GREMLIN Database
Q97W80 - Phosphatase, putative (NagD-like)
UniProt: Q97W80 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (249)
Sequences: 4223 (2912)
Seq/√Len: 184.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
226_G233_T5.3521.00
8_Q211_K5.1011.00
7_Y232_D3.9811.00
36_Q71_M3.3181.00
213_L234_A3.3181.00
224_Q228_N2.9741.00
153_V174_A2.8631.00
194_T198_E2.8371.00
232_D254_K2.5851.00
178_I184_D2.4951.00
54_I69_P2.4401.00
206_V212_I2.2931.00
34_N38_N2.2891.00
178_I185_P2.2211.00
91_S110_L2.1811.00
9_L204_S2.1151.00
207_K210_D2.0471.00
223_I233_T2.0261.00
259_T262_D2.0131.00
34_N37_N1.9531.00
258_N262_D1.9021.00
58_R62_Y1.7901.00
33_R37_N1.7811.00
9_L206_V1.7801.00
201_M212_I1.7061.00
12_S215_I1.6981.00
24_P29_I1.6841.00
94_A104_L1.6701.00
214_V231_A1.6541.00
158_R179_Y1.6511.00
21_E163_K1.6451.00
237_L258_N1.6441.00
54_I58_R1.6241.00
79_A126_V1.6221.00
242_N245_D1.5931.00
20_R23_D1.5781.00
175_S178_I1.5491.00
151_F185_P1.5451.00
197_V225_M1.5441.00
43_I203_I1.5381.00
14_V44_F1.5211.00
79_A152_I1.5111.00
11_I45_V1.5091.00
134_T137_K1.4961.00
57_S69_P1.4701.00
227_Y254_K1.4661.00
50_G129_L1.4651.00
237_L256_V1.4611.00
241_S245_D1.4521.00
175_S179_Y1.4401.00
130_D137_K1.4371.00
10_I213_L1.4371.00
241_S246_V1.4361.00
18_I44_F1.4331.00
14_V19_V1.4291.00
53_R77_L1.4281.00
25_I259_T1.4271.00
197_V214_V1.4181.00
29_I33_R1.4051.00
152_I189_A1.3541.00
86_K150_K1.3521.00
80_A107_H1.3351.00
193_N228_N1.3241.00
97_E131_R1.3221.00
33_R66_K1.3111.00
145_I177_I1.3081.00
30_Q261_L1.3051.00
8_Q40_V1.3011.00
87_L124_A1.3011.00
90_K123_D1.2991.00
35_I40_V1.2821.00
143_R164_D1.2761.00
199_I202_R1.2731.00
57_S61_S1.2711.00
7_Y213_L1.2711.00
98_E102_E1.2661.00
234_A257_V1.2611.00
91_S123_D1.2581.00
51_F59_Q1.2201.00
10_I40_V1.2141.00
55_L58_R1.2061.00
143_R146_S1.2031.00
160_W169_G1.2021.00
44_F67_V1.2011.00
237_L241_S1.2011.00
102_E105_K1.2011.00
18_I65_L1.1991.00
10_I35_I1.1941.00
36_Q42_I1.1921.00
61_S69_P1.1871.00
41_K71_M1.1831.00
58_R61_S1.1721.00
28_N65_L1.1611.00
30_Q33_R1.1571.00
52_S55_L1.1561.00
92_V109_F1.1551.00
78_A196_I1.1531.00
18_I32_L1.1531.00
12_S31_A1.1511.00
243_V247_D1.1391.00
127_M174_A1.1341.00
237_L243_V1.1291.00
57_S72_I1.1281.00
53_R103_E1.1111.00
224_Q251_V1.1091.00
162_A167_K1.1041.00
49_S75_S1.1021.00
11_I200_A1.1021.00
29_I65_L1.1011.00
14_V17_V1.0951.00
138_L176_S1.0941.00
81_I85_E1.0801.00
76_G80_A1.0741.00
124_A150_K1.0701.00
218_Q221_T1.0691.00
84_K109_F1.0681.00
122_P144_C1.0671.00
27_E30_Q1.0631.00
24_P63_L1.0591.00
235_L241_S1.0561.00
197_V231_A1.0541.00
68_T71_M1.0471.00
145_I181_L1.0431.00
12_S42_I1.0371.00
207_K211_K1.0321.00
243_V258_N1.0231.00
