GREMLIN Database
Q97W78 - Succinate dehydrogenase subunit B (SdhB)
UniProt: Q97W78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (249)
Sequences: 266 (175)
Seq/√Len: 11.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_I28_K4.3301.00
43_R47_E4.2310.99
11_L44_I4.0070.99
67_G99_M3.3400.97
11_L40_A3.3340.97
74_P164_A3.2000.96
53_S109_I2.9520.94
69_K163_S2.9190.94
124_P225_P2.7310.91
12_K95_T2.6280.89
67_G144_E2.5020.87
11_L142_K2.4320.85
41_L54_Y2.4240.85
54_Y157_W2.3590.83
96_I109_I2.3470.83
55_R176_G2.3430.83
51_T118_R2.2520.80
118_R168_V2.2390.80
17_N20_K2.2300.80
141_L190_P2.1750.78
45_K57_S2.1200.76
8_E28_K2.0900.75
123_K127_Y2.0170.72
40_A82_V2.0140.72
76_L191_R1.9540.70
203_I236_T1.9380.69
27_Y164_A1.9210.68
17_N26_E1.9200.68
74_P214_Q1.8770.66
69_K100_D1.8590.66
156_I229_I1.8550.65
12_K26_E1.8490.65
32_D35_T1.8460.65
12_K93_V1.8380.65
44_I52_L1.8000.63
206_S232_T1.7880.62
43_R53_S1.7640.61
154_Q223_I1.7490.61
17_N23_W1.7430.60
228_A231_K1.7410.60
45_K225_P1.7320.60
17_N21_G1.7290.60
45_K124_P1.7040.59
126_L186_F1.7000.58
120_F232_T1.7000.58
76_L189_D1.6880.58
14_K22_Y1.6850.58
76_L185_R1.6580.56
18_P22_Y1.6470.56
30_K43_R1.6460.56
187_L232_T1.6310.55
151_K228_A1.6270.55
185_R189_D1.6090.54
166_P182_K1.5780.53
104_P109_I1.5680.52
29_L199_M1.5590.52
152_F228_A1.5200.50
10_I26_E1.5100.49
253_V256_I1.4540.47
187_L199_M1.4450.46
246_A254_E1.4430.46
180_H232_T1.4400.46
247_E250_E1.4330.46
39_E55_R1.4320.46
176_G198_R1.4260.45
178_A202_L1.4110.45
181_A223_I1.3920.44
76_L192_D1.3720.43
115_F124_P1.3680.42
120_F148_E1.3640.42
252_H256_I1.3540.42
19_E125_R1.3460.41
71_N94_I1.3430.41
185_R191_R1.3210.40
30_K201_I1.3180.40
110_V119_M1.3180.40
179_A218_V1.3140.40
26_E190_P1.3080.40
38_T156_I1.3070.40
65_S180_H1.3070.40
12_K94_I1.3050.40
82_V147_R1.2960.39
253_V259_S1.2790.38
174_F216_F1.2630.38
106_K195_T1.2630.38
110_V163_S1.2600.37
247_E251_K1.2590.37
25_A54_Y1.2550.37
114_E168_V1.2410.37
47_E104_P1.2140.35
84_D240_K1.2080.35
96_I122_I1.2060.35
11_L145_D1.2060.35
164_A190_P1.1920.34
9_V31_V1.1800.34
204_D208_R1.1740.34
10_I93_V1.1710.34
14_K118_R1.1640.33
123_K201_I1.1540.33
115_F176_G1.1510.33
62_V180_H1.1490.33
130_K193_T1.1470.33
166_P228_A1.1420.32
26_E93_V1.1410.32
49_D124_P1.1390.32
174_F188_A1.1350.32
182_K252_H1.1270.32
29_L83_L1.1160.31
91_N172_Q1.1140.31
249_G255_A1.1050.31
26_E195_T1.1050.31
28_K130_K1.0960.30
28_K204_D1.0950.30
186_F190_P1.0810.30
73_E251_K1.0710.29
39_E56_A1.0690.29
38_T59_H1.0670.29
55_R115_F1.0510.29
29_L108_L1.0500.29
27_Y114_E1.0450.28
105_I193_T1.0420.28
174_F181_A1.0390.28
79_K106_K1.0350.28
141_L146_Q1.0330.28
124_P141_L1.0320.28
207_W211_Y1.0280.28
