GREMLIN Database
Q97W83 - Geranylgeranyl hydrogenase, putative
UniProt: Q97W83 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (316)
Sequences: 2632 (1970)
Seq/√Len: 110.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_E56_D5.0421.00
48_Q52_K4.8571.00
278_N282_I4.8421.00
136_N205_R4.3721.00
99_V260_I4.1451.00
69_K111_K3.6611.00
102_T106_T3.3121.00
99_V231_I3.2821.00
99_V229_A3.2341.00
69_K81_V3.0531.00
51_A61_I2.9621.00
67_A80_A2.9531.00
81_V92_E2.7051.00
185_S188_E2.6811.00
85_R89_E2.5651.00
100_D108_F2.4641.00
237_T252_S2.4161.00
236_F252_S2.3791.00
262_N280_C2.3671.00
73_I94_K2.3661.00
34_V37_E2.3291.00
96_K264_F2.2341.00
259_A280_C2.1731.00
191_N195_D2.1411.00
258_K280_C2.0781.00
292_L295_F2.0551.00
101_A231_I2.0511.00
82_L93_A2.0331.00
71_I81_V2.0001.00
33_T37_E1.9571.00
257_G261_L1.9501.00
78_E94_K1.9321.00
224_V275_W1.8851.00
149_I152_T1.8821.00
146_Y152_T1.8711.00
192_K195_D1.8641.00
162_W174_G1.8331.00
54_A59_V1.8221.00
289_Q292_L1.8111.00
67_A70_P1.7871.00
262_N276_D1.7841.00
70_P98_T1.7841.00
253_A257_G1.6461.00
254_Y258_K1.6291.00
148_R152_T1.6191.00
229_A260_I1.6151.00
73_I76_K1.6131.00
25_S28_M1.5961.00
215_P218_R1.5891.00
78_E92_E1.5761.00
54_A58_G1.5591.00
192_K196_Y1.5561.00
292_L296_R1.5471.00
145_P152_T1.5411.00
236_F281_Y1.5311.00
252_S281_Y1.5121.00
97_I260_I1.5031.00
126_D130_A1.4701.00
121_T124_D1.4641.00
229_A256_V1.4571.00
145_P151_I1.4551.00
128_D131_Y1.4551.00
130_A133_E1.4451.00
331_Q334_T1.4411.00
55_R61_I1.4411.00
62_L65_T1.4401.00
84_N87_T1.4391.00
53_E57_R1.4221.00
230_V234_S1.4191.00
251_I255_C1.4131.00
70_P112_L1.4021.00
145_P149_I1.3841.00
276_D279_E1.3771.00
43_S47_V1.3661.00
147_L152_T1.3651.00
293_D296_R1.3561.00
308_N311_M1.3531.00
304_D308_N1.3431.00
214_V217_R1.3341.00
304_D307_I1.3201.00
222_T278_N1.3181.00
100_D230_V1.3120.99
305_D308_N1.3090.99
187_H191_N1.3080.99
147_L150_F1.2830.99
71_I78_E1.2770.99
220_L223_I1.2760.99
255_C259_A1.2730.99
77_V98_T1.2710.99
146_Y150_F1.2650.99
52_K92_E1.2640.99
160_Y176_G1.2630.99
62_L91_I1.2610.99
306_E309_Y1.2460.99
78_E81_V1.2450.99
123_D126_D1.2400.99
199_P202_D1.2380.99
65_T82_L1.2340.99
187_H190_Y1.2280.99
160_Y164_F1.2140.99
308_N313_R1.2120.99
276_D280_C1.2090.99
68_M90_T1.2020.99
128_D132_R1.1970.99
176_G243_G1.1930.99
288_K295_F1.1860.99
100_D228_V1.1830.99
146_Y151_I1.1820.99
82_L91_I1.1820.99
15_E18_V1.1820.99
304_D311_M1.1810.99
309_Y312_N1.1740.99
102_T228_V1.1720.99
295_F299_L1.1640.99
146_Y149_I1.1610.99
307_I312_N1.1540.99
319_E322_L1.1540.99
