GREMLIN Database
Q97W90 - Transcriptional regulatory protein, AsnC family (AsnC)
UniProt: Q97W90 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 153 (139)
Sequences: 13692 (8801)
Seq/√Len: 746.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_K57_F2.9281.00
18_I33_M2.9251.00
77_K135_S2.5511.00
105_E137_Y2.4691.00
98_E111_K2.4551.00
115_P119_D2.2751.00
27_F45_I2.2611.00
64_D118_E2.0831.00
55_K62_D2.0491.00
12_D44_R2.0301.00
47_R51_N2.0041.00
18_I25_I2.0001.00
93_M126_K1.8971.00
79_D134_T1.8831.00
71_V111_K1.8511.00
97_Y113_R1.8011.00
73_F100_Y1.7771.00
25_I33_M1.7641.00
55_K60_E1.7581.00
11_I36_L1.7341.00
93_M123_V1.6761.00
46_K50_E1.6731.00
18_I21_Q1.6471.00
36_L40_T1.6441.00
28_S32_K1.6081.00
75_L139_M1.5961.00
116_T119_D1.5541.00
89_Q130_M1.5331.00
29_R32_K1.4901.00
119_D122_K1.4851.00
95_E119_D1.4721.00
89_Q92_E1.4541.00
28_S38_E1.4521.00
36_L41_I1.4461.00
86_I90_L1.4301.00
37_S40_T1.4191.00
76_I110_L1.4011.00
15_I30_L1.3961.00
82_K85_N1.3841.00
27_F42_Y1.3831.00
24_R57_F1.3641.00
34_L41_I1.3571.00
87_L91_V1.3361.00
77_K105_E1.3271.00
74_I112_V1.3241.00
84_D88_K1.3191.00
122_K125_D1.3151.00
10_D14_K1.2991.00
29_R33_M1.2761.00
25_I30_L1.2671.00
75_L106_Y1.2631.00
19_L45_I1.2621.00
70_V117_R1.2551.00
68_L115_P1.2441.00
77_K134_T1.2111.00
78_A86_I1.2081.00
87_L143_R1.2071.00
121_A143_R1.2001.00
11_I14_K1.1921.00
46_K49_K1.1891.00
21_Q33_M1.1751.00
95_E126_K1.1671.00
26_P29_R1.1441.00
25_I29_R1.1311.00
22_D33_M1.1121.00
18_I30_L1.1091.00
56_G60_E1.1051.00
71_V113_R1.0971.00
9_D44_R1.0841.00
11_I34_L1.0751.00
14_K17_N1.0451.00
14_K18_I1.0391.00
75_L137_Y1.0321.00
27_F31_A1.0281.00
96_I112_V1.0241.00
22_D25_I1.0171.00
23_S57_F0.9921.00
42_Y46_K0.9821.00
114_V119_D0.9771.00
87_L108_A0.9771.00
85_N89_Q0.9711.00
31_A41_I0.9701.00
38_E42_Y0.9641.00
88_K91_V0.9621.00
99_I110_L0.9571.00
17_N21_Q0.9541.00
14_K34_L0.9421.00
73_F109_V0.9411.00
24_R49_K0.9381.00
100_Y111_K0.9381.00
102_V109_V0.9271.00
114_V120_L0.9261.00
114_V123_V0.9111.00
112_V123_V0.9071.00
73_F111_K0.9041.00
62_D65_K0.9011.00
8_L13_K0.8831.00
88_K92_E0.8791.00
27_F38_E0.8781.00
63_F113_R0.8531.00
31_A36_L0.8451.00
48_L53_V0.8431.00
69_S116_T0.8401.00
73_F141_V0.8401.00
28_S42_Y0.8371.00
79_D82_K0.8261.00
23_S59_T0.8201.00
12_D47_R0.8131.00
105_E135_S0.8081.00
96_I110_L0.8081.00
96_I99_I0.8071.00
13_K17_N0.7901.00
89_Q93_M0.7891.00
15_I44_R0.7841.00
124_L138_T0.7791.00
106_Y137_Y0.7771.00
100_Y144_S0.7661.00
9_D12_D0.7581.00
100_Y141_V0.7571.00
39_A43_V0.7481.00
76_I86_I0.7471.00
90_L99_I0.7471.00
128_G136_T0.7461.00
75_L109_V0.7451.00
122_K126_K0.7421.00
30_L41_I0.7391.00
15_I41_I0.7381.00
84_D87_L0.7331.00
8_L53_V0.7251.00
83_Y108_A0.7251.00
18_I22_D0.7221.00
75_L105_E0.7161.00
77_K106_Y0.7061.00
68_L113_R0.7061.00
30_L45_I0.7051.00
68_L95_E0.7041.00
85_N88_K0.6981.00
72_A120_L0.6831.00
95_E123_V0.6741.00
74_I136_T0.6731.00
87_L145_I0.6721.00
53_V65_K0.6691.00
103_T140_L0.6671.00
118_E121_A0.6621.00
74_I110_L0.6491.00
43_V47_R0.6491.00
10_D13_K0.6481.00
85_N132_G0.6461.00
16_L48_L0.6451.00
79_D132_G0.6451.00
71_V141_V0.6411.00
101_D108_A0.6391.00
118_E122_K0.6361.00
86_I108_A0.6351.00
95_E115_P0.6341.00
31_A38_E0.6321.00
15_I45_I0.6271.00
93_M130_M0.6241.00
117_R140_L0.6231.00
39_A42_Y0.6191.00
124_L136_T0.6181.00
43_V46_K0.6111.00
72_A140_L0.6111.00
15_I18_I0.6101.00
126_K130_M0.6091.00
23_S56_G0.6091.00
52_G55_K0.6081.00
44_R48_L0.6071.00
12_D48_L0.6011.00
90_L110_L0.5951.00
21_Q25_I0.5941.00
15_I48_L0.5911.00
27_F41_I0.5861.00
83_Y128_G0.5831.00
15_I25_I0.5801.00
62_D66_I0.5791.00
102_V106_Y0.5791.00
71_V144_S0.5771.00
76_I133_V0.5751.00
61_I66_I0.5741.00
123_V127_I0.5721.00
119_D123_V0.5711.00
71_V100_Y0.5691.00
84_D129_N0.5571.00
89_Q131_D0.5561.00
117_R142_L0.5511.00
60_E63_F0.5481.00
75_L102_V0.5461.00
82_K131_D0.5441.00
11_I40_T0.5431.00
123_V126_K0.5431.00
17_N20_Q0.5391.00
101_D128_G0.5381.00
76_I136_T0.5351.00
54_I57_F0.5301.00
85_N131_D0.5301.00
72_A138_T0.5271.00
20_Q58_Y0.5261.00
47_R50_E0.5241.00
99_I145_I0.5201.00
101_D142_L0.5161.00
89_Q132_G0.5151.00
102_V141_V0.5141.00
22_D29_R0.5141.00
28_S31_A0.5121.00
128_G135_S0.5111.00
102_V139_M0.5101.00
80_P134_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.8889 100 0.159 Contact Map
4un1A 1 0.9281 100 0.187 Contact Map
2e1cA 1 0.9608 100 0.19 Contact Map
4pcqA 2 0.9608 100 0.203 Contact Map
4un1B 1 0.9739 100 0.204 Contact Map
2p5vA 5 0.9869 100 0.209 Contact Map
3i4pA 5 0.9477 100 0.229 Contact Map
2pn6A 5 0.9542 100 0.234 Contact Map
2ia0A 2 0.9346 100 0.236 Contact Map
2cg4A 6 0.9608 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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