Q97WC2 - SULSO - GREMLIN Contacts

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Q97WC2 - Uncharacterized protein

UniProt:	Q97WC2	Sequences: MPTVKLTKNITIMTGSPNTLIYDNRVVIDLGGKNSSVDINAEVQLATHGHADHIAGLLKKDAKIRYLPKEDYWSLTLMGRRAMIYGCSSKDSDIFTFDYVKENIESIDIEVRTSEIEVIKLPGHTPGHSGYIVDNVLYAGDAFFGEKVLEGFSVPFYTDFWTALESLNKVKELAKSVNNIVISHGPVYTNKNKMVSILESNIIYAQNLIGKILDMLSNNELTVEEIVVKLKQDLTPSNVLLNSVVVRSILFGLENIEYNVSQKGLVFRRRVH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	272 (234)
Sequences:	4873 (3842)
Seq/√Len:	251.1

BACSU - YQJP YYBB YFLN PKSB
HALSA - Q9HRG5 Q9HNJ9 Q9HSD1
SULSO - Q97WC2 Q97VU4 Q97VU0 Q97UV2 Q7LYK3 Q97UR2 Q97U88

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
168_N	202_I	4.365	1.00
171_K	199_E	4.249	1.00
121_L	130_G	3.990	1.00
46_A	57_L	3.264	1.00
41_A	44_Q	3.201	1.00
106_S	169_K	3.140	1.00
45_L	131_Y	3.055	1.00
222_T	225_E	3.020	1.00
171_K	202_I	2.994	1.00
28_I	47_T	2.940	1.00
135_N	178_N	2.909	1.00
193_K	196_S	2.871	1.00
108_D	115_E	2.800	1.00
110_E	115_E	2.662	1.00
28_I	138_Y	2.601	1.00
118_V	129_S	2.583	1.00
128_H	140_G	2.570	1.00
47_T	140_G	2.440	1.00
149_L	152_F	2.259	1.00
108_D	117_E	2.257	1.00
118_V	131_Y	2.210	1.00
199_E	203_I	2.205	1.00
68_P	120_K	2.141	1.00
136_V	181_V	2.096	1.00
38_D	41_A	1.937	1.00
39_I	43_V	1.922	1.00
68_P	129_S	1.906	1.00
121_L	166_S	1.837	1.00
39_I	44_Q	1.825	1.00
168_N	206_Q	1.791	1.00
159_D	162_T	1.684	1.00
20_L	138_Y	1.663	1.00
168_N	172_E	1.663	1.00
58_L	61_D	1.628	1.00
116_I	133_V	1.623	1.00
139_A	180_I	1.622	1.00
20_L	181_V	1.590	1.00
36_S	40_N	1.582	1.00
40_N	44_Q	1.572	1.00
121_L	128_H	1.548	1.00
36_S	39_I	1.538	1.00
37_V	41_A	1.526	1.00
179_N	189_T	1.521	1.00
38_D	44_Q	1.518	1.00
21_I	27_V	1.490	1.00
114_S	133_V	1.455	1.00
22_Y	28_I	1.453	1.00
66_Y	102_E	1.449	1.00
169_K	172_E	1.429	1.00
171_K	195_V	1.426	1.00
142_A	170_V	1.407	1.00
221_L	229_K	1.398	1.00
174_A	195_V	1.396	1.00
221_L	225_E	1.392	1.00
164_L	206_Q	1.390	1.00
164_L	202_I	1.383	1.00
94_I	98_D	1.382	1.00
123_G	166_S	1.360	1.00
132_I	135_N	1.347	1.00
26_V	116_I	1.340	1.00
71_D	75_L	1.335	1.00
57_L	65_R	1.327	1.00
38_D	43_V	1.326	1.00
137_L	173_L	1.322	1.00
161_W	165_E	1.320	1.00
251_F	254_E	1.312	1.00
96_T	100_V	1.289	1.00
115_E	134_D	1.281	1.00
104_I	129_S	1.266	1.00
197_I	201_N	1.261	1.00