55_R225_P1.0120.27
37_F71_N1.0110.27
82_V93_V0.9960.26
211_Y252_H0.9900.26
142_K190_P0.9820.26
55_R138_E0.9800.26
49_D225_P0.9780.26
159_G163_S0.9720.26
39_E115_F0.9620.25
36_Q59_H0.9570.25
128_Q193_T0.9530.25
101_Y163_S0.9410.24
27_Y106_K0.9370.24
176_G218_V0.9310.24
115_F225_P0.9280.24
68_M77_A0.9250.24
122_I179_A0.9200.24
148_E197_E0.9190.24
31_V231_K0.9130.23
200_K240_K0.9070.23
166_P259_S0.9000.23
125_R237_K0.8950.23
46_S50_P0.8940.23
154_Q179_A0.8940.23
138_E238_T0.8920.23
171_D233_R0.8920.23
117_E120_F0.8910.23
13_V20_K0.8860.23
19_E126_L0.8820.22
67_G201_I0.8810.22
55_R198_R0.8780.22
57_S126_L0.8720.22
209_C215_C0.8710.22
200_K204_D0.8600.22
168_V190_P0.8600.22
106_K254_E0.8550.22
176_G220_P0.8500.21
141_L183_G0.8490.21
71_N105_I0.8470.21
14_K168_V0.8460.21
115_F179_A0.8450.21
251_K260_I0.8440.21
26_E148_E0.8410.21
215_C219_C0.8410.21
209_C219_C0.8410.21
196_E240_K0.8360.21
174_F184_Y0.8210.20
152_F223_I0.8180.20
250_E256_I0.8170.20
145_D148_E0.8150.20
81_L174_F0.8130.20
59_H225_P0.8080.20
48_Q51_T0.8070.20
11_L129_A0.8060.20
228_A233_R0.8040.20
62_V77_A0.8040.20
71_N202_L0.8010.20
42_R54_Y0.7980.20
250_E253_V0.7930.20
106_K128_Q0.7900.19
37_F156_I0.7890.19
213_Y229_I0.7870.19
192_D198_R0.7860.19
119_M166_P0.7860.19
110_V210_T0.7860.19
77_A189_D0.7830.19
255_A259_S0.7780.19
173_Q204_D0.7770.19
121_K200_K0.7720.19
184_Y188_A0.7680.19
59_H62_V0.7650.19
9_V96_I0.7650.19
82_V239_Y0.7630.19
31_V82_V0.7620.19
42_R46_S0.7540.18
9_V238_T0.7510.18
106_K201_I0.7480.18
202_L206_S0.7480.18
94_I173_Q0.7460.18
109_I199_M0.7440.18
118_R260_I0.7420.18
176_G179_A0.7400.18
148_E238_T0.7380.18
115_F178_A0.7340.18
142_K145_D0.7330.18
16_F126_L0.7260.18
124_P191_R0.7260.18
186_F233_R0.7220.17
163_S212_C0.7210.17
11_L80_T0.7210.17
39_E258_E0.7200.17
177_P225_P0.7120.17
102_F114_E0.7100.17
29_L43_R0.7060.17
8_E20_K0.6970.17
15_R107_D0.6970.17
30_K121_K0.6960.17
23_W109_I0.6890.17
26_E200_K0.6860.17
124_P185_R0.6840.16
138_E185_R0.6820.16
166_P178_A0.6820.16
44_I142_K0.6800.16
142_K257_H0.6760.16
20_K234_S0.6760.16
96_I110_V0.6730.16
8_E18_P0.6710.16
160_L169_V0.6700.16
38_T146_Q0.6680.16
57_S178_A0.6670.16
94_I117_E0.6660.16
38_T62_V0.6650.16
26_E240_K0.6650.16
13_V96_I0.6620.16
83_L222_D0.6570.16
88_K173_Q0.6560.16
136_K251_K0.6550.16
105_I173_Q0.6540.16
103_K214_Q0.6510.16
181_A225_P0.6490.16
221_R253_V0.6480.16
37_F80_T0.6460.15
10_I82_V0.6410.15
49_D189_D0.6380.15
48_Q147_R0.6380.15
116_Y145_D0.6350.15
76_L177_P0.6270.15
129_A193_T0.6260.15
55_R177_P0.6190.15
23_W47_E0.6170.15
16_F117_E0.6170.15
12_K24_W0.6160.15
159_G181_A0.6150.15
69_K212_C0.6120.15
56_A233_R0.6100.15
51_T124_P0.6080.15
