Q97WC0 - SULSO - GREMLIN Contacts

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Q97WC0 - Transposon ISC1190

UniProt:	Q97WC0	Sequences: MEAPVAGIDVSKDKLVVYFQGKYYEFQNNKQGFEGVKQVLPKGCKVAIESTGVYHINLAKYLGKEYDVRIINPLVLKKFKNIRGKKSDKNDAKKLAELVISMGSEFTTSEAKELTSQWDFITRSIVRVKNRLRRDLILLGYKDSLSKKNLNEVLRGEDNIVLSEVRFLLDELERLEVRKREIEEELEDLVPKDSLIFTIPGIGRTLGCIILARVGDVKRFGDKKRFVAYCGLDPLVESSGKSVVSRGISRRGDAVLRRAFYLAALTAIKVNPIIKRFYEEHKENLKGKKLITACARKLAVITWAVLYYNKPFDASE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (308)
Sequences:	4573 (3487)
Seq/√Len:	198.7

SULSO - Q97WC0 Q97VS0 Q97XK2 Q97Y59 Q97WZ5 Q97X07 Q97ZN4 Q97X26 Q97UF7 Q97X12 Q97X29 Q97UQ6 Q97YE1 Q97XM7 Q97UU8 Q97VB2 Q97Y06 Q97Z62 Q97XR9 Q97WY7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_A	99_V	4.388	1.00
282_K	287_G	3.352	1.00
125_I	176_E	3.178	1.00
195_L	311_P	2.781	1.00
18_Y	92_A	2.776	1.00
226_F	299_A	2.654	1.00
167_F	178_R	2.602	1.00
170_D	178_R	2.585	1.00
281_H	284_N	2.531	1.00
76_L	95_L	2.457	1.00
163_S	185_E	2.383	1.00
124_S	127_R	2.286	1.00
47_A	95_L	2.252	1.00
214_V	226_F	2.222	1.00
46_V	66_Y	2.169	1.00
230_C	256_L	2.168	1.00
118_W	122_T	2.112	1.00
275_K	279_E	2.085	1.00
87_S	236_V	2.083	1.00
198_T	311_P	2.045	1.00
210_I	302_T	2.043	1.00
248_I	292_T	2.018	1.00
125_I	179_K	2.001	1.00
221_G	225_R	1.997	1.00
124_S	131_R	1.947	1.00
174_R	178_R	1.945	1.00
296_R	300_V	1.943	1.00
238_S	243_V	1.927	1.00
14_K	25_E	1.920	1.00
118_W	183_E	1.896	1.00
126_V	130_N	1.869	1.00
195_L	305_V	1.867	1.00
171_E	174_R	1.864	1.00
124_S	171_E	1.838	1.00
171_E	178_R	1.835	1.00
222_D	225_R	1.814	1.00
8_I	36_V	1.800	1.00
199_I	302_T	1.788	1.00
202_I	207_G	1.774	1.00
185_E	188_D	1.762	1.00
6_A	19_F	1.758	1.00
286_K	289_K	1.756	1.00
146_S	149_N	1.753	1.00
125_I	172_L	1.747	1.00
8_I	15_L	1.743	1.00
310_K	313_D	1.737	1.00
119_D	258_R	1.729	1.00
232_L	295_A	1.725	1.00
121_I	179_K	1.691	1.00
220_F	229_Y	1.685	1.00
45_K	69_R	1.672	1.00
196_I	302_T	1.670	1.00
230_C	299_A	1.662	1.00
116_S	213_R	1.628	1.00
48_I	68_V	1.618	1.00
305_V	311_P	1.618	1.00
132_L	172_L	1.602	1.00
280_E	284_N	1.564	1.00
206_L	259_A	1.564	1.00
17_V	36_V	1.559	1.00
209_I	259_A	1.522	1.00
8_I	58_L	1.518	1.00
97_E	101_S	1.513	1.00
150_L	157_E	1.513	1.00
304_A	308_Y	1.506	1.00
150_L	153_V	1.498	1.00
11_S	16_V	1.493	1.00
154_L	157_E	1.491	1.00
274_I	301_I	1.490	1.00
195_L	198_T	1.489	1.00
