Q97WC5 - SULSO - GREMLIN Contacts

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Q97WC5 - Cobalamin biosynthesis precorrin-3 methylase, putative (CbiH)

UniProt:	Q97WC5	Sequences: MKMGRLYIVGIGPGSKEQRTIKAQEVLEKSNVIIGYNTYLRLISDVLDGKKEVIGARMKEEIFRANTAIEKALESNNTVALVSSGDPQVYGMAGLVYDLIARRNLDLDVEVVPGVTAALAAAARLGSPLSLDFVVISLSDLLIPREEILHKVTKAAEADFVIVFYNLINENLLIEVMDIISKHRKPNTPVGLVKSAYRNNENIIITTLSSWKEYMNEISMSTTMIIGNSLTYRYKNYMITPRGYERKYEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	250 (220)
Sequences:	13011 (8438)
Seq/√Len:	568.9

ECOLI - CYSG RSMI
BACSU - NASF SUMT RSMI
HALSA - Q9HPM9 Q9HPN0 Q9HPN2 Q9HMY4 Q9HPM0 Q9HPN3
SULSO - Q97WC5 Q97WC9 Q97UT5 Q97W12 Q97WD1 Q97WC8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
17_E	25_E	4.004	1.00
24_Q	28_E	3.364	1.00
7_Y	26_V	2.683	1.00
124_R	201_E	2.622	1.00
71_K	77_N	2.590	1.00
30_S	80_A	2.572	1.00
5_R	110_E	2.554	1.00
194_K	202_N	2.489	1.00
186_P	209_S	2.486	1.00
206_T	210_S	2.467	1.00
5_R	108_D	2.389	1.00
9_V	80_A	2.238	1.00
25_E	29_K	2.221	1.00
73_L	103_R	2.215	1.00
21_I	24_Q	2.134	1.00
52_E	71_K	2.126	1.00
7_Y	78_T	2.105	1.00
121_A	196_A	2.093	1.00
117_A	165_Y	2.081	1.00
193_V	196_A	2.026	1.00
207_T	210_S	2.017	1.00
31_N	78_T	2.003	1.00
206_T	214_Y	1.939	1.00
9_V	23_A	1.903	1.00
195_S	200_N	1.889	1.00
71_K	75_S	1.882	1.00
69_I	103_R	1.882	1.00
31_N	77_N	1.817	1.00
10_G	112_V	1.782	1.00
151_K	154_K	1.721	1.00
25_E	28_E	1.709	1.00
99_L	103_R	1.701	1.00
190_V	211_W	1.698	1.00
26_V	112_V	1.692	1.00
5_R	78_T	1.667	1.00
32_V	71_K	1.661	1.00
17_E	22_K	1.657	1.00
99_L	102_R	1.636	1.00
7_Y	110_E	1.576	1.00
153_T	182_K	1.573	1.00
193_V	203_I	1.568	1.00
41_R	45_D	1.568	1.00
210_S	214_Y	1.555	1.00
189_P	227_G	1.548	1.00
67_T	71_K	1.492	1.00
116_T	119_L	1.456	1.00
124_R	203_I	1.455	1.00
70_E	75_S	1.438	1.00
179_I	183_H	1.430	1.00
15_S	22_K	1.421	1.00
22_K	110_E	1.416	1.00
184_R	188_T	1.415	1.00
118_A	165_Y	1.411	1.00
214_Y	218_I	1.408	1.00
187_N	209_S	1.408	1.00
69_I	73_L	1.396	1.00
35_G	53_V	1.390	1.00
206_T	211_W	1.390	1.00
29_K	78_T	1.376	1.00
67_T	70_E	1.371	1.00
19_R	24_Q	1.340	1.00
125_L	191_G	1.337	1.00
195_S	198_R	1.331	1.00
66_N	70_E	1.329	1.00
121_A	193_V	1.313	1.00
10_G	86_D	1.311	1.00
220_M	226_I	1.309	1.00
88_Q	93_A	1.302	1.00
116_T	165_Y	1.299	1.00
174_I	216_N	1.270	1.00
228_N	231_T	1.267	1.00
20_T	115_V	1.244	1.00
65_A	99_L	1.239	1.00
73_L	107_L	1.233	1.00
213_E	217_E	1.223	1.00
177_M	181_S	1.213	1.00
26_V	80_A	1.207	1.00
33_I	47_L	1.205	1.00
6_L	100_I	1.199	1.00
202_N	218_I	1.198	1.00
57_R	60_E	1.195	1.00
111_V	123_A	1.195	1.00
63_F	66_N	1.192	1.00
204_I	214_Y	1.191	1.00
24_Q	46_V	1.185	1.00
52_E	77_N	1.172	1.00
37_N	59_K	1.168	1.00
61_E	65_A	1.154	1.00
164_F	226_I	1.152	1.00
214_Y	217_E	1.143	1.00
72_A	107_L	1.135	1.00
6_L	72_A	1.129	1.00
34_I	79_V	1.129	1.00
178_D	181_S	1.124	1.00
190_V	208_L	1.106	1.00
221_S	226_I	1.102	1.00