147_L151_I1.1470.99
330_L333_S1.1440.99
287_A290_A1.1430.99
148_R151_I1.1350.98
145_P148_R1.1290.98
33_T36_G1.1290.98
291_S295_F1.1270.98
288_K291_S1.1270.98
190_Y194_V1.1160.98
145_P150_F1.1150.98
51_A63_D1.1110.98
288_K296_R1.1110.98
191_N194_V1.1110.98
332_L335_A1.1060.98
295_F298_F1.1020.98
162_W172_N1.0980.98
224_V229_A1.0960.98
77_V227_G1.0950.98
73_I78_E1.0930.98
132_R172_N1.0900.98
288_K292_L1.0880.98
259_A273_G1.0830.98
255_C280_C1.0690.98
71_I94_K1.0650.98
318_E322_L1.0610.98
291_S296_R1.0540.98
296_R300_Q1.0480.97
222_T225_W1.0480.97
211_G214_V1.0450.97
190_Y193_Y1.0430.97
106_T233_D1.0430.97
289_Q295_F1.0380.97
320_D324_A1.0340.97
255_C258_K1.0250.97
81_V90_T1.0210.97
184_P192_K1.0200.97
219_P222_T1.0190.97
225_W228_V1.0140.97
72_V226_D1.0120.97
259_A276_D1.0080.97
261_L265_E1.0040.97
213_L216_T1.0010.97
100_D243_G0.9860.96
129_I133_E0.9840.96
71_I74_G0.9820.96
316_I321_L0.9810.96
101_A234_S0.9720.96
203_K206_L0.9570.96
285_Y289_Q0.9530.96
186_I190_Y0.9530.96
273_G276_D0.9500.95
249_A253_A0.9500.95
72_V77_V0.9480.95
244_G247_G0.9480.95
222_T271_A0.9420.95
160_Y243_G0.9320.95
95_A98_T0.9300.95
194_V198_A0.9220.95
317_R322_L0.9210.95
223_I237_T0.9210.95
188_E192_K0.9170.95
253_A256_V0.9150.94
52_K55_R0.9130.94
18_V23_L0.9120.94
223_I285_Y0.9080.94
287_A291_S0.9000.94
135_L138_K0.8980.94
214_V218_R0.8970.94
204_N208_V0.8940.94
269_F272_K0.8920.94
252_S255_C0.8910.94
229_A277_A0.8890.94
213_L218_R0.8880.94
219_P223_I0.8860.93
219_P224_V0.8850.93
25_S29_K0.8810.93
24_Y29_K0.8790.93
172_N176_G0.8770.93
66_T84_N0.8760.93
62_L93_A0.8720.93
308_N312_N0.8710.93
97_I229_A0.8680.93
186_I196_Y0.8650.93
133_E136_N0.8640.93
74_G77_V0.8630.93
194_V197_Y0.8630.93
80_A95_A0.8620.93
264_F269_F0.8620.93
318_E321_L0.8600.92
296_R299_L0.8600.92
166_K172_N0.8550.92
43_S172_N0.8550.92
20_G146_Y0.8540.92
68_M84_N0.8510.92
144_Y166_K0.8490.92
85_R91_I0.8450.92
85_R88_N0.8450.92
319_E323_E0.8440.92
68_M81_V0.8370.91
304_D312_N0.8360.91
305_D312_N0.8330.91
130_A160_Y0.8290.91
120_E123_D0.8290.91
286_G289_Q0.8280.91
54_A57_R0.8240.91
242_H246_K0.8230.91
9_P13_E0.8220.91
72_V112_L0.8210.91
213_L217_R0.8210.91
160_Y172_N0.8200.91
164_F174_G0.8190.90
45_S48_Q0.8180.90
315_V321_L0.8170.90
102_T109_R0.8140.90
275_W279_E0.8120.90
9_P52_K0.8120.90
205_R208_V0.8110.90
231_I253_A0.8020.90
282_I286_G0.7990.89
71_I92_E0.7980.89
185_S189_F0.7970.89
212_A216_T0.7920.89
9_P56_D0.7880.89
67_A82_L0.7870.89
55_R58_G0.7870.89
200_D203_K0.7800.88
307_I311_M0.7790.88
200_D208_V0.7780.88
