Q97WC3 - SULSO - GREMLIN Contacts

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Q97WC3 - Cofactor biosynthesis protein

UniProt:	Q97WC3	Sequences: MSTLKPMIFGNVKRALLGLGVRKLPLIAGHKLLYTCNLRCRMCPFWRRKDEKLLSLEEEVLMLKSLEKAGVLFMGFEGGEPLLRRDLEDILEESYKRFYTSLVTNGWLLKDRAKSISNYLDYLFVSIDGIGEVHDKIRGISGAFERAVEGIKEARKYLPVAISFTITKENMDQVKDVIELARKLNVNISIQVEYDYSTAEKLSPDKRRLYDALRLIIELKKRGYQIIESSDYFEAIIKSWYNGIPWRCKPWLTINIDPQGRIVLPCYVLNEYSGTDKVWEVDIVKLWNSYPWEKYESCNACALACYLEPSLFSWSNGKMVKEKIIDNMASYVYNASPIKFLLSR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (286)
Sequences:	10327 (8020)
Seq/√Len:	474.2

ECOLI - ASLB YDEM MOAA
BACSU - ALBA SKFB MOAA YYDG
HALSA - Q9HQF5 MOAA Q9HQF7
SULSO - Q97WC3 Q97XA7 Q97XS7 Q97XZ2 Q7LXV3 Q97XA6 Q97XS8 Q97WK5 Q97Y04 MOAA Q980E0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
38_L	107_W	4.175	1.00
60_V	93_E	3.678	1.00
152_K	184_L	3.432	1.00
131_G	145_E	3.356	1.00
110_K	153_E	2.976	1.00
88_E	115_S	2.906	1.00
114_K	157_Y	2.851	1.00
64_K	93_E	2.756	1.00
248_C	266_C	2.718	1.00
135_D	142_G	2.628	1.00
58_E	279_W	2.616	1.00
55_S	58_E	2.616	1.00
261_R	277_K	2.448	1.00
37_N	105_N	2.412	1.00
61_L	65_S	2.291	1.00
133_V	173_Q	2.285	1.00
153_E	156_K	2.265	1.00
56_L	89_D	2.233	1.00
282_D	285_K	2.210	1.00
114_K	118_N	2.202	1.00
144_F	180_L	2.141	1.00
95_Y	121_D	2.070	1.00
88_E	112_R	2.068	1.00
28_A	66_L	2.064	1.00
128_D	138_R	2.037	1.00
35_T	53_L	2.012	1.00
173_Q	176_D	1.978	1.00
130_I	133_V	1.972	1.00
93_E	96_K	1.946	1.00
130_I	173_Q	1.944	1.00
63_L	94_S	1.930	1.00
59_E	90_I	1.921	1.00
164_F	177_V	1.894	1.00
106_G	125_V	1.866	1.00
162_I	181_A	1.789	1.00
56_L	60_V	1.760	1.00
152_K	156_K	1.754	1.00
115_S	118_N	1.752	1.00
86_D	89_D	1.750	1.00
277_K	280_E	1.747	1.00
60_V	89_D	1.747	1.00
257_D	261_R	1.734	1.00
149_E	152_K	1.721	1.00
205_D	208_R	1.707	1.00
37_N	108_L	1.700	1.00
146_R	149_E	1.675	1.00
125_V	151_I	1.662	1.00
42_M	128_D	1.659	1.00
117_S	157_Y	1.646	1.00
58_E	61_L	1.636	1.00
175_K	215_L	1.630	1.00
257_D	264_L	1.627	1.00
168_K	208_R	1.620	1.00
153_E	157_Y	1.616	1.00
144_F	148_V	1.586	1.00
92_E	96_K	1.586	1.00
82_L	102_L	1.571	1.00
180_L	184_L	1.554	1.00
56_L	86_D	1.554	1.00
281_V	285_K	1.554	1.00
152_K	155_R	1.551	1.00
112_R	115_S	1.543	1.00