167_L	198_L	1.257	1.00
117_E	132_I	1.256	1.00
26_V	45_L	1.248	1.00
132_I	137_L	1.241	1.00
182_I	185_G	1.234	1.00
206_Q	210_G	1.222	1.00
45_L	129_S	1.214	1.00
132_I	175_K	1.206	1.00
215_M	229_K	1.196	1.00
95_F	98_D	1.193	1.00
135_N	174_A	1.191	1.00
203_I	207_N	1.182	1.00
143_F	198_L	1.174	1.00
21_I	25_R	1.174	1.00
36_S	43_V	1.168	1.00
23_D	112_R	1.164	1.00
180_I	194_M	1.161	1.00
64_I	102_E	1.153	1.00
210_G	214_D	1.153	1.00
104_I	118_V	1.152	1.00
226_I	246_V	1.148	1.00
164_L	168_N	1.137	1.00
210_G	213_L	1.134	1.00
98_D	101_K	1.127	1.00
168_N	171_K	1.124	1.00
40_N	43_V	1.120	1.00
92_S	95_F	1.118	1.00
223_V	227_V	1.105	1.00
120_K	129_S	1.098	1.00
93_D	101_K	1.094	1.00
136_V	179_N	1.084	1.00
175_K	178_N	1.069	1.00
70_E	73_W	1.064	1.00
106_S	120_K	1.062	1.00
74_S	77_L	1.060	1.00
196_S	200_S	1.060	1.00
203_I	206_Q	1.048	1.00
163_A	167_L	1.032	1.00
19_T	30_L	1.032	1.00
10_I	13_M	1.025	1.00
99_Y	102_E	1.017	1.00
66_Y	104_I	1.008	1.00
54_I	57_L	1.002	1.00
117_E	173_L	1.001	1.00
93_D	100_V	0.999	1.00
92_S	96_T	0.997	1.00
107_I	117_E	0.995	1.00
153_S	156_F	0.982	1.00
202_I	206_Q	0.981	1.00
212_I	246_V	0.978	1.00
228_V	239_V	0.972	1.00
18_N	183_S	0.960	1.00
213_L	217_S	0.960	1.00
227_V	246_V	0.958	1.00
93_D	97_F	0.957	1.00
73_W	76_T	0.941	1.00
20_L	183_S	0.934	1.00
238_N	241_L	0.934	1.00
38_D	42_E	0.931	1.00
179_N	187_V	0.927	1.00
119_I	132_I	0.926	1.00
116_I	131_Y	0.924	1.00
94_I	100_V	0.913	1.00
70_E	74_S	0.913	1.00
26_V	111_V	0.911	1.00
204_Y	208_L	0.906	1.00
226_I	230_L	0.905	1.00
130_G	137_L	0.904	1.00
142_A	166_S	0.902	1.00
22_Y	133_V	0.898	1.00
224_E	228_V	0.895	1.00
232_Q	239_V	0.890	1.00
39_I	42_E	0.884	1.00
138_Y	181_V	0.882	1.00
53_H	141_D	0.879	1.00
37_V	40_N	0.879	1.00
234_L	239_V	0.878	1.00
224_E	243_S	0.878	1.00
70_E	127_G	0.877	1.00
19_T	31_G	0.876	1.00
29_D	48_H	0.874	1.00
171_K	198_L	0.871	1.00
161_W	252_G	0.869	1.00
209_I	252_G	0.865	0.99
30_L	57_L	0.863	0.99
235_T	238_N	0.862	0.99
46_A	54_I	0.856	0.99
236_P	239_V	0.853	0.99
154_V	157_Y	0.847	0.99
60_K	63_K	0.843	0.99
33_K	56_G	0.841	0.99
162_T	165_E	0.840	0.99
225_E	228_V	0.833	0.99
93_D	96_T	0.832	0.99
214_D	217_S	0.830	0.99
114_S	134_D	0.828	0.99
180_I	188_Y	0.822	0.99
164_L	209_I	0.822	0.99
156_F	159_D	0.821	0.99
94_I	99_Y	0.818	0.99
218_N	221_L	0.817	0.99
