GREMLIN Database
HEXPP - Hexaprenyl pyrophosphate synthase
UniProt: Q97W92 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (259)
Sequences: 9895 (6682)
Seq/√Len: 415.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_T63_S3.6801.00
178_H181_T3.3861.00
170_V186_L3.3591.00
88_A98_V3.1281.00
166_K186_L3.0671.00
166_K190_K2.5891.00
158_E190_K2.5731.00
115_T118_R2.4951.00
89_T94_K2.4551.00
170_V182_K2.4551.00
243_K260_E2.3551.00
131_T170_V2.3201.00
208_K211_E2.2911.00
215_G218_K2.2901.00
131_T174_Y2.2461.00
84_V143_A2.1361.00
263_S267_F2.1141.00
155_R159_L2.1051.00
173_A185_M2.0941.00
52_F185_M2.0701.00
52_F169_T1.9991.00
10_A54_V1.9681.00
56_L181_T1.9341.00
17_L68_L1.8991.00
101_G104_K1.8721.00
169_T189_G1.8511.00
17_L65_G1.8271.00
240_Y267_F1.7961.00
187_D191_Y1.7961.00
242_Q246_E1.7521.00
183_Q187_D1.7471.00
239_E242_Q1.7461.00
241_K245_D1.7331.00
167_L171_L1.7311.00
80_L110_N1.7091.00
177_K181_T1.6991.00
65_G122_T1.6821.00
80_L109_T1.6801.00
35_S39_K1.6631.00
104_K144_L1.6611.00
231_E270_N1.6471.00
17_L20_Q1.6261.00
19_E35_S1.5921.00
15_D43_R1.5901.00
218_K222_K1.5901.00
130_N134_E1.5891.00
243_K246_E1.5511.00
237_Y240_Y1.5391.00
118_R134_E1.5381.00
173_A177_K1.5371.00
259_S263_S1.5161.00
53_T58_G1.5071.00
122_T130_N1.5031.00
51_F54_V1.4931.00
87_D218_K1.4921.00
260_E263_S1.4751.00
79_A96_A1.4691.00
145_R155_R1.4671.00
262_R266_E1.4511.00
121_Q129_L1.4411.00
231_E235_S1.4401.00
166_K170_V1.4301.00
172_S175_A1.4261.00
131_T135_L1.4261.00
153_Y157_I1.4201.00
207_T212_E1.4111.00
235_S238_L1.4041.00
143_A146_D1.3851.00
265_P270_N1.3561.00
179_Y183_Q1.3511.00
209_K216_S1.3421.00
29_D148_Y1.3401.00
52_F56_L1.3381.00
132_S135_L1.3281.00
83_I102_N1.3261.00
15_D18_I1.3051.00
69_A120_I1.2981.00
16_R20_Q1.2961.00
50_M67_A1.2951.00
72_I119_I1.2851.00
158_E194_I1.2781.00
259_S262_R1.2781.00
164_L168_S1.2771.00
29_D101_G1.2761.00
31_V35_S1.2561.00
77_S139_T1.2541.00
231_E234_R1.2531.00
248_I266_E1.2311.00
37_I96_A1.2301.00
138_D159_L1.2251.00
145_R159_L1.2221.00
209_K215_G1.2081.00
173_A182_K1.2011.00
260_E264_L1.1981.00
245_D249_S1.1941.00
181_T184_Q1.1891.00
66_G171_L1.1821.00
256_K259_S1.1801.00
56_L175_A1.1751.00
66_G120_I1.1731.00
203_V212_E1.1671.00
13_T64_Y1.1661.00
202_F206_K1.1631.00
50_M64_Y1.1571.00
125_G128_A1.1531.00
265_P269_A1.1501.00
12_A15_D1.1481.00
149_D156_T1.1441.00
17_L21_F1.1381.00
56_L172_S1.1281.00
19_E39_K1.1271.00
48_L169_T1.1201.00
145_R156_T1.1181.00
155_R158_E1.1131.00
169_T185_M1.1061.00
94_K98_V1.1031.00
39_K93_D1.0991.00
33_I96_A1.0961.00
130_N135_L1.0961.00
170_V174_Y1.0921.00
180_N184_Q1.0841.00
157_I194_I1.0791.00
14_I18_I1.0771.00
163_S166_K1.0751.00
265_P268_L1.0741.00
154_I158_E1.0661.00
11_K15_D1.0631.00
56_L177_K1.0611.00
16_R19_E1.0591.00
261_I265_P1.0531.00