145_E	149_E	1.534	1.00
76_F	94_S	1.530	1.00
89_D	92_E	1.517	1.00
74_M	94_S	1.517	1.00
110_K	156_K	1.499	1.00
41_R	136_K	1.478	1.00
125_V	150_G	1.469	1.00
92_E	115_S	1.456	1.00
60_V	64_K	1.446	1.00
179_E	183_K	1.436	1.00
67_E	98_F	1.436	1.00
129_G	133_V	1.431	1.00
113_A	153_E	1.397	1.00
149_E	153_E	1.395	1.00
136_K	169_E	1.374	1.00
211_D	215_L	1.373	1.00
155_R	185_N	1.373	1.00
179_E	219_L	1.372	1.00
95_Y	100_T	1.360	1.00
285_K	289_S	1.360	1.00
32_L	76_F	1.349	1.00
290_Y	293_E	1.323	1.00
26_L	72_L	1.321	1.00
134_H	143_A	1.315	1.00
123_L	154_A	1.313	1.00
131_G	173_Q	1.311	1.00
30_H	59_E	1.308	1.00
176_D	179_E	1.305	1.00
72_L	99_Y	1.300	1.00
147_A	150_G	1.294	1.00
84_R	90_I	1.258	1.00
284_V	288_N	1.247	1.00
76_F	100_T	1.246	1.00
94_S	100_T	1.239	1.00
110_K	157_Y	1.238	1.00
54_L	58_E	1.234	1.00
210_Y	214_R	1.231	1.00
82_L	108_L	1.228	1.00
164_F	188_I	1.220	1.00
209_L	212_A	1.214	1.00
103_V	124_F	1.197	1.00
65_S	282_D	1.191	1.00
113_A	150_G	1.190	1.00
175_K	179_E	1.188	1.00
206_K	210_Y	1.187	1.00
148_V	184_L	1.185	1.00
211_D	214_R	1.179	1.00
134_H	147_A	1.173	1.00
95_Y	119_Y	1.172	1.00
53_L	84_R	1.167	1.00
113_A	117_S	1.167	1.00
91_L	120_L	1.164	1.00
290_Y	294_K	1.158	1.00
214_R	218_E	1.115	1.00
56_L	93_E	1.109	1.00
148_V	152_K	1.109	1.00
89_D	93_E	1.108	1.00
179_E	182_R	1.106	1.00
216_I	220_K	1.103	1.00
207_R	211_D	1.102	1.00
208_R	211_D	1.096	1.00
215_L	219_L	1.086	1.00
135_D	143_A	1.085	1.00
133_V	136_K	1.082	1.00
155_R	184_L	1.074	1.00
133_V	172_D	1.072	1.00
87_L	91_L	1.069	1.00
131_G	135_D	1.063	1.00
204_P	208_R	1.058	1.00
65_S	69_A	1.051	1.00
130_I	180_L	1.043	1.00
148_V	180_L	1.038	1.00
137_I	167_T	1.035	1.00
129_G	144_F	1.034	1.00
181_A	186_V	1.032	1.00
155_R	186_V	1.031	1.00
162_I	186_V	1.031	1.00
62_M	256_I	1.028	1.00
54_L	59_E	1.016	1.00
28_A	254_I	1.014	1.00
135_D	138_R	1.009	1.00
33_L	53_L	1.005	1.00
281_V	289_S	1.005	1.00
73_F	101_S	0.998	1.00
203_S	206_K	0.992	1.00
112_R	116_I	0.990	1.00
61_L	64_K	0.990	1.00
151_I	162_I	0.990	1.00
261_R	275_T	0.989	1.00
109_L	113_A	0.986	1.00
90_I	94_S	0.985	1.00
52_K	259_Q	0.981	1.00
215_L	218_E	0.980	1.00
113_A	157_Y	0.973	1.00
34_Y	258_P	0.971	1.00
117_S	158_L	0.969	1.00
150_G	153_E	0.958	1.00
