GREMLIN Database
Q97WC0 - Transposon ISC1190
UniProt: Q97WC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (308)
Sequences: 4573 (3487)
Seq/√Len: 198.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A99_V4.3881.00
282_K287_G3.3521.00
125_I176_E3.1781.00
195_L311_P2.7811.00
18_Y92_A2.7761.00
226_F299_A2.6541.00
167_F178_R2.6021.00
170_D178_R2.5851.00
281_H284_N2.5311.00
76_L95_L2.4571.00
163_S185_E2.3831.00
124_S127_R2.2861.00
47_A95_L2.2521.00
214_V226_F2.2221.00
46_V66_Y2.1691.00
230_C256_L2.1681.00
118_W122_T2.1121.00
275_K279_E2.0851.00
87_S236_V2.0831.00
198_T311_P2.0451.00
210_I302_T2.0431.00
248_I292_T2.0181.00
125_I179_K2.0011.00
221_G225_R1.9971.00
124_S131_R1.9471.00
174_R178_R1.9451.00
296_R300_V1.9431.00
238_S243_V1.9271.00
14_K25_E1.9201.00
118_W183_E1.8961.00
126_V130_N1.8691.00
195_L305_V1.8671.00
171_E174_R1.8641.00
124_S171_E1.8381.00
171_E178_R1.8351.00
222_D225_R1.8141.00
8_I36_V1.8001.00
199_I302_T1.7881.00
202_I207_G1.7741.00
185_E188_D1.7621.00
6_A19_F1.7581.00
286_K289_K1.7561.00
146_S149_N1.7531.00
125_I172_L1.7471.00
8_I15_L1.7431.00
310_K313_D1.7371.00
119_D258_R1.7291.00
232_L295_A1.7251.00
121_I179_K1.6911.00
220_F229_Y1.6851.00
45_K69_R1.6721.00
196_I302_T1.6701.00
230_C299_A1.6621.00
116_S213_R1.6281.00
48_I68_V1.6181.00
305_V311_P1.6181.00
132_L172_L1.6021.00
280_E284_N1.5641.00
206_L259_A1.5641.00
17_V36_V1.5591.00
209_I259_A1.5221.00
8_I58_L1.5181.00
97_E101_S1.5131.00
150_L157_E1.5131.00
304_A308_Y1.5061.00
150_L153_V1.4981.00
11_S16_V1.4931.00
154_L157_E1.4911.00
274_I301_I1.4901.00
195_L198_T1.4891.00
122_T125_I1.4711.00
262_L265_L1.4551.00
13_D241_K1.4531.00
197_F204_R1.4461.00
199_I305_V1.4431.00
279_E283_E1.4411.00
132_L165_V1.4301.00
29_N32_G1.4291.00
61_Y64_K1.4201.00
190_V197_F1.4161.00
48_I59_A1.4111.00
60_K109_S1.3991.00
285_L289_K1.3951.00
180_R183_E1.3901.00
24_Y39_V1.3871.00
183_E186_L1.3811.00
274_I294_C1.3811.00
268_I278_Y1.3711.00
122_T179_K1.3571.00
16_V25_E1.3491.00
18_Y93_K1.3461.00
264_A295_A1.3401.00
188_D192_K1.3391.00
149_N152_E1.3371.00
278_Y294_C1.3311.00
277_F297_K1.3031.00
85_K236_V1.2981.00
170_D177_V1.2961.00
278_Y290_L1.2961.00
170_D174_R1.2951.00
264_A298_L1.2941.00
146_S157_E1.2881.00
128_V131_R1.2871.00
149_N157_E1.2771.00
149_N154_L1.2741.00
118_W205_T1.2721.00
303_W307_Y1.2691.00
119_D255_V1.2651.00
172_L176_E1.2491.00
227_V233_D1.2341.00
258_R262_L1.2321.00
272_P276_R1.2281.00
167_F181_E1.2261.00
264_A294_C1.2211.00
