Q97W78 - SULSO - GREMLIN Contacts

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Q97W78 - Succinate dehydrogenase subunit B (SdhB)

UniProt:	Q97W78	Sequences: MTQSQEEEVILKVKRFNPEKGYWWAEYKLKVDRFTQFTEALRRIKSEQDPTLSYRASCHMAVCGSCGMKINGEPRLACKTLVLDVVKKYNNNVITIEPMDYFKPIKDLIVDWDEFYERMFKIKPRLYQAKEVLEGKAEHRLKPEDQRELWKFAQCIWCGLCVSACPAVVIDQQFLGPAAHAKGYRFLADPRDTITEERMKILIDSSWRCTYCYQCFNVCPRDIEPVTAIKKTRSFTKTYKDKSEIAERGEKHVEAIHESILKTGKLAEAPVYLKTYGVLQSLVDLVYMSKTGKLKYALVQERPVQNINEIKKIIGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (249)
Sequences:	266 (175)
Seq/√Len:	11.1

ECOLI - FRDB SDHB
BACSU - SDHB
HALSA - Q9HQ65
SULSO - Q97W78

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
10_I	28_K	4.330	1.00
43_R	47_E	4.231	0.99
11_L	44_I	4.007	0.99
67_G	99_M	3.340	0.97
11_L	40_A	3.334	0.97
74_P	164_A	3.200	0.96
53_S	109_I	2.952	0.94
69_K	163_S	2.919	0.94
124_P	225_P	2.731	0.91
12_K	95_T	2.628	0.89
67_G	144_E	2.502	0.87
11_L	142_K	2.432	0.85
41_L	54_Y	2.424	0.85
54_Y	157_W	2.359	0.83
96_I	109_I	2.347	0.83
55_R	176_G	2.343	0.83
51_T	118_R	2.252	0.80
118_R	168_V	2.239	0.80
17_N	20_K	2.230	0.80
141_L	190_P	2.175	0.78
45_K	57_S	2.120	0.76
8_E	28_K	2.090	0.75
123_K	127_Y	2.017	0.72
40_A	82_V	2.014	0.72
76_L	191_R	1.954	0.70
203_I	236_T	1.938	0.69
27_Y	164_A	1.921	0.68
17_N	26_E	1.920	0.68
74_P	214_Q	1.877	0.66
69_K	100_D	1.859	0.66
156_I	229_I	1.855	0.65
12_K	26_E	1.849	0.65
32_D	35_T	1.846	0.65
12_K	93_V	1.838	0.65
44_I	52_L	1.800	0.63
206_S	232_T	1.788	0.62
43_R	53_S	1.764	0.61
154_Q	223_I	1.749	0.61
17_N	23_W	1.743	0.60
228_A	231_K	1.741	0.60
45_K	225_P	1.732	0.60
17_N	21_G	1.729	0.60
45_K	124_P	1.704	0.59
126_L	186_F	1.700	0.58
120_F	232_T	1.700	0.58
76_L	189_D	1.688	0.58
14_K	22_Y	1.685	0.58
76_L	185_R	1.658	0.56
18_P	22_Y	1.647	0.56
30_K	43_R	1.646	0.56
187_L	232_T	1.631	0.55
151_K	228_A	1.627	0.55
185_R	189_D	1.609	0.54
166_P	182_K	1.578	0.53
104_P	109_I	1.568	0.52
29_L	199_M	1.559	0.52
152_F	228_A	1.520	0.50
10_I	26_E	1.510	0.49
253_V	256_I	1.454	0.47
187_L	199_M	1.445	0.46
246_A	254_E	1.443	0.46
180_H	232_T	1.440	0.46
247_E	250_E	1.433	0.46
39_E	55_R	1.432	0.46
176_G	198_R	1.426	0.45
178_A	202_L	1.411	0.45
181_A	223_I	1.392	0.44
76_L	192_D	1.372	0.43
115_F	124_P	1.368	0.42
120_F	148_E	1.364	0.42
252_H	256_I	1.354	0.42
19_E	125_R	1.346	0.41
71_N	94_I	1.343	0.41
185_R	191_R	1.321	0.40
30_K	201_I	1.318	0.40
110_V	119_M	1.318	0.40