146_R	150_G	0.954	1.00
109_L	150_G	0.952	1.00
296_E	299_N	0.949	1.00
151_I	160_V	0.948	1.00
132_E	136_K	0.945	1.00
88_E	92_E	0.943	1.00
130_I	176_D	0.941	1.00
37_N	80_E	0.940	1.00
134_H	138_R	0.938	1.00
38_L	143_A	0.938	1.00
125_V	154_A	0.938	1.00
124_F	163_S	0.936	1.00
111_D	114_K	0.936	1.00
30_H	62_M	0.932	1.00
207_R	210_Y	0.931	1.00
262_I	286_L	0.929	1.00
82_L	112_R	0.922	1.00
61_L	279_W	0.912	1.00
162_I	188_I	0.912	1.00
110_K	149_E	0.909	1.00
37_N	107_W	0.909	1.00
26_L	252_L	0.905	1.00
32_L	87_L	0.903	1.00
66_L	74_M	0.895	1.00
154_A	160_V	0.888	1.00
123_L	158_L	0.887	1.00
155_R	160_V	0.884	1.00
87_L	102_L	0.882	1.00
102_L	116_I	0.880	1.00
74_M	98_F	0.875	1.00
213_L	216_I	0.865	1.00
82_L	87_L	0.864	1.00
102_L	123_L	0.861	1.00
254_I	283_I	0.854	1.00
65_S	284_V	0.853	1.00
154_A	158_L	0.852	1.00
230_S	233_F	0.848	1.00
289_S	292_W	0.846	1.00
84_R	87_L	0.845	1.00
76_F	91_L	0.840	1.00
291_P	294_K	0.834	1.00
30_H	256_I	0.832	1.00
32_L	90_I	0.828	1.00
209_L	216_I	0.828	1.00
177_V	181_A	0.826	1.00
42_M	137_I	0.825	1.00
127_I	162_I	0.821	1.00
178_I	182_R	0.821	1.00
271_E	274_G	0.817	1.00
41_R	137_I	0.815	1.00
224_Y	227_I	0.813	1.00
287_W	291_P	0.812	1.00
204_P	207_R	0.809	1.00
44_P	77_E	0.808	1.00
145_E	148_V	0.806	1.00
54_L	62_M	0.803	1.00
28_A	256_I	0.802	1.00
232_Y	235_A	0.796	1.00
114_K	117_S	0.795	1.00
91_L	100_T	0.788	1.00
206_K	209_L	0.784	1.00
224_Y	228_E	0.784	1.00
73_F	99_Y	0.783	1.00
126_S	165_T	0.783	1.00
276_D	281_V	0.783	1.00
92_E	119_Y	0.782	1.00
131_G	144_F	0.781	1.00
216_I	219_L	0.781	1.00
228_E	232_Y	0.778	1.00
104_T	125_V	0.776	1.00
85_R	112_R	0.774	1.00
279_W	282_D	0.772	1.00
57_E	60_V	0.769	1.00
281_V	286_L	0.769	1.00
113_A	154_A	0.767	1.00
226_I	230_S	0.766	1.00
109_L	116_I	0.763	1.00
102_L	120_L	0.760	1.00
134_H	142_G	0.758	1.00
193_E	199_A	0.758	1.00
129_G	173_Q	0.757	1.00
230_S	234_E	0.756	1.00
228_E	233_F	0.756	1.00
134_H	144_F	0.755	1.00
80_E	105_N	0.753	1.00
64_K	68_K	0.751	1.00
88_E	91_L	0.750	1.00
105_N	108_L	0.749	1.00
31_K	255_N	0.747	1.00
254_I	287_W	0.747	1.00
180_L	183_K	0.744	1.00
63_L	74_M	0.743	1.00
140_I	143_A	0.739	1.00
225_Q	228_E	0.737	1.00
63_L	98_F	0.737	1.00
122_Y	161_A	0.737	1.00
31_K	258_P	0.736	1.00