191_G	205_I	1.100	1.00
34_I	54_I	1.096	1.00
8_I	93_A	1.090	1.00
19_R	23_A	1.090	1.00
34_I	68_A	1.089	1.00
192_L	222_T	1.078	1.00
163_V	225_I	1.064	1.00
30_S	78_T	1.051	1.00
64_R	67_T	1.049	1.00
69_I	99_L	1.043	1.00
32_V	79_V	1.039	1.00
191_G	203_I	1.037	1.00
42_L	45_D	1.025	1.00
134_V	160_F	1.009	1.00
94_G	131_L	1.005	1.00
164_F	167_L	1.004	1.00
81_L	96_V	0.994	1.00
100_I	107_L	0.988	1.00
139_S	151_K	0.985	1.00
18_Q	22_K	0.977	1.00
192_L	215_M	0.969	1.00
212_K	216_N	0.965	1.00
7_Y	112_V	0.957	1.00
101_A	205_I	0.957	1.00
136_I	160_F	0.956	1.00
17_E	21_I	0.952	1.00
180_I	184_R	0.951	1.00
86_D	123_A	0.945	1.00
97_Y	109_V	0.945	1.00
173_L	215_M	0.933	1.00
101_A	126_G	0.932	1.00
153_T	157_E	0.931	1.00
23_A	112_V	0.928	1.00
178_D	182_K	0.927	1.00
180_I	208_L	0.927	1.00
146_E	179_I	0.927	1.00
139_S	152_V	0.924	1.00
61_E	95_L	0.921	1.00
10_G	87_P	0.908	1.00
220_M	223_T	0.906	1.00
120_A	197_Y	0.904	1.00
21_I	25_E	0.904	1.00
32_V	77_N	0.901	1.00
154_K	157_E	0.895	1.00
34_I	71_K	0.892	1.00
65_A	69_I	0.891	1.00
111_V	203_I	0.890	1.00
132_D	136_I	0.890	1.00
42_L	46_V	0.882	1.00
47_L	51_K	0.878	1.00
34_I	67_T	0.875	1.00
32_V	54_I	0.874	1.00
127_S	191_G	0.870	1.00
170_E	175_E	0.866	1.00
128_P	131_L	0.865	1.00
7_Y	30_S	0.863	1.00
154_K	158_A	0.860	1.00
163_V	223_T	0.856	1.00
103_R	106_D	0.853	1.00
9_V	26_V	0.848	1.00
174_I	212_K	0.848	1.00
166_N	170_E	0.847	1.00
122_A	129_L	0.845	1.00
9_V	112_V	0.844	1.00
153_T	156_A	0.840	1.00
88_Q	111_V	0.840	1.00
213_E	216_N	0.839	1.00
187_N	207_T	0.832	1.00
43_I	47_L	0.826	1.00
144_P	150_H	0.826	1.00
26_V	29_K	0.819	1.00
54_I	67_T	0.819	1.00
89_V	119_L	0.816	1.00
98_D	102_R	0.816	1.00
68_A	72_A	0.815	1.00
94_G	98_D	0.814	1.00
43_I	46_V	0.810	1.00
180_I	183_H	0.805	1.00
175_E	178_D	0.803	1.00
139_S	159_D	0.799	1.00
174_I	213_E	0.790	1.00
70_E	73_L	0.784	1.00
153_T	183_H	0.781	1.00
19_R	43_I	0.779	1.00
173_L	224_M	0.778	1.00
26_V	110_E	0.769	1.00
16_K	42_L	0.766	1.00
179_I	182_K	0.765	1.00
149_L	175_E	0.765	1.00
66_N	103_R	0.765	1.00
55_G	60_E	0.763	1.00
173_L	211_W	0.762	1.00
140_D	151_K	0.761	1.00
22_K	25_E	0.756	1.00
72_A	79_V	0.754	1.00
36_Y	39_Y	0.753	1.00
62_I	99_L	0.752	1.00
26_V	78_T	0.749	1.00
86_D	111_V	0.746	1.00
13_P	18_Q	0.743	1.00
185_K	188_T	0.742	1.00
101_A	109_V	0.740	1.00
121_A	225_I	0.739	1.00
33_I	51_K	0.738	1.00
61_E	64_R	0.737	1.00
136_I	151_K	0.737	1.00
54_I	64_R	0.732	1.00
66_N	99_L	0.731	1.00
87_P	91_G	0.729	1.00
140_D	165_Y	0.728	1.00
60_E	169_N	0.728	1.00
189_P	207_T	0.724	1.00
215_M	218_I	0.723	1.00
22_K	112_V	0.711	1.00
139_S	160_F	0.708	1.00
204_I	211_W	0.704	1.00
94_G	128_P	0.704	1.00
159_D	184_R	0.703	1.00
93_A	97_Y	0.703	1.00
204_I	218_I	0.701	1.00
34_I	56_A	0.700	1.00
178_D	212_K	0.700	1.00
222_T	226_I	0.697	1.00
54_I	71_K	0.697	1.00
63_F	67_T	0.696	1.00
146_E	149_L	0.695	1.00
120_A	196_A	0.694	1.00
118_A	163_V	0.691	1.00
