Q97W77 - SULSO - GREMLIN Contacts

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Q97W77 - Succinate dehydrogenase subunit C (SdhC)

UniProt:	Q97W77	Sequences: MIGMKIAYYPGCATHGLSKDVDIATKKVAEVLGVELVEVPDWNCCGGGFYDEYDEVGHVALNLRNLSQVEKMGLTKMVTPCSVCLHSHRLATYKYKEDKDIKRKTDKRLEGTSVKYEGKVDAEHIVWVLLRDVGLENIKKHVKKPLTALKVGTYYGCQMLRPEQIMGFEKAYNPSSLSELVAVTGATPVPFPAMTSCCGFPLVGSNPKGALKLAFNVLNSAKQSGADLVIHPCSLCHLQLDSLQLKVKAEFNIGWTMPAIYVTQLLGLSFGFSPEELGIGKLAIEVLRSKGVI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	293 (237)
Sequences:	6762 (4230)
Seq/√Len:	274.8

ECOLI - YKGE GLCF GLPC YDIJ
BACSU - GLCF FADF LUTA
HALSA - Q9HHI4 Q9HMZ3 Q9HNS2 Q9HMR2
SULSO - Q97W77 Q97Z11 Q97Z15 Q97VI0 Q97U89 Q97U61 Q7LX43

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
150_K	187_T	4.076	1.00
260_I	268_L	3.937	1.00
27_K	267_G	3.873	1.00
5_K	35_E	3.716	1.00
24_A	264_Q	3.670	1.00
125_I	263_T	3.312	1.00
150_K	189_V	3.294	1.00
123_E	131_R	2.813	1.00
54_D	57_G	2.737	1.00
70_E	104_K	2.696	1.00
79_T	85_L	2.659	1.00
44_C	84_C	2.526	1.00
20_D	264_Q	2.420	1.00
14_T	22_D	2.353	1.00
228_L	260_I	2.301	1.00
5_K	37_V	2.290	1.00
25_T	80_P	2.227	1.00
214_A	243_L	2.198	1.00
192_P	223_Q	2.093	1.00
25_T	125_I	2.092	1.00
6_I	128_V	2.052	1.00
191_F	221_A	2.035	1.00
149_L	228_L	2.016	1.00
155_Y	175_S	1.994	1.00
149_L	227_D	1.947	1.00
34_V	128_V	1.886	1.00
12_C	44_C	1.860	1.00
89_R	127_W	1.854	1.00
106_D	110_E	1.853	1.00
179_E	183_V	1.852	1.00
230_I	265_L	1.844	1.00
67_S	104_K	1.810	1.00
8_Y	80_P	1.805	1.00
151_V	186_A	1.770	1.00
152_G	191_F	1.743	1.00
219_N	223_Q	1.733	1.00
21_V	264_Q	1.698	1.00
50_Y	87_S	1.697	1.00
220_S	223_Q	1.615	1.00
103_R	106_D	1.611	1.00
12_C	84_C	1.600	1.00
45_C	84_C	1.587	1.00
43_N	64_R	1.547	1.00
32_L	270_F	1.546	1.00
123_E	127_W	1.530	1.00
4_M	34_V	1.520	1.00
126_V	262_V	1.516	1.00
78_V	128_V	1.505	1.00
28_V	270_F	1.498	1.00
103_R	107_K	1.493	1.00
193_A	220_S	1.490	1.00
150_K	227_D	1.488	1.00
28_V	266_L	1.487	1.00
214_A	239_Q	1.471	1.00
152_G	224_S	1.470	1.00
211_L	243_L	1.453	1.00
123_E	128_V	1.452	1.00
26_K	36_L	1.436	1.00
151_V	230_I	1.418	1.00
59_V	63_L	1.412	1.00
151_V	265_L	1.400	1.00
63_L	67_S	1.396	1.00
67_S	70_E	1.376	1.00
64_R	68_Q	1.365	1.00
181_V	184_T	1.364	1.00
175_S	190_P	1.362	1.00
130_L	179_E	1.360	1.00
221_A	229_V	1.320	1.00
62_N	92_T	1.303	1.00