131_T167_L1.0511.00
40_D43_R1.0511.00
49_N70_I1.0511.00
83_I106_I1.0481.00
205_Y228_K1.0341.00
153_Y230_E1.0331.00
13_T61_K1.0231.00
258_L262_R1.0221.00
84_V107_F1.0201.00
53_T175_A1.0131.00
154_I194_I1.0131.00
86_L102_N1.0081.00
97_W102_N1.0061.00
243_K247_L1.0051.00
238_L242_Q1.0041.00
205_Y220_L1.0011.00
191_Y246_E0.9981.00
28_W32_D0.9961.00
14_I68_L0.9931.00
49_N63_S0.9901.00
212_E216_S0.9851.00
15_D19_E0.9781.00
13_T60_I0.9771.00
169_T188_V0.9731.00
244_Y261_I0.9591.00
263_S266_E0.9551.00
206_K237_Y0.9551.00
149_D152_D0.9521.00
29_D32_D0.9511.00
95_A98_V0.9461.00
246_E250_N0.9331.00
118_R137_K0.9321.00
183_Q186_L0.9281.00
94_K99_V0.9281.00
257_Y265_P0.9251.00
34_S111_Y0.9221.00
150_N225_R0.9211.00
199_I240_Y0.9191.00
12_A16_R0.9191.00
89_T209_K0.9141.00
72_I115_T0.9131.00
59_D62_D0.9111.00
43_R46_G0.9071.00
135_L167_L0.9061.00
50_M63_S0.9061.00
118_R122_T0.9061.00
232_Y265_P0.9051.00
168_S172_S0.9001.00
184_Q188_V0.8971.00
131_T134_E0.8951.00
202_F233_V0.8871.00
36_Y99_V0.8801.00
96_A100_Y0.8751.00
236_V240_Y0.8721.00
88_A97_W0.8711.00
156_T224_Y0.8671.00
14_I50_M0.8621.00
36_Y93_D0.8621.00
266_E269_A0.8581.00
58_G63_S0.8581.00
46_G75_S0.8561.00
187_D190_K0.8561.00
13_T16_R0.8521.00
21_F122_T0.8511.00
55_A185_M0.8491.00
36_Y100_Y0.8461.00
242_Q245_D0.8381.00
54_V60_I0.8361.00
170_V183_Q0.8351.00
146_D224_Y0.8331.00
76_A113_I0.8321.00
68_L119_I0.8301.00
166_K189_G0.8301.00
190_K194_I0.8281.00
37_I75_S0.8231.00
11_K47_T0.8211.00
10_A13_T0.8171.00
264_L267_F0.8161.00
182_K186_L0.8121.00
79_A105_V0.8121.00
21_F119_I0.8111.00
186_L190_K0.8041.00
65_G123_S0.8031.00
145_R149_D0.8021.00
32_D36_Y0.7991.00
244_Y248_I0.7981.00
240_Y268_L0.7871.00
233_V245_D0.7771.00
49_N67_A0.7741.00
123_S126_D0.7741.00
174_Y182_K0.7741.00
96_A99_V0.7721.00
29_D104_K0.7671.00
229_L248_I0.7631.00
111_Y140_S0.7591.00
21_F65_G0.7541.00
250_N257_Y0.7501.00
260_E266_E0.7481.00
255_S258_L0.7461.00
48_L192_L0.7381.00
114_P140_S0.7381.00
212_E215_G0.7371.00
203_V207_T0.7361.00
37_I79_A0.7341.00
238_L241_K0.7341.00
34_S112_L0.7321.00
33_I108_I0.7321.00
151_S154_I0.7311.00
266_E270_N0.7301.00
196_Y200_D0.7281.00
13_T17_L0.7271.00
118_R130_N0.7261.00
117_L133_I0.7241.00
10_A50_M0.7231.00
228_K231_E0.7221.00
139_T165_F0.7221.00
84_V140_S0.7191.00
207_T211_E0.7191.00
77_S164_L0.7161.00
200_D203_V0.7131.00
45_R196_Y0.7121.00
113_I140_S0.7081.00
49_N172_S0.7071.00
74_H77_S0.7071.00
232_Y264_L0.7021.00
65_G119_I0.7021.00
236_V264_L0.6981.00
132_S171_L0.6971.00
198_V202_F0.6911.00
249_S252_P0.6911.00
199_I202_F0.6891.00
232_Y270_N0.6891.00
49_N168_S0.6891.00
103_R147_M0.6871.00
227_G231_E0.6831.00
156_T159_L0.6831.00
247_L261_I0.6781.00
70_I171_L0.6751.00
158_E163_S0.6741.00
204_D218_K0.6731.00
127_D130_N0.6731.00
191_Y194_I0.6680.99