124_S128_V1.2141.00
47_A71_I1.2131.00
125_I129_K1.2071.00
187_E204_R1.2021.00
40_L46_V1.2001.00
8_I17_V1.1911.00
261_Y295_A1.1901.00
213_R253_D1.1901.00
27_Q32_G1.1861.00
143_D146_S1.1851.00
11_S14_K1.1681.00
199_I298_L1.1681.00
10_V15_L1.1671.00
120_F131_R1.1661.00
227_V296_R1.1591.00
169_L173_E1.1581.00
248_I257_R1.1371.00
118_W179_K1.1301.00
202_I206_L1.1291.00
196_I207_G1.1191.00
149_N153_V1.1151.00
145_L153_V1.1101.00
146_S151_N1.1091.00
33_F57_N1.1071.00
117_Q121_I1.1041.00
16_V23_Y1.0961.00
206_L263_A1.0951.00
127_R130_N1.0891.00
147_K151_N1.0881.00
150_L156_G1.0821.00
146_S156_G1.0811.00
282_K290_L1.0801.00
74_L78_K1.0801.00
33_F61_Y1.0791.00
261_Y292_T1.0701.00
23_Y93_K1.0701.00
202_I302_T1.0701.00
263_A298_L1.0671.00
71_I76_L1.0611.00
277_F294_C1.0611.00
174_R177_V1.0611.00
145_L149_N1.0601.00
301_I305_V1.0491.00
123_R127_R1.0491.00
281_H290_L1.0461.00
115_T255_V1.0371.00
277_F293_A1.0321.00
183_E187_E1.0311.00
145_L150_L1.0281.00
46_V62_L1.0271.00
304_A307_Y1.0271.00
6_A46_V1.0241.00
7_G96_A1.0161.00
45_K67_D1.0111.00
153_V156_G1.0111.00
6_A17_V1.0091.00
151_N154_L1.0071.00
149_N156_G1.0041.00
264_A291_I0.9981.00
93_K97_E0.9961.00
176_E180_R0.9901.00
146_S153_V0.9861.00
145_L148_K0.9861.00
105_E108_T0.9861.00
277_F281_H0.9851.00
305_V310_K0.9821.00
147_K150_L0.9750.99
153_V157_E0.9640.99
146_S154_L0.9630.99
17_V39_V0.9620.99
26_F39_V0.9620.99
12_K137_I0.9590.99
146_S150_L0.9580.99
37_K61_Y0.9520.99
278_Y287_G0.9520.99
114_L182_I0.9490.99
143_D153_V0.9430.99
196_I306_L0.9430.99
261_Y265_L0.9430.99
86_K91_D0.9420.99
178_R181_E0.9410.99
6_A40_L0.9330.99
128_V132_L0.9320.99
148_K151_N0.9280.99
265_L287_G0.9250.99
59_A68_V0.9230.99
145_L154_L0.9190.99
143_D147_K0.9180.99
250_R257_R0.9170.99
151_N155_R0.9120.99
160_I163_S0.9090.99
150_L155_R0.9020.99
167_F185_E0.9000.99
5_V99_V0.8980.99
55_H70_I0.8960.99
146_S155_R0.8960.99
185_E189_L0.8870.99
59_A70_I0.8860.99
84_G228_A0.8830.99
26_F32_G0.8800.99
265_L268_I0.8800.99
260_F299_A0.8710.99
150_L154_L0.8690.99
217_V306_L0.8680.99
112_K213_R0.8680.99
117_Q167_F0.8670.99
148_K152_E0.8650.99
69_R99_V0.8580.99
115_T186_L0.8560.99
115_T208_C0.8560.99
287_G291_I0.8510.99
145_L152_E0.8510.99
281_H286_K0.8460.99
73_P213_R0.8450.99
146_S152_E0.8430.99
122_T126_V0.8420.98
38_Q41_P0.8420.98
145_L156_G0.8400.98
5_V100_I0.8390.98
147_K154_L0.8320.98
50_S73_P0.8270.98
129_K172_L0.8270.98
214_V217_V0.8260.98
288_K291_I0.8250.98
176_E179_K0.8230.98
