GREMLIN Database
Q97WC2 - Uncharacterized protein
UniProt: Q97WC2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (234)
Sequences: 4873 (3842)
Seq/√Len: 251.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_N202_I4.3651.00
171_K199_E4.2491.00
121_L130_G3.9901.00
46_A57_L3.2641.00
41_A44_Q3.2011.00
106_S169_K3.1401.00
45_L131_Y3.0551.00
222_T225_E3.0201.00
171_K202_I2.9941.00
28_I47_T2.9401.00
135_N178_N2.9091.00
193_K196_S2.8711.00
108_D115_E2.8001.00
110_E115_E2.6621.00
28_I138_Y2.6011.00
118_V129_S2.5831.00
128_H140_G2.5701.00
47_T140_G2.4401.00
149_L152_F2.2591.00
108_D117_E2.2571.00
118_V131_Y2.2101.00
199_E203_I2.2051.00
68_P120_K2.1411.00
136_V181_V2.0961.00
38_D41_A1.9371.00
39_I43_V1.9221.00
68_P129_S1.9061.00
121_L166_S1.8371.00
39_I44_Q1.8251.00
168_N206_Q1.7911.00
159_D162_T1.6841.00
20_L138_Y1.6631.00
168_N172_E1.6631.00
58_L61_D1.6281.00
116_I133_V1.6231.00
139_A180_I1.6221.00
20_L181_V1.5901.00
36_S40_N1.5821.00
40_N44_Q1.5721.00
121_L128_H1.5481.00
36_S39_I1.5381.00
37_V41_A1.5261.00
179_N189_T1.5211.00
38_D44_Q1.5181.00
21_I27_V1.4901.00
114_S133_V1.4551.00
22_Y28_I1.4531.00
66_Y102_E1.4491.00
169_K172_E1.4291.00
171_K195_V1.4261.00
142_A170_V1.4071.00
221_L229_K1.3981.00
174_A195_V1.3961.00
221_L225_E1.3921.00
164_L206_Q1.3901.00
164_L202_I1.3831.00
94_I98_D1.3821.00
123_G166_S1.3601.00
132_I135_N1.3471.00
26_V116_I1.3401.00
71_D75_L1.3351.00
57_L65_R1.3271.00
38_D43_V1.3261.00
137_L173_L1.3221.00
161_W165_E1.3201.00
251_F254_E1.3121.00
96_T100_V1.2891.00
115_E134_D1.2811.00
104_I129_S1.2661.00
197_I201_N1.2611.00
167_L198_L1.2571.00
117_E132_I1.2561.00
26_V45_L1.2481.00
132_I137_L1.2411.00
182_I185_G1.2341.00
206_Q210_G1.2221.00
45_L129_S1.2141.00
132_I175_K1.2061.00
215_M229_K1.1961.00
95_F98_D1.1931.00
135_N174_A1.1911.00
203_I207_N1.1821.00
143_F198_L1.1741.00
21_I25_R1.1741.00
36_S43_V1.1681.00
23_D112_R1.1641.00
180_I194_M1.1611.00
64_I102_E1.1531.00
210_G214_D1.1531.00
104_I118_V1.1521.00
226_I246_V1.1481.00
164_L168_N1.1371.00
210_G213_L1.1341.00
98_D101_K1.1271.00
168_N171_K1.1241.00
40_N43_V1.1201.00
92_S95_F1.1181.00
223_V227_V1.1051.00
120_K129_S1.0981.00
93_D101_K1.0941.00
136_V179_N1.0841.00
175_K178_N1.0691.00
70_E73_W1.0641.00
106_S120_K1.0621.00
74_S77_L1.0601.00
196_S200_S1.0601.00
203_I206_Q1.0481.00
163_A167_L1.0321.00
19_T30_L1.0321.00
10_I13_M1.0251.00
99_Y102_E1.0171.00
66_Y104_I1.0081.00
54_I57_L1.0021.00
117_E173_L1.0011.00
93_D100_V0.9991.00
92_S96_T0.9971.00
107_I117_E0.9951.00
153_S156_F0.9821.00
