GREMLIN Database
Q97W75 - Uncharacterized protein
UniProt: Q97W75 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (394)
Sequences: 343 (233)
Seq/√Len: 11.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_G278_L4.5751.00
288_G389_E3.3780.98
222_S389_E3.2030.97
273_E313_L3.1370.96
369_S419_V3.1020.96
369_S401_A3.0820.96
288_G324_R3.0660.96
418_S432_S2.9430.95
122_S126_R2.8820.94
324_R389_E2.7700.93
379_I382_G2.6450.91
379_I414_S2.5900.90
255_I274_G2.5860.90
316_Y332_D2.5690.90
222_S291_Y2.5620.90
416_L432_S2.4540.87
222_S259_E2.4360.87
396_G432_S2.4300.87
379_I390_I2.4130.86
222_S288_G2.4120.86
144_E394_T2.3780.86
122_S125_E2.3750.85
289_P388_S2.3110.84
309_K313_L2.2790.83
218_L318_R2.2700.83
245_G293_L2.1960.81
222_S256_V2.1950.80
295_D395_D2.1940.80
291_Y378_D2.1500.79
127_E131_E2.0960.77
375_A390_I2.0620.76
292_L347_S2.0500.76
329_R332_D2.0280.75
307_W391_I2.0280.75
241_G310_A1.9790.73
245_G300_M1.9480.72
108_N246_Y1.9410.71
111_E377_E1.9370.71
296_K305_I1.9300.71
384_V438_T1.9120.70
368_I392_L1.9030.70
299_S364_G1.8860.69
144_E396_G1.8470.67
377_E407_R1.8380.67
56_P391_I1.8380.67
222_S388_S1.8290.67
222_S324_R1.8260.66
396_G416_L1.8240.66
160_L274_G1.7950.65
273_E309_K1.7940.65
289_P324_R1.7860.65
371_S390_I1.7660.64
300_M308_A1.7460.63
299_S395_D1.7430.63
295_D299_S1.7430.63
288_G331_F1.7400.63
289_P302_G1.7340.62
213_E216_K1.7310.62
218_L315_L1.7080.61
208_L312_A1.7060.61
148_Q161_R1.7020.61
297_S364_G1.6810.60
256_V259_E1.6720.59
252_I277_L1.6610.59
266_L269_L1.6510.58
259_E309_K1.6410.58
160_L421_I1.6370.58
374_S377_E1.6160.57
312_A375_A1.6070.56
267_F288_G1.6070.56
222_S305_I1.6030.56
288_G388_S1.5930.56
299_S366_T1.5880.55
297_S395_D1.5710.54
267_F324_R1.5690.54
250_S321_R1.5630.54
324_R388_S1.5480.53
92_I219_E1.5430.53
140_S410_K1.5420.53
337_P370_R1.5290.52
240_K270_K1.5270.52
291_Y332_D1.5130.52
256_V291_Y1.5110.51
140_S424_D1.5100.51
296_K330_F1.5060.51
390_I414_S1.5010.51
223_G398_D1.4860.50
279_Y371_S1.4840.50
396_G418_S1.4820.50
307_W311_V1.4490.48
160_L255_I1.4440.48
222_S329_R1.4360.48
279_Y398_D1.4340.48
305_I357_I1.4330.48
394_T436_L1.4250.47
78_T93_V1.4180.47
368_I396_G1.4140.47
280_Q422_R1.4100.46
293_L326_F1.3980.46
324_R331_F1.3930.46
257_Y293_L1.3920.46
45_V117_K1.3890.45
160_L271_L1.3890.45
222_S267_F1.3780.45
254_R279_Y1.3730.45
331_F389_E1.3680.44
297_S366_T1.3640.44
279_Y330_F1.3620.44
206_L376_C1.3590.44
119_T124_E1.3500.44
53_L61_K1.3480.43
393_L419_V1.3440.43
279_Y368_I1.3360.43
167_A171_A1.3180.42
