GREMLIN Database
RF1 - Peptide chain release factor subunit 1
UniProt: Q97W96 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (330)
Sequences: 875 (581)
Seq/√Len: 32.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
333_A338_V8.7091.00
142_I151_I4.8141.00
307_M312_I4.7521.00
80_K84_I4.7141.00
80_K83_K4.2771.00
195_L230_F4.0091.00
221_G262_M3.8011.00
79_N84_I3.7411.00
79_N83_K3.7301.00
78_L84_I3.5131.00
142_I202_V3.2751.00
81_I84_I3.1471.00
78_L83_K3.1401.00
353_V361_V3.1081.00
79_N82_P3.1001.00
78_L82_P2.8691.00
220_L231_Y2.8671.00
313_E365_R2.8181.00
140_G206_F2.6511.00
297_I362_G2.5951.00
144_V230_F2.4420.99
305_K308_E2.4090.99
230_F233_E2.1880.99
288_H363_K2.1880.99
314_A341_F2.1790.99
332_D335_N2.1480.99
58_I103_K2.1250.98
301_E305_K2.1090.98
149_A198_V2.1060.98
229_D232_K2.0530.98
152_G259_L2.0500.98
285_L357_F2.0150.98
328_K332_D1.9790.97
249_I262_M1.9600.97
253_D366_Y1.9580.97
284_E288_H1.9410.97
141_L221_G1.9250.97
303_I362_G1.9050.97
54_I92_F1.8790.96
238_Y244_I1.8780.96
113_V244_I1.8720.96
312_I362_G1.8520.96
144_V222_G1.8390.96
152_G161_I1.8210.96
25_A29_V1.8000.95
96_N277_E1.7900.95
277_E339_K1.7680.95
140_G215_M1.7680.95
206_F215_M1.7210.94
145_E254_Q1.7170.94
281_L341_F1.7050.94
43_D128_F1.6680.93
79_N102_F1.6640.93
238_Y241_K1.6390.93
52_Y117_F1.6270.92
95_E102_F1.6190.92
149_A194_F1.6090.92
145_E167_G1.6030.92
278_V344_G1.6000.92
238_Y242_N1.5980.92
33_L115_L1.5950.92
270_L360_I1.5840.91
141_L262_M1.5230.89
223_P261_E1.5150.89
312_I315_I1.5150.89
194_F230_F1.4990.89
141_L152_G1.4990.89
25_A28_T1.4960.89
228_E248_L1.4580.87
215_M218_V1.4480.87
147_D194_F1.4040.85
78_L81_I1.3990.85
282_L343_V1.3990.85
40_P60_L1.3930.85
105_F220_L1.3610.83
44_V49_R1.3560.83
108_S111_D1.3540.83
103_K117_F1.3460.83
248_L362_G1.3430.83
292_D295_L1.3290.82
144_V154_L1.3170.81
60_L103_K1.3110.81
44_V107_F1.3070.81
31_L129_L1.3020.80
285_L289_L1.2960.80
288_H295_L1.2910.80
240_I244_I1.2740.79
51_E60_L1.2740.79
39_R43_D1.2730.79
159_I263_I1.2500.78
314_A339_K1.2490.78
241_K244_I1.2340.77
288_H293_D1.2230.76
42_P104_C1.2220.76
187_I191_Y1.2190.76
218_V243_L1.2150.76
63_T71_I1.2010.75
222_G254_Q1.1910.74
40_P52_Y1.1910.74
42_P46_N1.1860.74
190_M226_A1.1830.74
294_G367_R1.1760.73
252_S261_E1.1690.73
316_V343_V1.1670.73
234_D241_K1.1580.72
309_I368_L1.1480.71
300_K325_E1.1470.71
32_S112_K1.1470.71
63_T68_L1.1450.71
170_P289_L1.1350.70
149_A165_I1.1280.70
28_T32_S1.1120.69
74_A80_K1.1110.69
54_I60_L1.1090.69
54_I58_I1.1010.68
306_A368_L1.0990.68
267_E271_K1.0920.67
145_E194_F1.0900.67
232_K235_Y1.0900.67
219_L269_L1.0860.67
253_D257_V1.0820.67
255_G258_G1.0770.66
