Q97W83 - SULSO - GREMLIN Contacts

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Q97W83 - Geranylgeranyl hydrogenase, putative

UniProt:	Q97W83	Sequences: MITWGMPYPQGKELEEKVEGIRLYSPDMKTIWTVKGEGFEIDSPSYVQRLAKEARDRGVEILDLTTAMKPIVIGNKVEGAVLFNRRTNETIEAKAKITVDATGYSTSFRNKLPFEFPVTETLDDKDADIAYREVLNTKDEIEEYPYLRIFITQKASPGGYWWYFPKGPNKVNVGLGIQGGMGYPSIHEFYNKYVDYYAPDIDKNRLLVKGGALVPTRRPLATIVWDGVAVIGDSAFTVNPVHGGGKGSAMISAYCVGKAILNAFEVNDFSAKGLWDANECYIERYGAKQASLDLFRRFLQRLSDDEINYGMNRKVIREEDLLEASANGDLQLSTAEKAMRVIMALGKPSLLFKLKTVAEYMKKVKDVYKHFPAEPKDLMKWKHSVDSIILEFNKALEK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	398 (316)
Sequences:	2632 (1970)
Seq/√Len:	110.8

ECOLI - FIXC UBII YDIS MHPA UBIH UBIF YGCN CBRA
BACSU - YHJG YETM
HALSA - Q9HS24 Q9HS01 Q9HQE5 Q9HMA0
SULSO - Q97W83 Q97V59 Q97V18

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_E	56_D	5.042	1.00
48_Q	52_K	4.857	1.00
278_N	282_I	4.842	1.00
136_N	205_R	4.372	1.00
99_V	260_I	4.145	1.00
69_K	111_K	3.661	1.00
102_T	106_T	3.312	1.00
99_V	231_I	3.282	1.00
99_V	229_A	3.234	1.00
69_K	81_V	3.053	1.00
51_A	61_I	2.962	1.00
67_A	80_A	2.953	1.00
81_V	92_E	2.705	1.00
185_S	188_E	2.681	1.00
85_R	89_E	2.565	1.00
100_D	108_F	2.464	1.00
237_T	252_S	2.416	1.00
236_F	252_S	2.379	1.00
262_N	280_C	2.367	1.00
73_I	94_K	2.366	1.00
34_V	37_E	2.329	1.00
96_K	264_F	2.234	1.00
259_A	280_C	2.173	1.00
191_N	195_D	2.141	1.00
258_K	280_C	2.078	1.00
292_L	295_F	2.055	1.00
101_A	231_I	2.051	1.00
82_L	93_A	2.033	1.00
71_I	81_V	2.000	1.00
33_T	37_E	1.957	1.00
257_G	261_L	1.950	1.00
78_E	94_K	1.932	1.00
224_V	275_W	1.885	1.00
149_I	152_T	1.882	1.00
146_Y	152_T	1.871	1.00
192_K	195_D	1.864	1.00
162_W	174_G	1.833	1.00
54_A	59_V	1.822	1.00
289_Q	292_L	1.811	1.00
67_A	70_P	1.787	1.00
262_N	276_D	1.784	1.00
70_P	98_T	1.784	1.00
253_A	257_G	1.646	1.00
254_Y	258_K	1.629	1.00
148_R	152_T	1.619	1.00
229_A	260_I	1.615	1.00
73_I	76_K	1.613	1.00
25_S	28_M	1.596	1.00
215_P	218_R	1.589	1.00
78_E	92_E	1.576	1.00
54_A	58_G	1.559	1.00
192_K	196_Y	1.556	1.00
292_L	296_R	1.547	1.00
145_P	152_T	1.541	1.00
236_F	281_Y	1.531	1.00
252_S	281_Y	1.512	1.00
97_I	260_I	1.503	1.00
126_D	130_A	1.470	1.00
121_T	124_D	1.464	1.00
229_A	256_V	1.457	1.00
145_P	151_I	1.455	1.00
128_D	131_Y	1.455	1.00
130_A	133_E	1.445	1.00
331_Q	334_T	1.441	1.00
55_R	61_I	1.441	1.00
62_L	65_T	1.440	1.00
84_N	87_T	1.439	1.00
53_E	57_R	1.422	1.00
230_V	234_S	1.419	1.00
251_I	255_C	1.413	1.00
