GREMLIN Database
Q97W87 - Asparinase, putative (AnsA-like)
UniProt: Q97W87 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (257)
Sequences: 2070 (1237)
Seq/√Len: 77.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_V103_K4.5981.00
53_I156_G4.3371.00
242_D246_N4.2551.00
152_N184_S3.8051.00
153_L187_A3.5421.00
54_Y103_K3.5031.00
58_E100_S3.4661.00
102_I156_G3.2241.00
96_L104_K3.1871.00
68_S78_M3.1231.00
206_V238_M3.0461.00
47_E106_L2.7801.00
217_D221_R2.6761.00
94_M118_I2.6601.00
215_T218_D2.6531.00
118_I170_V2.5811.00
28_T59_S2.5551.00
106_L110_F2.5331.00
70_R76_I2.5041.00
209_L214_F2.4071.00
75_Y97_R2.3911.00
33_L259_G2.3861.00
201_L204_K2.3711.00
71_N75_Y2.2691.00
117_M125_S2.1791.00
49_V146_A2.1161.00
71_N77_E2.1151.00
50_V106_L2.0071.00
84_V87_T1.9651.00
82_I102_I1.9511.00
39_E43_G1.8771.00
221_R225_N1.8501.00
104_K131_A1.7781.00
50_V82_I1.7621.00
214_F222_A1.6931.00
88_L181_Y1.6611.00
147_L241_L1.6581.00
92_G116_L1.6461.00
205_E208_I1.6451.00
25_A61_V1.6341.00
175_I178_A1.6301.00
81_G180_Y1.6211.00
107_E111_Q1.6201.00
73_A124_S1.6131.00
188_V240_G1.6051.00
202_P223_V1.6051.00
216_I240_G1.6011.00
48_A52_A1.5961.00
120_S124_S1.5931.00
90_V176_P1.5800.99
157_T189_S1.5750.99
90_V115_V1.5410.99
125_S129_N1.5300.99
197_I236_I1.5080.99
95_G118_I1.4990.99
98_E123_N1.4990.99
220_L240_G1.4880.99
209_L222_A1.4780.99
53_I102_I1.4770.99
262_S265_G1.4640.99
23_D27_L1.4630.99
224_V252_N1.4610.99
39_E48_A1.4550.99
32_A55_Y1.4540.99
53_I142_V1.4340.99
35_R55_Y1.4300.99
122_Y126_N1.4060.99
52_A144_A1.4020.99
8_L33_L1.3800.99
35_R38_Y1.3710.99
22_Q26_K1.3650.98
147_L153_L1.3590.98
86_N184_S1.3460.98
162_I193_I1.3360.98
58_E99_G1.3130.98
50_V54_Y1.3110.98
204_K208_I1.3100.98
205_E212_L1.3020.98
153_L182_A1.3000.98
188_V203_A1.2930.98
247_A260_V1.2880.98
49_V156_G1.2880.98
107_E129_N1.2800.98
84_V89_Q1.2690.98
94_M170_V1.2660.98
31_E59_S1.2490.97
175_I198_L1.2360.97
103_K106_L1.2150.97
183_T211_S1.2020.97
112_N166_L1.1910.96
108_I112_N1.1910.96
235_N253_T1.1780.96
189_S239_I1.1750.96
145_V187_A1.1710.96
32_A36_G1.1700.96
190_S238_M1.1630.96
45_A146_A1.1480.96
111_Q129_N1.1480.96
197_I202_P1.1460.96
77_E97_R1.1310.95
228_T231_F1.1290.95
155_A180_Y1.1260.95
34_E261_I1.1260.95
36_G52_A1.1200.95
84_V152_N1.1070.95
208_I211_S1.1070.95
100_S103_K1.0780.94
45_A154_V1.0660.93
206_V240_G1.0620.93
107_E131_A1.0520.93
78_M96_L1.0510.93
51_E54_Y1.0480.93
37_Y41_R1.0440.93
54_Y100_S1.0430.93
202_P227_V1.0420.93
30_S34_E1.0300.92
116_L175_I1.0300.92
191_T256_M1.0230.92
186_V207_D1.0230.92
86_N152_N1.0090.91
28_T32_A1.0070.91
43_G47_E1.0000.91
8_L261_I1.0000.91
109_L112_N0.9950.91
123_N127_S0.9900.91
10_V32_A0.9880.90
119_G126_N0.9860.90
32_A51_E0.9830.90
35_R51_E0.9800.90
28_T31_E0.9770.90
