Q97W74 - SULSO - GREMLIN Contacts

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Q97W74 - Uncharacterized protein

UniProt:	Q97W74	Sequences: MSEKTLLELPKKFMEALMAPFIGREEEAKVITLALLSKEHVILIGEPGTAKSALARRAAELLNAKFFMYLLTKYTEPAELFGALDINALKDGQYKRITKDRLPESQIAFLDEIFNANSAILNALLSLLNERVIYDGYNVIKVPLRTLISASNRVPDEPELEALYDRLLLRHYARPVGEELWKQLLDATWEIEFTNRWAVKEPIMNIEHLDKLYSYLSQVDLSGVKNKLLKLYAMLEEKGIHLSDRRKGKVLKVVSAHAILNSRLKATEEDLIVLKYIAPREIDDFEKVAALLSEELKTPIKYMKELNEIYNNIKEAAKYVEAANESDPRLIELIRSLRATRDRIVALGKESGDEKVEEFSKEVLSEIDKLIEKVARKLGIYP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	382 (321)
Sequences:	8912 (5637)
Seq/√Len:	314.6

ECOLI - RAVA RUVB RARA YEHL
BACSU - YEAC RUVB
HALSA - Q9HSH7
SULSO - Q97W74

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
11_K	15_E	5.801	1.00
88_A	91_D	3.397	1.00
76_E	79_E	2.840	1.00
177_G	180_L	2.739	1.00
86_I	89_L	2.570	1.00
281_E	285_F	2.543	1.00
264_L	268_E	2.390	1.00
276_Y	280_R	2.385	1.00
182_K	186_D	2.251	1.00
264_L	267_T	2.242	1.00
68_M	71_L	2.222	1.00
86_I	90_K	2.207	1.00
339_A	343_R	2.170	1.00
277_I	281_E	2.168	1.00
283_D	287_K	2.128	1.00
86_I	91_D	2.115	1.00
296_L	299_P	2.070	1.00
248_G	252_K	2.015	1.00
102_L	105_S	2.009	1.00
244_D	247_K	2.008	1.00
87_N	91_D	1.999	1.00
342_D	346_A	1.981	1.00
243_S	251_L	1.973	1.00
321_E	333_L	1.973	1.00
296_L	300_I	1.971	1.00
67_F	70_L	1.964	1.00
241_H	244_D	1.931	1.00
87_N	90_K	1.920	1.00
290_A	294_E	1.917	1.00
280_R	284_D	1.909	1.00
253_V	256_A	1.908	1.00
27_E	30_V	1.877	1.00
263_R	267_T	1.864	1.00
232_Y	236_E	1.853	1.00
244_D	248_G	1.849	1.00
181_W	213_Y	1.759	1.00
345_V	348_G	1.748	1.00
66_F	70_L	1.738	1.00
70_L	73_K	1.737	1.00
216_L	220_D	1.701	1.00
346_A	350_E	1.667	1.00
245_R	248_G	1.665	1.00
240_I	244_D	1.661	1.00
228_L	232_Y	1.646	1.00
265_K	269_E	1.636	1.00
279_P	283_D	1.631	1.00
289_A	293_S	1.603	1.00
282_I	286_E	1.600	1.00
305_E	309_I	1.596	1.00
131_R	134_Y	1.596	1.00
245_R	249_K	1.589	1.00
263_R	270_D	1.578	1.00
82_G	123_A	1.562	1.00
205_N	208_H	1.555	1.00
64_A	71_L	1.544	1.00
293_S	297_K	1.525	1.00
271_L	275_K	1.520	1.00
251_L	255_S	1.509	1.00
224_V	228_L	1.505	1.00
94_Y	97_I	1.503	1.00
268_E	272_I	1.500	1.00
225_K	228_L	1.490	1.00
213_Y	217_S	1.483	1.00
328_P	331_I	1.480	1.00
309_I	312_N	1.472	1.00
315_E	319_Y	1.463	1.00
342_D	345_V	1.446	1.00
80_L	83_A	1.423	1.00
292_L	295_E	1.405	1.00
275_K	281_E	1.388	1.00
107_I	111_D	1.387	1.00
247_K	254_V	1.356	1.00
42_I	113_I	1.354	1.00
327_D	330_L	1.352	1.00