70_P	112_L	1.402	1.00
145_P	149_I	1.384	1.00
276_D	279_E	1.377	1.00
43_S	47_V	1.366	1.00
147_L	152_T	1.365	1.00
293_D	296_R	1.356	1.00
308_N	311_M	1.353	1.00
304_D	308_N	1.343	1.00
214_V	217_R	1.334	1.00
304_D	307_I	1.320	1.00
222_T	278_N	1.318	1.00
100_D	230_V	1.312	0.99
305_D	308_N	1.309	0.99
187_H	191_N	1.308	0.99
147_L	150_F	1.283	0.99
71_I	78_E	1.277	0.99
220_L	223_I	1.276	0.99
255_C	259_A	1.273	0.99
77_V	98_T	1.271	0.99
146_Y	150_F	1.265	0.99
52_K	92_E	1.264	0.99
160_Y	176_G	1.263	0.99
62_L	91_I	1.261	0.99
306_E	309_Y	1.246	0.99
78_E	81_V	1.245	0.99
123_D	126_D	1.240	0.99
199_P	202_D	1.238	0.99
65_T	82_L	1.234	0.99
187_H	190_Y	1.228	0.99
160_Y	164_F	1.214	0.99
308_N	313_R	1.212	0.99
276_D	280_C	1.209	0.99
68_M	90_T	1.202	0.99
128_D	132_R	1.197	0.99
176_G	243_G	1.193	0.99
288_K	295_F	1.186	0.99
100_D	228_V	1.183	0.99
146_Y	151_I	1.182	0.99
82_L	91_I	1.182	0.99
15_E	18_V	1.182	0.99
304_D	311_M	1.181	0.99
309_Y	312_N	1.174	0.99
102_T	228_V	1.172	0.99
295_F	299_L	1.164	0.99
146_Y	149_I	1.161	0.99
307_I	312_N	1.154	0.99
319_E	322_L	1.154	0.99
147_L	151_I	1.147	0.99
330_L	333_S	1.144	0.99
287_A	290_A	1.143	0.99
148_R	151_I	1.135	0.98
145_P	148_R	1.129	0.98
33_T	36_G	1.129	0.98
291_S	295_F	1.127	0.98
288_K	291_S	1.127	0.98
190_Y	194_V	1.116	0.98
145_P	150_F	1.115	0.98
51_A	63_D	1.111	0.98
288_K	296_R	1.111	0.98
191_N	194_V	1.111	0.98
332_L	335_A	1.106	0.98
295_F	298_F	1.102	0.98
162_W	172_N	1.098	0.98
224_V	229_A	1.096	0.98
77_V	227_G	1.095	0.98
73_I	78_E	1.093	0.98
132_R	172_N	1.090	0.98
288_K	292_L	1.088	0.98
259_A	273_G	1.083	0.98
255_C	280_C	1.069	0.98
71_I	94_K	1.065	0.98
318_E	322_L	1.061	0.98
291_S	296_R	1.054	0.98
296_R	300_Q	1.048	0.97
222_T	225_W	1.048	0.97
211_G	214_V	1.045	0.97
190_Y	193_Y	1.043	0.97
106_T	233_D	1.043	0.97
289_Q	295_F	1.038	0.97
320_D	324_A	1.034	0.97
255_C	258_K	1.025	0.97
81_V	90_T	1.021	0.97
184_P	192_K	1.020	0.97
219_P	222_T	1.019	0.97
225_W	228_V	1.014	0.97
72_V	226_D	1.012	0.97
259_A	276_D	1.008	0.97
261_L	265_E	1.004	0.97
213_L	216_T	1.001	0.97
100_D	243_G	0.986	0.96
129_I	133_E	0.984	0.96
71_I	74_G	0.982	0.96
316_I	321_L	0.981	0.96
101_A	234_S	0.972	0.96
203_K	206_L	0.957	0.96
285_Y	289_Q	0.953	0.96
186_I	190_Y	0.953	0.96
273_G	276_D	0.950	0.95
249_A	253_A	0.950	0.95
72_V	77_V	0.948	0.95
244_G	247_G	0.948	0.95
222_T	271_A	0.942	0.95
160_Y	243_G	0.932	0.95
95_A	98_T	0.930	0.95
194_V	198_A	0.922	0.95
317_R	322_L	0.921	0.95
