GREMLIN Database
Q97W95 - Purine phosphoribosyltransferase (GpT-1)
UniProt: Q97W95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (162)
Sequences: 2667 (1652)
Seq/√Len: 129.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_D138_Y3.8641.00
121_K137_D3.6521.00
108_R112_M3.0801.00
90_N118_T3.0431.00
17_L20_K2.8811.00
90_N119_E2.7591.00
10_T13_E2.6291.00
87_S116_R2.6081.00
26_K54_G2.5831.00
37_A46_A2.5321.00
35_I50_A2.4961.00
19_T52_V2.4901.00
17_L141_E2.4771.00
26_K55_V2.3661.00
105_E109_K2.0071.00
68_E156_W1.9831.00
31_N90_N1.9821.00
38_I107_A1.9701.00
117_P120_V1.9451.00
33_N92_L1.9401.00
11_W15_V1.9331.00
22_A26_K1.9111.00
102_D134_I1.8621.00
48_L51_D1.8411.00
48_L151_Y1.8351.00
143_I148_W1.8011.00
33_N89_K1.7391.00
43_L58_I1.7071.00
6_V146_W1.6831.00
21_L140_A1.6151.00
28_D121_K1.6131.00
31_N118_T1.6121.00
25_I49_V1.6021.00
80_Y83_K1.5971.00
128_I133_K1.5891.00
15_V52_V1.5881.00
108_R122_T1.5511.00
35_I92_L1.5321.00
98_T136_P1.5291.00
38_I61_I1.4831.00
35_I53_L1.4651.00
43_L47_R1.4501.00
17_L24_K1.4021.00
44_V50_A1.3891.00
22_A53_L1.3781.00
13_E16_S1.3771.00
127_Y148_W1.3651.00
24_K28_D1.3501.00
110_Y115_F1.3371.00
37_A42_G1.3261.00
88_D118_T1.3251.00
25_I53_L1.3231.00
4_I149_F1.3151.00
19_T23_E1.3051.00
128_I142_E1.3041.00
21_L123_A1.2991.00
20_K141_E1.2831.00
11_W52_V1.2691.00
81_P115_F1.2591.00
44_V47_R1.2481.00
127_Y165_K1.2311.00
49_V94_I1.2181.00
148_W153_W1.2060.99
95_D124_T1.2030.99
26_K53_L1.1660.99
11_W163_V1.1530.99
12_D16_S1.1520.99
47_R51_D1.1500.99
25_I123_A1.1370.99
23_E27_A1.1300.99
136_P139_Y1.1240.99
24_K27_A1.1040.99
23_E26_K1.0840.99
59_L80_Y1.0710.99
93_I108_R1.0650.99
16_S20_K1.0490.99
109_K113_E1.0420.98
131_A145_S1.0320.98
34_V89_K1.0270.98
18_S45_P1.0230.98
45_P123_A1.0180.98
109_K112_M1.0150.98
61_I78_V1.0000.98
43_L60_S0.9980.98
50_A58_I0.9870.98
82_F86_L0.9710.98
43_L50_A0.9690.98
32_V89_K0.9420.97
25_I92_L0.9410.97
127_Y143_I0.9410.97
40_R157_E0.9350.97
15_V48_L0.9330.97
131_A144_V0.9300.97
36_V82_F0.9140.96
86_L117_P0.9120.96
128_I132_A0.9100.96
38_I106_L0.9070.96
44_V51_D0.8980.96
9_V143_I0.8960.96
95_D122_T0.8890.96
106_L109_K0.8870.96
23_E54_G0.8860.96
39_A60_S0.8830.96
130_P142_E0.8690.95
93_I122_T0.8500.95
46_A58_I0.8450.95
20_K24_K0.8440.94
105_E135_I0.8410.94
62_K80_Y0.8330.94
8_V148_W0.8330.94
93_I111_V0.8250.94
124_T139_Y0.8230.94
32_V158_D0.8190.94
75_E85_D0.8110.93
34_V84_V0.8070.93
110_Y113_E0.8060.93
132_A145_S0.8010.93
103_S107_A0.7800.92
123_A138_Y0.7770.92
49_V53_L0.7650.91
57_D161_N0.7570.91
67_I73_T0.7550.90
14_I125_L0.7460.90
15_V51_D0.7410.90
131_A142_E0.7390.90
125_L165_K0.7320.89
91_V120_V0.7300.89
33_N90_N0.7290.89
24_K138_Y0.7290.89