236_F244_G0.7770.88
323_E332_L0.7730.88
325_S328_G0.7680.87
211_G216_T0.7670.87
189_F194_V0.7630.87
272_K276_D0.7630.87
270_S273_G0.7620.87
97_I263_A0.7610.87
47_V51_A0.7570.87
86_R89_E0.7560.87
76_K92_E0.7560.87
114_F220_L0.7550.87
292_L297_R0.7540.86
67_A108_F0.7500.86
71_I227_G0.7500.86
321_L325_S0.7490.86
109_R236_F0.7470.86
42_D166_K0.7470.86
76_K226_D0.7440.86
190_Y196_Y0.7430.86
41_I165_P0.7380.85
184_P198_A0.7360.85
127_A132_R0.7340.85
127_A130_A0.7330.85
281_Y285_Y0.7320.85
160_Y246_K0.7310.85
100_D106_T0.7300.85
126_D129_I0.7290.85
123_D132_R0.7290.85
295_F300_Q0.7270.84
76_K96_K0.7270.84
76_K94_K0.7260.84
98_T274_L0.7250.84
294_L297_R0.7250.84
139_D143_E0.7220.84
284_R289_Q0.7220.84
189_F193_Y0.7210.84
317_R321_L0.7200.84
72_V227_G0.7190.84
316_I319_E0.7170.84
331_Q335_A0.7150.83
85_R90_T0.7150.83
41_I46_Y0.7150.83
268_D272_K0.7140.83
240_P243_G0.7140.83
309_Y313_R0.7130.83
160_Y244_G0.7120.83
284_R292_L0.7120.83
80_A98_T0.7110.83
98_T227_G0.7110.83
230_V277_A0.7080.83
285_Y295_F0.7070.83
13_E16_E0.7070.83
324_A328_G0.7060.83
47_V63_D0.7060.83
329_D333_S0.7050.83
162_W165_P0.7050.83
292_L298_F0.7040.82
216_T293_D0.7030.82
311_M315_V0.7030.82
64_L86_R0.7010.82
274_L278_N0.6970.82
123_D127_A0.6930.81
315_V319_E0.6920.81
84_N90_T0.6910.81
318_E333_S0.6910.81
231_I277_A0.6910.81
52_K56_D0.6890.81
130_A149_I0.6890.81
65_T91_I0.6870.81
262_N272_K0.6860.81
281_Y288_K0.6820.80
47_V174_G0.6810.80
295_F302_L0.6800.80
75_N227_G0.6800.80
130_A176_G0.6800.80
18_V243_G0.6780.80
244_G288_K0.6780.80
266_V273_G0.6760.80
43_S239_N0.6750.80
211_G215_P0.6730.80
184_P188_E0.6690.79
226_D271_A0.6640.79
304_D309_Y0.6620.78
307_I313_R0.6620.78
128_D133_E0.6610.78
72_V225_W0.6600.78
241_V292_L0.6590.78
109_R247_G0.6570.78
250_M257_G0.6560.78
73_I227_G0.6540.78
133_E138_K0.6540.78
16_E21_I0.6490.77
125_K128_D0.6480.77
22_R31_I0.6470.77
185_S196_Y0.6470.77
102_T230_V0.6460.77
193_Y197_Y0.6430.76
20_G240_P0.6410.76
286_G290_A0.6400.76
246_K249_A0.6400.76
112_L228_V0.6370.76
323_E328_G0.6360.76
188_E194_V0.6350.76
202_D207_L0.6340.75
129_I132_R0.6340.75
191_N206_L0.6330.75
51_A55_R0.6320.75
43_S246_K0.6310.75
131_Y134_V0.6280.75
219_P282_I0.6270.75
47_V239_N0.6240.74
133_E194_V0.6240.74
239_N242_H0.6230.74
102_T236_F0.6220.74
24_Y28_M0.6190.74
64_L88_N0.6180.74
164_F243_G0.6170.73
104_Y246_K0.6160.73
303_S309_Y0.6140.73
84_N88_N0.6110.73
267_N270_S0.6090.72
286_G294_L0.6090.72
223_I235_A0.6080.72
46_Y172_N0.6060.72
171_V174_G0.6060.72
324_A327_N0.6050.72