223_I	237_T	0.921	0.95
188_E	192_K	0.917	0.95
253_A	256_V	0.915	0.94
52_K	55_R	0.913	0.94
18_V	23_L	0.912	0.94
223_I	285_Y	0.908	0.94
287_A	291_S	0.900	0.94
135_L	138_K	0.898	0.94
214_V	218_R	0.897	0.94
204_N	208_V	0.894	0.94
269_F	272_K	0.892	0.94
252_S	255_C	0.891	0.94
229_A	277_A	0.889	0.94
213_L	218_R	0.888	0.94
219_P	223_I	0.886	0.93
219_P	224_V	0.885	0.93
25_S	29_K	0.881	0.93
24_Y	29_K	0.879	0.93
172_N	176_G	0.877	0.93
66_T	84_N	0.876	0.93
62_L	93_A	0.872	0.93
308_N	312_N	0.871	0.93
97_I	229_A	0.868	0.93
186_I	196_Y	0.865	0.93
133_E	136_N	0.864	0.93
74_G	77_V	0.863	0.93
194_V	197_Y	0.863	0.93
80_A	95_A	0.862	0.93
264_F	269_F	0.862	0.93
318_E	321_L	0.860	0.92
296_R	299_L	0.860	0.92
166_K	172_N	0.855	0.92
43_S	172_N	0.855	0.92
20_G	146_Y	0.854	0.92
68_M	84_N	0.851	0.92
144_Y	166_K	0.849	0.92
85_R	91_I	0.845	0.92
85_R	88_N	0.845	0.92
319_E	323_E	0.844	0.92
68_M	81_V	0.837	0.91
304_D	312_N	0.836	0.91
305_D	312_N	0.833	0.91
130_A	160_Y	0.829	0.91
120_E	123_D	0.829	0.91
286_G	289_Q	0.828	0.91
54_A	57_R	0.824	0.91
242_H	246_K	0.823	0.91
9_P	13_E	0.822	0.91
72_V	112_L	0.821	0.91
213_L	217_R	0.821	0.91
160_Y	172_N	0.820	0.91
164_F	174_G	0.819	0.90
45_S	48_Q	0.818	0.90
315_V	321_L	0.817	0.90
102_T	109_R	0.814	0.90
275_W	279_E	0.812	0.90
9_P	52_K	0.812	0.90
205_R	208_V	0.811	0.90
231_I	253_A	0.802	0.90
282_I	286_G	0.799	0.89
71_I	92_E	0.798	0.89
185_S	189_F	0.797	0.89
212_A	216_T	0.792	0.89
9_P	56_D	0.788	0.89
67_A	82_L	0.787	0.89
55_R	58_G	0.787	0.89
200_D	203_K	0.780	0.88
307_I	311_M	0.779	0.88
200_D	208_V	0.778	0.88
236_F	244_G	0.777	0.88
323_E	332_L	0.773	0.88
325_S	328_G	0.768	0.87
211_G	216_T	0.767	0.87
189_F	194_V	0.763	0.87
272_K	276_D	0.763	0.87
270_S	273_G	0.762	0.87
97_I	263_A	0.761	0.87
47_V	51_A	0.757	0.87
86_R	89_E	0.756	0.87
76_K	92_E	0.756	0.87
114_F	220_L	0.755	0.87
292_L	297_R	0.754	0.86
67_A	108_F	0.750	0.86
71_I	227_G	0.750	0.86
321_L	325_S	0.749	0.86
109_R	236_F	0.747	0.86
42_D	166_K	0.747	0.86
76_K	226_D	0.744	0.86
190_Y	196_Y	0.743	0.86
41_I	165_P	0.738	0.85
184_P	198_A	0.736	0.85
127_A	132_R	0.734	0.85
127_A	130_A	0.733	0.85
281_Y	285_Y	0.732	0.85
160_Y	246_K	0.731	0.85
100_D	106_T	0.730	0.85
126_D	129_I	0.729	0.85
123_D	132_R	0.729	0.85
295_F	300_Q	0.727	0.84
76_K	96_K	0.727	0.84
76_K	94_K	0.726	0.84
98_T	274_L	0.725	0.84
294_L	297_R	0.725	0.84
139_D	143_E	0.722	0.84
284_R	289_Q	0.722	0.84
189_F	193_Y	0.721	0.84
317_R	321_L	0.720	0.84
72_V	227_G	0.719	0.84
