_Q28_E3.3641.00
7_Y26_V2.6831.00
124_R201_E2.6221.00
71_K77_N2.5901.00
30_S80_A2.5721.00
5_R110_E2.5541.00
194_K202_N2.4891.00
186_P209_S2.4861.00
206_T210_S2.4671.00
5_R108_D2.3891.00
9_V80_A2.2381.00
25_E29_K2.2211.00
73_L103_R2.2151.00
21_I24_Q2.1341.00
52_E71_K2.1261.00
7_Y78_T2.1051.00
121_A196_A2.0931.00
117_A165_Y2.0811.00
193_V196_A2.0261.00
207_T210_S2.0171.00
31_N78_T2.0031.00
206_T214_Y1.9391.00
9_V23_A1.9031.00
195_S200_N1.8891.00
71_K75_S1.8821.00
69_I103_R1.8821.00
31_N77_N1.8171.00
10_G112_V1.7821.00
151_K154_K1.7211.00
25_E28_E1.7091.00
99_L103_R1.7011.00
190_V211_W1.6981.00
26_V112_V1.6921.00
5_R78_T1.6671.00
32_V71_K1.6611.00
17_E22_K1.6571.00
99_L102_R1.6361.00
7_Y110_E1.5761.00
153_T182_K1.5731.00
193_V203_I1.5681.00
41_R45_D1.5681.00
210_S214_Y1.5551.00
189_P227_G1.5481.00
67_T71_K1.4921.00
116_T119_L1.4561.00
124_R203_I1.4551.00
70_E75_S1.4381.00
179_I183_H1.4301.00
15_S22_K1.4211.00
22_K110_E1.4161.00
184_R188_T1.4151.00
118_A165_Y1.4111.00
214_Y218_I1.4081.00
187_N209_S1.4081.00
69_I73_L1.3961.00
35_G53_V1.3901.00
206_T211_W1.3901.00
29_K78_T1.3761.00
67_T70_E1.3711.00
19_R24_Q1.3401.00
125_L191_G1.3371.00
195_S198_R1.3311.00
66_N70_E1.3291.00
121_A193_V1.3131.00
10_G86_D1.3111.00
220_M226_I1.3091.00
88_Q93_A1.3021.00
116_T165_Y1.2991.00
174_I216_N1.2701.00
228_N231_T1.2671.00
20_T115_V1.2441.00
65_A99_L1.2391.00
73_L107_L1.2331.00
213_E217_E1.2231.00
177_M181_S1.2131.00
26_V80_A1.2071.00
33_I47_L1.2051.00
6_L100_I1.1991.00
202_N218_I1.1981.00
57_R60_E1.1951.00
111_V123_A1.1951.00
63_F66_N1.1921.00
204_I214_Y1.1911.00
24_Q46_V1.1851.00
52_E77_N1.1721.00
37_N59_K1.1681.00
61_E65_A1.1541.00
164_F226_I1.1521.00
214_Y217_E1.1431.00
72_A107_L1.1351.00
6_L72_A1.1291.00
34_I79_V1.1291.00
178_D181_S1.1241.00
190_V208_L1.1061.00
221_S226_I1.1021.00
191_G205_I1.1001.00
34_I54_I1.0961.00
8_I93_A1.0901.00
19_R23_A1.0901.00
34_I68_A1.0891.00
192_L222_T1.0781.00
163_V225_I1.0641.00
30_S78_T1.0511.00
64_R67_T1.0491.00
69_I99_L1.0431.00
32_V79_V1.0391.00
191_G203_I1.0371.00
42_L45_D1.0251.00
134_V160_F1.0091.00
94_G131_L1.0051.00
164_F167_L1.0041.00
81_L96_V0.9941.00
100_I107_L0.9881.00
139_S151_K0.9851.00
18_Q22_K0.9771.00
192_L215_M0.9691.00
212_K216_N0.9651.00
7_Y112_V0.9571.00
101_A205_I0.9571.00
136_I160_F0.9561.00
17_E21_I0.9521.00
180_I184_R0.9511.00
86_D123_A0.9451.00
97_Y109_V0.9451.00
173_L215_M0.9331.00
101_A126_G0.9321.00
153_T157_E0.9311.00
23_A112_V0.9281.00
178_D182_K0.9271.00
180_I208_L0.9271.00
146_E179_I0.9271.00
139_S152_V0.9241.00
61_E95_L0.9211.00
10_G87_P0.9081.00
220_M223_T0.9061.00
120_A197_Y0.9041.00
21_I25_E0.9041.00
32_V77_N0.9011.00
154_K157_E0.8951.00
34_I71_K0.8921.00
65_A69_I0.8911.00
111_V203_I0.8901.00
132_D136_I0.8901.00
42_L46_V0.8821.00
47_L51_K0.8781.00
34_I67_T0.8751.00
32_V54_I0.8741.00
127_S191_G0.8701.00
170_E175_E0.8661.00
128_P131_L0.8651.00
7_Y30_S0.8631.00
154_K158_A0.8601.00
163_V223_T0.8561.00
103_R106_D0.8531.00
9_V26_V0.8481.00
174_I212_K0.8481.00
166_N170_E0.8471.00
122_A129_L0.8451.00
9_V112_V0.8441.00
153_T156_A0.8401.00
88_Q111_V0.8401.00
213_E216_N0.8391.00
187_N207_T0.8321.00
43_I47_L0.8261.00
144_P150_H0.8261.00
26_V29_K0.8191.00
54_I67_T0.8191.00
89_V119_L0.8161.00
98_D102_R0.8161.00
68_A72_A0.8151.00
94_G98_D0.8141.00
43_I46_V0.8101.00
180_I183_H0.8051.00
175_E178_D0.8031.00
139_S159_D0.7991.00
174_I213_E0.7901.00
70_E73_L0.7841.00
153_T183_H0.7811.00