80_E	83_L	0.735	1.00
151_I	186_V	0.730	1.00
88_E	118_N	0.729	1.00
82_L	150_G	0.728	1.00
131_G	176_D	0.728	1.00
59_E	84_R	0.727	1.00
135_D	140_I	0.724	1.00
296_E	300_A	0.724	1.00
65_S	68_K	0.724	1.00
272_Y	275_T	0.723	1.00
60_V	96_K	0.723	1.00
115_S	119_Y	0.714	1.00
62_M	66_L	0.712	1.00
135_D	141_S	0.710	1.00
56_L	84_R	0.708	1.00
175_K	178_I	0.706	1.00
42_M	138_R	0.704	1.00
111_D	115_S	0.700	1.00
287_W	290_Y	0.697	1.00
282_D	286_L	0.695	1.00
127_I	144_F	0.692	1.00
222_R	225_Q	0.691	1.00
56_L	90_I	0.690	1.00
75_G	103_V	0.689	1.00
68_K	284_V	0.686	1.00
109_L	125_V	0.685	1.00
210_Y	213_L	0.684	1.00
77_E	103_V	0.682	1.00
29_G	253_T	0.681	1.00
283_I	287_W	0.678	1.00
150_G	154_A	0.675	1.00
171_M	208_R	0.675	1.00
169_E	202_L	0.675	1.00
228_E	234_E	0.674	1.00
107_W	150_G	0.671	1.00
277_K	281_V	0.671	1.00
66_L	71_V	0.670	1.00
205_D	213_L	0.670	1.00
135_D	144_F	0.668	1.00
75_G	101_S	0.663	1.00
191_Q	194_Y	0.662	1.00
86_D	90_I	0.660	1.00
214_R	217_I	0.660	1.00
255_N	267_Y	0.659	1.00
143_A	146_R	0.657	1.00
103_V	163_S	0.656	1.00
31_K	77_E	0.656	1.00
58_E	62_M	0.652	1.00
164_F	181_A	0.651	1.00
166_I	174_V	0.651	1.00
32_L	84_R	0.651	1.00
64_K	67_E	0.650	1.00
229_S	232_Y	0.648	1.00
85_R	88_E	0.645	1.00
227_I	230_S	0.644	1.00
127_I	148_V	0.644	1.00
59_E	62_M	0.644	1.00
230_S	235_A	0.641	1.00
175_K	219_L	0.639	1.00
231_D	235_A	0.639	1.00
35_T	51_E	0.634	1.00
46_W	139_G	0.631	1.00
262_I	283_I	0.630	1.00
139_G	142_G	0.630	1.00
45_F	77_E	0.627	0.99
28_A	71_V	0.625	0.99
213_L	217_I	0.622	0.99
59_E	63_L	0.621	0.99
127_I	147_A	0.619	0.99
226_I	229_S	0.619	0.99
109_L	154_A	0.618	0.99
212_A	220_K	0.617	0.99
205_D	209_L	0.615	0.99
196_Y	199_A	0.613	0.99
217_I	220_K	0.612	0.99
33_L	84_R	0.612	0.99
181_A	184_L	0.609	0.99
77_E	267_Y	0.607	0.99
174_V	178_I	0.605	0.99
74_M	100_T	0.604	0.99
37_N	83_L	0.603	0.99
29_G	267_Y	0.600	0.99
91_L	115_S	0.600	0.99
208_R	216_I	0.600	0.99
124_F	161_A	0.599	0.99
114_K	153_E	0.598	0.99
303_L	306_Y	0.595	0.99
83_L	108_L	0.594	0.99
179_E	216_I	0.593	0.99
91_L	94_S	0.593	0.99
103_V	267_Y	0.591	0.99
129_G	138_R	0.590	0.99
40_C	43_C	0.583	0.99
204_P	210_Y	0.580	0.99
94_S	98_F	0.580	0.99
163_S	191_Q	0.579	0.99
261_R	264_L	0.578	0.99
218_E	221_K	0.576	0.99
