Q97W89 - SULSO - GREMLIN Contacts

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Q97W89 - Geranylgeranyl hydrogenase, putative

UniProt:	Q97W89	Sequences: MTRIAIVGAGPAGLSLAYFLKGSRKVEATVYESMPEPGLKPCAWGLITGIENIIPIPNETIISEIRGFRIYLDNKLVFDIRTDNKLGYIIDKPLFLKRLSQEVNVEFNSKVVKKDDKYYINDKSLDHDKVIFATGHYSVSKSMSIPAIQYITDYEIDKEVVEFYFYSGFLGYAWVFPDREGSKIGIGGYAEVPELKERLKQILKGRIRTFHGARVTDYGVIEDRLDGNYTGEALGTVYAITGEGIRPSIISSKILADSILNRKDFKKEFKKSKLYWSLNWHAKIIKMTKENDPGTARLSKALLNNDPQLILKFAIGEFNRVDLIKIFGRSLI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	332 (291)
Sequences:	28177 (22104)
Seq/√Len:	1295.8

ECOLI - MHPA UBII UBIF CBRA YDIS UBIH FIXC YGCN
BACSU - YETM YHJG
HALSA - Q9HS24 Q9HMA0 Q9HS01 Q9HQE5
SULSO - Q97W89 Q97ZK8 Q97V18 Q97V59

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
12_A	248_S	3.671	1.00
5_A	127_H	3.650	1.00
3_R	27_E	3.212	1.00
3_R	128_D	3.104	1.00
273_K	277_S	3.060	1.00
31_Y	125_L	2.912	1.00
16_L	131_I	2.740	1.00
5_A	31_Y	2.576	1.00
19_F	256_A	2.566	1.00
24_R	260_L	2.500	1.00
110_K	143_M	2.398	1.00
196_K	200_K	2.273	1.00
97_K	101_Q	2.269	1.00
119_Y	126_D	2.221	1.00
12_A	230_T	2.213	1.00
18_Y	102_E	2.184	1.00
132_F	140_S	2.168	1.00
119_Y	124_S	2.149	1.00
15_S	249_I	2.135	1.00
117_K	126_D	2.098	1.00
258_S	275_Y	1.995	1.00
59_E	101_Q	1.965	1.00
191_E	194_E	1.960	1.00
252_S	256_A	1.950	1.00
112_V	119_Y	1.924	1.00
110_K	121_N	1.893	1.00
114_K	119_Y	1.883	1.00
258_S	271_K	1.871	1.00
26_V	260_L	1.856	1.00
224_R	270_K	1.829	1.00
222_E	225_L	1.802	1.00
121_N	124_S	1.788	1.00
4_I	20_L	1.774	1.00
277_S	281_H	1.741	1.00
5_A	120_I	1.728	1.00
53_I	253_K	1.724	1.00
224_R	229_Y	1.723	1.00
145_I	149_Q	1.696	1.00
112_V	121_N	1.696	1.00
133_A	230_T	1.677	1.00
59_E	102_E	1.672	1.00
3_R	29_T	1.663	1.00
134_T	138_S	1.663	1.00
4_I	26_V	1.661	1.00
50_I	246_R	1.654	1.00
104_N	107_F	1.642	1.00
29_T	125_L	1.637	1.00
192_V	196_K	1.629	1.00
254_I	258_S	1.628	1.00
114_K	117_K	1.605	1.00
113_K	225_L	1.586	1.00
17_A	30_V	1.577	1.00
18_Y	22_G	1.559	1.00
139_V	143_M	1.555	1.00
195_L	199_L	1.550	1.00
195_L	203_L	1.531	1.00
11_P	245_I	1.527	1.00
5_A	125_L	1.525	1.00
250_I	279_N	1.519	1.00
145_I	148_I	1.515	1.00
198_R	202_I	1.511	1.00
108_N	120_I	1.510	1.00
129_K	269_F	1.507	1.00