122_T	125_I	1.471	1.00
262_L	265_L	1.455	1.00
13_D	241_K	1.453	1.00
197_F	204_R	1.446	1.00
199_I	305_V	1.443	1.00
279_E	283_E	1.441	1.00
132_L	165_V	1.430	1.00
29_N	32_G	1.429	1.00
61_Y	64_K	1.420	1.00
190_V	197_F	1.416	1.00
48_I	59_A	1.411	1.00
60_K	109_S	1.399	1.00
285_L	289_K	1.395	1.00
180_R	183_E	1.390	1.00
24_Y	39_V	1.387	1.00
183_E	186_L	1.381	1.00
274_I	294_C	1.381	1.00
268_I	278_Y	1.371	1.00
122_T	179_K	1.357	1.00
16_V	25_E	1.349	1.00
18_Y	93_K	1.346	1.00
264_A	295_A	1.340	1.00
188_D	192_K	1.339	1.00
149_N	152_E	1.337	1.00
278_Y	294_C	1.331	1.00
277_F	297_K	1.303	1.00
85_K	236_V	1.298	1.00
170_D	177_V	1.296	1.00
278_Y	290_L	1.296	1.00
170_D	174_R	1.295	1.00
264_A	298_L	1.294	1.00
146_S	157_E	1.288	1.00
128_V	131_R	1.287	1.00
149_N	157_E	1.277	1.00
149_N	154_L	1.274	1.00
118_W	205_T	1.272	1.00
303_W	307_Y	1.269	1.00
119_D	255_V	1.265	1.00
172_L	176_E	1.249	1.00
227_V	233_D	1.234	1.00
258_R	262_L	1.232	1.00
272_P	276_R	1.228	1.00
167_F	181_E	1.226	1.00
264_A	294_C	1.221	1.00
124_S	128_V	1.214	1.00
47_A	71_I	1.213	1.00
125_I	129_K	1.207	1.00
187_E	204_R	1.202	1.00
40_L	46_V	1.200	1.00
8_I	17_V	1.191	1.00
261_Y	295_A	1.190	1.00
213_R	253_D	1.190	1.00
27_Q	32_G	1.186	1.00
143_D	146_S	1.185	1.00
11_S	14_K	1.168	1.00
199_I	298_L	1.168	1.00
10_V	15_L	1.167	1.00
120_F	131_R	1.166	1.00
227_V	296_R	1.159	1.00
169_L	173_E	1.158	1.00
248_I	257_R	1.137	1.00
118_W	179_K	1.130	1.00
202_I	206_L	1.129	1.00
196_I	207_G	1.119	1.00
149_N	153_V	1.115	1.00
145_L	153_V	1.110	1.00
146_S	151_N	1.109	1.00
33_F	57_N	1.107	1.00
117_Q	121_I	1.104	1.00
16_V	23_Y	1.096	1.00
206_L	263_A	1.095	1.00
127_R	130_N	1.089	1.00
147_K	151_N	1.088	1.00
150_L	156_G	1.082	1.00
146_S	156_G	1.081	1.00
282_K	290_L	1.080	1.00
74_L	78_K	1.080	1.00
33_F	61_Y	1.079	1.00
261_Y	292_T	1.070	1.00
23_Y	93_K	1.070	1.00
202_I	302_T	1.070	1.00
263_A	298_L	1.067	1.00
71_I	76_L	1.061	1.00
277_F	294_C	1.061	1.00
174_R	177_V	1.061	1.00
145_L	149_N	1.060	1.00
301_I	305_V	1.049	1.00
123_R	127_R	1.049	1.00
281_H	290_L	1.046	1.00
115_T	255_V	1.037	1.00
277_F	293_A	1.032	1.00
183_E	187_E	1.031	1.00
145_L	150_L	1.028	1.00
46_V	62_L	1.027	1.00
304_A	307_Y	1.027	1.00
6_A	46_V	1.024	1.00
7_G	96_A	1.016	1.00
45_K	67_D	1.011	1.00
153_V	156_G	1.011	1.00
6_A	17_V	1.009	1.00
151_N	154_L	1.007	1.00
149_N	156_G	1.004	1.00
264_A	291_I	0.998	1.00
93_K	97_E	0.996	1.00