316_I	319_E	0.717	0.84
331_Q	335_A	0.715	0.83
85_R	90_T	0.715	0.83
41_I	46_Y	0.715	0.83
268_D	272_K	0.714	0.83
240_P	243_G	0.714	0.83
309_Y	313_R	0.713	0.83
160_Y	244_G	0.712	0.83
284_R	292_L	0.712	0.83
80_A	98_T	0.711	0.83
98_T	227_G	0.711	0.83
230_V	277_A	0.708	0.83
285_Y	295_F	0.707	0.83
13_E	16_E	0.707	0.83
324_A	328_G	0.706	0.83
47_V	63_D	0.706	0.83
329_D	333_S	0.705	0.83
162_W	165_P	0.705	0.83
292_L	298_F	0.704	0.82
216_T	293_D	0.703	0.82
311_M	315_V	0.703	0.82
64_L	86_R	0.701	0.82
274_L	278_N	0.697	0.82
123_D	127_A	0.693	0.81
315_V	319_E	0.692	0.81
84_N	90_T	0.691	0.81
318_E	333_S	0.691	0.81
231_I	277_A	0.691	0.81
52_K	56_D	0.689	0.81
130_A	149_I	0.689	0.81
65_T	91_I	0.687	0.81
262_N	272_K	0.686	0.81
281_Y	288_K	0.682	0.80
47_V	174_G	0.681	0.80
295_F	302_L	0.680	0.80
75_N	227_G	0.680	0.80
130_A	176_G	0.680	0.80
18_V	243_G	0.678	0.80
244_G	288_K	0.678	0.80
266_V	273_G	0.676	0.80
43_S	239_N	0.675	0.80
211_G	215_P	0.673	0.80
184_P	188_E	0.669	0.79
226_D	271_A	0.664	0.79
304_D	309_Y	0.662	0.78
307_I	313_R	0.662	0.78
128_D	133_E	0.661	0.78
72_V	225_W	0.660	0.78
241_V	292_L	0.659	0.78
109_R	247_G	0.657	0.78
250_M	257_G	0.656	0.78
73_I	227_G	0.654	0.78
133_E	138_K	0.654	0.78
16_E	21_I	0.649	0.77
125_K	128_D	0.648	0.77
22_R	31_I	0.647	0.77
185_S	196_Y	0.647	0.77
102_T	230_V	0.646	0.77
193_Y	197_Y	0.643	0.76
20_G	240_P	0.641	0.76
286_G	290_A	0.640	0.76
246_K	249_A	0.640	0.76
112_L	228_V	0.637	0.76
323_E	328_G	0.636	0.76
188_E	194_V	0.635	0.76
202_D	207_L	0.634	0.75
129_I	132_R	0.634	0.75
191_N	206_L	0.633	0.75
51_A	55_R	0.632	0.75
43_S	246_K	0.631	0.75
131_Y	134_V	0.628	0.75
219_P	282_I	0.627	0.75
47_V	239_N	0.624	0.74
133_E	194_V	0.624	0.74
239_N	242_H	0.623	0.74
102_T	236_F	0.622	0.74
24_Y	28_M	0.619	0.74
64_L	88_N	0.618	0.74
164_F	243_G	0.617	0.73
104_Y	246_K	0.616	0.73
303_S	309_Y	0.614	0.73
84_N	88_N	0.611	0.73
267_N	270_S	0.609	0.72
286_G	294_L	0.609	0.72
223_I	235_A	0.608	0.72
46_Y	172_N	0.606	0.72
171_V	174_G	0.606	0.72
324_A	327_N	0.605	0.72
74_G	78_E	0.604	0.72
208_V	211_G	0.603	0.72
224_V	278_N	0.603	0.72
184_P	189_F	0.603	0.72
76_K	81_V	0.599	0.71
151_I	157_P	0.599	0.71
329_D	334_T	0.599	0.71
77_V	228_V	0.598	0.71
210_G	214_V	0.593	0.70
133_E	211_G	0.590	0.70
307_I	315_V	0.587	0.70
125_K	132_R	0.587	0.70
292_L	299_L	0.586	0.70
100_D	112_L	0.585	0.69
126_D	132_R	0.584	0.69
176_G	244_G	0.584	0.69
239_N	248_S	0.583	0.69
49_R	53_E	0.583	0.69
