GREMLIN Database
Q97WA2 - Uncharacterized protein
UniProt: Q97WA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (213)
Sequences: 5762 (3679)
Seq/√Len: 252.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_S107_I4.4641.00
30_Y105_I3.6581.00
193_K200_E3.2021.00
33_V103_S3.1281.00
29_Y242_R2.8051.00
19_S34_L2.6921.00
73_V78_F2.4651.00
72_S101_K2.4281.00
26_L107_I2.3551.00
213_A216_I2.3421.00
28_E238_S2.2891.00
47_Y73_V2.2371.00
18_I237_I2.1921.00
20_Y47_Y2.1051.00
64_F67_N2.0761.00
20_Y43_I2.0281.00
201_E205_G2.0121.00
44_S77_S2.0101.00
192_L199_L2.0001.00
16_S46_I1.9711.00
49_I73_V1.9211.00
94_Y98_K1.9181.00
26_L105_I1.8671.00
229_K234_P1.8641.00
20_Y46_I1.8431.00
199_L203_I1.8101.00
199_L202_F1.7581.00
194_G199_L1.7201.00
33_V106_V1.7191.00
193_K196_E1.7161.00
222_S225_Q1.7091.00
72_S103_S1.7081.00
40_S115_H1.6771.00
215_F240_I1.6401.00
197_S200_E1.6261.00
74_I78_F1.6171.00
6_V107_I1.6161.00
156_V159_N1.6111.00
42_T150_K1.5981.00
23_A107_I1.5871.00
231_I234_P1.5801.00
195_Q200_E1.5591.00
139_L151_Y1.5411.00
152_L208_I1.5301.00
7_V110_H1.5241.00
46_I146_I1.5191.00
190_K219_Y1.4991.00
141_L147_P1.4741.00
235_K238_S1.4741.00
239_D243_Y1.4681.00
53_I56_F1.4671.00
91_A95_L1.4551.00
232_D235_K1.4541.00
139_L155_T1.4511.00
35_V106_V1.4421.00
200_E203_I1.4351.00
202_F205_G1.4121.00
18_I140_V1.3951.00
239_D242_R1.3751.00
18_I187_I1.3711.00
85_N156_V1.3681.00
45_R149_K1.3541.00
57_L60_R1.3501.00
25_Q29_Y1.3361.00
37_K108_V1.3261.00
24_R28_E1.3211.00
17_T223_L1.3011.00
7_V154_Y1.2991.00
25_Q241_T1.2831.00
29_Y238_S1.2751.00
193_K202_F1.2741.00
221_L224_T1.2531.00
237_I241_T1.2511.00
4_I184_V1.2431.00
31_N102_D1.2211.00
234_P241_T1.2161.00
226_R229_K1.2101.00
218_P236_E1.2051.00
93_K97_S1.2031.00
187_I240_I1.1921.00
35_V108_V1.1821.00
235_K239_D1.1751.00
18_I22_L1.1711.00
74_I99_L1.1681.00
226_R230_D1.1551.00
5_N110_H1.1551.00
103_S106_V1.1441.00
62_E65_Y1.1401.00
110_H118_A1.1371.00
55_S60_R1.1341.00
49_I78_F1.1261.00
88_D91_A1.1261.00
63_L68_K1.1241.00
136_N182_K1.1211.00
53_I74_I1.1211.00
16_S43_I1.1131.00
227_H230_D1.1001.00
199_L205_G1.0941.00
206_D213_A1.0921.00
185_A212_S1.0911.00
65_Y68_K1.0871.00
55_S58_K1.0781.00
76_M79_L1.0751.00
236_E239_D1.0631.00
34_L43_I1.0581.00
137_T158_L1.0511.00
201_E204_R1.0331.00
52_N56_F1.0311.00
222_S228_F1.0301.00
5_N133_F1.0191.00
124_K127_M1.0181.00
234_P237_I1.0181.00
199_L204_R1.0141.00
24_R71_L1.0101.00
230_D235_K0.9991.00
47_Y71_L0.9981.00
56_F59_G0.9951.00
52_N55_S0.9921.00
86_G89_F0.9901.00
198_K202_F0.9841.00
200_E204_R0.9741.00
24_R69_N0.9681.00
27_S71_L0.9671.00
228_F231_I0.9621.00
56_F60_R0.9541.00
26_L32_V0.9501.00
90_N93_K0.9391.00
95_L99_L0.9261.00
233_P236_E0.9241.00
76_M80_N0.9231.00
198_K203_I0.9211.00
227_H234_P0.9191.00
228_F234_P0.9161.00
234_P238_S0.9081.00
77_S80_N0.9081.00
63_L66_I0.9061.00
196_E200_E0.9051.00
192_L201_E0.9021.00
92_F95_L0.9021.00
81_E84_L0.8961.00
191_I216_I0.8931.00
235_K241_T0.8791.00
227_H233_P0.8751.00
215_F220_Y0.8731.00
136_N184_V0.8731.00
31_N104_D0.8711.00
85_N89_F0.8701.00
53_I58_K0.8691.00
43_I73_V0.8691.00
233_P237_I0.8600.99
230_D234_P0.8590.99
74_I79_L0.8560.99
23_A34_L0.8510.99
84_L160_D0.8500.99
229_K241_T0.8470.99
206_D215_F0.8450.99
238_S241_T0.8440.99
52_N58_K0.8410.99
62_E67_N0.8410.99
60_R65_Y0.8370.99
149_K153_N0.8370.99
221_L225_Q0.8300.99
214_R220_Y0.8290.99
238_S242_R0.8270.99
128_E132_N0.8220.99
87_I157_L0.8140.99
51_N54_F0.8120.99
27_S70_N0.8070.99