27_V	30_L	0.814	0.99
36_S	44_Q	0.811	0.99
223_V	250_L	0.810	0.99
197_I	200_S	0.807	0.99
91_D	94_I	0.802	0.99
209_I	213_L	0.800	0.99
132_I	173_L	0.797	0.99
48_H	141_D	0.790	0.99
91_D	95_F	0.789	0.99
111_V	114_S	0.775	0.99
130_G	142_A	0.773	0.99
244_V	247_R	0.768	0.99
121_L	142_A	0.768	0.99
72_Y	75_L	0.760	0.99
215_M	230_L	0.751	0.99
93_D	99_Y	0.748	0.99
155_P	158_T	0.747	0.98
67_L	70_E	0.745	0.98
211_K	215_M	0.740	0.98
96_T	99_Y	0.739	0.98
22_Y	116_I	0.738	0.98
214_D	218_N	0.733	0.98
225_E	229_K	0.733	0.98
223_V	247_R	0.732	0.98
188_Y	197_I	0.732	0.98
211_K	214_D	0.726	0.98
58_L	62_A	0.723	0.98
212_I	226_I	0.722	0.98
174_A	178_N	0.721	0.98
69_K	72_Y	0.720	0.98
239_V	243_S	0.718	0.98
110_E	113_T	0.716	0.98
130_G	170_V	0.710	0.98
133_V	136_V	0.702	0.98
8_K	11_T	0.702	0.98
19_T	27_V	0.701	0.98
128_H	142_A	0.697	0.98
198_L	202_I	0.697	0.98
205_A	249_I	0.697	0.98
76_T	79_G	0.697	0.98
125_T	128_H	0.696	0.98
45_L	116_I	0.691	0.98
216_L	220_E	0.690	0.97
160_F	163_A	0.689	0.97
165_E	169_K	0.685	0.97
59_K	62_A	0.685	0.97
145_G	188_Y	0.683	0.97
166_S	169_K	0.681	0.97
72_Y	76_T	0.680	0.97
45_L	109_I	0.679	0.97
75_L	80_R	0.678	0.97
70_E	125_T	0.677	0.97
245_V	249_I	0.675	0.97
94_I	102_E	0.674	0.97
9_N	13_M	0.673	0.97
139_A	182_I	0.672	0.97
28_I	131_Y	0.670	0.97
144_F	147_K	0.669	0.97
242_N	245_V	0.667	0.97
94_I	97_F	0.667	0.97
204_Y	207_N	0.663	0.97
143_F	201_N	0.660	0.97
98_D	102_E	0.659	0.97
163_A	205_A	0.652	0.96
215_M	218_N	0.652	0.96
228_V	236_P	0.651	0.96
212_I	249_I	0.650	0.96
142_A	163_A	0.649	0.96
74_S	78_M	0.648	0.96
215_M	219_N	0.647	0.96
77_L	80_R	0.644	0.96
123_G	128_H	0.644	0.96
71_D	103_N	0.642	0.96
94_I	101_K	0.640	0.96
8_K	13_M	0.639	0.96
93_D	98_D	0.637	0.96
182_I	188_Y	0.636	0.96
198_L	201_N	0.633	0.96
116_I	138_Y	0.631	0.96
215_M	226_I	0.626	0.96
36_S	42_E	0.626	0.96
92_S	100_V	0.625	0.96
175_K	180_I	0.623	0.95
97_F	102_E	0.622	0.95
45_L	66_Y	0.619	0.95
95_F	101_K	0.616	0.95
119_I	130_G	0.614	0.95
137_L	180_I	0.612	0.95
143_F	194_M	0.611	0.95
218_N	229_K	0.609	0.95
215_M	220_E	0.608	0.95
224_E	227_V	0.607	0.95
78_M	81_R	0.606	0.95
71_D	74_S	0.604	0.95
26_V	112_R	0.604	0.95
227_V	243_S	0.603	0.95
49_G	127_G	0.603	0.95
78_M	82_A	0.603	0.95
76_T	80_R	0.602	0.95
128_H	183_S	0.600	0.94
18_N	185_G	0.598	0.94
104_I	109_I	0.596	0.94