73_I199_I1.0181.00
9_L41_K1.0171.00
17_V129_L1.0100.99
42_I71_M0.9980.99
95_V141_A0.9950.99
143_R167_K0.9950.99
156_M188_I0.9880.99
91_S121_L0.9880.99
218_Q240_I0.9840.99
232_D255_Y0.9830.99
139_S143_R0.9730.99
81_I199_I0.9720.99
125_V141_A0.9710.99
54_I102_E0.9690.99
174_A188_I0.9670.99
9_L212_I0.9660.99
198_E202_R0.9600.99
73_I200_A0.9570.99
93_F144_C0.9570.99
101_I105_K0.9570.99
85_E202_R0.9540.99
139_S167_K0.9460.99
43_I204_S0.9450.99
246_V253_P0.9430.99
12_S260_L0.9400.99
158_R175_S0.9400.99
45_V214_V0.9370.99
145_I148_G0.9360.99
139_S168_L0.9330.99
25_I28_N0.9310.99
36_Q66_K0.9300.99
46_T74_T0.9270.99
158_R220_E0.9240.99
213_L232_D0.9230.99
227_Y233_T0.9200.99
56_L72_I0.9190.99
82_Y152_I0.9190.99
79_A189_A0.9140.99
82_Y189_A0.9100.99
98_E101_I0.9090.99
23_D163_K0.9080.99
198_E208_K0.9080.99
246_V256_V0.9040.99
129_L133_S0.9040.99
101_I113_S0.9010.99
22_G62_Y0.9010.99
43_I71_M0.8970.99
141_A177_I0.8960.99
56_L74_T0.8950.99
150_K187_F0.8940.99
140_L144_C0.8930.99
19_V44_F0.8920.99
22_G59_Q0.8870.99
223_I227_Y0.8820.99
27_E261_L0.8770.99
79_A154_T0.8710.98
61_S66_K0.8690.98
187_F195_W0.8670.98
28_N260_L0.8610.98
73_I203_I0.8610.98
153_V170_A0.8590.98
82_Y86_K0.8570.98
104_L126_V0.8540.98
59_Q63_L0.8540.98
200_A204_S0.8530.98
17_V197_V0.8510.98
45_V196_I0.8500.98
220_E240_I0.8440.98
157_D221_T0.8420.98
153_V188_I0.8390.98
170_A174_A0.8330.98
136_D140_L0.8320.98
127_M173_L0.8300.98
142_M180_A0.8270.98
80_A103_E0.8180.98
92_V126_V0.8170.98
19_V63_L0.8120.98
145_I151_F0.8100.98
172_A176_S0.8080.97
201_M231_A0.8070.97
76_G79_A0.8000.97
145_I183_R0.7970.97
235_L256_V0.7970.97
43_I73_I0.7960.97
80_A84_K0.7960.97
94_A101_I0.7920.97
105_K111_V0.7900.97
102_E106_N0.7880.97
44_F65_L0.7870.97
199_I203_I0.7860.97
7_Y254_K0.7770.97
77_L103_E0.7730.97
18_I260_L0.7720.97
83_M126_V0.7700.97
200_A225_M0.7680.97
27_E259_T0.7570.96
75_S154_T0.7550.96
148_G183_R0.7480.96
172_A179_Y0.7470.96
214_V225_M0.7470.96
31_A42_I0.7400.96
55_L102_E0.7380.96
17_V225_M0.7370.96
93_F125_V0.7360.96
96_G100_L0.7340.96
93_F141_A0.7330.96
32_L44_F0.7320.96
233_T254_K0.7310.95
103_E106_N0.7280.95
87_L90_K0.7250.95
78_A199_I0.7240.95
20_R163_K0.7220.95
54_I106_N0.7210.95
243_V246_V0.7180.95
133_S173_L0.7180.95
83_M109_F0.7180.95
84_K107_H0.7150.95
24_P65_L0.7130.95
75_S155_N0.7130.95
14_V18_I0.7110.95
157_D161_P0.7090.95
127_M151_F0.7080.95
51_F56_L0.7040.94
41_K204_S0.7040.94
133_S138_L0.7000.94
49_S128_G0.6990.94
7_Y10_I0.6960.94
99_G103_E0.6960.94
176_S179_Y0.6940.94
67_V71_M0.6940.94
26_W261_L0.6920.94
227_Y251_V0.6910.94
29_I64_G0.6860.94
133_S137_K0.6850.94
149_S183_R0.6700.93
80_A109_F0.6690.93
172_A180_A0.6670.93