7_K10_T0.7280.89
72_H102_D0.7260.89
111_V120_V0.7250.89
98_T124_T0.7230.88
9_V141_E0.7190.88
35_I46_A0.7130.88
3_K159_E0.7090.88
63_I103_S0.6930.86
128_I131_A0.6920.86
104_I122_T0.6890.86
33_N55_V0.6880.86
86_L111_V0.6840.86
75_E106_L0.6800.85
162_L166_I0.6690.84
18_S52_V0.6570.83
95_D98_T0.6560.83
65_H99_D0.6560.83
123_A136_P0.6520.83
128_I136_P0.6520.83
36_V59_L0.6490.83
15_V19_T0.6460.82
50_A57_D0.6450.82
26_K56_F0.6390.82
22_A52_V0.6380.81
86_L91_V0.6350.81
112_M120_V0.6310.81
22_A25_I0.6300.81
86_L120_V0.6290.81
38_I42_G0.6260.80
150_M160_I0.6250.80
92_L121_K0.6240.80
37_A44_V0.6210.80
40_R84_V0.6180.79
155_Y159_E0.6150.79
53_L56_F0.6150.79
63_I79_K0.6130.79
121_K138_Y0.6130.79
72_H76_A0.6120.79
93_I161_N0.6090.78
124_T130_P0.6080.78
92_L138_Y0.6060.78
111_V117_P0.6040.78
29_E32_V0.6020.78
77_K83_K0.6010.77
128_I139_Y0.5960.77
7_K166_I0.5960.77
102_D135_I0.5960.77
41_G96_D0.5950.77
9_V37_A0.5950.77
113_E116_R0.5930.77
62_K79_K0.5930.77
125_L141_E0.5900.76
67_I71_S0.5860.76
18_S49_V0.5830.75
67_I156_W0.5830.75
104_I136_P0.5790.75
35_I94_I0.5780.75
11_W164_N0.5770.75
18_S151_Y0.5750.74
36_V111_V0.5750.74
5_P157_E0.5710.74
22_A49_V0.5710.74
77_K110_Y0.5670.73
66_W154_N0.5640.73
9_V13_E0.5630.73
106_L110_Y0.5630.73
25_I33_N0.5590.72
139_Y142_E0.5580.72
52_V163_V0.5570.72
147_A155_Y0.5560.72
147_A154_N0.5530.71
122_T137_D0.5520.71
31_N119_E0.5480.71
93_I104_I0.5480.71
34_V86_L0.5470.71
147_A150_M0.5440.70
3_K158_D0.5430.70
38_I95_D0.5410.70
39_A43_L0.5410.70
17_L140_A0.5410.70
25_I28_D0.5400.70
105_E112_M0.5380.69
66_W99_D0.5370.69
70_A156_W0.5360.69
48_L52_V0.5340.69
90_N121_K0.5340.69
13_E17_L0.5330.69
45_P60_S0.5320.69
149_F159_E0.5300.68
69_T73_T0.5290.68
46_A104_I0.5280.68
9_V17_L0.5240.67
78_V110_Y0.5230.67
105_E108_R0.5220.67
51_D151_Y0.5210.67
30_Y90_N0.5210.67
9_V144_V0.5210.67
29_E33_N0.5200.67
71_S75_E0.5200.67
71_S139_Y0.5190.67
65_H72_H0.5180.67
92_L99_D0.5170.66
17_L139_Y0.5170.66
18_S44_V0.5090.65
32_V118_T0.5080.65
9_V148_W0.5070.65
42_G62_K0.5070.65
97_I143_I0.5060.65
44_V123_A0.5060.65
7_K164_N0.5040.64
43_L161_N0.5020.64
78_V115_F0.5010.64
42_G47_R0.5010.64
82_F115_F0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4trbA 2 0.981 100 0.352 Contact Map
5bqpA 3 0.8143 100 0.444 Contact Map
4raoA 4 0.8 100 0.454 Contact Map
3ozfA 4 0.8381 100 0.455 Contact Map
2jbhA 4 0.8238 100 0.458 Contact Map
4qriA 2 0.7381 100 0.461 Contact Map
4qyiA 3 0.7952 100 0.461 Contact Map
4rqaA 3 0.781 100 0.462 Contact Map
1fsgA 4 0.8333 100 0.463 Contact Map
1tc1A 2 0.8048 100 0.466 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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