170_N	173_Q	0.574	0.99
39_R	46_W	0.574	0.99
172_D	175_K	0.573	0.99
231_D	234_E	0.573	0.99
175_K	218_E	0.572	0.99
91_L	119_Y	0.572	0.99
193_E	198_T	0.570	0.99
84_R	89_D	0.568	0.99
82_L	109_L	0.568	0.99
76_F	90_I	0.566	0.99
172_D	208_R	0.560	0.99
209_L	213_L	0.560	0.99
63_L	76_F	0.560	0.99
235_A	238_K	0.560	0.99
261_R	273_S	0.559	0.99
128_D	165_T	0.558	0.99
289_S	293_E	0.558	0.99
167_T	170_N	0.556	0.99
173_Q	177_V	0.556	0.99
67_E	97_R	0.556	0.99
277_K	282_D	0.555	0.99
51_E	55_S	0.552	0.99
129_G	134_H	0.549	0.99
100_T	121_D	0.549	0.99
217_I	221_K	0.548	0.99
36_C	40_C	0.548	0.99
298_C	307_L	0.547	0.99
130_I	144_F	0.544	0.99
27_I	73_F	0.544	0.99
38_L	147_A	0.543	0.99
260_G	278_V	0.543	0.99
29_G	77_E	0.543	0.99
110_K	114_K	0.540	0.99
304_A	308_E	0.538	0.98
297_S	300_A	0.537	0.98
125_V	147_A	0.536	0.98
178_I	188_I	0.533	0.98
174_V	190_I	0.532	0.98
209_L	220_K	0.529	0.98
99_Y	122_Y	0.529	0.98
223_G	227_I	0.529	0.98
36_C	43_C	0.528	0.98
208_R	212_A	0.526	0.98
164_F	190_I	0.526	0.98
260_G	277_K	0.525	0.98
222_R	229_S	0.524	0.98
227_I	231_D	0.519	0.98
265_P	269_L	0.519	0.98
298_C	301_C	0.518	0.98
177_V	188_I	0.518	0.98
30_H	63_L	0.516	0.98
107_W	146_R	0.516	0.98
181_A	188_I	0.514	0.98
25_P	287_W	0.513	0.98
69_A	284_V	0.512	0.98
239_S	242_N	0.511	0.98
41_R	139_G	0.510	0.98
32_L	59_E	0.510	0.98
42_M	45_F	0.509	0.98
101_S	122_Y	0.509	0.98
203_S	209_L	0.508	0.98
205_D	220_K	0.508	0.98
229_S	233_F	0.507	0.98
56_L	59_E	0.505	0.98
57_E	61_L	0.505	0.98
31_K	45_F	0.504	0.98
204_P	209_L	0.502	0.98
38_L	134_H	0.502	0.98
229_S	234_E	0.502	0.98
225_Q	229_S	0.502	0.98
27_I	75_G	0.502	0.98
250_P	266_C	0.501	0.98
39_R	140_I	0.501	0.98
228_E	231_D	0.501	0.98
71_V	99_Y	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k36A	1	0.9302	100	0.345	Contact Map
1tv8A	2	0.8372	100	0.493	Contact Map
4m7tA	1	0.6483	100	0.543	Contact Map
4rtbA	2	0.8837	100	0.608	Contact Map
3c8fA	1	0.6279	99.9	0.62	Contact Map
4wcxA	1	0.9506	99.9	0.645	Contact Map
3rfaA	1	0.7355	99.9	0.647	Contact Map
2z2uA	1	0.6483	99.9	0.649	Contact Map
2yx0A	1	0.7238	99.9	0.651	Contact Map
2a5hA	4	0.875	99.9	0.666	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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