262_S	267_T	1.350	1.00
281_E	284_D	1.337	1.00
308_E	311_N	1.336	1.00
66_F	71_L	1.331	1.00
262_S	266_A	1.331	1.00
189_W	204_M	1.331	1.00
307_N	311_N	1.321	1.00
241_H	247_K	1.318	1.00
25_E	180_L	1.317	1.00
263_R	274_L	1.310	1.00
270_D	275_K	1.309	1.00
288_V	291_L	1.308	1.00
341_R	345_V	1.307	1.00
212_L	216_L	1.303	1.00
345_V	349_K	1.299	1.00
227_K	230_K	1.297	1.00
34_A	41_V	1.295	1.00
93_Q	97_I	1.293	1.00
11_K	14_M	1.293	1.00
288_V	296_L	1.291	1.00
72_T	76_E	1.279	1.00
240_I	243_S	1.276	1.00
208_H	211_K	1.272	1.00
287_K	291_L	1.267	1.00
330_L	334_I	1.266	1.00
306_L	310_Y	1.262	1.00
95_K	100_D	1.262	1.00
272_I	275_K	1.260	1.00
310_Y	314_K	1.246	1.00
277_I	280_R	1.239	1.00
240_I	247_K	1.229	1.00
334_I	338_R	1.220	1.00
185_L	200_K	1.218	1.00
347_L	350_E	1.217	1.00
67_F	71_L	1.217	1.00
263_R	266_A	1.212	1.00
290_A	293_S	1.202	1.00
344_I	348_G	1.201	1.00
271_L	274_L	1.201	1.00
312_N	316_A	1.195	1.00
340_T	343_R	1.193	1.00
260_L	263_R	1.192	1.00
49_T	173_A	1.190	1.00
230_K	233_A	1.189	1.00
12_K	17_L	1.186	1.00
336_S	339_A	1.184	1.00
125_L	128_L	1.182	1.00
332_E	335_R	1.181	1.00
210_D	213_Y	1.180	1.00
294_E	298_T	1.171	1.00
346_A	349_K	1.163	1.00
262_S	270_D	1.162	1.00
243_S	247_K	1.160	1.00
251_L	254_V	1.159	1.00
208_H	212_L	1.157	1.00
313_I	317_A	1.153	1.00
241_H	248_G	1.152	1.00
108_A	111_D	1.150	1.00
270_D	274_L	1.148	1.00
224_V	227_K	1.147	1.00
288_V	295_E	1.146	1.00
225_K	229_L	1.143	1.00
291_L	295_E	1.143	1.00
181_W	185_L	1.140	1.00
327_D	331_I	1.138	1.00
220_D	223_G	1.137	1.00
332_E	336_S	1.136	1.00
269_E	272_I	1.132	1.00
224_V	232_Y	1.132	1.00
288_V	292_L	1.131	1.00
292_L	296_L	1.130	1.00
178_E	214_S	1.128	1.00
65_K	70_L	1.125	1.00
230_K	234_M	1.123	1.00
285_F	289_A	1.122	1.00
247_K	253_V	1.115	1.00
300_I	303_M	1.111	1.00
126_S	130_E	1.104	1.00
252_K	255_S	1.103	1.00
277_I	284_D	1.102	1.00
67_F	72_T	1.101	1.00
12_K	15_E	1.097	1.00
267_T	271_L	1.089	1.00
258_A	261_N	1.088	1.00
247_K	251_L	1.084	1.00
285_F	288_V	1.079	1.00
337_L	341_R	1.079	1.00
266_A	270_D	1.078	1.00
277_I	288_V	1.075	1.00
55_A	148_I	1.073	1.00
308_E	312_N	1.070	1.00
240_I	248_G	1.064	1.00
273_V	276_Y	1.062	1.00
226_N	229_L	1.061	1.00
65_K	72_T	1.059	1.00
231_L	235_L	1.058	1.00
248_G	251_L	1.058	1.00
263_R	271_L	1.054	1.00
96_R	100_D	1.052	1.00
263_R	268_E	1.052	1.00
278_A	281_E	1.046	1.00
246_R	253_V	1.041	1.00
224_V	236_E	1.038	1.00
311_N	315_E	1.037	1.00
77_P	80_L	1.033	1.00
279_P	282_I	1.032	1.00
225_K	236_E	1.030	1.00
269_E	273_V	1.029	1.00