179_A	218_V	1.314	0.40
26_E	190_P	1.308	0.40
38_T	156_I	1.307	0.40
65_S	180_H	1.307	0.40
12_K	94_I	1.305	0.40
82_V	147_R	1.296	0.39
253_V	259_S	1.279	0.38
174_F	216_F	1.263	0.38
106_K	195_T	1.263	0.38
110_V	163_S	1.260	0.37
247_E	251_K	1.259	0.37
25_A	54_Y	1.255	0.37
114_E	168_V	1.241	0.37
47_E	104_P	1.214	0.35
84_D	240_K	1.208	0.35
96_I	122_I	1.206	0.35
11_L	145_D	1.206	0.35
164_A	190_P	1.192	0.34
9_V	31_V	1.180	0.34
204_D	208_R	1.174	0.34
10_I	93_V	1.171	0.34
14_K	118_R	1.164	0.33
123_K	201_I	1.154	0.33
115_F	176_G	1.151	0.33
62_V	180_H	1.149	0.33
130_K	193_T	1.147	0.33
166_P	228_A	1.142	0.32
26_E	93_V	1.141	0.32
49_D	124_P	1.139	0.32
174_F	188_A	1.135	0.32
182_K	252_H	1.127	0.32
29_L	83_L	1.116	0.31
91_N	172_Q	1.114	0.31
249_G	255_A	1.105	0.31
26_E	195_T	1.105	0.31
28_K	130_K	1.096	0.30
28_K	204_D	1.095	0.30
186_F	190_P	1.081	0.30
73_E	251_K	1.071	0.29
39_E	56_A	1.069	0.29
38_T	59_H	1.067	0.29
55_R	115_F	1.051	0.29
29_L	108_L	1.050	0.29
27_Y	114_E	1.045	0.28
105_I	193_T	1.042	0.28
174_F	181_A	1.039	0.28
79_K	106_K	1.035	0.28
141_L	146_Q	1.033	0.28
124_P	141_L	1.032	0.28
207_W	211_Y	1.028	0.28
55_R	225_P	1.012	0.27
37_F	71_N	1.011	0.27
82_V	93_V	0.996	0.26
211_Y	252_H	0.990	0.26
142_K	190_P	0.982	0.26
55_R	138_E	0.980	0.26
49_D	225_P	0.978	0.26
159_G	163_S	0.972	0.26
39_E	115_F	0.962	0.25
36_Q	59_H	0.957	0.25
128_Q	193_T	0.953	0.25
101_Y	163_S	0.941	0.24
27_Y	106_K	0.937	0.24
176_G	218_V	0.931	0.24
115_F	225_P	0.928	0.24
68_M	77_A	0.925	0.24
122_I	179_A	0.920	0.24
148_E	197_E	0.919	0.24
31_V	231_K	0.913	0.23
200_K	240_K	0.907	0.23
166_P	259_S	0.900	0.23
125_R	237_K	0.895	0.23
46_S	50_P	0.894	0.23
154_Q	179_A	0.894	0.23
138_E	238_T	0.892	0.23
171_D	233_R	0.892	0.23
117_E	120_F	0.891	0.23
13_V	20_K	0.886	0.23
19_E	126_L	0.882	0.22
67_G	201_I	0.881	0.22
55_R	198_R	0.878	0.22
57_S	126_L	0.872	0.22
209_C	215_C	0.871	0.22
200_K	204_D	0.860	0.22
168_V	190_P	0.860	0.22
106_K	254_E	0.855	0.22
176_G	220_P	0.850	0.21
141_L	183_G	0.849	0.21
71_N	105_I	0.847	0.21
14_K	168_V	0.846	0.21
115_F	179_A	0.845	0.21
251_K	260_I	0.844	0.21
26_E	148_E	0.841	0.21
215_C	219_C	0.841	0.21
209_C	219_C	0.841	0.21
196_E	240_K	0.836	0.21
174_F	184_Y	0.821	0.20
152_F	223_I	0.818	0.20
250_E	256_I	0.817	0.20
145_D	148_E	0.815	0.20
81_L	174_F	0.813	0.20
59_H	225_P	0.808	0.20
48_Q	51_T	0.807	0.20
11_L	129_A	0.806	0.20
228_A	233_R	0.804	0.20
62_V	77_A	0.804	0.20
71_N	202_L	0.801	0.20