194_E	197_E	1.500	1.00
222_E	273_K	1.488	1.00
16_L	252_S	1.480	1.00
192_V	195_L	1.472	1.00
145_I	150_Y	1.468	1.00
144_S	147_A	1.459	1.00
254_I	275_Y	1.457	1.00
195_L	198_R	1.450	1.00
223_D	280_W	1.442	1.00
199_L	203_L	1.440	1.00
131_I	230_T	1.432	1.00
193_P	196_K	1.431	1.00
183_K	187_G	1.431	1.00
114_K	126_D	1.430	1.00
117_K	120_I	1.427	1.00
229_Y	255_L	1.419	1.00
197_E	201_Q	1.417	1.00
27_E	106_E	1.413	1.00
190_A	194_E	1.412	1.00
264_D	267_K	1.384	1.00
184_I	187_G	1.383	1.00
251_S	276_W	1.383	1.00
50_I	53_I	1.370	1.00
223_D	273_K	1.354	1.00
111_V	130_V	1.349	1.00
257_D	275_Y	1.342	1.00
207_I	210_F	1.337	1.00
217_D	288_T	1.336	1.00
116_D	120_I	1.331	1.00
16_L	20_L	1.318	1.00
18_Y	103_V	1.315	1.00
147_A	150_Y	1.291	1.00
131_I	229_Y	1.285	1.00
235_G	251_S	1.278	1.00
58_N	62_I	1.277	1.00
7_V	134_T	1.273	1.00
191_E	195_L	1.263	1.00
258_S	261_N	1.260	1.00
193_P	197_E	1.246	1.00
59_E	62_I	1.244	1.00
7_V	108_N	1.241	1.00
199_L	202_I	1.232	1.00
190_A	195_L	1.230	1.00
6_I	16_L	1.224	1.00
139_V	142_S	1.222	1.00
224_R	273_K	1.210	1.00
196_K	203_L	1.202	1.00
200_K	203_L	1.187	1.00
5_A	29_T	1.184	1.00
258_S	268_E	1.181	1.00
194_E	198_R	1.173	1.00
195_L	204_K	1.158	1.00
108_N	111_V	1.151	1.00
94_L	97_K	1.151	1.00
113_K	118_Y	1.139	1.00
9_A	14_L	1.139	1.00
91_D	94_L	1.130	1.00
200_K	204_K	1.130	1.00
21_K	105_V	1.128	1.00
57_P	61_I	1.115	1.00
21_K	104_N	1.111	1.00
72_L	75_K	1.104	1.00
218_Y	236_T	1.100	1.00
3_R	26_V	1.096	1.00
44_W	245_I	1.095	1.00
113_K	227_G	1.094	1.00
17_A	28_A	1.087	1.00
112_V	124_S	1.086	1.00
174_W	185_G	1.081	1.00
190_A	193_P	1.072	1.00
109_S	121_N	1.070	1.00
136_H	236_T	1.067	1.00
152_T	155_E	1.063	1.00
50_I	249_I	1.060	1.00
109_S	122_D	1.060	1.00
197_E	200_K	1.057	1.00
146_P	150_Y	1.054	1.00
7_V	140_S	1.053	1.00
174_W	178_D	1.048	1.00
127_H	130_V	1.042	1.00
120_I	127_H	1.041	1.00
59_E	98_R	1.040	1.00
148_I	151_I	1.039	1.00
144_S	150_Y	1.035	1.00
196_K	199_L	1.032	1.00
63_S	94_L	1.027	1.00
198_R	201_Q	1.025	1.00
76_L	79_D	1.025	1.00
6_I	17_A	1.024	1.00
195_L	202_I	1.021	1.00
16_L	230_T	1.018	1.00
15_S	19_F	1.015	1.00
225_L	228_N	1.014	1.00
270_K	274_L	1.006	1.00
29_T	106_E	1.004	1.00
192_V	199_L	1.002	1.00
68_F	72_L	1.001	1.00
237_V	284_I	1.001	1.00
14_L	103_V	0.994	1.00