216_L	223_G	1.023	1.00
339_A	342_D	1.022	1.00
264_L	270_D	1.021	1.00
267_T	275_K	1.020	1.00
249_K	253_V	1.019	1.00
179_E	183_Q	1.014	1.00
268_E	271_L	1.005	1.00
318_K	322_A	1.002	1.00
59_A	107_I	1.000	1.00
228_L	235_L	0.998	1.00
18_M	60_E	0.998	1.00
109_F	150_A	0.992	1.00
268_E	275_K	0.986	1.00
30_V	33_L	0.983	1.00
303_M	306_L	0.979	1.00
312_N	315_E	0.979	1.00
178_E	213_Y	0.978	1.00
253_V	257_H	0.977	1.00
250_V	254_V	0.976	1.00
297_K	301_K	0.974	1.00
79_E	83_A	0.973	1.00
331_I	335_R	0.970	1.00
298_T	301_K	0.970	1.00
270_D	273_V	0.970	1.00
232_Y	235_L	0.965	1.00
273_V	277_I	0.963	1.00
292_L	300_I	0.963	1.00
229_L	233_A	0.961	1.00
286_E	289_A	0.957	1.00
262_S	268_E	0.952	1.00
298_T	302_Y	0.951	1.00
75_T	83_A	0.951	1.00
228_L	237_E	0.950	1.00
65_K	71_L	0.948	1.00
293_S	296_L	0.947	1.00
311_N	314_K	0.944	1.00
277_I	283_D	0.943	1.00
213_Y	216_L	0.943	1.00
343_R	346_A	0.941	1.00
69_Y	72_T	0.941	1.00
260_L	267_T	0.938	1.00
281_E	292_L	0.935	1.00
343_R	347_L	0.934	1.00
246_R	249_K	0.932	1.00
280_R	283_D	0.932	1.00
321_E	324_N	0.931	1.00
217_S	220_D	0.929	1.00
31_I	58_A	0.924	1.00
274_L	277_I	0.923	1.00
297_K	303_M	0.922	1.00
107_I	110_L	0.920	1.00
299_P	303_M	0.919	1.00
310_Y	337_L	0.912	1.00
212_L	215_Y	0.911	1.00
178_E	182_K	0.910	1.00
258_A	264_L	0.904	1.00
336_S	340_T	0.899	1.00
304_K	308_E	0.896	1.00
277_I	282_I	0.896	1.00
79_E	82_G	0.891	1.00
65_K	68_M	0.885	1.00
198_A	201_E	0.882	1.00
267_T	270_D	0.878	1.00
313_I	337_L	0.877	1.00
122_N	125_L	0.874	1.00
275_K	279_P	0.872	1.00
228_L	231_L	0.871	1.00
244_D	253_V	0.870	1.00
316_A	319_Y	0.868	1.00
90_K	93_Q	0.861	1.00
307_N	310_Y	0.856	1.00
296_L	303_M	0.846	1.00
66_F	69_Y	0.843	1.00
271_L	281_E	0.841	1.00
63_N	66_F	0.840	1.00
319_Y	323_A	0.838	1.00
320_V	324_N	0.837	1.00
256_A	259_I	0.833	1.00
29_K	32_T	0.829	1.00
97_I	102_L	0.825	1.00
331_I	334_I	0.820	1.00
109_F	112_E	0.815	1.00
344_I	347_L	0.808	1.00
43_L	173_A	0.805	1.00
209_L	213_Y	0.802	1.00
286_E	290_A	0.802	1.00
10_P	13_F	0.801	1.00
229_L	236_E	0.799	1.00
241_H	254_V	0.798	1.00
123_A	127_L	0.798	1.00
211_K	214_S	0.797	1.00
300_I	304_K	0.797	1.00
264_L	271_L	0.792	1.00
231_L	236_E	0.788	1.00
333_L	336_S	0.788	1.00
152_N	155_P	0.787	1.00
149_S	167_L	0.784	1.00
288_V	299_P	0.781	1.00
257_H	261_N	0.781	1.00
302_Y	310_Y	0.781	1.00
282_I	285_F	0.778	1.00
24_R	27_E	0.776	1.00
113_I	148_I	0.776	1.00
125_L	129_N	0.775	1.00
306_L	309_I	0.768	0.99
254_V	260_L	0.767	0.99
65_K	69_Y	0.766	0.99
