GREMLIN Database
Q97WC3 - Cofactor biosynthesis protein
UniProt: Q97WC3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (286)
Sequences: 10327 (8020)
Seq/√Len: 474.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_L107_W4.1751.00
60_V93_E3.6781.00
152_K184_L3.4321.00
131_G145_E3.3561.00
110_K153_E2.9761.00
88_E115_S2.9061.00
114_K157_Y2.8511.00
64_K93_E2.7561.00
248_C266_C2.7181.00
135_D142_G2.6281.00
58_E279_W2.6161.00
55_S58_E2.6161.00
261_R277_K2.4481.00
37_N105_N2.4121.00
61_L65_S2.2911.00
133_V173_Q2.2851.00
153_E156_K2.2651.00
56_L89_D2.2331.00
282_D285_K2.2101.00
114_K118_N2.2021.00
144_F180_L2.1411.00
95_Y121_D2.0701.00
88_E112_R2.0681.00
28_A66_L2.0641.00
128_D138_R2.0371.00
35_T53_L2.0121.00
173_Q176_D1.9781.00
130_I133_V1.9721.00
93_E96_K1.9461.00
130_I173_Q1.9441.00
63_L94_S1.9301.00
59_E90_I1.9211.00
164_F177_V1.8941.00
106_G125_V1.8661.00
162_I181_A1.7891.00
56_L60_V1.7601.00
152_K156_K1.7541.00
115_S118_N1.7521.00
86_D89_D1.7501.00
277_K280_E1.7471.00
60_V89_D1.7471.00
257_D261_R1.7341.00
149_E152_K1.7211.00
205_D208_R1.7071.00
37_N108_L1.7001.00
146_R149_E1.6751.00
125_V151_I1.6621.00
42_M128_D1.6591.00
117_S157_Y1.6461.00
58_E61_L1.6361.00
175_K215_L1.6301.00
257_D264_L1.6271.00
168_K208_R1.6201.00
153_E157_Y1.6161.00
144_F148_V1.5861.00
92_E96_K1.5861.00
82_L102_L1.5711.00
180_L184_L1.5541.00
56_L86_D1.5541.00
281_V285_K1.5541.00
152_K155_R1.5511.00
112_R115_S1.5431.00
145_E149_E1.5341.00
76_F94_S1.5301.00
89_D92_E1.5171.00
74_M94_S1.5171.00
110_K156_K1.4991.00
41_R136_K1.4781.00
125_V150_G1.4691.00
92_E115_S1.4561.00
60_V64_K1.4461.00
179_E183_K1.4361.00
67_E98_F1.4361.00
129_G133_V1.4311.00
113_A153_E1.3971.00
149_E153_E1.3951.00
136_K169_E1.3741.00
211_D215_L1.3731.00
155_R185_N1.3731.00
179_E219_L1.3721.00
95_Y100_T1.3601.00
285_K289_S1.3601.00
32_L76_F1.3491.00
290_Y293_E1.3231.00
26_L72_L1.3211.00
134_H143_A1.3151.00
123_L154_A1.3131.00
131_G173_Q1.3111.00
30_H59_E1.3081.00
176_D179_E1.3051.00
72_L99_Y1.3001.00
147_A150_G1.2941.00
84_R90_I1.2581.00
284_V288_N1.2471.00
76_F100_T1.2461.00
94_S100_T1.2391.00
110_K157_Y1.2381.00
54_L58_E1.2341.00
210_Y214_R1.2311.00
82_L108_L1.2281.00
164_F188_I1.2201.00
209_L212_A1.2141.00
103_V124_F1.1971.00
65_S282_D1.1911.00
113_A150_G1.1901.00
175_K179_E1.1881.00
206_K210_Y1.1871.00
148_V184_L1.1851.00
211_D214_R1.1791.00
134_H147_A1.1731.00
95_Y119_Y1.1721.00
53_L84_R1.1671.00
113_A117_S1.1671.00
91_L120_L1.1641.00
290_Y294_K1.1581.00
214_R218_E1.1151.00
56_L93_E1.1091.00
148_V152_K1.1091.00
89_D93_E1.1081.00
179_E182_R1.1061.00
216_I220_K1.1031.00
207_R211_D1.1021.00
208_R211_D1.0961.00
215_L219_L1.0861.00
135_D143_A1.0851.00
133_V136_K1.0821.00
155_R184_L1.0741.00
133_V172_D1.0721.00
87_L91_L1.0691.00
131_G135_D1.0631.00
204_P208_R1.0581.00
65_S69_A1.0511.00
130_I180_L1.0431.00
148_V180_L1.0381.00
137_I167_T1.0351.00
129_G144_F1.0341.00
181_A186_V1.0321.00
155_R186_V1.0311.00
162_I186_V1.0311.00
62_M256_I1.0281.00
54_L59_E1.0161.00
28_A254_I1.0141.00
135_D138_R1.0091.00
33_L53_L1.0051.00
