GREMLIN Database
Q97WA4 - Second ORF in transposon ISC1058
UniProt: Q97WA4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 168 (156)
Sequences: 275 (161)
Seq/√Len: 12.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_V96_V3.2740.98
149_L152_A2.8450.95
151_S155_R2.6280.93
50_I150_F2.6260.93
114_K117_L2.5240.91
28_T31_Q2.4930.90
45_F91_Y2.4430.90
89_K108_K2.2290.85
26_T44_K2.1990.84
141_G144_W2.1790.83
49_E71_S2.1470.82
64_V161_V2.1470.82
110_N120_R2.1410.82
119_R134_W2.1090.81
16_E29_G2.0130.78
153_V161_V1.9580.76
20_D23_G1.9420.75
24_I161_V1.8750.72
25_S31_Q1.8220.70
27_N44_K1.8060.69
42_D46_L1.7750.68
30_G108_K1.7650.68
140_Y147_E1.7550.67
92_D119_R1.7190.66
92_D134_W1.7180.65
17_V60_V1.7080.65
138_K141_G1.6520.62
29_G33_I1.6320.61
107_P111_A1.6050.60
107_P122_A1.5850.59
21_A71_S1.5840.59
101_V145_R1.5720.58
16_E54_N1.5580.58
51_V55_N1.5510.57
87_G98_K1.5400.57
61_N101_V1.5180.56
57_F152_A1.4920.54
24_I152_A1.4660.53
25_S92_D1.4010.50
111_A123_V1.3990.49
103_V122_A1.3970.49
53_D90_T1.3670.48
113_T123_V1.3560.47
77_D109_K1.3550.47
57_F149_L1.3520.47
25_S28_T1.3520.47
28_T59_V1.3370.46
107_P119_R1.3310.46
63_E70_E1.3140.45
24_I64_V1.3040.44
44_K67_N1.2950.44
37_W45_F1.2920.44
46_L152_A1.2610.42
17_V51_V1.2420.41
35_A40_T1.2390.41
97_Y106_P1.2210.40
96_V114_K1.2070.40
74_T77_D1.1940.39
89_K92_D1.1820.38
136_E155_R1.1700.38
48_I107_P1.1640.37
148_S151_S1.1620.37
18_I54_N1.1590.37
153_V157_F1.1550.37
45_F71_S1.1500.37
35_A41_R1.1350.36
15_L146_V1.1140.35
109_K112_S1.1110.35
33_I145_R1.1080.35
125_E129_L1.1040.35
68_E126_F1.0980.34
140_Y143_R1.0660.33
25_S150_F1.0440.32
121_K124_R1.0380.32
132_D135_R1.0360.31
78_L91_Y1.0360.31
152_A161_V1.0270.31
57_F126_F1.0200.31
157_F162_R1.0140.30
70_E73_K1.0130.30
130_G134_W1.0060.30
65_T163_Q1.0000.30
149_L163_Q0.9990.30
23_G32_Y0.9990.30
61_N79_Q0.9950.30
119_R123_V0.9910.29
114_K141_G0.9900.29
21_A32_Y0.9840.29
19_A79_Q0.9820.29
27_N41_R0.9800.29
16_E28_T0.9760.29
39_K160_S0.9710.29
56_E141_G0.9600.28
92_D130_G0.9590.28
45_F49_E0.9410.27
79_Q101_V0.9380.27
32_Y49_E0.9350.27
143_R147_E0.9340.27
74_T109_K0.8920.25
113_T124_R0.8850.25
18_I86_Y0.8830.25
48_I83_K0.8630.24
12_S123_V0.8600.24
10_E105_V0.8540.24
134_W164_V0.8440.24
70_E144_W0.8440.24
145_R149_L0.8420.23
158_G161_V0.8400.23
64_V153_V0.8400.23
24_I149_L0.8340.23
19_A44_K0.8300.23
119_R130_G0.8180.23
58_N63_E0.8170.23
60_V128_K0.8150.22
33_I86_Y0.8150.22
75_V97_Y0.8140.22
61_N160_S0.8110.22
85_F101_V0.8010.22
107_P126_F0.8010.22
22_T48_I0.8000.22
68_E109_K0.7980.22
52_M145_R0.7980.22
26_T38_G0.7960.22