102_L	127_L	0.766	0.99
338_R	342_D	0.765	0.99
254_V	257_H	0.757	0.99
278_A	285_F	0.755	0.99
249_K	254_V	0.755	0.99
303_M	310_Y	0.753	0.99
281_E	288_V	0.752	0.99
243_S	246_R	0.748	0.99
316_A	328_P	0.745	0.99
227_K	231_L	0.745	0.99
227_K	236_E	0.742	0.99
316_A	320_V	0.742	0.99
265_K	271_L	0.740	0.99
310_Y	313_I	0.740	0.99
262_S	265_K	0.737	0.99
247_K	252_K	0.734	0.99
215_Y	219_V	0.734	0.99
313_I	316_A	0.732	0.99
72_T	78_A	0.732	0.99
278_A	288_V	0.730	0.99
247_K	289_A	0.729	0.99
78_A	82_G	0.728	0.99
113_I	158_P	0.726	0.99
282_I	296_L	0.726	0.99
69_Y	73_K	0.724	0.99
278_A	282_I	0.723	0.99
317_A	320_V	0.720	0.99
120_I	125_L	0.719	0.99
242_L	252_K	0.719	0.99
66_F	76_E	0.714	0.99
281_E	295_E	0.710	0.99
248_G	253_V	0.709	0.99
70_L	74_Y	0.709	0.99
181_W	188_T	0.708	0.99
187_A	191_I	0.708	0.99
341_R	348_G	0.705	0.99
305_E	308_E	0.704	0.99
333_L	338_R	0.702	0.99
185_L	188_T	0.701	0.99
334_I	337_L	0.701	0.99
267_T	272_I	0.700	0.99
121_L	131_R	0.698	0.99
71_L	74_Y	0.696	0.99
262_S	272_I	0.694	0.99
258_A	262_S	0.692	0.99
216_L	219_V	0.691	0.99
251_L	256_A	0.690	0.99
243_S	255_S	0.690	0.99
183_Q	186_D	0.688	0.99
338_R	341_R	0.687	0.99
251_L	257_H	0.686	0.99
70_L	79_E	0.681	0.99
254_V	258_A	0.679	0.99
325_E	328_P	0.679	0.99
331_I	337_L	0.679	0.99
322_A	326_S	0.678	0.99
63_N	69_Y	0.676	0.99
92_G	96_R	0.675	0.99
205_N	212_L	0.674	0.99
265_K	272_I	0.671	0.99
289_A	292_L	0.669	0.99
209_L	212_L	0.669	0.99
296_L	306_L	0.668	0.99
72_T	79_E	0.661	0.98
224_V	235_L	0.660	0.98
313_I	336_S	0.660	0.98
71_L	76_E	0.659	0.98
30_V	35_L	0.657	0.98
320_V	325_E	0.655	0.98
31_I	171_H	0.654	0.98
259_I	262_S	0.654	0.98
31_I	54_L	0.653	0.98
243_S	250_V	0.649	0.98
208_H	216_L	0.649	0.98
345_V	350_E	0.649	0.98
326_S	330_L	0.648	0.98
66_F	72_T	0.644	0.98
252_K	256_A	0.643	0.98
228_L	233_A	0.642	0.98
74_Y	78_A	0.640	0.98
242_L	248_G	0.639	0.98
335_R	339_A	0.639	0.98
123_A	129_N	0.634	0.98
305_E	310_Y	0.634	0.98
309_I	313_I	0.634	0.98
295_E	303_M	0.633	0.98
59_A	66_F	0.633	0.98
188_T	191_I	0.630	0.98
342_D	347_L	0.630	0.98
52_S	111_D	0.630	0.98
253_V	260_L	0.629	0.98
295_E	299_P	0.627	0.98
321_E	330_L	0.623	0.98
247_K	256_A	0.623	0.98
265_K	268_E	0.622	0.98
288_V	298_T	0.621	0.98
301_K	305_E	0.621	0.98
331_I	336_S	0.621	0.98
259_I	263_R	0.614	0.97
281_E	291_L	0.614	0.97
337_L	347_L	0.614	0.97
125_L	130_E	0.612	0.97
259_I	267_T	0.609	0.97
335_R	338_R	0.604	0.97
262_S	271_L	0.603	0.97
93_Q	96_R	0.603	0.97
330_L	333_L	0.602	0.97
328_P	332_E	0.601	0.97