37_P	100_S	0.976	1.00
281_H	285_I	0.971	1.00
237_V	247_P	0.971	1.00
19_F	54_I	0.970	1.00
118_Y	227_G	0.968	1.00
213_A	216_T	0.968	1.00
198_R	203_L	0.968	1.00
254_I	257_D	0.961	1.00
98_R	101_Q	0.955	1.00
230_T	272_S	0.955	1.00
22_G	102_E	0.953	1.00
192_V	203_L	0.953	1.00
21_K	28_A	0.950	1.00
92_K	96_L	0.948	1.00
190_A	198_R	0.940	1.00
51_E	57_P	0.938	1.00
138_S	141_K	0.933	1.00
191_E	196_K	0.933	1.00
163_F	166_Y	0.929	1.00
6_I	28_A	0.929	1.00
25_K	28_A	0.925	1.00
210_F	213_A	0.923	1.00
190_A	203_L	0.921	1.00
147_A	151_I	0.918	1.00
161_V	164_Y	0.918	1.00
29_T	127_H	0.914	1.00
288_T	292_D	0.906	1.00
271_K	274_L	0.906	1.00
7_V	130_V	0.903	1.00
21_K	103_V	0.902	1.00
164_Y	167_S	0.900	1.00
56_I	102_E	0.900	1.00
162_E	165_F	0.897	1.00
261_N	271_K	0.897	1.00
201_Q	204_K	0.893	1.00
111_V	143_M	0.893	1.00
20_L	26_V	0.887	1.00
229_Y	272_S	0.886	1.00
19_F	24_R	0.885	1.00
96_L	100_S	0.880	1.00
172_Y	176_F	0.879	1.00
98_R	102_E	0.879	1.00
14_L	96_L	0.877	1.00
223_D	234_L	0.877	1.00
14_L	100_S	0.877	1.00
108_N	140_S	0.875	1.00
195_L	200_K	0.873	1.00
154_Y	157_D	0.873	1.00
224_R	266_K	0.864	1.00
15_S	54_I	0.854	1.00
19_F	22_G	0.854	1.00
11_P	249_I	0.851	1.00
45_G	87_G	0.848	1.00
146_P	149_Q	0.848	1.00
18_Y	54_I	0.837	1.00
197_E	204_K	0.831	1.00
146_P	151_I	0.831	1.00
155_E	158_K	0.827	1.00
183_K	186_I	0.827	1.00
49_G	250_I	0.825	1.00
189_Y	195_L	0.823	1.00
162_E	166_Y	0.822	1.00
140_S	228_N	0.819	1.00
132_F	228_N	0.815	1.00
80_I	83_D	0.805	1.00
54_I	57_P	0.801	1.00
9_A	32_E	0.798	1.00
145_I	151_I	0.798	1.00
120_I	130_V	0.797	1.00
56_I	98_R	0.795	1.00
197_E	203_L	0.793	1.00
20_L	256_A	0.785	1.00
144_S	149_Q	0.785	1.00
152_T	157_D	0.784	1.00
194_E	199_L	0.781	1.00
132_F	138_S	0.780	1.00
44_W	92_K	0.779	1.00
256_A	260_L	0.776	1.00
31_Y	127_H	0.776	1.00
129_K	229_Y	0.775	1.00
3_R	127_H	0.774	1.00
271_K	275_Y	0.771	1.00
253_K	257_D	0.770	1.00
237_V	241_T	0.770	1.00
63_S	97_K	0.767	1.00
196_K	202_I	0.765	1.00
172_Y	175_V	0.764	1.00
116_D	119_Y	0.761	1.00
20_L	259_I	0.761	1.00
59_E	63_S	0.759	1.00
159_E	162_E	0.759	1.00
19_F	253_K	0.758	1.00
69_R	72_L	0.758	1.00
189_Y	192_V	0.757	1.00
166_Y	169_F	0.755	1.00
58_N	61_I	0.755	1.00
241_T	287_M	0.754	1.00
3_R	125_L	0.754	1.00
192_V	202_I	0.751	1.00
