GREMLIN Database
MTAP - S-methyl-5'-thioadenosine phosphorylase
UniProt: Q97W94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (239)
Sequences: 3886 (2393)
Seq/√Len: 154.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_C205_C4.1651.00
146_I159_S3.3731.00
163_I185_A3.0591.00
163_I179_W3.0201.00
178_T183_Y2.9451.00
106_V187_I2.9041.00
145_A207_A2.7721.00
97_R186_D2.5661.00
165_I179_W2.5601.00
140_S205_C2.4641.00
9_S85_R2.4601.00
45_I54_A2.3651.00
136_P196_V2.2771.00
151_E249_K2.2761.00
145_A246_L2.2701.00
118_R169_R2.2301.00
24_F27_S2.1791.00
245_A248_Q2.1671.00
24_F28_K2.1461.00
101_K104_D2.1351.00
9_S52_S2.0471.00
66_P69_K1.9781.00
147_E249_K1.9491.00
115_T164_C1.9331.00
151_E245_A1.9241.00
71_N198_L1.9061.00
47_K52_S1.8791.00
26_E47_K1.8751.00
9_S51_K1.8631.00
112_I185_A1.8041.00
29_E42_F1.8011.00
98_M180_R1.7971.00
230_R234_E1.7631.00
42_F57_P1.7631.00
187_I212_V1.7621.00
86_W205_C1.7311.00
11_G79_L1.7271.00
109_D159_S1.6831.00
143_K147_E1.6781.00
107_I156_T1.6561.00
162_Y189_G1.6301.00
107_I146_I1.5931.00
148_T245_A1.5911.00
49_G248_Q1.5801.00
148_T152_L1.5781.00
24_F29_E1.5761.00
152_L241_K1.5531.00
124_D201_E1.5501.00
95_S212_V1.5351.00
87_V204_M1.4901.00
152_L245_A1.4631.00
80_K202_A1.4561.00
107_I142_R1.4561.00
13_I76_I1.4551.00
226_E230_R1.4421.00
171_S214_D1.4281.00
13_I89_S1.4221.00
35_P225_A1.4181.00
23_I244_Y1.3951.00
49_G244_Y1.3781.00
176_S214_D1.3771.00
43_I54_A1.3701.00
60_G63_H1.3691.00
113_D116_K1.3641.00
149_A156_T1.3571.00
47_K50_N1.3531.00
89_S196_V1.3431.00
33_Y38_Q1.3381.00
91_S210_A1.3351.00
97_R100_Y1.3191.00
135_D173_R1.3171.00
231_V234_E1.3141.00
25_S47_K1.2931.00
176_S216_D1.2911.00
61_R67_P1.2901.00
135_D139_N1.2831.00
103_G231_V1.2801.00
43_I78_A1.2751.00
142_R146_I1.2641.00
37_G225_A1.2641.00
154_I238_K1.2611.00
96_L176_S1.2611.00
137_F192_L1.2591.00
76_I202_A1.2531.00
35_P38_Q1.2421.00
121_S166_E1.2371.00
31_K42_F1.2291.00
155_K158_E1.2181.00
80_K204_M1.2151.00
170_F228_V1.2041.00
148_T249_K1.1911.00
77_W81_E1.1911.00
106_V212_V1.1891.00
108_P208_T1.1881.00
10_I247_I1.1851.00
30_I33_Y1.1751.00
177_R181_E1.1741.00
112_I163_I1.1601.00
176_S218_F1.1571.00
20_D240_K1.1541.00
24_F55_F1.1391.00
233_A236_T1.1351.00
35_P77_W1.1311.00
80_K85_R1.1311.00
116_K166_E1.1251.00
221_I227_E1.1221.00
245_A249_K1.1171.00
24_F32_V1.1141.00
31_K38_Q1.1111.00
179_W185_A1.1100.99
102_L215_Y1.1000.99
231_V235_N1.0980.99
28_K32_V1.0960.99
224_T227_E1.0850.99
111_F137_F1.0730.99
100_Y212_V1.0560.99
86_W141_L1.0530.99
21_P48_I1.0510.99
27_S30_I1.0400.99
95_S100_Y1.0400.99
234_E238_K1.0290.99