176_E	180_R	0.990	1.00
146_S	153_V	0.986	1.00
145_L	148_K	0.986	1.00
105_E	108_T	0.986	1.00
277_F	281_H	0.985	1.00
305_V	310_K	0.982	1.00
147_K	150_L	0.975	0.99
153_V	157_E	0.964	0.99
146_S	154_L	0.963	0.99
17_V	39_V	0.962	0.99
26_F	39_V	0.962	0.99
12_K	137_I	0.959	0.99
146_S	150_L	0.958	0.99
37_K	61_Y	0.952	0.99
278_Y	287_G	0.952	0.99
114_L	182_I	0.949	0.99
143_D	153_V	0.943	0.99
196_I	306_L	0.943	0.99
261_Y	265_L	0.943	0.99
86_K	91_D	0.942	0.99
178_R	181_E	0.941	0.99
6_A	40_L	0.933	0.99
128_V	132_L	0.932	0.99
148_K	151_N	0.928	0.99
265_L	287_G	0.925	0.99
59_A	68_V	0.923	0.99
145_L	154_L	0.919	0.99
143_D	147_K	0.918	0.99
250_R	257_R	0.917	0.99
151_N	155_R	0.912	0.99
160_I	163_S	0.909	0.99
150_L	155_R	0.902	0.99
167_F	185_E	0.900	0.99
5_V	99_V	0.898	0.99
55_H	70_I	0.896	0.99
146_S	155_R	0.896	0.99
185_E	189_L	0.887	0.99
59_A	70_I	0.886	0.99
84_G	228_A	0.883	0.99
26_F	32_G	0.880	0.99
265_L	268_I	0.880	0.99
260_F	299_A	0.871	0.99
150_L	154_L	0.869	0.99
217_V	306_L	0.868	0.99
112_K	213_R	0.868	0.99
117_Q	167_F	0.867	0.99
148_K	152_E	0.865	0.99
69_R	99_V	0.858	0.99
115_T	186_L	0.856	0.99
115_T	208_C	0.856	0.99
287_G	291_I	0.851	0.99
145_L	152_E	0.851	0.99
281_H	286_K	0.846	0.99
73_P	213_R	0.845	0.99
146_S	152_E	0.843	0.99
122_T	126_V	0.842	0.98
38_Q	41_P	0.842	0.98
145_L	156_G	0.840	0.98
5_V	100_I	0.839	0.98
147_K	154_L	0.832	0.98
50_S	73_P	0.827	0.98
129_K	172_L	0.827	0.98
214_V	217_V	0.826	0.98
288_K	291_I	0.825	0.98
176_E	179_K	0.823	0.98
239_S	243_V	0.819	0.98
95_L	98_L	0.815	0.98
202_I	298_L	0.813	0.98
32_G	35_G	0.806	0.98
121_I	182_I	0.805	0.98
40_L	62_L	0.805	0.98
261_Y	288_K	0.801	0.98
105_E	109_S	0.799	0.98
281_H	285_L	0.799	0.98
152_E	156_G	0.797	0.98
158_D	161_V	0.793	0.98
144_S	148_K	0.792	0.98
128_V	172_L	0.792	0.98
265_L	288_K	0.792	0.98
167_F	171_E	0.790	0.98
177_V	181_E	0.787	0.98
10_V	48_I	0.786	0.98
277_F	280_E	0.786	0.98
273_I	312_F	0.776	0.97
115_T	209_I	0.776	0.97
276_R	280_E	0.769	0.97
143_D	149_N	0.768	0.97
36_V	40_L	0.768	0.97
274_I	298_L	0.767	0.97
15_L	58_L	0.757	0.97
16_V	89_K	0.757	0.97
197_F	207_G	0.753	0.97
265_L	295_A	0.750	0.97
302_T	305_V	0.749	0.97
193_D	211_L	0.745	0.97
145_L	155_R	0.745	0.97
238_S	244_V	0.744	0.97
31_Q	35_G	0.744	0.97
151_N	156_G	0.744	0.97
11_S	15_L	0.743	0.97
144_S	147_K	0.742	0.97
168_L	171_E	0.741	0.97
272_P	275_K	0.738	0.97