213_A	218_Y	0.750	1.00
236_T	251_S	0.749	1.00
161_V	166_Y	0.737	1.00
144_S	148_I	0.735	1.00
49_G	243_E	0.735	1.00
15_S	99_L	0.732	1.00
131_I	255_L	0.728	1.00
171_G	174_W	0.727	1.00
219_G	277_S	0.725	1.00
51_E	88_Y	0.723	1.00
60_T	98_R	0.723	1.00
9_A	30_V	0.719	1.00
224_R	269_F	0.718	1.00
46_L	50_I	0.714	1.00
278_L	282_A	0.711	1.00
173_A	177_P	0.710	1.00
161_V	167_S	0.707	1.00
21_K	106_E	0.706	1.00
71_Y	74_N	0.706	1.00
192_V	198_R	0.698	1.00
118_Y	130_V	0.697	1.00
17_A	103_V	0.696	1.00
265_F	268_E	0.695	1.00
171_G	178_D	0.695	1.00
41_P	44_W	0.692	1.00
90_I	95_F	0.692	1.00
172_Y	178_D	0.691	1.00
223_D	277_S	0.686	1.00
47_I	246_R	0.686	1.00
153_D	157_D	0.686	1.00
49_G	52_N	0.685	1.00
108_N	139_V	0.682	1.00
240_I	291_N	0.676	1.00
237_V	287_M	0.676	1.00
194_E	203_L	0.675	1.00
113_K	226_D	0.675	1.00
194_E	204_K	0.674	1.00
21_K	24_R	0.673	1.00
275_Y	278_L	0.668	1.00
81_R	84_N	0.668	1.00
265_F	269_F	0.668	1.00
160_V	165_F	0.668	1.00
266_K	270_K	0.664	1.00
191_E	197_E	0.663	1.00
47_I	50_I	0.663	1.00
190_A	196_K	0.661	1.00
219_G	281_H	0.660	1.00
159_E	164_Y	0.658	1.00
115_D	118_Y	0.657	1.00
285_I	289_K	0.657	1.00
152_T	156_I	0.657	1.00
45_G	89_I	0.656	1.00
262_R	265_F	0.655	1.00
190_A	199_L	0.655	1.00
60_T	63_S	0.655	1.00
192_V	197_E	0.654	1.00
28_A	103_V	0.653	1.00
71_Y	75_K	0.650	1.00
245_I	248_S	0.648	1.00
160_V	163_F	0.647	1.00
174_W	177_P	0.647	1.00
116_D	227_G	0.645	1.00
262_R	266_K	0.644	1.00
24_R	256_A	0.644	1.00
110_K	113_K	0.643	1.00
159_E	163_F	0.642	1.00
56_I	59_E	0.641	1.00
154_Y	158_K	0.640	1.00
280_W	284_I	0.640	1.00
37_P	96_L	0.640	1.00
63_S	98_R	0.640	1.00
267_K	271_K	0.639	1.00
129_K	265_F	0.638	1.00
130_V	228_N	0.637	1.00
161_V	165_F	0.637	1.00
229_Y	269_F	0.636	1.00
247_P	280_W	0.636	1.00
18_Y	21_K	0.632	1.00
19_F	252_S	0.631	1.00
100_S	107_F	0.631	1.00
243_E	247_P	0.629	1.00
108_N	143_M	0.628	1.00
132_F	139_V	0.625	1.00
68_F	73_D	0.622	1.00
189_Y	196_K	0.619	1.00
111_V	140_S	0.618	1.00
191_E	203_L	0.618	1.00
165_F	168_G	0.618	1.00
188_G	195_L	0.615	1.00
94_L	179_R	0.614	1.00
205_G	208_R	0.614	1.00
80_I	84_N	0.611	1.00
129_K	259_I	0.604	1.00
163_F	167_S	0.604	1.00
215_V	238_Y	0.603	1.00
241_T	290_E	0.602	1.00
282_A	285_I	0.602	1.00
264_D	268_E	0.600	1.00
160_V	164_Y	0.599	1.00