127_W	131_R	1.294	1.00
260_I	264_Q	1.281	1.00
178_S	181_V	1.278	1.00
130_L	178_S	1.247	1.00
47_G	83_V	1.240	1.00
198_C	236_C	1.237	1.00
214_A	218_L	1.225	1.00
107_K	110_E	1.214	1.00
12_C	45_C	1.197	1.00
24_A	267_G	1.194	1.00
222_K	255_W	1.193	1.00
183_V	186_A	1.192	1.00
5_K	75_T	1.177	1.00
160_L	166_M	1.176	1.00
215_F	219_N	1.168	1.00
232_P	262_V	1.165	1.00
108_R	122_A	1.164	1.00
221_A	257_M	1.164	1.00
7_A	72_M	1.155	1.00
179_E	182_A	1.150	1.00
79_T	88_H	1.142	1.00
34_V	132_D	1.129	1.00
7_A	74_L	1.122	1.00
179_E	184_T	1.115	1.00
105_T	109_L	1.115	1.00
27_K	271_G	1.112	1.00
85_L	122_A	1.110	1.00
258_P	268_L	1.102	1.00
85_L	163_E	1.086	1.00
241_D	245_L	1.072	1.00
260_I	265_L	1.060	1.00
165_I	173_N	1.056	1.00
6_I	34_V	1.055	1.00
207_P	211_L	1.054	1.00
26_K	30_E	1.053	1.00
156_G	231_H	1.046	1.00
81_C	233_C	1.033	1.00
70_E	107_K	1.031	1.00
77_M	108_R	1.028	1.00
23_I	27_K	1.027	1.00
131_R	135_L	1.025	1.00
37_V	72_M	1.024	1.00
11_G	81_C	1.020	1.00
151_V	228_L	1.019	1.00
219_N	222_K	1.019	1.00
218_L	244_Q	1.017	1.00
10_P	38_E	1.015	1.00
193_A	196_S	1.013	1.00
47_G	51_D	1.012	1.00
28_V	263_T	1.012	1.00
207_P	242_S	1.011	1.00
146_L	149_L	1.006	1.00
107_K	121_D	1.001	1.00
92_T	109_L	1.001	1.00
39_V	42_W	0.994	1.00
10_P	22_D	0.992	1.00
128_V	132_D	0.990	1.00
193_A	216_N	0.987	1.00
62_N	95_Y	0.987	1.00
127_W	173_N	0.983	1.00
10_P	42_W	0.973	1.00
30_E	36_L	0.969	1.00
25_T	29_A	0.968	1.00
6_I	78_V	0.968	1.00
28_V	267_G	0.956	1.00
31_V	270_F	0.941	1.00
132_D	135_L	0.939	1.00
244_Q	259_A	0.939	1.00
8_Y	22_D	0.937	1.00
31_V	267_G	0.937	1.00
152_G	221_A	0.926	1.00
181_V	186_A	0.925	1.00
145_P	184_T	0.920	1.00
110_E	122_A	0.911	1.00
127_W	165_I	0.904	1.00
27_K	31_V	0.891	1.00
92_T	96_K	0.878	1.00
160_L	195_T	0.874	1.00
221_A	240_L	0.859	1.00
49_F	57_G	0.859	1.00
184_T	266_L	0.859	1.00
181_V	188_P	0.855	1.00
51_D	83_V	0.849	1.00
203_V	206_N	0.849	1.00
125_I	129_L	0.849	1.00
157_C	197_C	0.848	1.00
132_D	137_N	0.848	1.00
203_V	210_A	0.842	1.00
23_I	26_K	0.840	1.00
65_N	68_Q	0.840	1.00
6_I	36_L	0.838	1.00
230_I	262_V	0.833	1.00
28_V	125_I	0.832	1.00
65_N	88_H	0.831	1.00
159_M	165_I	0.828	0.99
64_R	67_S	0.827	0.99
73_G	121_D	0.823	0.99
218_L	222_K	0.822	0.99
98_D	104_K	0.820	0.99
194_M	220_S	0.819	0.99
244_Q	255_W	0.818	0.99
20_D	23_I	0.817	0.99
145_P	185_G	0.817	0.99