30_K	34_E	0.736	0.96
229_Y	253_D	0.735	0.96
292_T	295_A	0.733	0.96
15_L	28_N	0.733	0.96
45_K	99_V	0.732	0.96
235_L	249_S	0.732	0.96
6_A	44_C	0.731	0.96
225_R	228_A	0.730	0.96
195_L	309_N	0.726	0.96
233_D	250_R	0.724	0.96
187_E	191_P	0.720	0.96
286_K	290_L	0.719	0.96
213_R	255_V	0.719	0.96
107_T	192_K	0.718	0.96
15_L	26_F	0.718	0.96
79_F	98_L	0.714	0.96
222_D	303_W	0.713	0.96
267_A	274_I	0.711	0.96
37_K	41_P	0.710	0.96
72_N	75_V	0.710	0.96
17_V	26_F	0.707	0.96
51_T	54_Y	0.707	0.96
143_D	157_E	0.707	0.96
115_T	212_A	0.701	0.95
84_G	251_R	0.698	0.95
143_D	151_N	0.694	0.95
233_D	249_S	0.690	0.95
88_D	239_S	0.690	0.95
147_K	157_E	0.689	0.95
85_K	90_N	0.687	0.95
7_G	92_A	0.686	0.95
128_V	175_L	0.685	0.95
71_I	98_L	0.682	0.95
270_V	275_K	0.682	0.95
119_D	123_R	0.681	0.95
128_V	168_L	0.676	0.94
175_L	178_R	0.672	0.94
210_I	256_L	0.671	0.94
50_S	70_I	0.665	0.94
181_E	185_E	0.665	0.94
32_G	36_V	0.665	0.94
236_V	243_V	0.662	0.94
262_L	288_K	0.662	0.94
131_R	168_L	0.659	0.94
43_G	67_D	0.658	0.94
268_I	282_K	0.656	0.93
132_L	169_L	0.655	0.93
18_Y	23_Y	0.654	0.93
37_K	66_Y	0.653	0.93
144_S	149_N	0.651	0.93
262_L	266_T	0.647	0.93
175_L	179_K	0.647	0.93
199_I	202_I	0.647	0.93
76_L	98_L	0.645	0.93
128_V	171_E	0.642	0.93
190_V	208_C	0.642	0.93
281_H	293_A	0.642	0.93
120_F	124_S	0.641	0.93
117_Q	182_I	0.641	0.93
122_T	183_E	0.639	0.93
289_K	293_A	0.639	0.93
7_G	62_L	0.633	0.92
278_Y	282_K	0.632	0.92
252_G	257_R	0.629	0.92
34_E	38_Q	0.628	0.92
130_N	134_R	0.626	0.92
143_D	156_G	0.626	0.92
109_S	113_E	0.626	0.92
144_S	150_L	0.625	0.92
202_I	210_I	0.625	0.92
116_S	255_V	0.621	0.91
121_I	175_L	0.621	0.91
233_D	236_V	0.620	0.91
248_I	252_G	0.617	0.91
33_F	39_V	0.617	0.91
216_D	219_R	0.615	0.91
79_F	101_S	0.615	0.91
32_G	39_V	0.613	0.91
144_S	157_E	0.611	0.91
265_L	291_I	0.609	0.91
98_L	102_M	0.607	0.91
209_I	213_R	0.605	0.90
131_R	134_R	0.604	0.90
233_D	257_R	0.602	0.90
125_I	175_L	0.602	0.90
48_I	70_I	0.602	0.90
260_F	295_A	0.601	0.90
147_K	153_V	0.601	0.90
280_E	283_E	0.599	0.90
265_L	269_K	0.599	0.90
159_N	185_E	0.597	0.90
160_I	185_E	0.593	0.90
144_S	156_G	0.592	0.89
114_L	185_E	0.591	0.89
107_T	110_E	0.590	0.89
41_P	66_Y	0.589	0.89
247_G	289_K	0.589	0.89
10_V	54_Y	0.589	0.89
271_N	312_F	0.588	0.89
43_G	66_Y	0.587	0.89
143_D	150_L	0.586	0.89
166_R	170_D	0.584	0.89
77_K	82_I	0.583	0.89
259_A	263_A	0.583	0.89