19_R43_I0.7791.00
173_L224_M0.7781.00
26_V110_E0.7691.00
16_K42_L0.7661.00
179_I182_K0.7651.00
149_L175_E0.7651.00
66_N103_R0.7651.00
55_G60_E0.7631.00
173_L211_W0.7621.00
140_D151_K0.7611.00
22_K25_E0.7561.00
72_A79_V0.7541.00
36_Y39_Y0.7531.00
62_I99_L0.7521.00
26_V78_T0.7491.00
86_D111_V0.7461.00
13_P18_Q0.7431.00
185_K188_T0.7421.00
101_A109_V0.7401.00
121_A225_I0.7391.00
33_I51_K0.7381.00
61_E64_R0.7371.00
136_I151_K0.7371.00
54_I64_R0.7321.00
66_N99_L0.7311.00
87_P91_G0.7291.00
140_D165_Y0.7281.00
60_E169_N0.7281.00
189_P207_T0.7241.00
215_M218_I0.7231.00
22_K112_V0.7111.00
139_S160_F0.7081.00
204_I211_W0.7041.00
94_G128_P0.7041.00
159_D184_R0.7031.00
93_A97_Y0.7031.00
204_I218_I0.7011.00
34_I56_A0.7001.00
178_D212_K0.7001.00
222_T226_I0.6971.00
54_I71_K0.6971.00
63_F67_T0.6961.00
146_E149_L0.6951.00
120_A196_A0.6941.00
118_A163_V0.6911.00
111_V124_R0.6881.00
15_S18_Q0.6861.00
10_G120_A0.6821.00
137_S160_F0.6791.00
174_I178_D0.6781.00
28_E46_V0.6761.00
89_V138_L0.6761.00
188_T228_N0.6751.00
175_E179_I0.6741.00
141_L146_E0.6731.00
30_S33_I0.6721.00
192_L211_W0.6711.00
174_I177_M0.6691.00
83_S91_G0.6681.00
145_R149_L0.6671.00
134_V158_A0.6671.00
88_Q123_A0.6661.00
7_Y80_A0.6651.00
44_S47_L0.6651.00
90_Y135_V0.6631.00
124_R197_Y0.6601.00
149_L179_I0.6591.00
143_I179_I0.6591.00
55_G58_M0.6571.00
26_V30_S0.6571.00
223_T226_I0.6541.00
180_I186_P0.6541.00
89_V129_L0.6531.00
121_A223_T0.6531.00
41_R44_S0.6501.00
149_L153_T0.6481.00
194_K222_T0.6481.00
154_K159_D0.6471.00
27_L33_I0.6461.00
10_G115_V0.6411.00
181_S212_K0.6401.00
37_N60_E0.6381.00
8_I97_Y0.6381.00
157_E183_H0.6341.00
47_L53_V0.6321.00
177_M183_H0.6311.00
204_I215_M0.6311.00
69_I100_I0.6311.00
15_S197_Y0.6271.00
39_Y43_I0.6261.00
181_S209_S0.6231.00
56_A61_E0.6221.00
140_D143_I0.6161.00
62_I66_N0.6081.00
97_Y101_A0.6071.00
22_K26_V0.6071.00
37_N55_G0.6051.00
215_M219_S0.5961.00
65_A68_A0.5961.00
62_I95_L0.5961.00
19_R47_L0.5941.00
60_E63_F0.5881.00
41_R53_V0.5871.00
58_M61_E0.5861.00
62_I65_A0.5861.00
137_S155_A0.5861.00
122_A225_I0.5841.00
168_I222_T0.5781.00
205_I230_L0.5781.00
103_R107_L0.5761.00
141_L145_R0.5751.00
120_A124_R0.5741.00
23_A80_A0.5710.99
56_A65_A0.5710.99
165_Y223_T0.5690.99
31_N48_D0.5660.99
27_L80_A0.5650.99
27_L47_L0.5650.99
129_L163_V0.5600.99
152_V176_V0.5580.99
177_M212_K0.5570.99
24_Q47_L0.5570.99
98_D131_L0.5550.99
21_I46_V0.5550.99
55_G64_R0.5520.99
164_F176_V0.5520.99
48_D51_K0.5480.99
191_G225_I0.5400.99
16_K45_D0.5390.99
190_V212_K0.5370.99
52_E67_T0.5340.99
162_I184_R0.5310.99
210_S213_E0.5230.99
155_A158_A0.5220.99
220_M224_M0.5190.99
153_T179_I0.5180.99
184_R208_L0.5180.99
196_A203_I0.5160.99
181_S208_L0.5140.99
65_A95_L0.5130.99
162_I226_I0.5100.99
173_L222_T0.5080.99
88_Q97_Y0.5080.99
140_D146_E0.5080.99
55_G59_K0.5070.99
151_K157_E0.5060.99
69_I72_A0.5060.99
51_K54_I0.5050.99
56_A59_K0.5050.99
131_L134_V0.5020.99
156_A184_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjqA 2 0.948 100 0.225 Contact Map
2yboA 2 0.932 100 0.229 Contact Map
1s4dA 4 0.956 100 0.235 Contact Map
2zvbA 2 0.94 100 0.235 Contact Map
3kwpA 2 0.896 100 0.241 Contact Map
3nutA 2 0.94 100 0.248 Contact Map
1ve2A 2 0.904 100 0.258 Contact Map
4e16A 2 0.888 100 0.266 Contact Map
1cbfA 2 0.9 100 0.267 Contact Map
3ndcA 2 0.928 100 0.273 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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