37_Y261_I0.9660.89
112_N125_S0.9640.89
18_Q21_D0.9540.89
72_S167_P0.9490.89
63_D69_V0.9460.88
221_R250_Y0.9440.88
46_I82_I0.9290.88
222_A226_K0.9280.88
85_G182_A0.9270.87
210_V240_G0.9110.87
108_I125_S0.9100.86
38_Y41_R0.9090.86
190_S203_A0.9050.86
159_T173_S0.9020.86
205_E209_L0.9010.86
9_V187_A0.9000.86
143_G189_S0.8930.85
208_I212_L0.8870.85
214_F218_D0.8860.85
38_Y42_K0.8770.84
50_V110_F0.8730.84
115_V195_E0.8690.84
8_L36_G0.8670.84
227_V230_T0.8620.83
35_R52_A0.8620.83
176_P180_Y0.8620.83
91_G108_I0.8610.83
159_T172_D0.8590.83
121_N125_S0.8500.82
210_V242_D0.8440.82
145_V189_S0.8440.82
81_G201_L0.8420.82
53_I144_A0.8380.82
171_G174_P0.8340.81
15_G63_D0.8310.81
32_A48_A0.8280.81
49_V154_V0.8280.81
182_A187_A0.8270.81
69_V165_K0.8240.80
148_D152_N0.8220.80
144_A156_G0.8200.80
45_A148_D0.8160.80
46_I154_V0.8110.79
46_I110_F0.8090.79
10_V259_G0.8090.79
94_M116_L0.8090.79
40_F48_A0.8040.79
188_V207_D0.7990.78
104_K125_S0.7880.77
93_I108_I0.7850.77
81_G176_P0.7850.77
51_E55_Y0.7850.77
56_M64_A0.7820.77
251_Y256_M0.7810.77
220_L238_M0.7760.76
157_T239_I0.7750.76
39_E51_E0.7710.76
10_V29_I0.7650.75
61_V197_I0.7600.75
54_Y58_E0.7580.75
39_E42_K0.7500.74
64_A142_V0.7460.74
140_D189_S0.7440.73
90_V180_Y0.7420.73
157_T180_Y0.7400.73
153_L242_D0.7370.73
68_S76_I0.7330.72
78_M123_N0.7320.72
200_I231_F0.7310.72
15_G25_A0.7300.72
122_Y125_S0.7300.72
124_S128_N0.7290.72
155_A182_A0.7270.72
46_I50_V0.7250.71
73_A167_P0.7230.71
40_F43_G0.7210.71
44_S150_H0.7150.70
28_T62_F0.7150.70
68_S160_G0.7140.70
238_M250_Y0.7140.70
77_E165_K0.7140.70
12_G62_F0.7140.70
115_V198_L0.7130.70
16_S257_A0.7110.70
190_S206_V0.7100.70
261_I265_G0.7100.70
178_A201_L0.7100.70
216_I248_S0.7080.70
97_R120_S0.7070.69
60_G66_K0.7040.69
108_I114_H0.7020.69
63_D70_R0.7010.69
90_V116_L0.6990.69
136_K139_G0.6970.68
140_D180_Y0.6900.68
35_R39_E0.6850.67
55_Y59_S0.6830.67
21_D24_K0.6820.67
183_T243_K0.6800.66
251_Y258_R0.6790.66
48_A51_E0.6770.66
44_S47_E0.6760.66
70_R162_I0.6700.65
63_D160_G0.6690.65
174_P190_S0.6690.65
91_G105_A0.6680.65
23_D30_S0.6660.65
79_D121_N0.6650.65
100_S132_I0.6640.65
115_V176_P0.6620.64
200_I204_K0.6580.64
83_M90_V0.6570.64
227_V231_F0.6540.63
15_G165_K0.6540.63
79_D170_V0.6530.63
202_P238_M0.6530.63
55_Y58_E0.6500.63
210_V213_G0.6470.63
17_W255_G0.6470.63
204_K209_L0.6400.62
56_M160_G0.6400.62
69_V163_K0.6400.62
224_V227_V0.6360.61
218_D222_A0.6350.61
79_D173_S0.6350.61
213_G219_A0.6340.61
8_L146_A0.6330.61
237_G251_Y0.6320.61
255_G258_R0.6310.61
218_D221_R0.6310.61
142_V158_S0.6310.61
19_I22_Q0.6300.61
157_T173_S0.6290.60
25_A29_I0.6280.60
225_N228_T0.6280.60
36_G146_A0.6260.60
214_F219_A0.6240.60
104_K107_E0.6240.60
15_G255_G0.6230.60
208_I226_K0.6230.60
107_E110_F0.6200.59
220_L250_Y0.6190.59