202_I206_Q0.9811.00
212_I246_V0.9781.00
228_V239_V0.9721.00
18_N183_S0.9601.00
213_L217_S0.9601.00
227_V246_V0.9581.00
93_D97_F0.9571.00
73_W76_T0.9411.00
20_L183_S0.9341.00
238_N241_L0.9341.00
38_D42_E0.9311.00
179_N187_V0.9271.00
119_I132_I0.9261.00
116_I131_Y0.9241.00
94_I100_V0.9131.00
70_E74_S0.9131.00
26_V111_V0.9111.00
204_Y208_L0.9061.00
226_I230_L0.9051.00
130_G137_L0.9041.00
142_A166_S0.9021.00
22_Y133_V0.8981.00
224_E228_V0.8951.00
232_Q239_V0.8901.00
39_I42_E0.8841.00
138_Y181_V0.8821.00
53_H141_D0.8791.00
37_V40_N0.8791.00
234_L239_V0.8781.00
224_E243_S0.8781.00
70_E127_G0.8771.00
19_T31_G0.8761.00
29_D48_H0.8741.00
171_K198_L0.8711.00
161_W252_G0.8691.00
209_I252_G0.8650.99
30_L57_L0.8630.99
235_T238_N0.8620.99
46_A54_I0.8560.99
236_P239_V0.8530.99
154_V157_Y0.8470.99
60_K63_K0.8430.99
33_K56_G0.8410.99
162_T165_E0.8400.99
225_E228_V0.8330.99
93_D96_T0.8320.99
214_D217_S0.8300.99
114_S134_D0.8280.99
180_I188_Y0.8220.99
164_L209_I0.8220.99
156_F159_D0.8210.99
94_I99_Y0.8180.99
218_N221_L0.8170.99
27_V30_L0.8140.99
36_S44_Q0.8110.99
223_V250_L0.8100.99
197_I200_S0.8070.99
91_D94_I0.8020.99
209_I213_L0.8000.99
132_I173_L0.7970.99
48_H141_D0.7900.99
91_D95_F0.7890.99
111_V114_S0.7750.99
130_G142_A0.7730.99
244_V247_R0.7680.99
121_L142_A0.7680.99
72_Y75_L0.7600.99
215_M230_L0.7510.99
93_D99_Y0.7480.99
155_P158_T0.7470.98
67_L70_E0.7450.98
211_K215_M0.7400.98
96_T99_Y0.7390.98
22_Y116_I0.7380.98
214_D218_N0.7330.98
225_E229_K0.7330.98
223_V247_R0.7320.98
188_Y197_I0.7320.98
211_K214_D0.7260.98
58_L62_A0.7230.98
212_I226_I0.7220.98
174_A178_N0.7210.98
69_K72_Y0.7200.98
239_V243_S0.7180.98
110_E113_T0.7160.98
130_G170_V0.7100.98
133_V136_V0.7020.98
8_K11_T0.7020.98
19_T27_V0.7010.98
128_H142_A0.6970.98
198_L202_I0.6970.98
205_A249_I0.6970.98
76_T79_G0.6970.98
125_T128_H0.6960.98
45_L116_I0.6910.98
216_L220_E0.6900.97
160_F163_A0.6890.97
165_E169_K0.6850.97
59_K62_A0.6850.97
145_G188_Y0.6830.97
166_S169_K0.6810.97
72_Y76_T0.6800.97
45_L109_I0.6790.97
75_L80_R0.6780.97
70_E125_T0.6770.97
245_V249_I0.6750.97
94_I102_E0.6740.97
9_N13_M0.6730.97
139_A182_I0.6720.97
28_I131_Y0.6700.97
144_F147_K0.6690.97
242_N245_V0.6670.97
94_I97_F0.6670.97
204_Y207_N0.6630.97
143_F201_N0.6600.97
98_D102_E0.6590.97
163_A205_A0.6520.96
215_M218_N0.6520.96
228_V236_P0.6510.96
212_I249_I0.6500.96
142_A163_A0.6490.96
74_S78_M0.6480.96
215_M219_N0.6470.96
77_L80_R0.6440.96
123_G128_H0.6440.96
71_D103_N0.6420.96
94_I101_K0.6400.96
8_K13_M0.6390.96
93_D98_D0.6370.96
182_I188_Y0.6360.96
