GREMLIN Database
Q97WA1 - Alcohol dehydrogenase (Zn containing) (Adh-6)
UniProt: Q97WA1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (300)
Sequences: 52609 (36325)
Seq/√Len: 2097.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_V145_W3.0551.00
39_R74_E2.9701.00
41_V72_V2.9131.00
14_D24_K2.7611.00
316_E319_E2.7491.00
172_I196_T2.6291.00
37_L74_E2.5241.00
84_N87_D2.5021.00
87_D138_K2.3801.00
88_K139_I2.3701.00
14_D22_K2.3451.00
36_V136_I2.3161.00
178_A199_A2.3001.00
28_E128_Y2.2981.00
312_Y323_E2.2761.00
12_V24_K2.2731.00
144_S147_V2.2711.00
191_K212_D2.2521.00
168_G171_D2.2351.00
310_K323_E2.2261.00
39_R128_Y2.2191.00
173_I190_A2.1701.00
39_R72_V2.1531.00
223_K226_E2.1311.00
146_D311_T2.1141.00
82_G133_D2.0851.00
69_L91_V2.0741.00
32_G35_D2.0501.00
33_P78_D2.0391.00
33_P79_H2.0181.00
142_S302_K2.0141.00
313_K316_E1.9991.00
37_L130_S1.9901.00
203_K207_K1.9831.00
163_K193_F1.9721.00
34_H79_H1.9391.00
196_T213_Y1.9381.00
54_N325_M1.9371.00
74_E128_Y1.9311.00
187_V211_A1.8931.00
299_N303_D1.8821.00
69_L124_G1.8651.00
322_K326_N1.8541.00
192_K305_K1.8481.00
88_K145_W1.8411.00
257_Q282_K1.7941.00
155_A185_F1.7921.00
70_A145_W1.7861.00
204_N208_E1.7681.00
234_D253_G1.7431.00
163_K296_E1.7291.00
203_K214_I1.7201.00
323_E328_N1.7201.00
257_Q284_V1.6961.00
174_V200_V1.6941.00
174_V233_A1.6931.00
139_I145_W1.6731.00
204_N207_K1.6691.00
319_E322_K1.6541.00
319_E323_E1.6281.00
9_K25_E1.6081.00
30_Q75_K1.5921.00
11_L317_G1.5881.00
198_I233_A1.5771.00
37_L128_Y1.5731.00
312_Y320_A1.5701.00
72_V88_K1.5621.00
205_W208_E1.5571.00
213_Y227_I1.5441.00
139_I148_A1.5431.00
196_T212_D1.5421.00
10_A26_V1.5201.00
252_L258_L1.5131.00
75_K85_K1.5011.00
176_F248_S1.4941.00
76_V85_K1.4911.00
37_L75_K1.4801.00
318_V322_K1.4731.00
236_V252_L1.4681.00
83_L87_D1.4571.00
34_H132_P1.4531.00
252_L281_I1.4481.00
35_D132_P1.4421.00
83_L138_K1.4301.00
165_L235_V1.4301.00
252_L256_G1.4191.00
40_V69_L1.4121.00
9_K315_D1.4061.00
35_D130_S1.4051.00
125_W321_V1.4031.00
77_G80_V1.3881.00
171_D257_Q1.3831.00
192_K300_L1.3661.00
42_K146_D1.3541.00
236_V248_S1.3481.00
88_K141_E1.3471.00
218_D223_K1.3451.00
31_L130_S1.3261.00
11_L23_V1.3171.00
72_V145_W1.3091.00
159_Y163_K1.3071.00
31_L37_L1.2971.00
299_N302_K1.2961.00
36_V83_L1.2951.00
73_V83_L1.2861.00
219_D222_Q1.2821.00
309_H323_E1.2711.00
9_K127_E1.2531.00
223_K227_I1.2511.00
186_A237_I1.2441.00
172_I198_I1.2431.00