180_L	184_T	0.814	0.99
9_Y	88_H	0.814	0.99
228_L	233_C	0.811	0.99
103_R	110_E	0.807	0.99
68_Q	71_K	0.806	0.99
83_V	235_L	0.805	0.99
66_L	104_K	0.804	0.99
192_P	220_S	0.803	0.99
86_H	162_P	0.802	0.99
150_K	225_G	0.802	0.99
22_D	26_K	0.801	0.99
129_L	266_L	0.800	0.99
231_H	237_H	0.800	0.99
18_S	21_V	0.799	0.99
86_H	90_L	0.796	0.99
137_N	140_K	0.794	0.99
237_H	259_A	0.789	0.99
202_L	210_A	0.787	0.99
29_A	34_V	0.784	0.99
229_V	240_L	0.782	0.99
149_L	268_L	0.780	0.99
5_K	74_L	0.779	0.99
131_R	173_N	0.777	0.99
211_L	215_F	0.767	0.99
93_Y	96_K	0.765	0.99
79_T	122_A	0.760	0.99
229_V	257_M	0.760	0.99
18_S	234_S	0.758	0.99
195_T	217_V	0.754	0.99
77_M	88_H	0.751	0.99
50_Y	58_H	0.751	0.99
18_S	238_L	0.744	0.99
104_K	107_K	0.742	0.99
93_Y	97_E	0.741	0.99
25_T	263_T	0.729	0.99
152_G	226_A	0.724	0.99
147_T	185_G	0.722	0.99
75_T	121_D	0.720	0.99
212_K	215_F	0.719	0.99
123_E	132_D	0.716	0.99
83_V	158_Q	0.715	0.99
19_K	23_I	0.715	0.99
56_V	59_V	0.713	0.98
215_F	243_L	0.711	0.98
30_E	35_E	0.710	0.98
60_A	63_L	0.708	0.98
264_Q	267_G	0.706	0.98
166_M	173_N	0.702	0.98
175_S	178_S	0.701	0.98
8_Y	25_T	0.695	0.98
93_Y	106_D	0.692	0.98
66_L	70_E	0.686	0.98
157_C	198_C	0.686	0.98
42_W	69_V	0.685	0.98
37_V	74_L	0.684	0.98
106_D	109_L	0.683	0.98
153_T	188_P	0.682	0.98
49_F	61_L	0.674	0.98
58_H	87_S	0.669	0.98
26_K	38_E	0.669	0.98
181_V	185_G	0.666	0.98
183_V	269_S	0.663	0.98
200_F	235_L	0.659	0.97
143_K	146_L	0.658	0.97
175_S	182_A	0.657	0.97
14_T	80_P	0.656	0.97
58_H	62_N	0.654	0.97
153_T	174_P	0.653	0.97
157_C	236_C	0.652	0.97
132_D	136_E	0.650	0.97
21_V	24_A	0.648	0.97
228_L	231_H	0.647	0.97
172_Y	192_P	0.645	0.97
7_A	69_V	0.644	0.97
7_A	37_V	0.644	0.97
149_L	265_L	0.641	0.97
146_L	186_A	0.638	0.97
147_T	187_T	0.638	0.97
62_N	96_K	0.637	0.97
89_R	163_E	0.636	0.97
81_C	234_S	0.630	0.97
202_L	205_S	0.629	0.97
130_L	134_G	0.628	0.97
138_I	270_F	0.628	0.97
30_E	34_V	0.626	0.97
88_H	108_R	0.618	0.96
66_L	105_T	0.614	0.96
32_L	132_D	0.613	0.96
92_T	95_Y	0.613	0.96
61_L	64_R	0.612	0.96
57_G	60_A	0.611	0.96
57_G	61_L	0.611	0.96
60_A	64_R	0.610	0.96
166_M	172_Y	0.607	0.96
91_A	96_K	0.606	0.96
240_L	244_Q	0.604	0.96
37_V	40_P	0.603	0.96
18_S	237_H	0.602	0.96
9_Y	45_C	0.600	0.96
208_K	212_K	0.600	0.96
41_D	68_Q	0.600	0.96
229_V	259_A	0.599	0.96
83_V	200_F	0.598	0.96
215_F	222_K	0.598	0.96