42_R	54_Y	0.798	0.20
250_E	253_V	0.793	0.20
106_K	128_Q	0.790	0.19
37_F	156_I	0.789	0.19
213_Y	229_I	0.787	0.19
192_D	198_R	0.786	0.19
119_M	166_P	0.786	0.19
110_V	210_T	0.786	0.19
77_A	189_D	0.783	0.19
255_A	259_S	0.778	0.19
173_Q	204_D	0.777	0.19
121_K	200_K	0.772	0.19
184_Y	188_A	0.768	0.19
59_H	62_V	0.765	0.19
9_V	96_I	0.765	0.19
82_V	239_Y	0.763	0.19
31_V	82_V	0.762	0.19
42_R	46_S	0.754	0.18
9_V	238_T	0.751	0.18
106_K	201_I	0.748	0.18
202_L	206_S	0.748	0.18
94_I	173_Q	0.746	0.18
109_I	199_M	0.744	0.18
118_R	260_I	0.742	0.18
176_G	179_A	0.740	0.18
148_E	238_T	0.738	0.18
115_F	178_A	0.734	0.18
142_K	145_D	0.733	0.18
16_F	126_L	0.726	0.18
124_P	191_R	0.726	0.18
186_F	233_R	0.722	0.17
163_S	212_C	0.721	0.17
11_L	80_T	0.721	0.17
39_E	258_E	0.720	0.17
177_P	225_P	0.712	0.17
102_F	114_E	0.710	0.17
29_L	43_R	0.706	0.17
8_E	20_K	0.697	0.17
15_R	107_D	0.697	0.17
30_K	121_K	0.696	0.17
23_W	109_I	0.689	0.17
26_E	200_K	0.686	0.17
124_P	185_R	0.684	0.16
138_E	185_R	0.682	0.16
166_P	178_A	0.682	0.16
44_I	142_K	0.680	0.16
142_K	257_H	0.676	0.16
20_K	234_S	0.676	0.16
96_I	110_V	0.673	0.16
8_E	18_P	0.671	0.16
160_L	169_V	0.670	0.16
38_T	146_Q	0.668	0.16
57_S	178_A	0.667	0.16
94_I	117_E	0.666	0.16
38_T	62_V	0.665	0.16
26_E	240_K	0.665	0.16
13_V	96_I	0.662	0.16
83_L	222_D	0.657	0.16
88_K	173_Q	0.656	0.16
136_K	251_K	0.655	0.16
105_I	173_Q	0.654	0.16
103_K	214_Q	0.651	0.16
181_A	225_P	0.649	0.16
221_R	253_V	0.648	0.16
37_F	80_T	0.646	0.15
10_I	82_V	0.641	0.15
49_D	189_D	0.638	0.15
48_Q	147_R	0.638	0.15
116_Y	145_D	0.635	0.15
76_L	177_P	0.627	0.15
129_A	193_T	0.626	0.15
55_R	177_P	0.619	0.15
23_W	47_E	0.617	0.15
16_F	117_E	0.617	0.15
12_K	24_W	0.616	0.15
159_G	181_A	0.615	0.15
69_K	212_C	0.612	0.15
56_A	233_R	0.610	0.15
51_T	124_P	0.608	0.15
59_H	220_P	0.605	0.14
99_M	189_D	0.605	0.14
76_L	156_I	0.600	0.14
60_M	152_F	0.594	0.14
188_A	235_F	0.593	0.14
97_E	118_R	0.592	0.14
113_D	236_T	0.590	0.14
146_Q	253_V	0.586	0.14
137_A	140_R	0.583	0.14
31_V	83_L	0.580	0.14
196_E	239_Y	0.578	0.14
71_N	91_N	0.573	0.14
73_E	80_T	0.569	0.14
176_G	259_S	0.567	0.14
20_K	105_I	0.567	0.14
96_I	174_F	0.565	0.14
161_C	165_C	0.564	0.14
58_C	78_C	0.564	0.14
58_C	64_G	0.564	0.14
58_C	155_C	0.564	0.14
63_C	78_C	0.564	0.14
58_C	158_C	0.564	0.14
58_C	63_C	0.564	0.14
58_C	161_C	0.564	0.14
58_C	165_C	0.564	0.14
158_C	165_C	0.564	0.14
78_C	155_C	0.564	0.14
63_C	155_C	0.564	0.14