281_V289_S1.0051.00
73_F101_S0.9981.00
203_S206_K0.9921.00
112_R116_I0.9901.00
61_L64_K0.9901.00
151_I162_I0.9901.00
261_R275_T0.9891.00
109_L113_A0.9861.00
90_I94_S0.9851.00
52_K259_Q0.9811.00
215_L218_E0.9801.00
113_A157_Y0.9731.00
34_Y258_P0.9711.00
117_S158_L0.9691.00
150_G153_E0.9581.00
146_R150_G0.9541.00
109_L150_G0.9521.00
296_E299_N0.9491.00
151_I160_V0.9481.00
132_E136_K0.9451.00
88_E92_E0.9431.00
130_I176_D0.9411.00
37_N80_E0.9401.00
134_H138_R0.9381.00
38_L143_A0.9381.00
125_V154_A0.9381.00
124_F163_S0.9361.00
111_D114_K0.9361.00
30_H62_M0.9321.00
207_R210_Y0.9311.00
262_I286_L0.9291.00
82_L112_R0.9221.00
61_L279_W0.9121.00
162_I188_I0.9121.00
110_K149_E0.9091.00
37_N107_W0.9091.00
26_L252_L0.9051.00
32_L87_L0.9031.00
66_L74_M0.8951.00
154_A160_V0.8881.00
123_L158_L0.8871.00
155_R160_V0.8841.00
87_L102_L0.8821.00
102_L116_I0.8801.00
74_M98_F0.8751.00
213_L216_I0.8651.00
82_L87_L0.8641.00
102_L123_L0.8611.00
254_I283_I0.8541.00
65_S284_V0.8531.00
154_A158_L0.8521.00
230_S233_F0.8481.00
289_S292_W0.8461.00
84_R87_L0.8451.00
76_F91_L0.8401.00
291_P294_K0.8341.00
30_H256_I0.8321.00
32_L90_I0.8281.00
209_L216_I0.8281.00
177_V181_A0.8261.00
42_M137_I0.8251.00
127_I162_I0.8211.00
178_I182_R0.8211.00
271_E274_G0.8171.00
41_R137_I0.8151.00
224_Y227_I0.8131.00
287_W291_P0.8121.00
204_P207_R0.8091.00
44_P77_E0.8081.00
145_E148_V0.8061.00
54_L62_M0.8031.00
28_A256_I0.8021.00
232_Y235_A0.7961.00
114_K117_S0.7951.00
91_L100_T0.7881.00
206_K209_L0.7841.00
224_Y228_E0.7841.00
73_F99_Y0.7831.00
126_S165_T0.7831.00
276_D281_V0.7831.00
92_E119_Y0.7821.00
131_G144_F0.7811.00
216_I219_L0.7811.00
228_E232_Y0.7781.00
104_T125_V0.7761.00
85_R112_R0.7741.00
279_W282_D0.7721.00
57_E60_V0.7691.00
281_V286_L0.7691.00
113_A154_A0.7671.00
226_I230_S0.7661.00
109_L116_I0.7631.00
102_L120_L0.7601.00
134_H142_G0.7581.00
193_E199_A0.7581.00
129_G173_Q0.7571.00
230_S234_E0.7561.00
228_E233_F0.7561.00
134_H144_F0.7551.00
80_E105_N0.7531.00
64_K68_K0.7511.00
88_E91_L0.7501.00
105_N108_L0.7491.00
31_K255_N0.7471.00
254_I287_W0.7471.00
180_L183_K0.7441.00
63_L74_M0.7431.00
140_I143_A0.7391.00
225_Q228_E0.7371.00
63_L98_F0.7371.00
122_Y161_A0.7371.00
31_K258_P0.7361.00
80_E83_L0.7351.00
151_I186_V0.7301.00
88_E118_N0.7291.00
82_L150_G0.7281.00
131_G176_D0.7281.00
59_E84_R0.7271.00
135_D140_I0.7241.00
296_E300_A0.7241.00
65_S68_K0.7241.00
272_Y275_T0.7231.00
60_V96_K0.7231.00
115_S119_Y0.7141.00
62_M66_L0.7121.00
135_D141_S0.7101.00
56_L84_R0.7081.00
175_K178_I0.7061.00
42_M138_R0.7041.00
111_D115_S0.7001.00
287_W290_Y0.6971.00
282_D286_L0.6951.00
127_I144_F0.6921.00
222_R225_Q0.6911.00
56_L90_I0.6901.00
75_G103_V0.6891.00
68_K284_V0.6861.00
109_L125_V0.6851.00
210_Y213_L0.6841.00
77_E103_V0.6821.00
29_G253_T0.6811.00
283_I287_W0.6781.00
150_G154_A0.6751.00
171_M208_R0.6751.00
169_E202_L0.6751.00
228_E234_E0.6741.00
107_W150_G0.6711.00
277_K281_V0.6711.00
66_L71_V0.6701.00
205_D213_L0.6701.00
135_D144_F0.6681.00
75_G101_S0.6631.00
191_Q194_Y0.6621.00
86_D90_I0.6601.00
214_R217_I0.6601.00
