GREMLIN Database
Q97W77 - Succinate dehydrogenase subunit C (SdhC)
UniProt: Q97W77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (237)
Sequences: 6762 (4230)
Seq/√Len: 274.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_K187_T4.0761.00
260_I268_L3.9371.00
27_K267_G3.8731.00
5_K35_E3.7161.00
24_A264_Q3.6701.00
125_I263_T3.3121.00
150_K189_V3.2941.00
123_E131_R2.8131.00
54_D57_G2.7371.00
70_E104_K2.6961.00
79_T85_L2.6591.00
44_C84_C2.5261.00
20_D264_Q2.4201.00
14_T22_D2.3531.00
228_L260_I2.3011.00
5_K37_V2.2901.00
25_T80_P2.2271.00
214_A243_L2.1981.00
192_P223_Q2.0931.00
25_T125_I2.0921.00
6_I128_V2.0521.00
191_F221_A2.0351.00
149_L228_L2.0161.00
155_Y175_S1.9941.00
149_L227_D1.9471.00
34_V128_V1.8861.00
12_C44_C1.8601.00
89_R127_W1.8541.00
106_D110_E1.8531.00
179_E183_V1.8521.00
230_I265_L1.8441.00
67_S104_K1.8101.00
8_Y80_P1.8051.00
151_V186_A1.7701.00
152_G191_F1.7431.00
219_N223_Q1.7331.00
21_V264_Q1.6981.00
50_Y87_S1.6971.00
220_S223_Q1.6151.00
103_R106_D1.6111.00
12_C84_C1.6001.00
45_C84_C1.5871.00
43_N64_R1.5471.00
32_L270_F1.5461.00
123_E127_W1.5301.00
4_M34_V1.5201.00
126_V262_V1.5161.00
78_V128_V1.5051.00
28_V270_F1.4981.00
103_R107_K1.4931.00
193_A220_S1.4901.00
150_K227_D1.4881.00
28_V266_L1.4871.00
214_A239_Q1.4711.00
152_G224_S1.4701.00
211_L243_L1.4531.00
123_E128_V1.4521.00
26_K36_L1.4361.00
151_V230_I1.4181.00
59_V63_L1.4121.00
151_V265_L1.4001.00
63_L67_S1.3961.00
67_S70_E1.3761.00
64_R68_Q1.3651.00
181_V184_T1.3641.00
175_S190_P1.3621.00
130_L179_E1.3601.00
221_A229_V1.3201.00
62_N92_T1.3031.00
127_W131_R1.2941.00
260_I264_Q1.2811.00
178_S181_V1.2781.00
130_L178_S1.2471.00
47_G83_V1.2401.00
198_C236_C1.2371.00
214_A218_L1.2251.00
107_K110_E1.2141.00
12_C45_C1.1971.00
24_A267_G1.1941.00
222_K255_W1.1931.00
183_V186_A1.1921.00
5_K75_T1.1771.00
160_L166_M1.1761.00
215_F219_N1.1681.00
232_P262_V1.1651.00
108_R122_A1.1641.00
221_A257_M1.1641.00
7_A72_M1.1551.00
179_E182_A1.1501.00
79_T88_H1.1421.00
34_V132_D1.1291.00
7_A74_L1.1221.00
179_E184_T1.1151.00
105_T109_L1.1151.00
27_K271_G1.1121.00
85_L122_A1.1101.00
258_P268_L1.1021.00
85_L163_E1.0861.00
241_D245_L1.0721.00
260_I265_L1.0601.00
165_I173_N1.0561.00
6_I34_V1.0551.00
207_P211_L1.0541.00
26_K30_E1.0531.00
156_G231_H1.0461.00
81_C233_C1.0331.00
70_E107_K1.0311.00
77_M108_R1.0281.00
23_I27_K1.0271.00
131_R135_L1.0251.00
37_V72_M1.0241.00
11_G81_C1.0201.00
151_V228_L1.0191.00
219_N222_K1.0191.00
218_L244_Q1.0171.00
10_P38_E1.0151.00
193_A196_S1.0131.00
47_G51_D1.0121.00
28_V263_T1.0121.00