239_S243_V0.8190.98
95_L98_L0.8150.98
202_I298_L0.8130.98
32_G35_G0.8060.98
121_I182_I0.8050.98
40_L62_L0.8050.98
261_Y288_K0.8010.98
105_E109_S0.7990.98
281_H285_L0.7990.98
152_E156_G0.7970.98
158_D161_V0.7930.98
144_S148_K0.7920.98
128_V172_L0.7920.98
265_L288_K0.7920.98
167_F171_E0.7900.98
177_V181_E0.7870.98
10_V48_I0.7860.98
277_F280_E0.7860.98
273_I312_F0.7760.97
115_T209_I0.7760.97
276_R280_E0.7690.97
143_D149_N0.7680.97
36_V40_L0.7680.97
274_I298_L0.7670.97
15_L58_L0.7570.97
16_V89_K0.7570.97
197_F207_G0.7530.97
265_L295_A0.7500.97
302_T305_V0.7490.97
193_D211_L0.7450.97
145_L155_R0.7450.97
238_S244_V0.7440.97
31_Q35_G0.7440.97
151_N156_G0.7440.97
11_S15_L0.7430.97
144_S147_K0.7420.97
168_L171_E0.7410.97
272_P275_K0.7380.97
30_K34_E0.7360.96
229_Y253_D0.7350.96
292_T295_A0.7330.96
15_L28_N0.7330.96
45_K99_V0.7320.96
235_L249_S0.7320.96
6_A44_C0.7310.96
225_R228_A0.7300.96
195_L309_N0.7260.96
233_D250_R0.7240.96
187_E191_P0.7200.96
286_K290_L0.7190.96
213_R255_V0.7190.96
107_T192_K0.7180.96
15_L26_F0.7180.96
79_F98_L0.7140.96
222_D303_W0.7130.96
267_A274_I0.7110.96
37_K41_P0.7100.96
72_N75_V0.7100.96
17_V26_F0.7070.96
51_T54_Y0.7070.96
143_D157_E0.7070.96
115_T212_A0.7010.95
84_G251_R0.6980.95
143_D151_N0.6940.95
233_D249_S0.6900.95
88_D239_S0.6900.95
147_K157_E0.6890.95
85_K90_N0.6870.95
7_G92_A0.6860.95
128_V175_L0.6850.95
71_I98_L0.6820.95
270_V275_K0.6820.95
119_D123_R0.6810.95
128_V168_L0.6760.94
175_L178_R0.6720.94
210_I256_L0.6710.94
50_S70_I0.6650.94
181_E185_E0.6650.94
32_G36_V0.6650.94
236_V243_V0.6620.94
262_L288_K0.6620.94
131_R168_L0.6590.94
43_G67_D0.6580.94
268_I282_K0.6560.93
132_L169_L0.6550.93
18_Y23_Y0.6540.93
37_K66_Y0.6530.93
144_S149_N0.6510.93
262_L266_T0.6470.93
175_L179_K0.6470.93
199_I202_I0.6470.93
76_L98_L0.6450.93
128_V171_E0.6420.93
190_V208_C0.6420.93
281_H293_A0.6420.93
120_F124_S0.6410.93
117_Q182_I0.6410.93
122_T183_E0.6390.93
289_K293_A0.6390.93
7_G62_L0.6330.92
278_Y282_K0.6320.92
252_G257_R0.6290.92
34_E38_Q0.6280.92
130_N134_R0.6260.92
143_D156_G0.6260.92
109_S113_E0.6260.92
144_S150_L0.6250.92
202_I210_I0.6250.92
116_S255_V0.6210.91
121_I175_L0.6210.91
233_D236_V0.6200.91
248_I252_G0.6170.91
33_F39_V0.6170.91
216_D219_R0.6150.91
79_F101_S0.6150.91
32_G39_V0.6130.91
144_S157_E0.6110.91
265_L291_I0.6090.91
98_L102_M0.6070.91
209_I213_R0.6050.90
131_R134_R0.6040.90
233_D257_R0.6020.90
125_I175_L0.6020.90
48_I70_I0.6020.90
260_F295_A0.6010.90