255_N267_Y0.6591.00
143_A146_R0.6571.00
103_V163_S0.6561.00
31_K77_E0.6561.00
58_E62_M0.6521.00
164_F181_A0.6511.00
166_I174_V0.6511.00
32_L84_R0.6511.00
64_K67_E0.6501.00
229_S232_Y0.6481.00
85_R88_E0.6451.00
227_I230_S0.6441.00
127_I148_V0.6441.00
59_E62_M0.6441.00
230_S235_A0.6411.00
175_K219_L0.6391.00
231_D235_A0.6391.00
35_T51_E0.6341.00
46_W139_G0.6311.00
262_I283_I0.6301.00
139_G142_G0.6301.00
45_F77_E0.6270.99
28_A71_V0.6250.99
213_L217_I0.6220.99
59_E63_L0.6210.99
127_I147_A0.6190.99
226_I229_S0.6190.99
109_L154_A0.6180.99
212_A220_K0.6170.99
205_D209_L0.6150.99
196_Y199_A0.6130.99
217_I220_K0.6120.99
33_L84_R0.6120.99
181_A184_L0.6090.99
77_E267_Y0.6070.99
174_V178_I0.6050.99
74_M100_T0.6040.99
37_N83_L0.6030.99
29_G267_Y0.6000.99
91_L115_S0.6000.99
208_R216_I0.6000.99
124_F161_A0.5990.99
114_K153_E0.5980.99
303_L306_Y0.5950.99
83_L108_L0.5940.99
179_E216_I0.5930.99
91_L94_S0.5930.99
103_V267_Y0.5910.99
129_G138_R0.5900.99
40_C43_C0.5830.99
204_P210_Y0.5800.99
94_S98_F0.5800.99
163_S191_Q0.5790.99
261_R264_L0.5780.99
218_E221_K0.5760.99
170_N173_Q0.5740.99
39_R46_W0.5740.99
172_D175_K0.5730.99
231_D234_E0.5730.99
175_K218_E0.5720.99
91_L119_Y0.5720.99
193_E198_T0.5700.99
84_R89_D0.5680.99
82_L109_L0.5680.99
76_F90_I0.5660.99
172_D208_R0.5600.99
209_L213_L0.5600.99
63_L76_F0.5600.99
235_A238_K0.5600.99
261_R273_S0.5590.99
128_D165_T0.5580.99
289_S293_E0.5580.99
167_T170_N0.5560.99
173_Q177_V0.5560.99
67_E97_R0.5560.99
277_K282_D0.5550.99
51_E55_S0.5520.99
129_G134_H0.5490.99
100_T121_D0.5490.99
217_I221_K0.5480.99
36_C40_C0.5480.99
298_C307_L0.5470.99
130_I144_F0.5440.99
27_I73_F0.5440.99
38_L147_A0.5430.99
260_G278_V0.5430.99
29_G77_E0.5430.99
110_K114_K0.5400.99
304_A308_E0.5380.98
297_S300_A0.5370.98
125_V147_A0.5360.98
178_I188_I0.5330.98
174_V190_I0.5320.98
209_L220_K0.5290.98
99_Y122_Y0.5290.98
223_G227_I0.5290.98
36_C43_C0.5280.98
208_R212_A0.5260.98
164_F190_I0.5260.98
260_G277_K0.5250.98
222_R229_S0.5240.98
227_I231_D0.5190.98
265_P269_L0.5190.98
298_C301_C0.5180.98
177_V188_I0.5180.98
30_H63_L0.5160.98
107_W146_R0.5160.98
181_A188_I0.5140.98
25_P287_W0.5130.98
69_A284_V0.5120.98
239_S242_N0.5110.98
41_R139_G0.5100.98
32_L59_E0.5100.98
42_M45_F0.5090.98
101_S122_Y0.5090.98
203_S209_L0.5080.98
205_D220_K0.5080.98
229_S233_F0.5070.98
56_L59_E0.5050.98
57_E61_L0.5050.98
31_K45_F0.5040.98
204_P209_L0.5020.98
38_L134_H0.5020.98
229_S234_E0.5020.98
225_Q229_S0.5020.98
27_I75_G0.5020.98
250_P266_C0.5010.98
39_R140_I0.5010.98
228_E231_D0.5010.98
71_V99_Y0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9302 100 0.345 Contact Map
1tv8A 2 0.8372 100 0.493 Contact Map
4m7tA 1 0.6483 100 0.543 Contact Map
4rtbA 2 0.8837 100 0.608 Contact Map
3c8fA 1 0.6279 99.9 0.62 Contact Map
4wcxA 1 0.9506 99.9 0.645 Contact Map
3rfaA 1 0.7355 99.9 0.647 Contact Map
2z2uA 1 0.6483 99.9 0.649 Contact Map
2yx0A 1 0.7238 99.9 0.651 Contact Map
2a5hA 4 0.875 99.9 0.666 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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