41_V88_K1.2391.00
176_F200_V1.2291.00
53_I321_V1.2201.00
222_Q226_E1.2161.00
40_V129_F1.2061.00
28_E37_L1.1781.00
203_K216_G1.1651.00
151_L301_C1.1631.00
83_L136_I1.1571.00
172_I234_D1.1541.00
15_K20_N1.1491.00
12_V26_V1.1471.00
34_H133_D1.1451.00
187_V199_A1.1411.00
291_R295_M1.1341.00
300_L305_K1.1341.00
219_D223_K1.1331.00
221_V250_Q1.1191.00
171_D234_D1.1171.00
167_V195_A1.1071.00
8_M28_E1.1071.00
296_E299_N1.0951.00
207_K214_I1.0921.00
250_Q275_S1.0921.00
160_H293_E1.0871.00
131_V136_I1.0801.00
188_Q307_K1.0791.00
158_S186_A1.0531.00
205_W330_E1.0481.00
38_I89_V1.0391.00
43_S125_W1.0321.00
198_I213_Y1.0311.00
165_L259_A1.0291.00
42_K145_W1.0271.00
317_G335_L1.0251.00
240_L244_M1.0241.00
190_A195_A1.0241.00
9_K23_V1.0201.00
163_K293_E1.0171.00
16_S61_M1.0141.00
167_V171_D1.0121.00
53_I325_M1.0071.00
23_V315_D1.0051.00
221_V225_K1.0041.00
80_V133_D1.0031.00
74_E85_K1.0011.00
159_Y296_E0.9951.00
38_I71_G0.9851.00
221_V247_N0.9781.00
322_K325_M0.9761.00
81_K133_D0.9751.00
247_N250_Q0.9741.00
11_L314_L0.9701.00
45_L320_A0.9661.00
31_L35_D0.9621.00
323_E333_I0.9621.00
296_E300_L0.9591.00
155_A297_L0.9571.00
147_V307_K0.9531.00
161_S261_F0.9361.00
200_V217_Y0.9331.00
161_S237_I0.9321.00
295_M299_N0.9301.00
275_S279_R0.9261.00
178_A187_V0.9261.00
178_A201_S0.9261.00
90_V298_I0.9261.00
207_K213_Y0.9251.00
14_D20_N0.9241.00
171_D235_V0.9211.00
199_A206_L0.9201.00
312_Y316_E0.9191.00
158_S189_L0.9181.00
184_L205_W0.9111.00
50_Y324_I0.9101.00
15_K19_E0.9081.00
246_E250_Q0.8981.00
143_M148_A0.8961.00
11_L21_L0.8941.00
125_W317_G0.8921.00
41_V70_A0.8901.00
10_A64_I0.8811.00
255_D280_H0.8811.00
187_V197_V0.8801.00
228_T232_M0.8761.00
63_H122_N0.8751.00
199_A211_A0.8681.00
76_V84_N0.8671.00
176_F236_V0.8651.00
42_K334_M0.8631.00
238_N241_G0.8621.00
43_S124_G0.8611.00
292_K296_E0.8581.00
202_R330_E0.8481.00
329_R333_I0.8481.00
174_V251_V0.8481.00
39_R127_E0.8461.00
76_V80_V0.8441.00
28_E75_K0.8421.00
156_L293_E0.8391.00
46_N68_E0.8361.00
224_V233_A0.8271.00
178_A206_L0.8261.00
166_E257_Q0.8241.00
201_S214_I0.8171.00
175_I190_A0.8151.00
12_V64_I0.8141.00
193_F296_E0.8071.00
198_I215_V0.8071.00
137_F295_M0.8071.00
172_I233_A0.8071.00
69_L129_F0.8071.00
272_N275_S0.8051.00
124_G129_F0.7961.00
26_V122_N0.7901.00
91_V131_V0.7891.00
292_K295_M0.7891.00
312_Y333_I0.7891.00
173_I195_A0.7851.00
28_E74_E0.7851.00
236_V258_L0.7841.00
44_G68_E0.7841.00