207_P242_S1.0111.00
146_L149_L1.0061.00
107_K121_D1.0011.00
92_T109_L1.0011.00
39_V42_W0.9941.00
10_P22_D0.9921.00
128_V132_D0.9901.00
193_A216_N0.9871.00
62_N95_Y0.9871.00
127_W173_N0.9831.00
10_P42_W0.9731.00
30_E36_L0.9691.00
25_T29_A0.9681.00
6_I78_V0.9681.00
28_V267_G0.9561.00
31_V270_F0.9411.00
132_D135_L0.9391.00
244_Q259_A0.9391.00
8_Y22_D0.9371.00
31_V267_G0.9371.00
152_G221_A0.9261.00
181_V186_A0.9251.00
145_P184_T0.9201.00
110_E122_A0.9111.00
127_W165_I0.9041.00
27_K31_V0.8911.00
92_T96_K0.8781.00
160_L195_T0.8741.00
221_A240_L0.8591.00
49_F57_G0.8591.00
184_T266_L0.8591.00
181_V188_P0.8551.00
51_D83_V0.8491.00
203_V206_N0.8491.00
125_I129_L0.8491.00
157_C197_C0.8481.00
132_D137_N0.8481.00
203_V210_A0.8421.00
23_I26_K0.8401.00
65_N68_Q0.8401.00
6_I36_L0.8381.00
230_I262_V0.8331.00
28_V125_I0.8321.00
65_N88_H0.8311.00
159_M165_I0.8280.99
64_R67_S0.8270.99
73_G121_D0.8230.99
218_L222_K0.8220.99
98_D104_K0.8200.99
194_M220_S0.8190.99
244_Q255_W0.8180.99
20_D23_I0.8170.99
145_P185_G0.8170.99
180_L184_T0.8140.99
9_Y88_H0.8140.99
228_L233_C0.8110.99
103_R110_E0.8070.99
68_Q71_K0.8060.99
83_V235_L0.8050.99
66_L104_K0.8040.99
192_P220_S0.8030.99
86_H162_P0.8020.99
150_K225_G0.8020.99
22_D26_K0.8010.99
129_L266_L0.8000.99
231_H237_H0.8000.99
18_S21_V0.7990.99
86_H90_L0.7960.99
137_N140_K0.7940.99
237_H259_A0.7890.99
202_L210_A0.7870.99
29_A34_V0.7840.99
229_V240_L0.7820.99
149_L268_L0.7800.99
5_K74_L0.7790.99
131_R173_N0.7770.99
211_L215_F0.7670.99
93_Y96_K0.7650.99
79_T122_A0.7600.99
229_V257_M0.7600.99
18_S234_S0.7580.99
195_T217_V0.7540.99
77_M88_H0.7510.99
50_Y58_H0.7510.99
18_S238_L0.7440.99
104_K107_K0.7420.99
93_Y97_E0.7410.99
25_T263_T0.7290.99
152_G226_A0.7240.99
147_T185_G0.7220.99
75_T121_D0.7200.99
212_K215_F0.7190.99
123_E132_D0.7160.99
83_V158_Q0.7150.99
19_K23_I0.7150.99
56_V59_V0.7130.98
215_F243_L0.7110.98
30_E35_E0.7100.98
60_A63_L0.7080.98
264_Q267_G0.7060.98
166_M173_N0.7020.98
175_S178_S0.7010.98
8_Y25_T0.6950.98
93_Y106_D0.6920.98
66_L70_E0.6860.98
157_C198_C0.6860.98
42_W69_V0.6850.98
37_V74_L0.6840.98
106_D109_L0.6830.98
153_T188_P0.6820.98
49_F61_L0.6740.98
58_H87_S0.6690.98
26_K38_E0.6690.98
181_V185_G0.6660.98
183_V269_S0.6630.98
200_F235_L0.6590.97
143_K146_L0.6580.97
175_S182_A0.6570.97
14_T80_P0.6560.97
58_H62_N0.6540.97
153_T174_P0.6530.97
157_C236_C0.6520.97
132_D136_E0.6500.97
21_V24_A0.6480.97
228_L231_H0.6470.97
172_Y192_P0.6450.97
7_A69_V0.6440.97
7_A37_V0.6440.97
149_L265_L0.6410.97
146_L186_A0.6380.97
147_T187_T0.6380.97