111_V	124_R	0.688	1.00
15_S	18_Q	0.686	1.00
10_G	120_A	0.682	1.00
137_S	160_F	0.679	1.00
174_I	178_D	0.678	1.00
28_E	46_V	0.676	1.00
89_V	138_L	0.676	1.00
188_T	228_N	0.675	1.00
175_E	179_I	0.674	1.00
141_L	146_E	0.673	1.00
30_S	33_I	0.672	1.00
192_L	211_W	0.671	1.00
174_I	177_M	0.669	1.00
83_S	91_G	0.668	1.00
145_R	149_L	0.667	1.00
134_V	158_A	0.667	1.00
88_Q	123_A	0.666	1.00
7_Y	80_A	0.665	1.00
44_S	47_L	0.665	1.00
90_Y	135_V	0.663	1.00
124_R	197_Y	0.660	1.00
149_L	179_I	0.659	1.00
143_I	179_I	0.659	1.00
55_G	58_M	0.657	1.00
26_V	30_S	0.657	1.00
223_T	226_I	0.654	1.00
180_I	186_P	0.654	1.00
89_V	129_L	0.653	1.00
121_A	223_T	0.653	1.00
41_R	44_S	0.650	1.00
149_L	153_T	0.648	1.00
194_K	222_T	0.648	1.00
154_K	159_D	0.647	1.00
27_L	33_I	0.646	1.00
10_G	115_V	0.641	1.00
181_S	212_K	0.640	1.00
37_N	60_E	0.638	1.00
8_I	97_Y	0.638	1.00
157_E	183_H	0.634	1.00
47_L	53_V	0.632	1.00
177_M	183_H	0.631	1.00
204_I	215_M	0.631	1.00
69_I	100_I	0.631	1.00
15_S	197_Y	0.627	1.00
39_Y	43_I	0.626	1.00
181_S	209_S	0.623	1.00
56_A	61_E	0.622	1.00
140_D	143_I	0.616	1.00
62_I	66_N	0.608	1.00
97_Y	101_A	0.607	1.00
22_K	26_V	0.607	1.00
37_N	55_G	0.605	1.00
215_M	219_S	0.596	1.00
65_A	68_A	0.596	1.00
62_I	95_L	0.596	1.00
19_R	47_L	0.594	1.00
60_E	63_F	0.588	1.00
41_R	53_V	0.587	1.00
58_M	61_E	0.586	1.00
62_I	65_A	0.586	1.00
137_S	155_A	0.586	1.00
122_A	225_I	0.584	1.00
168_I	222_T	0.578	1.00
205_I	230_L	0.578	1.00
103_R	107_L	0.576	1.00
141_L	145_R	0.575	1.00
120_A	124_R	0.574	1.00
23_A	80_A	0.571	0.99
56_A	65_A	0.571	0.99
165_Y	223_T	0.569	0.99
31_N	48_D	0.566	0.99
27_L	80_A	0.565	0.99
27_L	47_L	0.565	0.99
129_L	163_V	0.560	0.99
152_V	176_V	0.558	0.99
177_M	212_K	0.557	0.99
24_Q	47_L	0.557	0.99
98_D	131_L	0.555	0.99
21_I	46_V	0.555	0.99
55_G	64_R	0.552	0.99
164_F	176_V	0.552	0.99
48_D	51_K	0.548	0.99
191_G	225_I	0.540	0.99
16_K	45_D	0.539	0.99
190_V	212_K	0.537	0.99
52_E	67_T	0.534	0.99
162_I	184_R	0.531	0.99
210_S	213_E	0.523	0.99
155_A	158_A	0.522	0.99
220_M	224_M	0.519	0.99
153_T	179_I	0.518	0.99
184_R	208_L	0.518	0.99
196_A	203_I	0.516	0.99
181_S	208_L	0.514	0.99
65_A	95_L	0.513	0.99
162_I	226_I	0.510	0.99
173_L	222_T	0.508	0.99
88_Q	97_Y	0.508	0.99
140_D	146_E	0.508	0.99
55_G	59_K	0.507	0.99
151_K	157_E	0.506	0.99
69_I	72_A	0.506	0.99
51_K	54_I	0.505	0.99
56_A	59_K	0.505	0.99
131_L	134_V	0.502	0.99
156_A	184_R	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pjqA	2	0.948	100	0.225	Contact Map
2yboA	2	0.932	100	0.229	Contact Map
1s4dA	4	0.956	100	0.235	Contact Map
2zvbA	2	0.94	100	0.235	Contact Map
3kwpA	2	0.896	100	0.241	Contact Map
3nutA	2	0.94	100	0.248	Contact Map
1ve2A	2	0.904	100	0.258	Contact Map
4e16A	2	0.888	100	0.266	Contact Map
1cbfA	2	0.9	100	0.267	Contact Map
3ndcA	2	0.928	100	0.273	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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