176_F244_M0.7821.00
45_L324_I0.7821.00
162_L190_A0.7821.00
220_V247_N0.7811.00
189_L297_L0.7771.00
248_S258_L0.7711.00
46_N67_A0.7691.00
221_V251_V0.7671.00
175_I186_A0.7671.00
141_E302_K0.7671.00
26_V64_I0.7661.00
36_V133_D0.7651.00
8_M127_E0.7631.00
84_N138_K0.7631.00
30_Q37_L0.7631.00
246_E268_E0.7581.00
310_K319_E0.7561.00
239_S261_F0.7541.00
32_G130_S0.7491.00
125_W335_L0.7411.00
300_L303_D0.7401.00
276_L283_V0.7391.00
323_E326_N0.7371.00
17_G20_N0.7361.00
190_A197_V0.7261.00
222_Q225_K0.7251.00
11_L318_V0.7251.00
198_I227_I0.7211.00
89_V136_I0.7181.00
82_G291_R0.7171.00
198_I224_V0.7171.00
246_E275_S0.7141.00
189_L300_L0.7131.00
158_S185_F0.7131.00
34_H78_D0.7131.00
23_V314_L0.7121.00
90_V139_I0.7111.00
31_L75_K0.7101.00
206_L211_A0.7101.00
46_N49_D0.7061.00
310_K333_I0.7061.00
201_S206_L0.7061.00
167_V235_V0.7051.00
201_S217_Y0.7011.00
48_I67_A0.7011.00
166_E282_K0.7001.00
298_I302_K0.6991.00
140_P302_K0.6981.00
50_Y325_M0.6981.00
70_A149_A0.6961.00
172_I231_K0.6931.00
34_H77_G0.6891.00
260_F283_V0.6871.00
201_S216_G0.6851.00
159_Y300_L0.6841.00
300_L304_C0.6811.00
143_M301_C0.6811.00
195_A235_V0.6791.00
166_E284_V0.6761.00
197_V212_D0.6751.00
161_S186_A0.6741.00
203_K206_L0.6721.00
219_D247_N0.6721.00
208_E307_K0.6711.00
308_V311_T0.6691.00
40_V43_S0.6681.00
19_E322_K0.6671.00
324_I333_I0.6661.00
59_T63_H0.6651.00
267_S270_K0.6641.00
8_M29_P0.6631.00
159_Y297_L0.6631.00
187_V209_F0.6621.00
245_W258_L0.6611.00
276_L281_I0.6611.00
205_W209_F0.6611.00
42_K311_T0.6601.00
238_N258_L0.6601.00
137_F294_L0.6591.00
175_I199_A0.6591.00
160_H280_H0.6571.00
60_P63_H0.6551.00
254_L279_R0.6551.00
36_V73_V0.6541.00
34_H134_K0.6521.00
87_D141_E0.6501.00
235_V259_A0.6471.00
323_E329_R0.6461.00
233_A236_V0.6461.00
31_L77_G0.6451.00
228_T231_K0.6421.00
159_Y293_E0.6421.00
13_F20_N0.6421.00
163_K189_L0.6411.00
188_Q209_F0.6401.00
243_S246_E0.6391.00
276_L285_G0.6351.00
42_K70_A0.6351.00
169_P194_G0.6341.00
191_K197_V0.6301.00
29_P130_S0.6301.00
38_I91_V0.6291.00
137_F298_I0.6271.00
211_A214_I0.6271.00
231_K253_G0.6261.00
150_S334_M0.6251.00
90_V152_P0.6241.00
157_T182_T0.6241.00
70_A139_I0.6231.00
164_E293_E0.6221.00
158_S182_T0.6201.00
213_Y216_G0.6181.00
160_H164_E0.6181.00
280_H290_S0.6151.00
91_V136_I0.6151.00
158_S162_L0.6111.00
235_V257_Q0.6101.00
225_K232_M0.6091.00
154_A185_F0.6091.00
161_S259_A0.6051.00
50_Y54_N0.6041.00