250_N253_F0.6670.99
235_S239_E0.6580.99
64_Y68_L0.6540.99
236_V268_L0.6520.99
262_R265_P0.6490.99
122_T134_E0.6470.99
159_L163_S0.6470.99
162_G194_I0.6450.99
161_T196_Y0.6420.99
165_F192_L0.6390.99
79_A112_L0.6380.99
141_V159_L0.6380.99
27_D31_V0.6370.99
58_G172_S0.6360.99
66_G123_S0.6360.99
70_I168_S0.6330.99
62_D123_S0.6300.99
23_N35_S0.6290.99
93_D99_V0.6280.99
114_P117_L0.6280.99
56_L185_M0.6270.99
65_G68_L0.6250.99
33_I104_K0.6240.99
121_Q133_I0.6230.99
34_S108_I0.6230.99
184_Q187_D0.6220.99
84_V147_M0.6200.99
73_L132_S0.6190.99
115_T137_K0.6190.99
153_Y227_G0.6170.99
151_S155_R0.6160.99
144_L148_Y0.6140.99
231_E239_E0.6110.99
188_V191_Y0.6110.99
262_R269_A0.6080.99
17_L64_Y0.6070.99
178_H183_Q0.6050.99
207_T216_S0.6020.99
79_A83_I0.6010.99
119_I122_T0.5990.99
204_D212_E0.5960.99
102_N106_I0.5940.99
252_P262_R0.5920.99
61_K65_G0.5900.99
121_Q130_N0.5900.99
61_K64_Y0.5890.99
23_N31_V0.5880.99
76_A114_P0.5870.99
198_V239_E0.5860.99
38_L75_S0.5850.99
152_D156_T0.5850.99
28_W31_V0.5830.99
264_L268_L0.5810.99
14_I64_Y0.5790.99
124_Y128_A0.5790.99
73_L116_A0.5750.98
173_A189_G0.5740.98
145_R152_D0.5740.98
45_R74_H0.5700.98
161_T165_F0.5690.98
127_D182_K0.5640.98
218_K221_F0.5640.98
87_D215_G0.5610.98
239_E243_K0.5600.98
134_E170_V0.5590.98
160_K197_Q0.5580.98
209_K212_E0.5580.98
232_Y268_L0.5570.98
256_K260_E0.5560.98
257_Y260_E0.5560.98
62_D125_G0.5550.98
18_I39_K0.5550.98
57_G60_I0.5500.98
19_E23_N0.5480.98
83_I103_R0.5470.98
117_L120_I0.5450.98
163_S190_K0.5450.98
49_N53_T0.5430.98
154_I198_V0.5430.98
50_M54_V0.5420.98
221_F255_S0.5420.98
79_A108_I0.5390.98
81_D85_D0.5390.98
140_S147_M0.5390.98
114_P136_W0.5380.98
45_R78_L0.5380.98
232_Y236_V0.5380.98
72_I112_L0.5360.98
247_L250_N0.5350.98
115_T119_I0.5320.97
253_F257_Y0.5300.97
255_S259_S0.5300.97
138_D141_V0.5290.97
260_E267_F0.5290.97
47_T51_F0.5280.97
138_D158_E0.5250.97
33_I36_Y0.5230.97
217_A258_L0.5220.97
260_E265_P0.5210.97
49_N171_L0.5210.97
87_D204_D0.5180.97
204_D215_G0.5180.97
234_R237_Y0.5160.97
153_Y228_K0.5110.97
179_Y182_K0.5110.97
150_N222_K0.5110.97
86_L97_W0.5100.97
52_F172_S0.5090.97
82_D90_R0.5060.97
156_T225_R0.5040.96
43_R47_T0.5020.96
150_N224_Y0.5020.96
32_D35_S0.5020.96
149_D225_R0.5020.96
145_R148_Y0.5020.96
238_L245_D0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oyrA 2 0.9964 100 0.092 Contact Map
3mzvA 2 1 100 0.1 Contact Map
1wy0A 2 0.9929 100 0.1 Contact Map
4jxyA 5 0.9253 100 0.102 Contact Map
3wjkA 2 0.9715 100 0.105 Contact Map
4dhdA 2 0.968 100 0.11 Contact Map
3rmgA 2 0.9324 100 0.112 Contact Map
4lobA 2 0.9359 100 0.112 Contact Map
3aqbB 1 0.9893 100 0.112 Contact Map
3lmdA 2 0.9217 100 0.116 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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