204_E371_S1.3100.42
326_F358_G1.2910.41
371_S421_I1.2870.40
259_E288_G1.2870.40
297_S300_M1.2840.40
307_W398_D1.2790.40
127_E132_I1.2680.40
309_K362_G1.2630.39
291_Y389_E1.2610.39
222_S293_L1.2610.39
255_I260_L1.2550.39
256_V389_E1.2510.39
293_L332_D1.2450.38
328_L367_D1.2390.38
76_N173_E1.2270.38
292_L298_G1.2210.37
276_L310_A1.2200.37
249_G288_G1.2130.37
287_L318_R1.2060.37
267_F389_E1.2010.36
41_E45_V1.2000.36
432_S438_T1.1990.36
246_Y275_Q1.1970.36
364_G395_D1.1970.36
295_D364_G1.1970.36
291_Y329_R1.1940.36
283_I333_N1.1870.36
288_G302_G1.1850.36
70_I349_D1.1840.36
46_D50_V1.1810.36
310_A319_A1.1810.36
253_E260_L1.1700.35
262_L276_L1.1650.35
332_D392_L1.1640.35
299_S389_E1.1620.35
396_G436_L1.1590.35
294_L357_I1.1590.35
368_I398_D1.1520.34
287_L370_R1.1450.34
267_F329_R1.1430.34
299_S331_F1.1400.34
58_T180_N1.1360.33
319_A394_T1.1330.33
160_L180_N1.1160.33
399_K419_V1.1150.33
218_L332_D1.1130.32
299_S324_R1.1080.32
181_M245_G1.1080.32
357_I362_G1.1070.32
42_T47_T1.1060.32
293_L432_S1.1060.32
90_Y144_E1.1030.32
79_L88_R1.0970.32
52_Y66_K1.0940.32
144_E148_Q1.0920.32
294_L340_K1.0920.32
106_V169_S1.0880.31
246_Y373_I1.0780.31
270_K313_L1.0780.31
222_S257_Y1.0780.31
249_G329_R1.0760.31
296_K300_M1.0750.31
256_V388_S1.0730.31
279_Y391_I1.0690.31
289_P389_E1.0650.30
288_G299_S1.0630.30
240_K371_S1.0630.30
335_P393_L1.0600.30
256_V288_G1.0570.30
160_L188_N1.0550.30
288_G291_Y1.0530.30
214_I339_I1.0510.30
47_T63_E1.0500.30
223_G280_Q1.0480.30
66_K252_I1.0470.30
218_L330_F1.0420.29
46_D52_Y1.0410.29
121_Q124_E1.0400.29
321_R407_R1.0390.29
174_D207_R1.0380.29
279_Y307_W1.0280.29
268_Y330_F1.0260.29
390_I416_L1.0250.29
302_G362_G1.0240.29
304_K384_V1.0220.29
409_L416_L1.0210.29
250_S339_I1.0120.28
293_L414_S1.0050.28
189_G313_L1.0050.28
289_P300_M1.0030.28
295_D300_M1.0020.28
300_M395_D1.0020.28
276_L305_I1.0010.28
368_I371_S0.9980.28
46_D49_Y0.9940.28
259_E433_D0.9920.27
341_V417_I0.9920.27
104_S114_E0.9910.27
63_E394_T0.9890.27
223_G259_E0.9870.27
392_L396_G0.9840.27
371_S398_D0.9820.27
245_G416_L0.9810.27
275_Q339_I0.9800.27
398_D418_S0.9790.27
208_L262_L0.9780.27
222_S296_K0.9780.27
221_L413_N0.9760.27
309_K319_A0.9690.27
291_Y388_S0.9610.26
117_K377_E0.9610.26
217_I225_P0.9580.26
299_S365_G0.9530.26
217_I410_K0.9530.26
218_L319_A0.9510.26
214_I357_I0.9470.26
297_S389_E0.9450.26
185_V340_K0.9430.26
358_G362_G0.9360.25
305_I362_G0.9360.25
297_S331_F0.9350.25
69_E230_I0.9350.25
309_K365_G0.9320.25
296_K313_L0.9310.25
140_S394_T0.9310.25