59_H220_P0.6050.14
99_M189_D0.6050.14
76_L156_I0.6000.14
60_M152_F0.5940.14
188_A235_F0.5930.14
97_E118_R0.5920.14
113_D236_T0.5900.14
146_Q253_V0.5860.14
137_A140_R0.5830.14
31_V83_L0.5800.14
196_E239_Y0.5780.14
71_N91_N0.5730.14
73_E80_T0.5690.14
176_G259_S0.5670.14
20_K105_I0.5670.14
96_I174_F0.5650.14
161_C165_C0.5640.14
58_C78_C0.5640.14
58_C64_G0.5640.14
58_C155_C0.5640.14
63_C78_C0.5640.14
58_C158_C0.5640.14
58_C63_C0.5640.14
58_C161_C0.5640.14
58_C165_C0.5640.14
158_C165_C0.5640.14
78_C155_C0.5640.14
63_C155_C0.5640.14
63_C158_C0.5640.14
155_C165_C0.5640.14
155_C161_C0.5640.14
64_G155_C0.5640.14
155_C158_C0.5640.14
64_G158_C0.5640.14
64_G161_C0.5640.14
64_G165_C0.5640.14
64_G78_C0.5640.14
78_C165_C0.5640.14
78_C161_C0.5640.14
63_C161_C0.5640.14
63_C165_C0.5640.14
158_C161_C0.5640.14
78_C158_C0.5640.14
49_D59_H0.5620.13
49_D76_L0.5620.13
75_R80_T0.5610.13
36_Q166_P0.5590.13
13_V82_V0.5590.13
193_T232_T0.5580.13
111_D249_G0.5570.13
27_Y251_K0.5570.13
33_R238_T0.5550.13
11_L52_L0.5550.13
79_K223_I0.5490.13
59_H183_G0.5480.13
120_F236_T0.5470.13
61_A156_I0.5470.13
13_V43_R0.5450.13
45_K185_R0.5430.13
145_D203_I0.5420.13
48_Q196_E0.5400.13
207_W252_H0.5400.13
8_E21_G0.5380.13
70_I75_R0.5380.13
27_Y102_F0.5380.13
25_A52_L0.5330.13
103_K173_Q0.5320.13
158_C209_C0.5290.13
64_G209_C0.5290.13
64_G215_C0.5290.13
78_C215_C0.5290.13
78_C209_C0.5290.13
155_C209_C0.5290.13
155_C215_C0.5290.13
58_C215_C0.5290.13
165_C215_C0.5290.13
58_C209_C0.5290.13
161_C215_C0.5290.13
161_C209_C0.5290.13
158_C215_C0.5290.13
63_C209_C0.5290.13
165_C209_C0.5290.13
63_C215_C0.5290.13
68_M112_W0.5290.13
117_E173_Q0.5260.13
24_W47_E0.5210.13
47_E105_I0.5200.13
50_P206_S0.5190.13
89_Y108_L0.5190.13
254_E257_H0.5180.13
121_K204_D0.5160.12
94_I188_A0.5150.12
32_D109_I0.5130.12
164_A213_Y0.5110.12
101_Y105_I0.5100.12
145_D204_D0.5090.12
8_E69_K0.5090.12
99_M157_W0.5080.12
44_I77_A0.5080.12
85_V207_W0.5070.12
12_K67_G0.5060.12
20_K222_D0.5060.12
11_L19_E0.5050.12
158_C219_C0.5020.12
64_G219_C0.5020.12
155_C219_C0.5020.12
63_C219_C0.5020.12
78_C219_C0.5020.12
161_C219_C0.5020.12
58_C219_C0.5020.12
165_C219_C0.5020.12
176_G225_P0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8481 100 0.54 Contact Map
2h88B 1 0.7342 100 0.576 Contact Map
4ysxB 1 0.7753 100 0.576 Contact Map
1kf6B 1 0.7563 100 0.593 Contact Map
2wdqB 1 0.731 100 0.594 Contact Map
2bs2B 1 0.7342 100 0.601 Contact Map
1ffvA 1 0.4905 99.9 0.816 Contact Map
3c8yA 1 0.8734 99.9 0.816 Contact Map
1t3qA 1 0.5127 99.9 0.821 Contact Map
1rm6C 1 0.4968 99.8 0.831 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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