63_C	158_C	0.564	0.14
155_C	165_C	0.564	0.14
155_C	161_C	0.564	0.14
64_G	155_C	0.564	0.14
155_C	158_C	0.564	0.14
64_G	158_C	0.564	0.14
64_G	161_C	0.564	0.14
64_G	165_C	0.564	0.14
64_G	78_C	0.564	0.14
78_C	165_C	0.564	0.14
78_C	161_C	0.564	0.14
63_C	161_C	0.564	0.14
63_C	165_C	0.564	0.14
158_C	161_C	0.564	0.14
78_C	158_C	0.564	0.14
49_D	59_H	0.562	0.13
49_D	76_L	0.562	0.13
75_R	80_T	0.561	0.13
36_Q	166_P	0.559	0.13
13_V	82_V	0.559	0.13
193_T	232_T	0.558	0.13
111_D	249_G	0.557	0.13
27_Y	251_K	0.557	0.13
33_R	238_T	0.555	0.13
11_L	52_L	0.555	0.13
79_K	223_I	0.549	0.13
59_H	183_G	0.548	0.13
120_F	236_T	0.547	0.13
61_A	156_I	0.547	0.13
13_V	43_R	0.545	0.13
45_K	185_R	0.543	0.13
145_D	203_I	0.542	0.13
48_Q	196_E	0.540	0.13
207_W	252_H	0.540	0.13
8_E	21_G	0.538	0.13
70_I	75_R	0.538	0.13
27_Y	102_F	0.538	0.13
25_A	52_L	0.533	0.13
103_K	173_Q	0.532	0.13
158_C	209_C	0.529	0.13
64_G	209_C	0.529	0.13
64_G	215_C	0.529	0.13
78_C	215_C	0.529	0.13
78_C	209_C	0.529	0.13
155_C	209_C	0.529	0.13
155_C	215_C	0.529	0.13
58_C	215_C	0.529	0.13
165_C	215_C	0.529	0.13
58_C	209_C	0.529	0.13
161_C	215_C	0.529	0.13
161_C	209_C	0.529	0.13
158_C	215_C	0.529	0.13
63_C	209_C	0.529	0.13
165_C	209_C	0.529	0.13
63_C	215_C	0.529	0.13
68_M	112_W	0.529	0.13
117_E	173_Q	0.526	0.13
24_W	47_E	0.521	0.13
47_E	105_I	0.520	0.13
50_P	206_S	0.519	0.13
89_Y	108_L	0.519	0.13
254_E	257_H	0.518	0.13
121_K	204_D	0.516	0.12
94_I	188_A	0.515	0.12
32_D	109_I	0.513	0.12
164_A	213_Y	0.511	0.12
101_Y	105_I	0.510	0.12
145_D	204_D	0.509	0.12
8_E	69_K	0.509	0.12
99_M	157_W	0.508	0.12
44_I	77_A	0.508	0.12
85_V	207_W	0.507	0.12
12_K	67_G	0.506	0.12
20_K	222_D	0.506	0.12
11_L	19_E	0.505	0.12
158_C	219_C	0.502	0.12
64_G	219_C	0.502	0.12
155_C	219_C	0.502	0.12
63_C	219_C	0.502	0.12
78_C	219_C	0.502	0.12
161_C	219_C	0.502	0.12
58_C	219_C	0.502	0.12
165_C	219_C	0.502	0.12
176_G	225_P	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3kwlA	1	0.8481	100	0.54	Contact Map
2h88B	1	0.7342	100	0.576	Contact Map
4ysxB	1	0.7753	100	0.576	Contact Map
1kf6B	1	0.7563	100	0.593	Contact Map
2wdqB	1	0.731	100	0.594	Contact Map
2bs2B	1	0.7342	100	0.601	Contact Map
1ffvA	1	0.4905	99.9	0.816	Contact Map
3c8yA	1	0.8734	99.9	0.816	Contact Map
1t3qA	1	0.5127	99.9	0.821	Contact Map
1rm6C	1	0.4968	99.8	0.831	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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