224_G261_E1.0740.66
251_V329_L1.0580.65
152_G222_G1.0570.65
104_C117_F1.0530.65
140_G202_V1.0530.65
164_E255_G1.0520.65
41_I73_A1.0480.64
33_L113_V1.0440.64
284_E287_Y1.0380.63
127_E334_E1.0370.63
107_F113_V1.0280.63
138_V216_K1.0170.62
151_I201_K1.0100.61
126_L130_E1.0020.61
66_A74_A1.0010.61
48_L54_I0.9970.60
76_D259_L0.9910.60
31_L259_L0.9900.60
143_I259_L0.9870.59
141_L219_L0.9850.59
287_Y291_K0.9850.59
227_K250_D0.9800.59
227_K248_L0.9800.59
301_E320_D0.9770.59
36_P40_P0.9740.58
51_E368_L0.9740.58
97_F317_I0.9740.58
250_D253_D0.9710.58
315_I361_V0.9710.58
152_G160_E0.9630.58
282_L348_P0.9580.57
171_G174_M0.9560.57
150_T255_G0.9530.57
284_E339_K0.9520.57
300_K303_I0.9520.57
192_H196_K0.9510.57
223_P227_K0.9510.57
104_C320_D0.9460.56
56_Q105_F0.9450.56
176_G185_R0.9440.56
126_L176_G0.9420.56
170_P190_M0.9400.56
222_G227_K0.9370.55
184_D187_I0.9340.55
313_E339_K0.9300.55
114_P319_E0.9260.55
28_T120_T0.9250.55
148_E254_Q0.9230.54
196_K200_E0.9230.54
129_L202_V0.9160.54
34_Y112_K0.9140.54
40_P115_L0.9090.53
28_T59_K0.9050.53
54_I82_P0.9050.53
151_I294_G0.9050.53
195_L226_A0.9030.53
139_Y252_S0.9010.53
147_D257_V0.9010.53
297_I302_Q0.8990.52
84_I155_K0.8910.52
205_Y345_D0.8900.52
143_I254_Q0.8860.51
132_M225_Y0.8820.51
93_C104_C0.8810.51
310_G348_P0.8760.51
285_L292_D0.8730.50
195_L233_E0.8720.50
337_G340_V0.8710.50
344_G350_A0.8690.50
88_G109_P0.8690.50
305_K309_I0.8690.50
55_A64_R0.8690.50
324_K328_K0.8680.50
288_H294_G0.8670.50
237_D368_L0.8670.50
194_F347_V0.8660.50
316_V353_V0.8650.50
40_P306_A0.8540.49
228_E232_K0.8530.49
35_I44_V0.8520.49
197_E201_K0.8480.48
359_G364_L0.8460.48
270_L273_Q0.8450.48
61_K73_A0.8440.48
129_L287_Y0.8420.48
35_I111_D0.8420.48
133_V203_N0.8400.48
264_M283_E0.8400.48
32_S35_I0.8390.47
174_M318_H0.8370.47
218_V334_E0.8350.47
235_Y241_K0.8310.47
54_I68_L0.8290.47
248_L283_E0.8280.47
57_N77_R0.8270.46
224_G227_K0.8230.46
50_Q338_V0.8230.46
223_P298_Y0.8220.46
53_S156_G0.8210.46
239_R365_R0.8100.45
323_D367_R0.8090.45
150_T164_E0.8080.45
147_D273_Q0.8030.45
52_Y60_L0.7990.44
222_G250_D0.7960.44
24_K28_T0.7960.44
195_L202_V0.7930.44
122_K152_G0.7920.44
304_K317_I0.7880.43
71_I75_I0.7870.43
129_L267_E0.7860.43
196_K233_E0.7850.43
320_D355_K0.7850.43
29_V303_I0.7850.43
26_P363_K0.7850.43
278_V296_I0.7850.43
232_K236_V0.7810.43
39_R152_G0.7800.43
91_L104_C0.7770.42
104_C159_I0.7760.42
59_K67_V0.7760.42
332_D336_Y0.7750.42
279_E332_D0.7720.42
273_Q343_V0.7700.42
151_I251_V0.7700.42
87_N92_F0.7670.42
107_F315_I0.7670.42
32_S114_P0.7650.41
76_D80_K0.7610.41
44_V47_L0.7610.41
31_L243_L0.7590.41
42_P52_Y0.7580.41
318_H355_K0.7570.41