180_L	183_V	0.596	0.95
265_L	269_S	0.596	0.95
124_H	159_M	0.595	0.95
94_K	97_E	0.593	0.95
175_S	181_V	0.591	0.95
21_V	234_S	0.589	0.95
41_D	72_M	0.586	0.95
70_E	121_D	0.585	0.95
58_H	95_Y	0.585	0.95
146_L	269_S	0.584	0.95
9_Y	65_N	0.583	0.95
63_L	98_D	0.582	0.95
228_L	258_P	0.581	0.95
222_K	256_T	0.580	0.95
27_K	30_E	0.579	0.95
51_D	235_L	0.578	0.95
4_M	132_D	0.578	0.95
14_T	21_V	0.577	0.95
154_Y	217_V	0.577	0.95
222_K	244_Q	0.576	0.95
191_F	224_S	0.576	0.95
133_V	138_I	0.575	0.95
126_V	232_P	0.575	0.95
241_D	258_P	0.574	0.94
8_Y	14_T	0.571	0.94
31_V	271_G	0.571	0.94
29_A	125_I	0.570	0.94
4_M	75_T	0.569	0.94
267_G	271_G	0.569	0.94
152_G	188_P	0.568	0.94
218_L	240_L	0.568	0.94
51_D	200_F	0.563	0.94
61_L	65_N	0.563	0.94
149_L	186_A	0.558	0.94
155_Y	173_N	0.558	0.94
134_G	178_S	0.556	0.94
29_A	36_L	0.554	0.93
165_I	174_P	0.554	0.93
7_A	39_V	0.551	0.93
50_Y	55_E	0.550	0.93
159_M	232_P	0.549	0.93
44_C	48_G	0.545	0.93
218_L	243_L	0.543	0.93
189_V	224_S	0.542	0.93
81_C	84_C	0.540	0.93
191_F	220_S	0.540	0.93
191_F	194_M	0.539	0.92
69_V	74_L	0.538	0.92
9_Y	42_W	0.538	0.92
150_K	258_P	0.537	0.92
86_H	158_Q	0.535	0.92
140_K	146_L	0.535	0.92
244_Q	257_M	0.535	0.92
69_V	77_M	0.533	0.92
126_V	180_L	0.532	0.92
137_N	141_H	0.532	0.92
21_V	237_H	0.531	0.92
166_M	195_T	0.528	0.92
10_P	15_H	0.528	0.92
161_R	233_C	0.527	0.92
48_G	51_D	0.525	0.91
121_D	131_R	0.523	0.91
24_A	28_V	0.521	0.91
227_D	256_T	0.518	0.91
109_L	122_A	0.517	0.91
196_S	220_S	0.516	0.91
82_S	156_G	0.512	0.90
31_V	139_K	0.510	0.90
149_L	258_P	0.510	0.90
32_L	138_I	0.510	0.90
47_G	200_F	0.509	0.90
196_S	216_N	0.507	0.90
158_Q	239_Q	0.507	0.90
12_C	81_C	0.507	0.90
7_A	75_T	0.506	0.90
268_L	271_G	0.504	0.90
156_G	233_C	0.503	0.90
126_V	130_L	0.501	0.89
83_V	203_V	0.501	0.89
210_A	239_Q	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3kwlA	1	0.8942	100	0.302	Contact Map
3cf4A	2	0.727	100	0.589	Contact Map
3c8yA	1	0.7884	98.5	0.855	Contact Map
3s81A	2	0.7645	88.8	0.928	Contact Map
1jflA	2	0.7235	88.7	0.928	Contact Map
2vvtA	2	0.7884	77.8	0.937	Contact Map
2dwuA	2	0.7918	74.4	0.939	Contact Map
2jfnA	1	0.7884	70	0.941	Contact Map
2eq5A	2	0.43	68	0.942	Contact Map
2gzmA	3	0.4266	67.1	0.942	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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