74_G78_E0.6040.72
208_V211_G0.6030.72
224_V278_N0.6030.72
184_P189_F0.6030.72
76_K81_V0.5990.71
151_I157_P0.5990.71
329_D334_T0.5990.71
77_V228_V0.5980.71
210_G214_V0.5930.70
133_E211_G0.5900.70
307_I315_V0.5870.70
125_K132_R0.5870.70
292_L299_L0.5860.70
100_D112_L0.5850.69
126_D132_R0.5840.69
176_G244_G0.5840.69
239_N248_S0.5830.69
49_R53_E0.5830.69
222_T228_V0.5830.69
233_D245_G0.5830.69
71_I77_V0.5820.69
21_I24_Y0.5820.69
199_P203_K0.5820.69
136_N207_L0.5790.69
64_L186_I0.5790.69
238_V248_S0.5780.69
326_A329_D0.5770.68
26_P30_T0.5770.68
72_V228_V0.5760.68
149_I242_H0.5740.68
102_T243_G0.5720.68
67_A111_K0.5710.68
298_F303_S0.5700.67
160_Y242_H0.5700.67
38_G160_Y0.5690.67
296_R303_S0.5680.67
165_P240_P0.5670.67
109_R256_V0.5660.67
27_D30_T0.5650.67
209_K213_L0.5640.67
315_V328_G0.5600.66
274_L279_E0.5600.66
172_N242_H0.5590.66
124_D130_A0.5580.66
164_F172_N0.5580.66
277_A299_L0.5580.66
252_S256_V0.5570.66
121_T130_A0.5560.66
55_R87_T0.5510.65
78_E266_V0.5510.65
322_L326_A0.5500.65
14_L18_V0.5490.65
266_V276_D0.5490.65
299_L303_S0.5480.64
97_I255_C0.5480.64
315_V318_E0.5480.64
164_F239_N0.5480.64
178_Q181_M0.5480.64
248_S285_Y0.5470.64
18_V40_E0.5470.64
223_I281_Y0.5470.64
43_S46_Y0.5450.64
325_S335_A0.5450.64
69_K90_T0.5450.64
164_F176_G0.5410.63
107_S110_N0.5400.63
11_G15_E0.5400.63
75_N96_K0.5400.63
75_N78_E0.5370.63
133_E137_T0.5350.63
160_Y239_N0.5320.62
299_L302_L0.5300.62
237_T242_H0.5290.62
152_T157_P0.5290.62
81_V87_T0.5290.62
284_R293_D0.5280.62
137_T171_V0.5280.62
298_F302_L0.5270.61
149_I164_F0.5260.61
317_R323_E0.5250.61
130_A134_V0.5250.61
76_K90_T0.5230.61
126_D131_Y0.5220.61
24_Y30_T0.5190.60
236_F247_G0.5170.60
108_F228_V0.5150.60
38_G164_F0.5150.60
190_Y197_Y0.5150.60
284_R288_K0.5130.59
239_N244_G0.5080.59
89_E140_E0.5080.59
200_D205_R0.5080.59
243_G246_K0.5080.59
189_F197_Y0.5070.59
212_A218_R0.5070.59
322_L325_S0.5060.58
300_Q303_S0.5060.58
74_G227_G0.5030.58
242_H292_L0.5010.58
259_A262_N0.5010.58
85_R199_P0.5000.58
160_Y241_V0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4opcA 1 0.9975 100 0.333 Contact Map
3oz2A 1 0.8417 100 0.477 Contact Map
4k22A 4 0.7211 100 0.502 Contact Map
4n9xA 5 0.7513 100 0.511 Contact Map
2x3nA 1 0.7312 100 0.515 Contact Map
2qa1A 2 0.9372 100 0.523 Contact Map
1pn0A 3 0.8593 100 0.523 Contact Map
2qa2A 2 0.9397 100 0.526 Contact Map
3i3lA 1 0.9146 100 0.528 Contact Map
4k5sA 2 0.9372 100 0.534 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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