116_S	253_D	0.582	0.89
223_K	303_W	0.581	0.89
163_S	166_R	0.579	0.88
28_N	33_F	0.579	0.88
31_Q	39_V	0.578	0.88
268_I	291_I	0.577	0.88
184_E	188_D	0.575	0.88
144_S	155_R	0.573	0.88
11_S	240_G	0.572	0.88
87_S	238_S	0.571	0.88
177_V	180_R	0.571	0.88
214_V	230_C	0.570	0.88
74_L	251_R	0.569	0.88
167_F	170_D	0.565	0.87
6_A	62_L	0.565	0.87
271_N	275_K	0.564	0.87
111_A	186_L	0.561	0.87
62_L	298_L	0.560	0.87
53_V	137_I	0.560	0.87
300_V	303_W	0.559	0.87
143_D	154_L	0.557	0.86
248_I	293_A	0.557	0.86
172_L	175_L	0.556	0.86
113_E	161_V	0.555	0.86
258_R	261_Y	0.553	0.86
171_E	175_L	0.553	0.86
307_Y	310_K	0.553	0.86
227_V	300_V	0.551	0.86
18_Y	96_A	0.551	0.86
146_S	158_D	0.550	0.86
16_V	239_S	0.549	0.86
119_D	209_I	0.548	0.86
202_I	263_A	0.548	0.86
145_L	151_N	0.547	0.85
145_L	157_E	0.546	0.85
76_L	94_K	0.546	0.85
232_L	296_R	0.546	0.85
173_E	176_E	0.545	0.85
117_Q	131_R	0.544	0.85
48_I	95_L	0.544	0.85
224_K	296_R	0.543	0.85
217_V	303_W	0.541	0.85
161_V	164_E	0.541	0.85
74_L	84_G	0.539	0.85
237_E	246_R	0.537	0.84
228_A	233_D	0.537	0.84
144_S	152_E	0.536	0.84
268_I	294_C	0.534	0.84
173_E	177_V	0.532	0.84
152_E	157_E	0.532	0.84
151_N	157_E	0.530	0.84
117_Q	128_V	0.529	0.84
120_F	127_R	0.528	0.83
114_L	118_W	0.528	0.83
25_E	28_N	0.527	0.83
271_N	276_R	0.527	0.83
111_A	189_L	0.525	0.83
97_E	100_I	0.524	0.83
111_A	193_D	0.524	0.83
190_V	193_D	0.524	0.83
90_N	94_K	0.522	0.83
183_E	205_T	0.521	0.83
23_Y	89_K	0.520	0.82
126_V	129_K	0.517	0.82
276_R	279_E	0.517	0.82
186_L	190_V	0.516	0.82
190_V	207_G	0.511	0.81
186_L	208_C	0.511	0.81
267_A	298_L	0.510	0.81
170_D	181_E	0.510	0.81
223_K	300_V	0.508	0.81
55_H	59_A	0.508	0.81
34_E	37_K	0.504	0.81
121_I	178_R	0.503	0.80
279_E	282_K	0.503	0.80
163_S	181_E	0.502	0.80
17_V	40_L	0.502	0.80
218_K	307_Y	0.501	0.80
249_S	252_G	0.501	0.80
183_E	204_R	0.500	0.80
264_A	274_I	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.3323	93.6	0.93	Contact Map
4ep4A	2	0.3418	91.6	0.934	Contact Map
1nu0A	1	0.3133	88	0.939	Contact Map
3c1yA	5	0.7658	85.1	0.942	Contact Map
3fhfA	1	0.6171	83.4	0.943	Contact Map
1vhxA	2	0.3323	80.4	0.945	Contact Map
1pu6A	1	0.6013	80.1	0.945	Contact Map
1keaA	2	0.6392	78.9	0.945	Contact Map
2a1jB	2	0.2437	78.8	0.945	Contact Map
2a1jA	1	0.1867	76.4	0.946	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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