198_L201_N0.6330.96
116_I138_Y0.6310.96
215_M226_I0.6260.96
36_S42_E0.6260.96
92_S100_V0.6250.96
175_K180_I0.6230.95
97_F102_E0.6220.95
45_L66_Y0.6190.95
95_F101_K0.6160.95
119_I130_G0.6140.95
137_L180_I0.6120.95
143_F194_M0.6110.95
218_N229_K0.6090.95
215_M220_E0.6080.95
224_E227_V0.6070.95
78_M81_R0.6060.95
71_D74_S0.6040.95
26_V112_R0.6040.95
227_V243_S0.6030.95
49_G127_G0.6030.95
78_M82_A0.6030.95
76_T80_R0.6020.95
128_H183_S0.6000.94
18_N185_G0.5980.94
104_I109_I0.5960.94
167_L171_K0.5950.94
237_S240_L0.5910.94
144_F160_F0.5890.94
31_G163_A0.5890.94
13_M16_S0.5870.94
8_K19_T0.5860.94
122_P166_S0.5850.94
194_M198_L0.5840.94
165_E168_N0.5800.93
223_V243_S0.5780.93
233_D237_S0.5770.93
133_V138_Y0.5770.93
79_G82_A0.5770.93
37_V43_V0.5750.93
243_S247_R0.5750.93
95_F99_Y0.5750.93
107_I123_G0.5740.93
209_I212_I0.5730.93
97_F100_V0.5710.93
107_I120_K0.5700.93
205_A209_I0.5680.93
205_A208_L0.5670.93
64_I101_K0.5670.93
154_V159_D0.5670.93
67_L74_S0.5660.93
52_D184_H0.5650.92
227_V231_K0.5640.92
241_L248_S0.5610.92
53_H184_H0.5600.92
152_F158_T0.5580.92
234_L241_L0.5560.92
158_T252_G0.5560.92
75_L78_M0.5520.92
164_L205_A0.5500.91
139_A143_F0.5500.91
170_V173_L0.5490.91
153_S244_V0.5470.91
49_G70_E0.5460.91
132_I174_A0.5450.91
245_V248_S0.5450.91
149_L153_S0.5420.91
167_L202_I0.5420.91
8_K16_S0.5410.91
104_I107_I0.5400.91
240_L251_F0.5390.91
209_I249_I0.5390.91
153_S158_T0.5370.90
150_E153_S0.5350.90
195_V199_E0.5350.90
8_K12_I0.5340.90
249_I252_G0.5320.90
91_D96_T0.5310.90
236_P240_L0.5310.90
199_E202_I0.5300.90
10_I14_T0.5300.90
130_G139_A0.5300.90
221_L226_I0.5290.90
58_L65_R0.5290.90
73_W77_L0.5270.90
29_D141_D0.5270.90
123_G162_T0.5250.89
205_A231_K0.5250.89
152_F185_G0.5240.89
143_F188_Y0.5220.89
250_L254_E0.5210.89
247_R251_F0.5180.89
227_V230_L0.5180.89
24_N42_E0.5180.89
229_K232_Q0.5130.88
104_I131_Y0.5100.88
49_G54_I0.5100.88
208_L211_K0.5100.88
181_V187_V0.5090.88
151_G156_F0.5060.88
18_N182_I0.5040.88
91_D97_F0.5030.87
140_G157_Y0.5020.87
242_N249_I0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9301 100 0.385 Contact Map
4ad9A 4 0.8971 100 0.423 Contact Map
2yheA 3 0.9816 100 0.443 Contact Map
2cfuA 2 0.9669 100 0.468 Contact Map
4nurA 2 0.9853 100 0.469 Contact Map
4pdxA 2 0.9706 100 0.472 Contact Map
2fhxA 2 0.7426 100 0.517 Contact Map
2vw8A 2 0.9338 100 0.52 Contact Map
3iogA 1 0.7279 100 0.531 Contact Map
1k07A 1 0.8015 100 0.533 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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