18_Q254_K0.6190.59
104_K126_N0.6180.59
237_G256_M0.6170.59
259_G263_S0.6090.58
126_N130_S0.6080.58
66_K100_S0.6070.58
81_G155_A0.6060.58
18_Q210_V0.6060.58
46_I109_L0.6050.57
78_M97_R0.6040.57
185_N243_K0.6040.57
260_V265_G0.6040.57
253_T256_M0.6030.57
183_T186_V0.6030.57
196_I200_I0.6010.57
71_N165_K0.6010.57
169_R194_G0.6000.57
220_L224_V0.5970.56
48_A146_A0.5950.56
219_A223_V0.5910.56
31_E34_E0.5910.56
123_N131_A0.5910.56
161_G169_R0.5910.56
121_N195_E0.5890.55
16_S254_K0.5870.55
44_S152_N0.5860.55
106_L109_L0.5860.55
31_E38_Y0.5860.55
217_D250_Y0.5860.55
153_L178_A0.5850.55
225_N231_F0.5830.55
81_G101_A0.5830.55
66_K76_I0.5820.55
256_M259_G0.5770.54
120_S123_N0.5760.54
38_Y51_E0.5750.54
147_L151_G0.5740.54
79_D91_G0.5730.53
249_A258_R0.5730.53
205_E226_K0.5720.53
217_D248_S0.5650.52
29_I33_L0.5650.52
58_E101_A0.5630.52
81_G90_V0.5630.52
141_T194_G0.5630.52
141_T169_R0.5620.52
224_V228_T0.5600.52
209_L212_L0.5590.52
234_D252_N0.5590.52
62_F69_V0.5580.52
204_K211_S0.5540.51
31_E35_R0.5540.51
33_L261_I0.5540.51
185_N211_S0.5510.51
224_V236_I0.5510.51
161_G168_G0.5480.50
209_L227_V0.5480.50
124_S127_S0.5470.50
95_G121_N0.5460.50
28_T55_Y0.5460.50
9_V247_A0.5420.50
41_R261_I0.5400.49
99_G132_I0.5400.49
140_D256_M0.5400.49
119_G122_Y0.5400.49
171_G194_G0.5400.49
143_G158_S0.5370.49
62_F157_T0.5360.49
34_E42_K0.5360.49
153_L246_N0.5360.49
16_S255_G0.5340.49
188_V238_M0.5330.48
54_Y156_G0.5300.48
157_T172_D0.5290.48
99_G124_S0.5280.48
10_V52_A0.5280.48
200_I227_V0.5270.48
47_E50_V0.5270.48
64_A160_G0.5270.48
17_W257_A0.5260.47
185_N207_D0.5240.47
133_Y136_K0.5240.47
157_T191_T0.5230.47
214_F217_D0.5220.47
29_I258_R0.5200.47
144_A256_M0.5200.47
147_L223_V0.5190.47
161_G165_K0.5190.47
12_G245_G0.5160.46
131_A185_N0.5150.46
52_A146_A0.5150.46
35_R243_K0.5140.46
82_I156_G0.5130.46
20_A25_A0.5130.46
48_A55_Y0.5120.46
164_G207_D0.5120.46
144_A187_A0.5110.46
32_A35_R0.5110.46
39_E146_A0.5080.45
150_H244_Y0.5080.45
143_G160_G0.5070.45
96_L101_A0.5070.45
209_L213_G0.5070.45
90_V112_N0.5060.45
209_L226_K0.5060.45
69_V160_G0.5050.45
43_G48_A0.5050.45
30_S42_K0.5040.45
174_P199_R0.5040.45
128_N166_L0.5030.45
17_W20_A0.5030.45
151_G154_V0.5010.44
215_T219_A0.5010.44
216_I224_V0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c17A 2 0.9819 100 0.096 Contact Map
4o0cA 2 0.9746 100 0.103 Contact Map
2a8jA 2 0.9638 100 0.127 Contact Map
1p4kA 2 0.942 100 0.216 Contact Map
4pv2A 1 0.4964 100 0.445 Contact Map
1k2xA 1 0.4964 100 0.547 Contact Map
2gezA 2 0.5761 100 0.56 Contact Map
1k2xB 2 0.4819 100 0.574 Contact Map
4pv2B 2 0.471 100 0.579 Contact Map
2gezB 2 0.4783 100 0.58 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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