GREMLIN Database
Q97W89 - Geranylgeranyl hydrogenase, putative
UniProt: Q97W89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (291)
Sequences: 28177 (22104)
Seq/√Len: 1295.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_A248_S3.6711.00
5_A127_H3.6501.00
3_R27_E3.2121.00
3_R128_D3.1041.00
273_K277_S3.0601.00
31_Y125_L2.9121.00
16_L131_I2.7401.00
5_A31_Y2.5761.00
19_F256_A2.5661.00
24_R260_L2.5001.00
110_K143_M2.3981.00
196_K200_K2.2731.00
97_K101_Q2.2691.00
119_Y126_D2.2211.00
12_A230_T2.2131.00
18_Y102_E2.1841.00
132_F140_S2.1681.00
119_Y124_S2.1491.00
15_S249_I2.1351.00
117_K126_D2.0981.00
258_S275_Y1.9951.00
59_E101_Q1.9651.00
191_E194_E1.9601.00
252_S256_A1.9501.00
112_V119_Y1.9241.00
110_K121_N1.8931.00
114_K119_Y1.8831.00
258_S271_K1.8711.00
26_V260_L1.8561.00
224_R270_K1.8291.00
222_E225_L1.8021.00
121_N124_S1.7881.00
4_I20_L1.7741.00
277_S281_H1.7411.00
5_A120_I1.7281.00
53_I253_K1.7241.00
224_R229_Y1.7231.00
145_I149_Q1.6961.00
112_V121_N1.6961.00
133_A230_T1.6771.00
59_E102_E1.6721.00
3_R29_T1.6631.00
134_T138_S1.6631.00
4_I26_V1.6611.00
50_I246_R1.6541.00
104_N107_F1.6421.00
29_T125_L1.6371.00
192_V196_K1.6291.00
254_I258_S1.6281.00
114_K117_K1.6051.00
113_K225_L1.5861.00
17_A30_V1.5771.00
18_Y22_G1.5591.00
139_V143_M1.5551.00
195_L199_L1.5501.00
195_L203_L1.5311.00
11_P245_I1.5271.00
5_A125_L1.5251.00
250_I279_N1.5191.00
145_I148_I1.5151.00
198_R202_I1.5111.00
108_N120_I1.5101.00
129_K269_F1.5071.00
194_E197_E1.5001.00
222_E273_K1.4881.00
16_L252_S1.4801.00
192_V195_L1.4721.00
145_I150_Y1.4681.00
144_S147_A1.4591.00
254_I275_Y1.4571.00
195_L198_R1.4501.00
223_D280_W1.4421.00
199_L203_L1.4401.00
131_I230_T1.4321.00
193_P196_K1.4311.00
183_K187_G1.4311.00
114_K126_D1.4301.00
117_K120_I1.4271.00
229_Y255_L1.4191.00
197_E201_Q1.4171.00
27_E106_E1.4131.00
190_A194_E1.4121.00
264_D267_K1.3841.00
184_I187_G1.3831.00
251_S276_W1.3831.00
50_I53_I1.3701.00
223_D273_K1.3541.00
111_V130_V1.3491.00
257_D275_Y1.3421.00
207_I210_F1.3371.00
217_D288_T1.3361.00
116_D120_I1.3311.00
16_L20_L1.3181.00
18_Y103_V1.3151.00
147_A150_Y1.2911.00
131_I229_Y1.2851.00
235_G251_S1.2781.00
58_N62_I1.2771.00
7_V134_T1.2731.00
191_E195_L1.2631.00
258_S261_N1.2601.00
193_P197_E1.2461.00
59_E62_I1.2441.00
7_V108_N1.2411.00
199_L202_I1.2321.00
190_A195_L1.2301.00
6_I16_L1.2241.00
139_V142_S1.2221.00
224_R273_K1.2101.00
196_K203_L1.2021.00
200_K203_L1.1871.00
5_A29_T1.1841.00
258_S268_E1.1811.00
194_E198_R1.1731.00
195_L204_K1.1581.00
108_N111_V1.1511.00
94_L97_K1.1511.00
113_K118_Y1.1391.00
9_A14_L1.1391.00
91_D94_L1.1301.00
200_K204_K1.1301.00
21_K105_V1.1281.00
57_P61_I1.1151.00
21_K104_N1.1111.00
72_L75_K1.1041.00
218_Y236_T1.1001.00
3_R26_V1.0961.00
44_W245_I1.0951.00
113_K227_G1.0941.00
17_A28_A1.0871.00
112_V124_S1.0861.00
174_W185_G1.0811.00
190_A193_P1.0721.00
109_S121_N1.0701.00
136_H236_T1.0671.00
152_T155_E1.0631.00
50_I249_I1.0601.00
109_S122_D1.0601.00
197_E200_K1.0571.00
146_P150_Y1.0541.00
7_V140_S1.0531.00
174_W178_D1.0481.00
127_H130_V1.0421.00
120_I127_H1.0411.00
59_E98_R1.0401.00
148_I151_I1.0391.00