148_T246_L1.0280.99
144_L249_K1.0260.99
211_M235_N1.0250.99
34_T38_Q1.0130.99
104_D155_K1.0060.99
89_S208_T1.0050.99
169_R197_N1.0040.99
146_I158_E0.9970.99
84_V204_M0.9970.99
101_K215_Y0.9880.99
114_M163_I0.9740.99
176_S219_A0.9640.99
207_A246_L0.9570.98
144_L147_E0.9540.98
76_I87_V0.9490.98
180_R219_A0.9490.98
154_I242_L0.9340.98
177_R180_R0.9260.98
142_R159_S0.9210.98
225_A229_T0.9100.98
164_C193_V0.9060.98
24_F30_I0.9040.98
105_F211_M0.9010.98
164_C194_P0.9000.98
229_T233_A0.8960.98
65_I69_K0.8920.98
117_N121_S0.8860.98
179_W188_I0.8840.97
176_S217_V0.8770.97
177_R186_D0.8740.97
133_M197_N0.8700.97
101_K155_K0.8690.97
165_I214_D0.8670.97
109_D142_R0.8650.97
65_I71_N0.8640.97
237_E241_K0.8590.97
77_W201_E0.8570.97
93_V212_V0.8560.97
149_A242_L0.8500.97
144_L246_L0.8450.97
41_D61_R0.8420.97
67_P71_N0.8420.97
29_E32_V0.8410.97
104_D158_E0.8410.97
54_A79_L0.8410.97
219_A223_V0.8370.97
105_F209_I0.8340.96
112_I178_T0.8340.96
132_S223_V0.8320.96
124_D127_V0.8310.96
171_S176_S0.8290.96
213_T232_M0.8260.96
107_I145_A0.8240.96
117_N166_E0.8210.96
39_P57_P0.8190.96
135_D138_C0.8160.96
170_F225_A0.8140.96
148_T151_E0.8110.96
141_L207_A0.8110.96
11_G84_V0.8090.96
192_L208_T0.8080.96
217_V223_V0.8060.96
235_N238_K0.7990.95
19_Y57_P0.7980.95
93_V187_I0.7910.95
211_M239_A0.7890.95
209_I242_L0.7870.95
43_I82_L0.7790.95
95_S215_Y0.7740.95
144_L148_T0.7720.95
138_C200_C0.7690.94
238_K241_K0.7680.94
91_S192_L0.7640.94
88_I243_L0.7620.94
67_P70_I0.7620.94
119_E124_D0.7620.94
88_I246_L0.7590.94
30_I45_I0.7590.94
146_I150_K0.7560.94
26_E29_E0.7560.94
16_S37_G0.7550.94
39_P42_F0.7480.94
147_E150_K0.7460.93
54_A84_V0.7440.93
135_D200_C0.7330.93
196_V206_Y0.7290.93
165_I171_S0.7290.93
60_G64_R0.7280.93
36_Y126_P0.7280.93
100_Y106_V0.7280.93
61_R166_E0.7260.93
96_L179_W0.7240.92
23_I240_K0.7220.92
108_P187_I0.7170.92
86_W138_C0.7150.92
120_Y193_V0.7130.92
165_I176_S0.7100.92
100_Y158_E0.7090.92
218_F223_V0.7090.92
111_F172_T0.7080.92
173_R217_V0.7060.91
120_Y197_N0.7040.91
225_A228_V0.7030.91
110_Q161_T0.7010.91
67_P115_T0.6990.91
156_T242_L0.6980.91
109_D160_G0.6900.91
80_K203_Q0.6820.90
54_A82_L0.6790.90
111_F193_V0.6780.90
214_D219_A0.6770.90
88_I207_A0.6760.90
107_I209_I0.6760.90
27_S32_V0.6710.89
139_N143_K0.6710.89
67_P194_P0.6710.89
176_S223_V0.6710.89
113_D118_R0.6620.89
114_M179_W0.6610.89
227_E230_R0.6600.88
56_L79_L0.6600.88
177_R219_A0.6580.88
241_K245_A0.6560.88
29_E61_R0.6560.88
19_Y55_F0.6530.88
111_F133_M0.6530.88
12_I247_I0.6510.88
63_H73_R0.6500.88
145_A242_L0.6490.88
58_R62_G0.6490.88
133_M136_P0.6480.88