147_K153_V0.6010.90
280_E283_E0.5990.90
265_L269_K0.5990.90
159_N185_E0.5970.90
160_I185_E0.5930.90
144_S156_G0.5920.89
114_L185_E0.5910.89
107_T110_E0.5900.89
41_P66_Y0.5890.89
247_G289_K0.5890.89
10_V54_Y0.5890.89
271_N312_F0.5880.89
43_G66_Y0.5870.89
143_D150_L0.5860.89
166_R170_D0.5840.89
77_K82_I0.5830.89
259_A263_A0.5830.89
116_S253_D0.5820.89
223_K303_W0.5810.89
163_S166_R0.5790.88
28_N33_F0.5790.88
31_Q39_V0.5780.88
268_I291_I0.5770.88
184_E188_D0.5750.88
144_S155_R0.5730.88
11_S240_G0.5720.88
87_S238_S0.5710.88
177_V180_R0.5710.88
214_V230_C0.5700.88
74_L251_R0.5690.88
167_F170_D0.5650.87
6_A62_L0.5650.87
271_N275_K0.5640.87
111_A186_L0.5610.87
62_L298_L0.5600.87
53_V137_I0.5600.87
300_V303_W0.5590.87
143_D154_L0.5570.86
248_I293_A0.5570.86
172_L175_L0.5560.86
113_E161_V0.5550.86
258_R261_Y0.5530.86
171_E175_L0.5530.86
307_Y310_K0.5530.86
227_V300_V0.5510.86
18_Y96_A0.5510.86
146_S158_D0.5500.86
16_V239_S0.5490.86
119_D209_I0.5480.86
202_I263_A0.5480.86
145_L151_N0.5470.85
145_L157_E0.5460.85
76_L94_K0.5460.85
232_L296_R0.5460.85
173_E176_E0.5450.85
117_Q131_R0.5440.85
48_I95_L0.5440.85
224_K296_R0.5430.85
217_V303_W0.5410.85
161_V164_E0.5410.85
74_L84_G0.5390.85
237_E246_R0.5370.84
228_A233_D0.5370.84
144_S152_E0.5360.84
268_I294_C0.5340.84
173_E177_V0.5320.84
152_E157_E0.5320.84
151_N157_E0.5300.84
117_Q128_V0.5290.84
120_F127_R0.5280.83
114_L118_W0.5280.83
25_E28_N0.5270.83
271_N276_R0.5270.83
111_A189_L0.5250.83
97_E100_I0.5240.83
111_A193_D0.5240.83
190_V193_D0.5240.83
90_N94_K0.5220.83
183_E205_T0.5210.83
23_Y89_K0.5200.82
126_V129_K0.5170.82
276_R279_E0.5170.82
186_L190_V0.5160.82
190_V207_G0.5110.81
186_L208_C0.5110.81
267_A298_L0.5100.81
170_D181_E0.5100.81
223_K300_V0.5080.81
55_H59_A0.5080.81
34_E37_K0.5040.81
121_I178_R0.5030.80
279_E282_K0.5030.80
163_S181_E0.5020.80
17_V40_L0.5020.80
218_K307_Y0.5010.80
249_S252_G0.5010.80
183_E204_R0.5000.80
264_A274_I0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.3323 93.6 0.93 Contact Map
4ep4A 2 0.3418 91.6 0.934 Contact Map
1nu0A 1 0.3133 88 0.939 Contact Map
3c1yA 5 0.7658 85.1 0.942 Contact Map
3fhfA 1 0.6171 83.4 0.943 Contact Map
1vhxA 2 0.3323 80.4 0.945 Contact Map
1pu6A 1 0.6013 80.1 0.945 Contact Map
1keaA 2 0.6392 78.9 0.945 Contact Map
2a1jB 2 0.2437 78.8 0.945 Contact Map
2a1jA 1 0.1867 76.4 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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