62_N96_K0.6370.97
89_R163_E0.6360.97
81_C234_S0.6300.97
202_L205_S0.6290.97
130_L134_G0.6280.97
138_I270_F0.6280.97
30_E34_V0.6260.97
88_H108_R0.6180.96
66_L105_T0.6140.96
32_L132_D0.6130.96
92_T95_Y0.6130.96
61_L64_R0.6120.96
57_G60_A0.6110.96
57_G61_L0.6110.96
60_A64_R0.6100.96
166_M172_Y0.6070.96
91_A96_K0.6060.96
240_L244_Q0.6040.96
37_V40_P0.6030.96
18_S237_H0.6020.96
9_Y45_C0.6000.96
208_K212_K0.6000.96
41_D68_Q0.6000.96
229_V259_A0.5990.96
83_V200_F0.5980.96
215_F222_K0.5980.96
180_L183_V0.5960.95
265_L269_S0.5960.95
124_H159_M0.5950.95
94_K97_E0.5930.95
175_S181_V0.5910.95
21_V234_S0.5890.95
41_D72_M0.5860.95
70_E121_D0.5850.95
58_H95_Y0.5850.95
146_L269_S0.5840.95
9_Y65_N0.5830.95
63_L98_D0.5820.95
228_L258_P0.5810.95
222_K256_T0.5800.95
27_K30_E0.5790.95
51_D235_L0.5780.95
4_M132_D0.5780.95
14_T21_V0.5770.95
154_Y217_V0.5770.95
222_K244_Q0.5760.95
191_F224_S0.5760.95
133_V138_I0.5750.95
126_V232_P0.5750.95
241_D258_P0.5740.94
8_Y14_T0.5710.94
31_V271_G0.5710.94
29_A125_I0.5700.94
4_M75_T0.5690.94
267_G271_G0.5690.94
152_G188_P0.5680.94
218_L240_L0.5680.94
51_D200_F0.5630.94
61_L65_N0.5630.94
149_L186_A0.5580.94
155_Y173_N0.5580.94
134_G178_S0.5560.94
29_A36_L0.5540.93
165_I174_P0.5540.93
7_A39_V0.5510.93
50_Y55_E0.5500.93
159_M232_P0.5490.93
44_C48_G0.5450.93
218_L243_L0.5430.93
189_V224_S0.5420.93
81_C84_C0.5400.93
191_F220_S0.5400.93
191_F194_M0.5390.92
69_V74_L0.5380.92
9_Y42_W0.5380.92
150_K258_P0.5370.92
86_H158_Q0.5350.92
140_K146_L0.5350.92
244_Q257_M0.5350.92
69_V77_M0.5330.92
126_V180_L0.5320.92
137_N141_H0.5320.92
21_V237_H0.5310.92
166_M195_T0.5280.92
10_P15_H0.5280.92
161_R233_C0.5270.92
48_G51_D0.5250.91
121_D131_R0.5230.91
24_A28_V0.5210.91
227_D256_T0.5180.91
109_L122_A0.5170.91
196_S220_S0.5160.91
82_S156_G0.5120.90
31_V139_K0.5100.90
149_L258_P0.5100.90
32_L138_I0.5100.90
47_G200_F0.5090.90
196_S216_N0.5070.90
158_Q239_Q0.5070.90
12_C81_C0.5070.90
7_A75_T0.5060.90
268_L271_G0.5040.90
156_G233_C0.5030.90
126_V130_L0.5010.89
83_V203_V0.5010.89
210_A239_Q0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8942 100 0.302 Contact Map
3cf4A 2 0.727 100 0.589 Contact Map
3c8yA 1 0.7884 98.5 0.855 Contact Map
3s81A 2 0.7645 88.8 0.928 Contact Map
1jflA 2 0.7235 88.7 0.928 Contact Map
2vvtA 2 0.7884 77.8 0.937 Contact Map
2dwuA 2 0.7918 74.4 0.939 Contact Map
2jfnA 1 0.7884 70 0.941 Contact Map
2eq5A 2 0.43 68 0.942 Contact Map
2gzmA 3 0.4266 67.1 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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