GREMLIN Database
Q97W91 - Ribosomal protein S6 modification protein (RimK-3)
UniProt: Q97W91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 230 (208)
Sequences: 30352 (17641)
Seq/√Len: 1223.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_N116_K3.5211.00
167_E171_K2.8151.00
94_D97_I2.6841.00
188_D191_N2.6711.00
71_E95_P2.6571.00
188_D193_G2.5961.00
67_M99_F2.5141.00
47_M196_I2.3961.00
18_R35_L2.2351.00
58_A72_R2.1911.00
53_P193_G2.1911.00
179_D182_G2.1901.00
44_L115_Q2.1061.00
41_F59_L2.0661.00
47_M172_S2.0431.00
95_P99_F2.0111.00
170_L174_R1.9851.00
91_K117_Y1.8581.00
62_D65_E1.8141.00
69_L73_W1.7901.00
18_R22_R1.7651.00
67_M95_P1.7341.00
19_E23_N1.7061.00
41_F45_M1.6871.00
39_D81_V1.6551.00
45_M49_R1.6531.00
42_A45_M1.6511.00
36_L42_A1.6461.00
69_L72_R1.6391.00
58_A69_L1.6131.00
36_L46_R1.5741.00
93_S97_I1.5691.00
48_R56_N1.5651.00
168_I194_Y1.5531.00
43_S47_M1.5511.00
45_M48_R1.5431.00
164_E168_I1.5271.00
173_V181_A1.5251.00
178_L182_G1.5241.00
171_K175_V1.5221.00
99_F103_K1.5131.00
218_K222_T1.5001.00
125_I187_E1.4941.00
50_A175_V1.4871.00
163_A167_E1.4801.00
123_R139_Y1.4431.00
215_N218_K1.4361.00
63_P99_F1.4291.00
90_V104_A1.4241.00
77_V91_K1.4221.00
35_L42_A1.4001.00
49_R175_V1.3891.00
187_E194_Y1.3791.00
41_F81_V1.3771.00
171_K174_R1.3521.00
67_M71_E1.3511.00
32_D36_L1.3451.00
164_E193_G1.3391.00
52_I196_I1.3361.00
102_A106_L1.3291.00
183_I199_V1.3251.00
53_P168_I1.3201.00
46_R49_R1.3201.00
63_P67_M1.3161.00
163_A166_E1.3161.00
168_I171_K1.3111.00
100_R104_A1.3101.00
186_I197_I1.3051.00
48_R54_V1.2981.00
19_E22_R1.2891.00
81_V111_P1.2741.00
30_R33_S1.2691.00
130_I219_Y1.2681.00
164_E167_E1.2631.00
77_V117_Y1.2431.00
76_V114_V1.2321.00
129_V173_V1.2281.00
21_E30_R1.2161.00
44_L54_V1.2081.00
118_V195_K1.2061.00
63_P103_K1.2051.00
77_V89_S1.2001.00
46_R175_V1.1891.00
20_L27_L1.1821.00
219_Y222_T1.1741.00
18_R31_P1.1481.00
140_R143_K1.1401.00
93_S119_K1.1391.00
21_E31_P1.1311.00
127_V165_L1.1151.00
155_T158_V1.1151.00
20_L25_V1.1101.00
21_E27_L1.1051.00
166_E170_L1.1041.00
127_V169_S1.0991.00
135_L138_I1.0971.00
188_D195_K1.0971.00
56_N73_W1.0841.00
116_K195_K1.0791.00
169_S185_I1.0701.00
68_R72_R1.0701.00
221_V225_I1.0471.00
214_I219_Y1.0421.00
92_V101_V1.0381.00
73_W76_V1.0361.00
53_P195_K1.0301.00
141_I144_S1.0251.00
59_L111_P1.0221.00
123_R187_E1.0141.00
60_V69_L1.0081.00
172_S175_V1.0051.00
118_V197_I1.0041.00
133_K179_D0.9961.00
41_F111_P0.9931.00
90_V101_V0.9901.00
46_R50_A0.9901.00
57_T115_Q0.9881.00
70_A76_V0.9871.00
76_V92_V0.9861.00
139_Y142_S0.9841.00
23_N26_V0.9771.00
82_V109_N0.9761.00
66_V98_A0.9751.00
106_L110_Q0.9741.00
56_N72_R0.9701.00
37_A176_L0.9661.00
125_I165_L0.9651.00
48_R57_T0.9651.00
105_I112_V0.9631.00
142_S145_G0.9541.00
45_M57_T0.9521.00
34_M201_A0.9501.00
147_K151_A0.9471.00
32_D35_L0.9471.00
61_E65_E0.9411.00
135_L139_Y0.9401.00
65_E68_R0.9391.00
154_A157_Q0.9331.00
178_L181_A0.9311.00
168_I172_S0.9301.00
165_L168_I0.9281.00
70_A95_P0.9271.00
104_A107_S0.9221.00
136_G140_R0.9211.00
61_E111_P0.9211.00
167_E170_L0.9151.00
55_P118_V0.9121.00
131_G137_S0.9041.00
64_F67_M0.9041.00
106_L112_V0.8961.00
129_V169_S0.8931.00
172_S176_L0.8891.00
68_R71_E0.8891.00
159_L211_A0.8791.00
37_A199_V0.8791.00
66_V102_A0.8791.00
103_K107_S0.8761.00
130_I223_H0.8711.00
63_P102_A0.8621.00
97_I100_R0.8581.00
18_R32_D0.8541.00
119_K188_D0.8511.00
221_V224_L0.8471.00
156_A159_L0.8471.00