228_L	236_E	0.598	0.97
299_P	310_Y	0.597	0.97
334_I	340_T	0.596	0.97
204_M	208_H	0.596	0.97
337_L	340_T	0.595	0.97
242_L	246_R	0.595	0.97
295_E	300_I	0.594	0.97
95_K	99_K	0.594	0.97
221_L	224_V	0.594	0.97
337_L	344_I	0.590	0.97
302_Y	305_E	0.587	0.97
317_A	329_R	0.587	0.97
281_E	299_P	0.587	0.97
327_D	333_L	0.585	0.97
241_H	245_R	0.585	0.97
288_V	297_K	0.585	0.97
206_I	210_D	0.584	0.97
107_I	112_E	0.583	0.97
30_V	36_L	0.577	0.96
227_K	234_M	0.576	0.96
221_L	228_L	0.569	0.96
225_K	232_Y	0.567	0.96
297_K	300_I	0.567	0.96
274_L	292_L	0.567	0.96
266_A	272_I	0.566	0.96
329_R	333_L	0.565	0.96
305_E	316_A	0.565	0.96
70_L	76_E	0.565	0.96
302_Y	306_L	0.562	0.96
282_I	288_V	0.562	0.96
122_N	126_S	0.562	0.96
44_I	170_R	0.561	0.96
44_I	154_V	0.557	0.96
266_A	271_L	0.556	0.96
276_Y	281_E	0.554	0.95
284_D	287_K	0.554	0.95
310_Y	317_A	0.553	0.95
234_M	237_E	0.552	0.95
69_Y	74_Y	0.551	0.95
246_R	251_L	0.550	0.95
288_V	293_S	0.549	0.95
298_T	303_M	0.549	0.95
232_Y	238_K	0.549	0.95
259_I	264_L	0.549	0.95
215_Y	218_Q	0.547	0.95
261_N	264_L	0.544	0.95
239_G	247_K	0.542	0.95
341_R	347_L	0.540	0.95
213_Y	219_V	0.540	0.95
66_F	73_K	0.538	0.95
240_I	249_K	0.537	0.95
243_S	248_G	0.537	0.95
218_Q	221_L	0.536	0.95
72_T	77_P	0.536	0.95
243_S	249_K	0.534	0.94
229_L	237_E	0.533	0.94
288_V	294_E	0.532	0.94
287_K	290_A	0.531	0.94
319_Y	322_A	0.531	0.94
223_G	227_K	0.530	0.94
73_K	76_E	0.527	0.94
247_K	250_V	0.525	0.94
291_L	297_K	0.524	0.94
265_K	270_D	0.522	0.94
233_A	237_E	0.517	0.93
244_D	250_V	0.516	0.93
276_Y	279_P	0.516	0.93
302_Y	313_I	0.514	0.93
64_A	70_L	0.513	0.93
178_E	217_S	0.513	0.93
244_D	252_K	0.513	0.93
241_H	251_L	0.511	0.93
108_A	112_E	0.510	0.93
186_D	190_E	0.509	0.93
339_A	346_A	0.508	0.93
222_S	226_N	0.508	0.93
242_L	247_K	0.508	0.93
303_M	309_I	0.508	0.93
272_I	276_Y	0.505	0.93
221_L	225_K	0.502	0.92
263_R	277_I	0.501	0.92
340_T	344_I	0.501	0.92
100_D	104_E	0.501	0.92
68_M	73_K	0.500	0.92
60_E	63_N	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rh7A	1	0.8927	100	0.395	Contact Map
3vkgA	2	0.9503	100	0.431	Contact Map
4r7yA	3	0.7225	100	0.568	Contact Map
2r44A	1	0.7906	100	0.577	Contact Map
4akgA	2	0.7906	100	0.581	Contact Map
3ja83	1	0.699	100	0.585	Contact Map
3ja82	1	0.7565	100	0.589	Contact Map
3ja84	1	0.7251	100	0.599	Contact Map
3nbxX	1	0.9476	100	0.6	Contact Map
3ja86	1	0.733	99.9	0.606	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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