101_L402_E0.9310.25
372_I392_L0.9300.25
221_L357_I0.9230.25
160_L323_N0.9230.25
295_D366_T0.9220.25
366_T395_D0.9220.25
47_T53_L0.9200.25
76_N106_V0.9180.25
432_S436_L0.9170.25
216_K277_L0.9150.25
209_A361_R0.9110.24
133_L139_G0.9100.24
358_G394_T0.9100.24
370_R376_C0.9080.24
297_S324_R0.9080.24
377_E381_E0.9060.24
199_E419_V0.9050.24
46_D53_L0.9020.24
248_E263_P0.8990.24
178_V371_S0.8910.24
259_E388_S0.8850.23
115_R381_E0.8850.23
246_Y385_K0.8760.23
369_S391_I0.8750.23
97_V100_A0.8740.23
329_R378_D0.8730.23
46_D56_P0.8720.23
208_L279_Y0.8710.23
160_L256_V0.8710.23
121_Q406_R0.8690.23
156_M189_G0.8640.23
166_K179_R0.8620.23
218_L414_S0.8590.23
228_G235_T0.8590.23
288_G297_S0.8580.22
267_F299_S0.8560.22
300_M364_G0.8560.22
416_L436_L0.8550.22
91_S94_N0.8530.22
105_Y108_N0.8520.22
326_F394_T0.8480.22
42_T53_L0.8460.22
300_M365_G0.8450.22
264_D290_I0.8450.22
245_G332_D0.8440.22
267_F276_L0.8420.22
272_A421_I0.8370.22
257_Y300_M0.8360.22
371_S375_A0.8330.22
107_Q129_A0.8320.22
68_Q77_S0.8270.21
276_L296_K0.8240.21
316_Y372_I0.8240.21
39_L42_T0.8230.21
120_S124_E0.8210.21
121_Q125_E0.8180.21
78_T100_A0.8180.21
310_A313_L0.8140.21
160_L341_V0.8140.21
292_L312_A0.8140.21
110_I393_L0.8140.21
48_Y310_A0.8130.21
169_S203_H0.8120.21
149_K275_Q0.8110.21
144_E358_G0.8080.21
251_D267_F0.8040.21
126_R130_E0.8040.21
48_Y53_L0.8030.21
252_I264_D0.8030.21
331_F395_D0.8020.21
295_D331_F0.8020.21
305_I393_L0.8020.21
194_S355_E0.8010.21
294_L312_A0.8000.21
341_V362_G0.7990.21
269_L313_L0.7970.20
293_L305_I0.7960.20
94_N98_S0.7950.20
380_K393_L0.7930.20
290_I410_K0.7930.20
210_R323_N0.7810.20
131_E408_S0.7810.20
205_V325_D0.7790.20
214_I294_L0.7770.20
391_I398_D0.7760.20
224_I427_D0.7750.20
250_S328_L0.7720.20
128_A132_I0.7720.20
120_S126_R0.7710.20
263_P393_L0.7700.20
264_D320_K0.7660.19
267_F271_L0.7640.19
201_E367_D0.7590.19
396_G420_M0.7590.19
417_I426_A0.7570.19
124_E127_E0.7560.19
148_Q396_G0.7560.19
69_E258_S0.7530.19
247_E275_Q0.7520.19
104_S113_L0.7500.19
217_I227_L0.7490.19
329_R335_P0.7490.19
249_G389_E0.7450.19
243_L410_K0.7420.19
240_K266_L0.7410.19
181_M365_G0.7410.19
332_D357_I0.7390.19
128_A250_S0.7390.19
163_A167_A0.7380.19
228_G394_T0.7360.19
387_V413_N0.7350.19
211_N400_I0.7350.19
262_L320_K0.7340.18
262_L358_G0.7310.18
101_L129_A0.7310.18
52_Y394_T0.7300.18
280_Q290_I0.7290.18
227_L390_I0.7280.18
132_I136_L0.7280.18
257_Y324_R0.7230.18
302_G389_E0.7180.18
115_R406_R0.7180.18
108_N374_S0.7180.18
330_F371_S0.7140.18
357_I394_T0.7140.18