159_L218_Q0.6670.93
59_Q62_Y0.6620.92
12_S18_I0.6590.92
253_P256_V0.6590.92
20_R25_I0.6540.92
11_I196_I0.6520.92
129_L160_W0.6500.92
197_V200_A0.6490.92
7_Y234_A0.6480.92
245_D248_R0.6470.92
36_Q68_T0.6440.91
24_P64_G0.6420.91
55_L99_G0.6410.91
213_L255_Y0.6390.91
122_P127_M0.6380.91
11_I212_I0.6370.91
81_I84_K0.6290.90
17_V160_W0.6280.90
219_I249_S0.6270.90
36_Q44_F0.6270.90
46_T56_L0.6260.90
14_V60_L0.6260.90
22_G163_K0.6250.90
201_M229_I0.6230.90
244_D247_D0.6230.90
201_M208_K0.6170.90
14_V56_L0.6160.90
127_M153_V0.6130.89
141_A145_I0.6120.89
236_V239_G0.6120.89
197_V226_G0.6100.89
219_I227_Y0.6100.89
28_N259_T0.6070.89
152_I187_F0.6040.89
129_L173_L0.6030.89
133_S176_S0.6020.88
159_L240_I0.6020.88
97_E100_L0.6010.88
13_D16_G0.5990.88
155_N170_A0.5990.88
197_V229_I0.5990.88
159_L166_L0.5990.88
214_V226_G0.5950.88
9_L43_I0.5940.88
142_M146_S0.5930.88
87_L150_K0.5890.87
145_I149_S0.5880.87
246_V252_K0.5850.87
89_V123_D0.5840.87
235_L238_T0.5810.87
142_M177_I0.5810.87
156_M174_A0.5790.86
19_V60_L0.5790.86
219_I223_I0.5780.86
19_V59_Q0.5770.86
51_F55_L0.5740.86
144_C147_K0.5730.86
12_S32_L0.5690.86
198_E201_M0.5660.85
92_V96_G0.5650.85
49_S79_A0.5610.85
156_M193_N0.5610.85
81_I107_H0.5600.85
122_P125_V0.5600.85
101_I111_V0.5590.85
49_S155_N0.5560.84
73_I78_A0.5530.84
31_A261_L0.5510.84
78_A189_A0.5460.83
35_I39_G0.5430.83
82_Y124_A0.5430.83
18_I24_P0.5420.83
36_Q39_G0.5420.83
100_L154_T0.5400.82
8_Q212_I0.5380.82
50_G160_W0.5370.82
195_W198_E0.5310.81
11_I231_A0.5290.81
91_S112_F0.5280.81
14_V221_T0.5270.81
30_Q34_N0.5270.81
83_M104_L0.5260.81
126_V152_I0.5240.81
22_G63_L0.5230.80
153_V156_M0.5210.80
57_S68_T0.5200.80
37_N248_R0.5180.80
78_A81_I0.5160.80
95_V137_K0.5160.80
80_A104_L0.5150.79
81_I203_I0.5150.79
150_K183_R0.5150.79
7_Y255_Y0.5130.79
237_L246_V0.5130.79
87_L248_R0.5130.79
139_S142_M0.5110.79
90_K109_F0.5110.79
236_V257_V0.5090.79
138_L177_I0.5080.78
28_N32_L0.5080.78
20_R169_G0.5070.78
202_R205_N0.5050.78
81_I202_R0.5040.78
225_M229_I0.5040.78
49_S127_M0.5030.78
144_C149_S0.5030.78
32_L36_Q0.5010.78
129_L169_G0.5000.77
76_G100_L0.5000.77
162_A166_L0.5000.77
176_S180_A0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kc2A 2 0.9508 100 0.385 Contact Map
2ho4A 1 0.928 100 0.424 Contact Map
1zjjA 2 0.9621 100 0.451 Contact Map
4i9fA 2 0.9621 100 0.485 Contact Map
2oycA 2 0.9886 100 0.491 Contact Map
3eprA 3 0.9583 100 0.502 Contact Map
3pdwA 1 0.9394 100 0.509 Contact Map
1vjrA 1 0.9735 100 0.51 Contact Map
1yv9A 2 0.9545 100 0.517 Contact Map
2hx1A 3 0.9924 100 0.525 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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