144_S150_Y1.0351.00
196_K199_L1.0321.00
63_S94_L1.0271.00
198_R201_Q1.0251.00
76_L79_D1.0251.00
6_I17_A1.0241.00
195_L202_I1.0211.00
16_L230_T1.0181.00
15_S19_F1.0151.00
225_L228_N1.0141.00
270_K274_L1.0061.00
29_T106_E1.0041.00
192_V199_L1.0021.00
68_F72_L1.0011.00
237_V284_I1.0011.00
14_L103_V0.9941.00
37_P100_S0.9761.00
281_H285_I0.9711.00
237_V247_P0.9711.00
19_F54_I0.9701.00
118_Y227_G0.9681.00
213_A216_T0.9681.00
198_R203_L0.9681.00
254_I257_D0.9611.00
98_R101_Q0.9551.00
230_T272_S0.9551.00
22_G102_E0.9531.00
192_V203_L0.9531.00
21_K28_A0.9501.00
92_K96_L0.9481.00
190_A198_R0.9401.00
51_E57_P0.9381.00
138_S141_K0.9331.00
191_E196_K0.9331.00
163_F166_Y0.9291.00
6_I28_A0.9291.00
25_K28_A0.9251.00
210_F213_A0.9231.00
190_A203_L0.9211.00
147_A151_I0.9181.00
161_V164_Y0.9181.00
29_T127_H0.9141.00
288_T292_D0.9061.00
271_K274_L0.9061.00
7_V130_V0.9031.00
21_K103_V0.9021.00
164_Y167_S0.9001.00
56_I102_E0.9001.00
162_E165_F0.8971.00
261_N271_K0.8971.00
201_Q204_K0.8931.00
111_V143_M0.8931.00
20_L26_V0.8871.00
229_Y272_S0.8861.00
19_F24_R0.8851.00
96_L100_S0.8801.00
172_Y176_F0.8791.00
98_R102_E0.8791.00
14_L96_L0.8771.00
223_D234_L0.8771.00
14_L100_S0.8771.00
108_N140_S0.8751.00
195_L200_K0.8731.00
154_Y157_D0.8731.00
224_R266_K0.8641.00
15_S54_I0.8541.00
19_F22_G0.8541.00
11_P249_I0.8511.00
45_G87_G0.8481.00
146_P149_Q0.8481.00
18_Y54_I0.8371.00
197_E204_K0.8311.00
146_P151_I0.8311.00
155_E158_K0.8271.00
183_K186_I0.8271.00
49_G250_I0.8251.00
189_Y195_L0.8231.00
162_E166_Y0.8221.00
140_S228_N0.8191.00
132_F228_N0.8151.00
80_I83_D0.8051.00
54_I57_P0.8011.00
9_A32_E0.7981.00
145_I151_I0.7981.00
120_I130_V0.7971.00
56_I98_R0.7951.00
197_E203_L0.7931.00
20_L256_A0.7851.00
144_S149_Q0.7851.00
152_T157_D0.7841.00
194_E199_L0.7811.00
132_F138_S0.7801.00
44_W92_K0.7791.00
256_A260_L0.7761.00
31_Y127_H0.7761.00
129_K229_Y0.7751.00
3_R127_H0.7741.00
271_K275_Y0.7711.00
253_K257_D0.7701.00
237_V241_T0.7701.00
63_S97_K0.7671.00
196_K202_I0.7651.00
172_Y175_V0.7641.00
116_D119_Y0.7611.00
20_L259_I0.7611.00
59_E63_S0.7591.00
159_E162_E0.7591.00
19_F253_K0.7581.00
69_R72_L0.7581.00
189_Y192_V0.7571.00
166_Y169_F0.7551.00
58_N61_I0.7551.00
241_T287_M0.7541.00
3_R125_L0.7541.00
192_V202_I0.7511.00
213_A218_Y0.7501.00
236_T251_S0.7491.00
161_V166_Y0.7371.00
144_S148_I0.7351.00
49_G243_E0.7351.00
15_S99_L0.7321.00
131_I255_L0.7281.00
171_G174_W0.7271.00
219_G277_S0.7251.00
51_E88_Y0.7231.00
60_T98_R0.7231.00
9_A30_V0.7191.00
224_R269_F0.7181.00
46_L50_I0.7141.00
278_L282_A0.7111.00
173_A177_P0.7101.00
161_V167_S0.7071.00
21_K106_E0.7061.00
71_Y74_N0.7061.00
192_V198_R0.6981.00
118_Y130_V0.6971.00
17_A103_V0.6961.00
265_F268_E0.6951.00
171_G178_D0.6951.00
41_P44_W0.6921.00
90_I95_F0.6921.00
172_Y178_D0.6911.00
223_D277_S0.6861.00
47_I246_R0.6861.00
153_D157_D0.6861.00
49_G52_N0.6851.00
108_N139_V0.6821.00
240_I291_N0.6761.00
237_V287_M0.6761.00
194_E203_L0.6751.00
113_K226_D0.6751.00
194_E204_K0.6741.00
21_K24_R0.6731.00
275_Y278_L0.6681.00
81_R84_N0.6681.00
265_F269_F0.6681.00
160_V165_F0.6681.00
266_K270_K0.6641.00
191_E197_E0.6631.00