135_L140_R0.8361.00
75_E117_Y0.8311.00
30_R179_D0.8251.00
152_Q155_T0.8231.00
39_D82_V0.8221.00
41_F113_Y0.8201.00
116_K188_D0.8201.00
70_A75_E0.8191.00
141_I145_G0.8171.00
140_R144_S0.8141.00
137_S140_R0.8111.00
127_V166_E0.8081.00
63_P106_L0.8081.00
26_V225_I0.8011.00
67_M70_A0.8001.00
180_Y202_A0.7971.00
81_V113_Y0.7931.00
165_L194_Y0.7911.00
138_I142_S0.7901.00
52_I171_K0.7891.00
90_V105_I0.7891.00
78_I114_V0.7751.00
118_V188_D0.7701.00
101_V105_I0.7681.00
138_I141_I0.7601.00
17_L27_L0.7601.00
18_R21_E0.7561.00
148_T153_G0.7541.00
185_I194_Y0.7531.00
100_R103_K0.7501.00
134_V140_R0.7491.00
129_V183_I0.7471.00
187_E192_G0.7391.00
222_T225_I0.7391.00
41_F57_T0.7381.00
37_A201_A0.7381.00
75_E93_S0.7341.00
131_G174_R0.7321.00
136_G139_Y0.7281.00
134_V139_Y0.7211.00
70_A98_A0.7131.00
39_D42_A0.7081.00
49_R176_L0.7021.00
168_I185_I0.7021.00
165_L185_I0.7021.00
78_I92_V0.7001.00
78_I101_V0.7001.00
82_V111_P0.6921.00
39_D111_P0.6881.00
132_D174_R0.6881.00
65_E69_L0.6871.00
32_D42_A0.6841.00
31_P35_L0.6831.00
60_V66_V0.6811.00
64_F68_R0.6811.00
118_V122_D0.6731.00
74_G116_K0.6721.00
139_Y145_G0.6701.00
149_N153_G0.6681.00
149_N152_Q0.6671.00
173_V176_L0.6641.00
192_G195_K0.6641.00
33_S177_G0.6611.00
75_E91_K0.6601.00
140_R145_G0.6581.00
55_P195_K0.6581.00
47_M199_V0.6511.00
129_V170_L0.6511.00
44_L57_T0.6501.00
53_P164_E0.6501.00
93_S117_Y0.6451.00
125_I185_I0.6421.00
135_L142_S0.6411.00
42_A46_R0.6401.00
150_I153_G0.6401.00
96_D99_F0.6361.00
130_I180_Y0.6331.00
139_Y166_E0.6301.00
101_V104_A0.6281.00
78_I112_V0.6271.00
129_V181_A0.6261.00
145_G148_T0.6261.00
16_V20_L0.6241.00
117_Y186_I0.6211.00
46_R172_S0.6211.00
52_I168_I0.6191.00
15_D18_R0.6151.00
54_V57_T0.6141.00
33_S37_A0.6121.00
138_I143_K0.6101.00
183_I196_I0.6071.00
147_K150_I0.6051.00
96_D100_R0.6041.00
71_E99_F0.5961.00
216_P220_I0.5961.00
92_V98_A0.5931.00
63_P66_V0.5921.00
164_E171_K0.5911.00
40_K89_S0.5901.00
131_G226_E0.5891.00
50_A176_L0.5891.00
17_L21_E0.5891.00
92_V97_I0.5891.00
59_L81_V0.5891.00
169_S183_I0.5851.00
220_I224_L0.5851.00
137_S141_I0.5851.00
188_D192_G0.5841.00
45_M59_L0.5831.00
217_A221_V0.5821.00
47_M54_V0.5821.00
146_W149_N0.5821.00
73_W116_K0.5791.00
27_L31_P0.5781.00
169_S172_S0.5781.00
119_K122_D0.5741.00
116_K193_G0.5681.00
147_K152_Q0.5681.00
164_E194_Y0.5641.00
154_A158_V0.5641.00
160_I192_G0.5621.00
119_K123_R0.5581.00
132_D136_G0.5521.00
52_I172_S0.5501.00
169_S199_V0.5471.00
148_T151_A0.5461.00
203_P216_P0.5451.00
90_V100_R0.5451.00
58_A73_W0.5401.00
44_L48_R0.5401.00
102_A112_V0.5391.00
155_T159_L0.5391.00
127_V185_I0.5351.00
172_S196_I0.5281.00
148_T152_Q0.5281.00
158_V161_P0.5231.00
210_A213_N0.5201.00
78_I102_A0.5201.00
154_A211_A0.5181.00
70_A73_W0.5171.00
139_Y143_K0.5171.00
140_R146_W0.5111.00
155_T160_I0.5101.00
46_R176_L0.5091.00
124_D184_D0.5061.00
50_A172_S0.5021.00
151_A154_A0.5021.00
137_S142_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vpbA 3 0.9957 100 0.29 Contact Map
3vpdA 3 0.987 100 0.295 Contact Map
4iwxA 3 0.9826 100 0.296 Contact Map
4fu0A 2 0.9783 100 0.304 Contact Map
3i12A 2 0.9783 100 0.318 Contact Map
3e5nA 2 0.9348 100 0.319 Contact Map
3lwbA 2 0.9826 100 0.321 Contact Map
2fb9A 2 0.9652 100 0.321 Contact Map
4eg0A 2 0.9217 100 0.323 Contact Map
2i87A 2 0.9391 100 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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