141_L250_L0.6480.88
214_D218_F0.6480.88
109_D161_T0.6480.88
142_R158_E0.6470.88
193_V196_V0.6470.88
34_T41_D0.6470.88
58_R63_H0.6440.87
163_I183_Y0.6430.87
100_Y104_D0.6410.87
134_A217_V0.6380.87
110_Q136_P0.6380.87
10_I51_K0.6310.86
144_L250_L0.6310.86
58_R67_P0.6300.86
115_T166_E0.6300.86
118_R121_S0.6300.86
118_R166_E0.6280.86
69_K124_D0.6270.86
104_D238_K0.6240.86
13_I87_V0.6240.86
114_M165_I0.6230.85
86_W140_S0.6230.85
48_I247_I0.6220.85
200_C203_Q0.6210.85
152_L242_L0.6190.85
150_K155_K0.6160.85
10_I86_W0.6160.85
20_D236_T0.6140.85
215_Y219_A0.6120.84
43_I79_L0.6110.84
58_R61_R0.6100.84
173_R214_D0.6090.84
16_S225_A0.6070.84
193_V197_N0.6030.84
136_P172_T0.6020.84
137_F208_T0.6000.83
178_T181_E0.5990.83
241_K244_Y0.5990.83
148_T207_A0.5950.83
41_D57_P0.5940.83
150_K158_E0.5940.83
135_D222_P0.5940.83
232_M236_T0.5940.83
48_I51_K0.5930.83
136_P173_R0.5910.82
8_A45_I0.5880.82
145_A209_I0.5870.82
113_D117_N0.5820.81
237_E240_K0.5820.81
112_I183_Y0.5810.81
109_D173_R0.5800.81
66_P124_D0.5800.81
91_S189_G0.5800.81
60_G73_R0.5790.81
67_P166_E0.5770.81
9_S86_W0.5770.81
236_T240_K0.5770.81
89_S206_Y0.5760.81
37_G170_F0.5730.80
162_Y192_L0.5720.80
96_L180_R0.5710.80
24_F46_G0.5650.79
115_T194_P0.5600.79
87_V199_A0.5590.79
76_I79_L0.5580.79
11_G54_A0.5570.79
60_G71_N0.5570.79
199_A206_Y0.5550.78
135_D142_R0.5520.78
29_E44_T0.5520.78
86_W250_L0.5510.78
110_Q134_A0.5510.78
72_Y78_A0.5510.78
97_R215_Y0.5500.78
219_A222_P0.5470.77
77_W198_L0.5460.77
13_I79_L0.5450.77
58_R66_P0.5440.77
100_Y187_I0.5410.77
30_I82_L0.5410.77
173_R223_V0.5410.77
28_K33_Y0.5370.76
7_K85_R0.5350.76
69_K125_G0.5350.76
93_V213_T0.5340.76
16_S170_F0.5340.76
67_P73_R0.5320.75
99_D158_E0.5300.75
67_P117_N0.5290.75
194_P198_L0.5270.75
178_T185_A0.5260.75
116_K120_Y0.5240.74
234_E237_E0.5230.74
98_M215_Y0.5210.74
209_I243_L0.5210.74
115_T165_I0.5140.73
214_D220_E0.5140.73
96_L218_F0.5130.73
22_G240_K0.5130.73
85_R205_C0.5110.72
24_F33_Y0.5100.72
165_I217_V0.5080.72
119_E197_N0.5070.72
105_F242_L0.5070.72
105_F239_A0.5010.71
111_F192_L0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p4sA 3 0.9259 100 0.359 Contact Map
3la8A 1 0.8259 100 0.367 Contact Map
4earA 3 0.9296 100 0.375 Contact Map
2a8yA 5 0.9704 100 0.384 Contact Map
1vmkA 3 0.8444 100 0.385 Contact Map
4m1eA 5 0.9111 100 0.386 Contact Map
1tcvA 3 0.9111 100 0.388 Contact Map
3khsA 3 0.8926 100 0.391 Contact Map
4l5cA 3 0.963 100 0.391 Contact Map
4gljA 3 0.9741 100 0.394 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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