47_I50_I0.6631.00
190_A196_K0.6611.00
219_G281_H0.6601.00
159_E164_Y0.6581.00
115_D118_Y0.6571.00
285_I289_K0.6571.00
152_T156_I0.6571.00
45_G89_I0.6561.00
262_R265_F0.6551.00
190_A199_L0.6551.00
60_T63_S0.6551.00
192_V197_E0.6541.00
28_A103_V0.6531.00
71_Y75_K0.6501.00
245_I248_S0.6481.00
160_V163_F0.6471.00
174_W177_P0.6471.00
116_D227_G0.6451.00
262_R266_K0.6441.00
24_R256_A0.6441.00
110_K113_K0.6431.00
159_E163_F0.6421.00
56_I59_E0.6411.00
154_Y158_K0.6401.00
280_W284_I0.6401.00
37_P96_L0.6401.00
63_S98_R0.6401.00
267_K271_K0.6391.00
129_K265_F0.6381.00
130_V228_N0.6371.00
161_V165_F0.6371.00
229_Y269_F0.6361.00
247_P280_W0.6361.00
18_Y21_K0.6321.00
19_F252_S0.6311.00
100_S107_F0.6311.00
243_E247_P0.6291.00
108_N143_M0.6281.00
132_F139_V0.6251.00
68_F73_D0.6221.00
189_Y196_K0.6191.00
111_V140_S0.6181.00
191_E203_L0.6181.00
165_F168_G0.6181.00
188_G195_L0.6151.00
94_L179_R0.6141.00
205_G208_R0.6141.00
80_I84_N0.6111.00
129_K259_I0.6041.00
163_F167_S0.6041.00
215_V238_Y0.6031.00
241_T290_E0.6021.00
282_A285_I0.6021.00
264_D268_E0.6001.00
160_V164_Y0.5991.00
19_F53_I0.5961.00
192_V204_K0.5941.00
193_P203_L0.5921.00
163_F168_G0.5921.00
191_E199_L0.5901.00
176_F179_R0.5851.00
28_A105_V0.5831.00
161_V168_G0.5811.00
191_E198_R0.5801.00
60_T95_F0.5781.00
53_I250_I0.5761.00
132_F143_M0.5751.00
188_G192_V0.5741.00
215_V218_Y0.5721.00
68_F71_Y0.5711.00
189_Y202_I0.5711.00
247_P283_K0.5711.00
245_I249_I0.5691.00
112_V120_I0.5661.00
235_G276_W0.5641.00
190_A202_I0.5631.00
160_V166_Y0.5621.00
78_F82_T0.5621.00
67_G160_V0.5611.00
212_G215_V0.5601.00
9_A37_P0.5581.00
290_E293_P0.5571.00
12_A131_I0.5541.00
140_S143_M0.5541.00
34_M38_G0.5531.00
69_R77_V0.5501.00
117_K128_D0.5501.00
3_R126_D0.5461.00
226_D266_K0.5451.00
189_Y203_L0.5451.00
243_E246_R0.5441.00
171_G176_F0.5431.00
55_P59_E0.5421.00
16_L256_A0.5421.00
70_I73_D0.5411.00
130_V227_G0.5411.00
173_A176_F0.5371.00
206_R210_F0.5341.00
191_E204_K0.5311.00
274_L278_L0.5301.00
113_K116_D0.5291.00
257_D261_N0.5281.00
91_D179_R0.5261.00
194_E200_K0.5251.00
27_E128_D0.5251.00
16_L19_F0.5251.00
178_D181_G0.5241.00
267_K270_K0.5241.00
263_K266_K0.5201.00
103_V107_F0.5201.00
153_D158_K0.5201.00
232_E248_S0.5201.00
189_Y193_P0.5191.00
238_Y241_T0.5181.00
14_L30_V0.5181.00
31_Y120_I0.5171.00
165_F169_F0.5161.00
230_T252_S0.5161.00
40_K43_A0.5161.00
159_E166_Y0.5131.00
196_K204_K0.5131.00
206_R209_T0.5051.00
34_M40_K0.5051.00
67_G71_Y0.5041.00
111_V228_N0.5041.00
42_C92_K0.5031.00
79_D83_D0.5031.00
137_Y216_T0.5011.00
182_S185_G0.5011.00
33_S137_Y0.5001.00
68_F75_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qa1A 2 0.9669 100 0.421 Contact Map
2qa2A 2 0.9699 100 0.426 Contact Map
1pn0A 3 0.997 100 0.427 Contact Map
4k5sA 2 0.9789 100 0.431 Contact Map
3oz2A 1 0.991 100 0.441 Contact Map
2dkhA 2 0.9548 100 0.442 Contact Map
4k2xA 2 0.9578 100 0.45 Contact Map
4k22A 4 0.8795 100 0.457 Contact Map
2x3nA 1 0.9036 100 0.457 Contact Map
3c96A 1 0.9187 100 0.462 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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