132_D138_K0.7950.22
76_K85_F0.7950.22
74_T85_F0.7920.22
86_Y117_L0.7890.22
88_D91_Y0.7880.22
72_V102_E0.7870.21
26_T42_D0.7870.21
47_K71_S0.7830.21
42_D146_V0.7800.21
82_G90_T0.7730.21
98_K142_V0.7660.21
18_I151_S0.7640.21
35_A114_K0.7630.21
70_E97_Y0.7630.21
16_E84_K0.7610.21
81_K158_G0.7550.20
21_A44_K0.7540.20
93_V96_V0.7530.20
88_D143_R0.7500.20
31_Q34_V0.7490.20
134_W147_E0.7460.20
135_R141_G0.7440.20
26_T48_I0.7400.20
64_V125_E0.7310.20
35_A155_R0.7280.19
125_E138_K0.7260.19
129_L133_R0.7220.19
40_T109_K0.7190.19
95_E124_R0.7170.19
15_L139_G0.7130.19
18_I26_T0.7080.19
17_V31_Q0.7030.19
82_G104_V0.7020.19
90_T164_V0.7010.19
91_Y106_P0.7000.19
20_D106_P0.6980.19
85_F103_V0.6780.18
52_M146_V0.6740.18
103_V118_A0.6680.18
35_A135_R0.6680.18
17_V55_N0.6660.18
14_E57_F0.6600.17
16_E26_T0.6570.17
49_E65_T0.6570.17
67_N124_R0.6560.17
80_D120_R0.6550.17
77_D124_R0.6540.17
59_V136_E0.6500.17
150_F154_R0.6460.17
58_N70_E0.6450.17
27_N152_A0.6450.17
19_A66_S0.6420.17
85_F96_V0.6400.17
90_T108_K0.6350.17
135_R153_V0.6310.17
140_Y154_R0.6310.17
83_K99_T0.6280.16
53_D104_V0.6270.16
53_D134_W0.6250.16
64_V100_G0.6250.16
48_I52_M0.6230.16
154_R163_Q0.6140.16
61_N131_Y0.6140.16
125_E128_K0.6120.16
24_I115_R0.6030.16
143_R154_R0.5970.16
44_K68_E0.5970.16
25_S37_W0.5960.16
149_L157_F0.5940.15
12_S136_E0.5880.15
28_T92_D0.5870.15
10_E14_E0.5860.15
28_T37_W0.5860.15
37_W150_F0.5850.15
65_T71_S0.5840.15
90_T120_R0.5810.15
17_V138_K0.5800.15
51_V67_N0.5790.15
74_T108_K0.5770.15
14_E65_T0.5710.15
21_A78_L0.5700.15
11_T14_E0.5600.15
62_A153_V0.5560.14
51_V57_F0.5530.14
82_G101_V0.5530.14
72_V160_S0.5520.14
48_I70_E0.5520.14
21_A47_K0.5520.14
43_S89_K0.5430.14
62_A69_V0.5380.14
94_N110_N0.5360.14
81_K164_V0.5310.14
17_V53_D0.5280.14
104_V125_E0.5270.14
16_E150_F0.5260.14
34_V67_N0.5250.14
21_A45_F0.5230.14
69_V95_E0.5210.14
99_T130_G0.5200.14
37_W131_Y0.5170.13
65_T82_G0.5170.13
43_S164_V0.5170.13
128_K165_L0.5160.13
52_M57_F0.5150.13
17_V29_G0.5120.13
41_R54_N0.5100.13
92_D108_K0.5080.13
92_D107_P0.5040.13
102_E125_E0.5030.13
45_F106_P0.5020.13
30_G111_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9881 92.4 0.915 Contact Map
4fw1A 2 0.6726 10.4 0.959 Contact Map
1xccA 2 0.7798 7.8 0.961 Contact Map
1c6vA 4 0.5774 7.6 0.962 Contact Map
2qhsA 1 0.4762 6.9 0.962 Contact Map
1bcoA 1 0.7976 6.2 0.963 Contact Map
2mw1A 1 0.4643 6 0.963 Contact Map
4a17F 1 0.7024 4.6 0.966 Contact Map
3j61G 1 0.7381 4.5 0.966 Contact Map
3l3uA 2 0.625 4.4 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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