222_T	228_V	0.583	0.69
233_D	245_G	0.583	0.69
71_I	77_V	0.582	0.69
21_I	24_Y	0.582	0.69
199_P	203_K	0.582	0.69
136_N	207_L	0.579	0.69
64_L	186_I	0.579	0.69
238_V	248_S	0.578	0.69
326_A	329_D	0.577	0.68
26_P	30_T	0.577	0.68
72_V	228_V	0.576	0.68
149_I	242_H	0.574	0.68
102_T	243_G	0.572	0.68
67_A	111_K	0.571	0.68
298_F	303_S	0.570	0.67
160_Y	242_H	0.570	0.67
38_G	160_Y	0.569	0.67
296_R	303_S	0.568	0.67
165_P	240_P	0.567	0.67
109_R	256_V	0.566	0.67
27_D	30_T	0.565	0.67
209_K	213_L	0.564	0.67
315_V	328_G	0.560	0.66
274_L	279_E	0.560	0.66
172_N	242_H	0.559	0.66
124_D	130_A	0.558	0.66
164_F	172_N	0.558	0.66
277_A	299_L	0.558	0.66
252_S	256_V	0.557	0.66
121_T	130_A	0.556	0.66
55_R	87_T	0.551	0.65
78_E	266_V	0.551	0.65
322_L	326_A	0.550	0.65
14_L	18_V	0.549	0.65
266_V	276_D	0.549	0.65
299_L	303_S	0.548	0.64
97_I	255_C	0.548	0.64
315_V	318_E	0.548	0.64
164_F	239_N	0.548	0.64
178_Q	181_M	0.548	0.64
248_S	285_Y	0.547	0.64
18_V	40_E	0.547	0.64
223_I	281_Y	0.547	0.64
43_S	46_Y	0.545	0.64
325_S	335_A	0.545	0.64
69_K	90_T	0.545	0.64
164_F	176_G	0.541	0.63
107_S	110_N	0.540	0.63
11_G	15_E	0.540	0.63
75_N	96_K	0.540	0.63
75_N	78_E	0.537	0.63
133_E	137_T	0.535	0.63
160_Y	239_N	0.532	0.62
299_L	302_L	0.530	0.62
237_T	242_H	0.529	0.62
152_T	157_P	0.529	0.62
81_V	87_T	0.529	0.62
284_R	293_D	0.528	0.62
137_T	171_V	0.528	0.62
298_F	302_L	0.527	0.61
149_I	164_F	0.526	0.61
317_R	323_E	0.525	0.61
130_A	134_V	0.525	0.61
76_K	90_T	0.523	0.61
126_D	131_Y	0.522	0.61
24_Y	30_T	0.519	0.60
236_F	247_G	0.517	0.60
108_F	228_V	0.515	0.60
38_G	164_F	0.515	0.60
190_Y	197_Y	0.515	0.60
284_R	288_K	0.513	0.59
239_N	244_G	0.508	0.59
89_E	140_E	0.508	0.59
200_D	205_R	0.508	0.59
243_G	246_K	0.508	0.59
189_F	197_Y	0.507	0.59
212_A	218_R	0.507	0.59
322_L	325_S	0.506	0.58
300_Q	303_S	0.506	0.58
74_G	227_G	0.503	0.58
242_H	292_L	0.501	0.58
259_A	262_N	0.501	0.58
85_R	199_P	0.500	0.58
160_Y	241_V	0.500	0.58

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4opcA	1	0.9975	100	0.333	Contact Map
3oz2A	1	0.8417	100	0.477	Contact Map
4k22A	4	0.7211	100	0.502	Contact Map
4n9xA	5	0.7513	100	0.511	Contact Map
2x3nA	1	0.7312	100	0.515	Contact Map
2qa1A	2	0.9372	100	0.523	Contact Map
1pn0A	3	0.8593	100	0.523	Contact Map
2qa2A	2	0.9397	100	0.526	Contact Map
3i3lA	1	0.9146	100	0.528	Contact Map
4k5sA	2	0.9372	100	0.534	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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