167_L	171_K	0.595	0.94
237_S	240_L	0.591	0.94
144_F	160_F	0.589	0.94
31_G	163_A	0.589	0.94
13_M	16_S	0.587	0.94
8_K	19_T	0.586	0.94
122_P	166_S	0.585	0.94
194_M	198_L	0.584	0.94
165_E	168_N	0.580	0.93
223_V	243_S	0.578	0.93
233_D	237_S	0.577	0.93
133_V	138_Y	0.577	0.93
79_G	82_A	0.577	0.93
37_V	43_V	0.575	0.93
243_S	247_R	0.575	0.93
95_F	99_Y	0.575	0.93
107_I	123_G	0.574	0.93
209_I	212_I	0.573	0.93
97_F	100_V	0.571	0.93
107_I	120_K	0.570	0.93
205_A	209_I	0.568	0.93
205_A	208_L	0.567	0.93
64_I	101_K	0.567	0.93
154_V	159_D	0.567	0.93
67_L	74_S	0.566	0.93
52_D	184_H	0.565	0.92
227_V	231_K	0.564	0.92
241_L	248_S	0.561	0.92
53_H	184_H	0.560	0.92
152_F	158_T	0.558	0.92
234_L	241_L	0.556	0.92
158_T	252_G	0.556	0.92
75_L	78_M	0.552	0.92
164_L	205_A	0.550	0.91
139_A	143_F	0.550	0.91
170_V	173_L	0.549	0.91
153_S	244_V	0.547	0.91
49_G	70_E	0.546	0.91
132_I	174_A	0.545	0.91
245_V	248_S	0.545	0.91
149_L	153_S	0.542	0.91
167_L	202_I	0.542	0.91
8_K	16_S	0.541	0.91
104_I	107_I	0.540	0.91
240_L	251_F	0.539	0.91
209_I	249_I	0.539	0.91
153_S	158_T	0.537	0.90
150_E	153_S	0.535	0.90
195_V	199_E	0.535	0.90
8_K	12_I	0.534	0.90
249_I	252_G	0.532	0.90
91_D	96_T	0.531	0.90
236_P	240_L	0.531	0.90
199_E	202_I	0.530	0.90
10_I	14_T	0.530	0.90
130_G	139_A	0.530	0.90
221_L	226_I	0.529	0.90
58_L	65_R	0.529	0.90
73_W	77_L	0.527	0.90
29_D	141_D	0.527	0.90
123_G	162_T	0.525	0.89
205_A	231_K	0.525	0.89
152_F	185_G	0.524	0.89
143_F	188_Y	0.522	0.89
250_L	254_E	0.521	0.89
247_R	251_F	0.518	0.89
227_V	230_L	0.518	0.89
24_N	42_E	0.518	0.89
229_K	232_Q	0.513	0.88
104_I	131_Y	0.510	0.88
49_G	54_I	0.510	0.88
208_L	211_K	0.510	0.88
181_V	187_V	0.509	0.88
151_G	156_F	0.506	0.88
18_N	182_I	0.504	0.88
91_D	97_F	0.503	0.87
140_G	157_Y	0.502	0.87
242_N	249_I	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zo4A	1	0.9301	100	0.385	Contact Map
4ad9A	4	0.8971	100	0.423	Contact Map
2yheA	3	0.9816	100	0.443	Contact Map
2cfuA	2	0.9669	100	0.468	Contact Map
4nurA	2	0.9853	100	0.469	Contact Map
4pdxA	2	0.9706	100	0.472	Contact Map
2fhxA	2	0.7426	100	0.517	Contact Map
2vw8A	2	0.9338	100	0.52	Contact Map
3iogA	1	0.7279	100	0.531	Contact Map
1k07A	1	0.8015	100	0.533	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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