64_R67_V0.7550.41
42_P224_G0.7520.40
161_I256_E0.7510.40
162_L205_Y0.7500.40
166_E339_K0.7480.40
38_G211_Q0.7470.40
51_E58_I0.7440.40
220_L244_I0.7430.40
251_V366_Y0.7430.40
231_Y235_Y0.7400.40
280_K283_E0.7390.39
48_L113_V0.7360.39
36_P45_V0.7360.39
214_K242_N0.7330.39
146_R191_Y0.7330.39
195_L215_M0.7320.39
324_K331_Q0.7290.39
26_P56_Q0.7270.38
355_K363_K0.7250.38
323_D326_L0.7190.38
165_I345_D0.7190.38
61_K96_N0.7190.38
141_L256_E0.7180.38
282_L286_K0.7180.38
282_L302_Q0.7170.38
74_A84_I0.7160.38
243_L269_L0.7150.38
76_D95_E0.7150.38
108_S149_A0.7130.37
245_L271_K0.7110.37
159_I171_G0.7100.37
146_R233_E0.7090.37
41_I91_L0.7090.37
317_I330_A0.7090.37
35_I146_R0.7070.37
54_I127_E0.7070.37
140_G235_Y0.7060.37
347_V350_A0.7060.37
133_V145_E0.7060.37
27_A64_R0.7040.37
136_T281_L0.7030.37
137_A216_K0.7030.37
184_D286_K0.7030.37
303_I321_S0.6990.36
166_E342_V0.6990.36
301_E304_K0.6990.36
259_L349_E0.6980.36
89_L286_K0.6980.36
289_L298_Y0.6970.36
110_P228_E0.6960.36
78_L97_F0.6960.36
284_E351_E0.6930.36
301_E360_I0.6920.36
278_V350_A0.6910.36
285_L363_K0.6900.36
350_A361_V0.6870.35
198_V290_A0.6870.35
29_V121_D0.6860.35
142_I310_G0.6840.35
40_P54_I0.6790.35
289_L358_N0.6790.35
42_P60_L0.6790.35
320_D365_R0.6780.35
306_A315_I0.6770.35
286_K334_E0.6760.35
33_L321_S0.6750.35
288_H296_I0.6740.34
282_L358_N0.6730.34
360_I368_L0.6730.34
144_V254_Q0.6720.34
125_H312_I0.6710.34
231_Y244_I0.6710.34
65_D69_S0.6690.34
338_V362_G0.6680.34
95_E307_M0.6670.34
66_A70_A0.6650.34
52_Y353_V0.6640.34
298_Y362_G0.6630.34
267_E295_L0.6600.33
145_E258_G0.6580.33
74_A143_I0.6570.33
44_V48_L0.6570.33
149_A243_L0.6520.33
147_D171_G0.6510.33
301_E368_L0.6500.33
40_P47_L0.6490.33
226_A258_G0.6480.33
81_I317_I0.6480.33
92_F103_K0.6450.32
60_L92_F0.6450.32
331_Q337_G0.6420.32
68_L71_I0.6400.32
290_A340_V0.6400.32
67_V70_A0.6380.32
155_K160_E0.6380.32
252_S289_L0.6340.32
37_P107_F0.6330.31
324_K335_N0.6320.31
344_G361_V0.6310.31
202_V234_D0.6290.31
269_L317_I0.6290.31
283_E310_G0.6280.31
172_K285_L0.6280.31
69_S76_D0.6270.31
141_L259_L0.6260.31
215_M289_L0.6230.31
307_M332_D0.6220.31
298_Y350_A0.6210.31
33_L295_L0.6210.31
322_T366_Y0.6210.31
145_E222_G0.6210.31
44_V368_L0.6210.31
175_M185_R0.6190.31
105_F318_H0.6180.30
217_G270_L0.6130.30
344_G347_V0.6070.30
326_L367_R0.6050.30
290_A335_N0.6050.30
193_N196_K0.6040.29
198_V356_T0.6020.29
67_V169_V0.6020.29
277_E301_E0.5990.29
55_A98_D0.5980.29
106_M111_D0.5970.29
304_K325_E0.5960.29
65_D72_G0.5940.29
249_I272_N0.5930.29
154_L304_K0.5920.29
69_S73_A0.5920.29
218_V235_Y0.5920.29
214_K268_D0.5910.29
27_A336_Y0.5900.29
325_E328_K0.5890.28