394_T414_S0.7140.18
332_D414_S0.7130.18
371_S378_D0.7120.18
289_P326_F0.7090.18
114_E403_T0.7090.18
357_I367_D0.7040.18
241_G428_L0.7030.18
262_L331_F0.7020.18
160_L238_F0.7010.18
72_Y77_S0.7010.18
259_E329_R0.7000.17
271_L328_L0.7000.17
215_K298_G0.6990.17
207_R241_G0.6980.17
121_Q131_E0.6980.17
102_T160_L0.6970.17
279_Y333_N0.6970.17
264_D416_L0.6920.17
293_L319_A0.6920.17
114_E131_E0.6910.17
86_K125_E0.6910.17
416_L422_R0.6910.17
267_F331_F0.6900.17
297_S365_G0.6900.17
259_E389_E0.6890.17
222_S332_D0.6890.17
245_G324_R0.6830.17
294_L385_K0.6830.17
65_E136_L0.6810.17
396_G414_S0.6810.17
198_F379_I0.6790.17
168_M308_A0.6780.17
152_N160_L0.6780.17
255_I278_L0.6770.17
242_E313_L0.6770.17
123_M126_R0.6770.17
292_L399_K0.6770.17
317_S413_N0.6750.17
167_A390_I0.6730.17
294_L415_Q0.6730.17
119_T129_A0.6700.17
381_E393_L0.6700.17
86_K108_N0.6670.17
305_I309_K0.6670.17
130_E136_L0.6660.17
296_K357_I0.6660.17
87_N250_S0.6660.17
229_S315_L0.6650.17
171_A291_Y0.6650.17
50_V138_K0.6640.16
197_T217_I0.6640.16
267_F293_L0.6640.16
271_L426_A0.6610.16
52_Y402_E0.6590.16
249_G252_I0.6590.16
99_L327_Y0.6580.16
259_E291_Y0.6580.16
209_A317_S0.6570.16
180_N354_I0.6560.16
52_Y252_I0.6560.16
127_E380_K0.6560.16
249_G320_K0.6540.16
259_E324_R0.6530.16
42_T46_D0.6530.16
272_A397_E0.6500.16
245_G291_Y0.6500.16
108_N411_E0.6500.16
94_N290_I0.6500.16
394_T420_M0.6500.16
271_L350_V0.6490.16
126_R132_I0.6470.16
270_K319_A0.6470.16
288_G293_L0.6450.16
40_N50_V0.6440.16
278_L388_S0.6410.16
275_Q346_K0.6410.16
140_S268_Y0.6390.16
398_D422_R0.6380.16
361_R368_I0.6380.16
46_D91_S0.6380.16
373_I380_K0.6370.16
392_L409_L0.6370.16
193_G256_V0.6370.16
264_D432_S0.6360.16
392_L420_M0.6360.16
250_S318_R0.6340.16
83_I204_E0.6340.16
267_F297_S0.6330.16
380_K407_R0.6320.16
355_E400_I0.6300.16
177_S351_I0.6290.16
100_A291_Y0.6290.16
218_L314_A0.6260.15
171_A377_E0.6250.15
347_S385_K0.6250.15
205_V329_R0.6250.15
244_Y363_G0.6220.15
243_L329_R0.6200.15
307_W421_I0.6200.15
144_E436_L0.6190.15
288_G295_D0.6190.15
288_G395_D0.6190.15
258_S261_A0.6180.15
89_E114_E0.6180.15
43_F53_L0.6170.15
376_C407_R0.6170.15
245_G288_G0.6140.15
182_Q381_E0.6130.15
140_S148_Q0.6120.15
129_A139_G0.6120.15
198_F225_P0.6100.15
193_G414_S0.6100.15
403_T407_R0.6100.15
325_D409_L0.6070.15
143_K384_V0.6070.15
134_N412_A0.6060.15
86_K219_E0.6050.15
183_K217_I0.6040.15
223_G334_I0.6020.15
328_L340_K0.6010.15
392_L426_A0.6010.15
257_Y288_G0.6010.15
201_E394_T0.6000.15
294_L379_I0.6000.15
78_T107_Q0.5990.15