19_F	53_I	0.596	1.00
192_V	204_K	0.594	1.00
193_P	203_L	0.592	1.00
163_F	168_G	0.592	1.00
191_E	199_L	0.590	1.00
176_F	179_R	0.585	1.00
28_A	105_V	0.583	1.00
161_V	168_G	0.581	1.00
191_E	198_R	0.580	1.00
60_T	95_F	0.578	1.00
53_I	250_I	0.576	1.00
132_F	143_M	0.575	1.00
188_G	192_V	0.574	1.00
215_V	218_Y	0.572	1.00
68_F	71_Y	0.571	1.00
189_Y	202_I	0.571	1.00
247_P	283_K	0.571	1.00
245_I	249_I	0.569	1.00
112_V	120_I	0.566	1.00
235_G	276_W	0.564	1.00
190_A	202_I	0.563	1.00
160_V	166_Y	0.562	1.00
78_F	82_T	0.562	1.00
67_G	160_V	0.561	1.00
212_G	215_V	0.560	1.00
9_A	37_P	0.558	1.00
290_E	293_P	0.557	1.00
12_A	131_I	0.554	1.00
140_S	143_M	0.554	1.00
34_M	38_G	0.553	1.00
69_R	77_V	0.550	1.00
117_K	128_D	0.550	1.00
3_R	126_D	0.546	1.00
226_D	266_K	0.545	1.00
189_Y	203_L	0.545	1.00
243_E	246_R	0.544	1.00
171_G	176_F	0.543	1.00
55_P	59_E	0.542	1.00
16_L	256_A	0.542	1.00
70_I	73_D	0.541	1.00
130_V	227_G	0.541	1.00
173_A	176_F	0.537	1.00
206_R	210_F	0.534	1.00
191_E	204_K	0.531	1.00
274_L	278_L	0.530	1.00
113_K	116_D	0.529	1.00
257_D	261_N	0.528	1.00
91_D	179_R	0.526	1.00
194_E	200_K	0.525	1.00
27_E	128_D	0.525	1.00
16_L	19_F	0.525	1.00
178_D	181_G	0.524	1.00
267_K	270_K	0.524	1.00
263_K	266_K	0.520	1.00
103_V	107_F	0.520	1.00
153_D	158_K	0.520	1.00
232_E	248_S	0.520	1.00
189_Y	193_P	0.519	1.00
238_Y	241_T	0.518	1.00
14_L	30_V	0.518	1.00
31_Y	120_I	0.517	1.00
165_F	169_F	0.516	1.00
230_T	252_S	0.516	1.00
40_K	43_A	0.516	1.00
159_E	166_Y	0.513	1.00
196_K	204_K	0.513	1.00
206_R	209_T	0.505	1.00
34_M	40_K	0.505	1.00
67_G	71_Y	0.504	1.00
111_V	228_N	0.504	1.00
42_C	92_K	0.503	1.00
79_D	83_D	0.503	1.00
137_Y	216_T	0.501	1.00
182_S	185_G	0.501	1.00
33_S	137_Y	0.500	1.00
68_F	75_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qa1A	2	0.9669	100	0.421	Contact Map
2qa2A	2	0.9699	100	0.426	Contact Map
1pn0A	3	0.997	100	0.427	Contact Map
4k5sA	2	0.9789	100	0.431	Contact Map
3oz2A	1	0.991	100	0.441	Contact Map
2dkhA	2	0.9548	100	0.442	Contact Map
4k2xA	2	0.9578	100	0.45	Contact Map
4k22A	4	0.8795	100	0.457	Contact Map
2x3nA	1	0.9036	100	0.457	Contact Map
3c96A	1	0.9187	100	0.462	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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