322_T325_E0.5880.28
89_L260_R0.5850.28
296_I338_V0.5850.28
34_Y92_F0.5830.28
192_H291_K0.5830.28
284_E314_A0.5820.28
66_A95_E0.5820.28
115_L245_L0.5810.28
152_G258_G0.5810.28
198_V202_V0.5790.28
63_T66_A0.5770.28
158_R230_F0.5760.28
284_E355_K0.5750.28
141_L361_V0.5730.27
85_D120_T0.5730.27
59_K62_R0.5730.27
311_A315_I0.5720.27
147_D225_Y0.5720.27
275_Y365_R0.5700.27
40_P103_K0.5680.27
190_M196_K0.5670.27
199_G230_F0.5670.27
53_S105_F0.5660.27
203_N314_A0.5650.27
144_V199_G0.5640.27
132_M358_N0.5640.27
136_T340_V0.5630.27
296_I317_I0.5620.27
139_Y198_V0.5610.27
106_M298_Y0.5600.27
24_K363_K0.5580.26
55_A62_R0.5580.26
151_I198_V0.5570.26
51_E140_G0.5560.26
159_I323_D0.5560.26
195_L225_Y0.5540.26
148_E256_E0.5530.26
42_P298_Y0.5530.26
127_E215_M0.5520.26
188_D229_D0.5510.26
124_F327_E0.5510.26
58_I91_L0.5500.26
29_V126_L0.5500.26
231_Y248_L0.5490.26
221_G278_V0.5480.26
101_D136_T0.5470.26
139_Y331_Q0.5460.26
258_G261_E0.5450.26
42_P342_V0.5440.26
343_V349_E0.5420.25
327_E331_Q0.5420.25
300_K307_M0.5410.25
219_L367_R0.5410.25
220_L240_I0.5400.25
31_L345_D0.5390.25
319_E346_E0.5370.25
69_S111_D0.5370.25
128_F132_M0.5360.25
300_K304_K0.5360.25
145_E148_E0.5350.25
51_E59_K0.5350.25
314_A331_Q0.5340.25
52_Y103_K0.5340.25
225_Y361_V0.5320.25
59_K64_R0.5310.25
261_E353_V0.5290.25
90_V110_P0.5280.25
305_K317_I0.5280.25
193_N206_F0.5270.25
347_V352_W0.5270.25
271_K277_E0.5260.24
96_N138_V0.5250.24
53_S97_F0.5250.24
36_P39_R0.5250.24
40_P117_F0.5240.24
74_A82_P0.5240.24
350_A358_N0.5220.24
139_Y360_I0.5210.24
224_G251_V0.5210.24
264_M303_I0.5210.24
258_G297_I0.5210.24
146_R258_G0.5190.24
274_Q350_A0.5180.24
295_L317_I0.5180.24
129_L234_D0.5170.24
193_N197_E0.5170.24
144_V195_L0.5160.24
188_D240_I0.5150.24
239_R300_K0.5140.24
93_C102_F0.5140.24
56_Q283_E0.5100.23
58_I352_W0.5100.23
120_T156_G0.5080.23
242_N267_E0.5060.23
48_L127_E0.5060.23
221_G259_L0.5050.23
25_A120_T0.5050.23
91_L365_R0.5040.23
103_K121_D0.5040.23
314_A366_Y0.5030.23
140_G156_G0.5030.23
96_N365_R0.5020.23
96_N101_D0.5020.23
236_V368_L0.5010.23
244_I313_E0.5010.23
164_E288_H0.5010.23
175_M191_Y0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qi2A 1 0.8184 100 0.272 Contact Map
3mcaB 1 0.8455 100 0.275 Contact Map
3obyA 1 0.8347 100 0.276 Contact Map
2vgnA 1 0.8726 100 0.29 Contact Map
4crnX 1 0.9946 100 0.316 Contact Map
3j15A 1 0.9051 100 0.318 Contact Map
3e20C 1 0.6179 100 0.318 Contact Map
1dt9A 1 0.9919 100 0.325 Contact Map
3wxmB 1 0.9051 100 0.333 Contact Map
3obwA 2 0.8266 100 0.343 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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