424_D429_R0.5970.15
216_K373_I0.5950.15
427_D439_Y0.5940.15
73_S89_E0.5940.15
201_E358_G0.5940.15
279_Y428_L0.5930.15
197_T354_I0.5930.15
49_Y53_L0.5930.15
43_F47_T0.5920.15
75_V88_R0.5920.15
304_K387_V0.5920.15
112_E321_R0.5890.15
394_T432_S0.5870.14
402_E405_V0.5850.14
323_N341_V0.5850.14
269_L384_V0.5850.14
206_L209_A0.5840.14
114_E252_I0.5820.14
243_L396_G0.5810.14
225_P242_E0.5810.14
122_S129_A0.5810.14
215_K328_L0.5800.14
171_A305_I0.5800.14
67_N357_I0.5790.14
256_V289_P0.5790.14
202_I233_R0.5750.14
228_G231_T0.5750.14
191_G410_K0.5750.14
288_G319_A0.5740.14
392_L416_L0.5740.14
280_Q437_I0.5720.14
178_V363_G0.5710.14
315_L318_R0.5700.14
248_E391_I0.5680.14
184_I251_D0.5670.14
45_V48_Y0.5650.14
312_A428_L0.5650.14
305_I332_D0.5640.14
78_T219_E0.5640.14
78_T97_V0.5640.14
362_G417_I0.5620.14
248_E311_V0.5600.14
199_E374_S0.5600.14
156_M290_I0.5580.14
167_A279_Y0.5570.14
409_L425_N0.5560.14
75_V79_L0.5530.14
197_T379_I0.5530.14
113_L126_R0.5530.14
118_K123_M0.5510.14
48_Y61_K0.5490.14
246_Y305_I0.5480.14
193_G209_A0.5470.14
276_L307_W0.5430.13
113_L138_K0.5430.13
105_Y221_L0.5420.13
214_I223_G0.5420.13
258_S312_A0.5400.13
54_P294_L0.5400.13
229_S380_K0.5400.13
119_T122_S0.5390.13
364_G389_E0.5350.13
331_F364_G0.5350.13
139_G290_I0.5340.13
368_I409_L0.5320.13
280_Q348_K0.5320.13
193_G334_I0.5310.13
180_N263_P0.5310.13
295_D389_E0.5280.13
389_E395_D0.5280.13
90_Y250_S0.5280.13
251_D321_R0.5270.13
266_L270_K0.5270.13
324_R364_G0.5260.13
269_L435_Y0.5240.13
222_S299_S0.5240.13
222_S331_F0.5230.13
239_S332_D0.5220.13
146_K154_Q0.5210.13
285_E292_L0.5210.13
102_T106_V0.5190.13
269_L319_A0.5180.13
245_G305_I0.5170.13
103_V108_N0.5160.13
79_L216_K0.5160.13
158_K246_Y0.5140.13
299_S302_G0.5130.13
70_I397_E0.5120.13
330_F368_I0.5120.13
187_G379_I0.5110.13
327_Y377_E0.5090.13
249_G324_R0.5070.13
128_A180_N0.5070.13
188_N327_Y0.5060.13
106_V136_L0.5060.13
120_S123_M0.5040.13
259_E395_D0.5040.13
259_E295_D0.5040.13
221_L290_I0.5030.13
90_Y394_T0.5020.13
418_S436_L0.5010.12
417_I425_N0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x31A 2 0.3606 99.7 0.845 Contact Map
4jduA 1 0.3473 99.7 0.851 Contact Map
1mjnA 1 0.3496 99.7 0.851 Contact Map
4igiA 1 0.3562 99.7 0.851 Contact Map
1atzA 1 0.3695 99.7 0.854 Contact Map
1n3yA 1 0.3584 99.7 0.854 Contact Map
1mf7A 1 0.3673 99.7 0.855 Contact Map
4rckA 2 0.3518 99.7 0.855 Contact Map
2odpA 1 0.3783 99.6 0.856 Contact Map
1q0pA 1 0.3385 99.6 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.012 seconds.