88_K142_S0.6031.00
133_D136_I0.6021.00
312_Y335_L0.6011.00
15_K22_K0.5971.00
70_A88_K0.5961.00
20_N318_V0.5961.00
213_Y223_K0.5941.00
233_A251_V0.5941.00
48_I52_V0.5921.00
45_L125_W0.5921.00
46_N154_A0.5911.00
246_E270_K0.5891.00
8_M126_S0.5881.00
165_L257_Q0.5841.00
321_V325_M0.5801.00
83_L133_D0.5801.00
154_A181_N0.5791.00
268_E272_N0.5781.00
38_I136_I0.5771.00
229_N232_M0.5771.00
151_L297_L0.5761.00
68_E153_V0.5721.00
132_P135_N0.5711.00
293_E296_E0.5711.00
137_F291_R0.5701.00
275_S278_G0.5691.00
29_P35_D0.5681.00
309_H312_Y0.5671.00
82_G85_K0.5651.00
203_K217_Y0.5611.00
76_V87_D0.5601.00
186_A261_F0.5591.00
46_N153_V0.5581.00
67_A153_V0.5571.00
215_V227_I0.5561.00
220_V224_V0.5561.00
21_L321_V0.5551.00
244_M248_S0.5541.00
202_R328_N0.5541.00
164_E282_K0.5521.00
48_I51_F0.5521.00
43_S335_L0.5511.00
81_K84_N0.5501.00
174_V236_V0.5471.00
173_I235_V0.5461.00
29_P128_Y0.5461.00
189_L193_F0.5451.00
188_Q306_V0.5451.00
70_A148_A0.5431.00
169_P193_F0.5431.00
47_P51_F0.5401.00
215_V223_K0.5391.00
224_V251_V0.5381.00
175_I187_V0.5381.00
66_G125_W0.5381.00
187_V206_L0.5371.00
244_M247_N0.5361.00
236_V251_V0.5331.00
246_E272_N0.5331.00
161_S286_T0.5321.00
92_Y137_F0.5311.00
225_K228_T0.5311.00
184_L209_F0.5311.00
164_E284_V0.5301.00
172_I228_T0.5301.00
185_F189_L0.5281.00
172_I213_Y0.5251.00
200_V215_V0.5251.00
13_F53_I0.5241.00
162_L189_L0.5221.00
76_V83_L0.5211.00
245_W260_F0.5201.00
45_L335_L0.5181.00
259_A286_T0.5181.00
268_E271_V0.5151.00
286_T289_G0.5151.00
82_G138_K0.5141.00
228_T233_A0.5141.00
162_L186_A0.5121.00
312_Y319_E0.5101.00
226_E229_N0.5101.00
44_G149_A0.5101.00
295_M298_I0.5101.00
91_V124_G0.5091.00
13_F16_S0.5091.00
28_E130_S0.5061.00
166_E193_F0.5051.00
259_A284_V0.5051.00
206_L214_I0.5051.00
238_N262_G0.5041.00
197_V200_V0.5041.00
320_A335_L0.5031.00
159_Y189_L0.5031.00
278_G287_T0.5021.00
287_T290_S0.5001.00
192_K306_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gi2A 2 1 100 0.167 Contact Map
1h2bA 4 0.9645 100 0.182 Contact Map
4c4oA 4 0.9645 100 0.19 Contact Map
4ej6A 1 0.9675 100 0.193 Contact Map
3ukoA 4 0.9852 100 0.194 Contact Map
1vj0A 4 0.9763 100 0.198 Contact Map
1f8fA 4 0.9734 100 0.2 Contact Map
3jv7A 4 0.9645 100 0.201 Contact Map
4j6fA 2 0.9763 100 0.202 Contact Map
1rjwA 4 0.9675 100 0.202 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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