229_K235_K0.7970.99
227_H241_T0.7960.99
34_L73_V0.7920.99
16_S42_T0.7910.99
126_F161_F0.7910.99
85_N88_D0.7840.99
59_G64_F0.7840.99
53_I57_L0.7820.99
206_D214_R0.7820.99
232_D236_E0.7820.99
54_F58_K0.7740.99
220_Y224_T0.7670.99
188_I191_I0.7660.99
92_F117_F0.7660.99
231_I236_E0.7630.99
230_D241_T0.7630.99
83_D86_G0.7600.99
60_R68_K0.7570.99
209_L212_S0.7560.99
59_G63_L0.7520.99
51_N66_I0.7440.98
84_L156_V0.7410.98
21_H24_R0.7390.98
49_I66_I0.7380.98
78_F81_E0.7300.98
228_F241_T0.7260.98
228_F235_K0.7200.98
59_G62_E0.7180.98
5_N137_T0.7180.98
77_S81_E0.7170.98
152_L209_L0.7100.98
209_L215_F0.7070.98
69_N72_S0.7060.98
138_V240_I0.7040.98
141_L186_V0.7040.98
70_N73_V0.7030.98
45_R50_N0.7000.98
136_N185_A0.7000.98
27_S69_N0.6950.98
212_S243_Y0.6870.97
70_N74_I0.6820.97
227_H231_I0.6810.97
217_I236_E0.6760.97
75_N79_L0.6740.97
220_Y233_P0.6570.97
133_F136_N0.6560.97
21_H25_Q0.6520.97
52_N57_L0.6510.96
142_S190_K0.6490.96
240_I243_Y0.6480.96
60_R63_L0.6390.96
5_N108_V0.6390.96
138_V214_R0.6380.96
25_Q28_E0.6370.96
7_V158_L0.6360.96
83_D89_F0.6350.96
149_K156_V0.6330.96
60_R66_I0.6310.96
75_N78_F0.6300.96
237_I240_I0.6280.96
207_E210_Q0.6260.96
66_I72_S0.6240.96
124_K128_E0.6230.95
73_V77_S0.6190.95
50_N82_D0.6180.95
206_D212_S0.6180.95
70_N75_N0.6160.95
22_L138_V0.6160.95
4_I105_I0.6160.95
138_V187_I0.6140.95
63_L74_I0.6100.95
22_L241_T0.6100.95
80_N86_G0.6090.95
212_S215_F0.6070.95
110_H154_Y0.6070.95
9_F154_Y0.6040.95
137_T181_L0.6030.95
145_E149_K0.6020.95
70_N79_L0.6020.95
63_L67_N0.6010.95
118_A154_Y0.6010.95
125_A128_E0.5990.94
226_R234_P0.5920.94
19_S43_I0.5900.94
223_L233_P0.5880.94
226_R231_I0.5880.94
51_N55_S0.5840.94
198_K201_E0.5820.94
64_F68_K0.5820.94
55_S59_G0.5810.94
186_V211_R0.5800.93
145_E152_L0.5800.93
34_L47_Y0.5800.93
238_S243_Y0.5740.93
228_F233_P0.5740.93
161_F180_F0.5740.93
231_I237_I0.5730.93
142_S150_K0.5730.93
45_R145_E0.5730.93
83_D152_L0.5720.93
11_G14_G0.5720.93
67_N72_S0.5720.93
212_S225_Q0.5710.93
18_I217_I0.5690.93
212_S220_Y0.5670.93
155_T209_L0.5660.93
213_A220_Y0.5640.92
44_S75_N0.5640.92
58_K100_T0.5620.92
227_H237_I0.5600.92
215_F221_L0.5600.92
147_P150_K0.5560.92
41_G114_P0.5550.92
37_K92_F0.5540.92
145_E148_I0.5530.92
6_V22_L0.5530.92
25_Q238_S0.5510.92
237_I243_Y0.5510.92
37_K110_H0.5490.91
20_Y73_V0.5480.91
64_F69_N0.5470.91
93_K128_E0.5440.91
236_E240_I0.5430.91
227_H232_D0.5390.91
137_T150_K0.5360.90
24_R47_Y0.5350.90
57_L100_T0.5350.90
155_T183_I0.5310.90
73_V81_E0.5290.90
118_A158_L0.5280.90
214_R225_Q0.5260.90
76_M82_D0.5260.90
209_L220_Y0.5260.90
17_T46_I0.5240.89
186_V206_D0.5220.89
233_P241_T0.5220.89
8_G113_I0.5200.89
215_F224_T0.5160.89
27_S32_V0.5150.89
231_I241_T0.5150.89
236_E241_T0.5140.89
11_G15_K0.5130.89
207_E220_Y0.5120.88
42_T117_F0.5120.88
73_V76_M0.5110.88
4_I138_V0.5080.88
59_G65_Y0.5070.88
192_L216_I0.5070.88
12_G15_K0.5050.88
71_L75_N0.5050.88
7_V139_L0.5000.87
42_T151_Y0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5aunB 2 0.8235 100 0.506 Contact Map
3pg5A 2 0.8824 100 0.511 Contact Map
4rz3A 2 0.8588 100 0.514 Contact Map
4v03A 2 0.8431 100 0.522 Contact Map
3kjhA 2 0.8471 100 0.524 Contact Map
1g3qA 1 0.8549 100 0.525 Contact Map
1hyqA 1 0.8431 100 0.526 Contact Map
4pfsA 1 0.8824 100 0.526 Contact Map
3ea0A 2 0.8471 100 0.527 Contact Map
3io3A 2 0.7529 100 0.534 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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