GREMLIN Database
Q97W74 - Uncharacterized protein
UniProt: Q97W74 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (321)
Sequences: 8912 (5637)
Seq/√Len: 314.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_K15_E5.8011.00
88_A91_D3.3971.00
76_E79_E2.8401.00
177_G180_L2.7391.00
86_I89_L2.5701.00
281_E285_F2.5431.00
264_L268_E2.3901.00
276_Y280_R2.3851.00
182_K186_D2.2511.00
264_L267_T2.2421.00
68_M71_L2.2221.00
86_I90_K2.2071.00
339_A343_R2.1701.00
277_I281_E2.1681.00
283_D287_K2.1281.00
86_I91_D2.1151.00
296_L299_P2.0701.00
248_G252_K2.0151.00
102_L105_S2.0091.00
244_D247_K2.0081.00
87_N91_D1.9991.00
342_D346_A1.9811.00
243_S251_L1.9731.00
321_E333_L1.9731.00
296_L300_I1.9711.00
67_F70_L1.9641.00
241_H244_D1.9311.00
87_N90_K1.9201.00
290_A294_E1.9171.00
280_R284_D1.9091.00
253_V256_A1.9081.00
27_E30_V1.8771.00
263_R267_T1.8641.00
232_Y236_E1.8531.00
244_D248_G1.8491.00
181_W213_Y1.7591.00
345_V348_G1.7481.00
66_F70_L1.7381.00
70_L73_K1.7371.00
216_L220_D1.7011.00
346_A350_E1.6671.00
245_R248_G1.6651.00
240_I244_D1.6611.00
228_L232_Y1.6461.00
265_K269_E1.6361.00
279_P283_D1.6311.00
289_A293_S1.6031.00
282_I286_E1.6001.00
305_E309_I1.5961.00
131_R134_Y1.5961.00
245_R249_K1.5891.00
263_R270_D1.5781.00
82_G123_A1.5621.00
205_N208_H1.5551.00
64_A71_L1.5441.00
293_S297_K1.5251.00
271_L275_K1.5201.00
251_L255_S1.5091.00
224_V228_L1.5051.00
94_Y97_I1.5031.00
268_E272_I1.5001.00
225_K228_L1.4901.00
213_Y217_S1.4831.00
328_P331_I1.4801.00
309_I312_N1.4721.00
315_E319_Y1.4631.00
342_D345_V1.4461.00
80_L83_A1.4231.00
292_L295_E1.4051.00
275_K281_E1.3881.00
107_I111_D1.3871.00
247_K254_V1.3561.00
42_I113_I1.3541.00
327_D330_L1.3521.00
262_S267_T1.3501.00
281_E284_D1.3371.00
308_E311_N1.3361.00
66_F71_L1.3311.00
262_S266_A1.3311.00
189_W204_M1.3311.00
307_N311_N1.3211.00
241_H247_K1.3181.00
25_E180_L1.3171.00
263_R274_L1.3101.00
270_D275_K1.3091.00
288_V291_L1.3081.00
341_R345_V1.3071.00
212_L216_L1.3031.00
345_V349_K1.2991.00
227_K230_K1.2971.00
34_A41_V1.2951.00
93_Q97_I1.2931.00
11_K14_M1.2931.00
288_V296_L1.2911.00
72_T76_E1.2791.00
240_I243_S1.2761.00
208_H211_K1.2721.00
287_K291_L1.2671.00
330_L334_I1.2661.00
306_L310_Y1.2621.00
95_K100_D1.2621.00
272_I275_K1.2601.00
310_Y314_K1.2461.00
277_I280_R1.2391.00
240_I247_K1.2291.00
334_I338_R1.2201.00
185_L200_K1.2181.00
347_L350_E1.2171.00
67_F71_L1.2171.00
263_R266_A1.2121.00
290_A293_S1.2021.00
344_I348_G1.2011.00
271_L274_L1.2011.00
312_N316_A1.1951.00
340_T343_R1.1931.00
260_L263_R1.1921.00
49_T173_A1.1901.00
230_K233_A1.1891.00
12_K17_L1.1861.00
336_S339_A1.1841.00
125_L128_L1.1821.00
332_E335_R1.1811.00
210_D213_Y1.1801.00
294_E298_T1.1711.00
346_A349_K1.1631.00
262_S270_D1.1621.00
243_S247_K1.1601.00
251_L254_V1.1591.00
208_H212_L1.1571.00
313_I317_A1.1531.00
241_H248_G1.1521.00
108_A111_D1.1501.00
270_D274_L1.1481.00
224_V227_K1.1471.00
288_V295_E1.1461.00
225_K229_L1.1431.00
291_L295_E1.1431.00
181_W185_L1.1401.00
327_D331_I1.1381.00
220_D223_G1.1371.00
332_E336_S1.1361.00
269_E272_I1.1321.00
224_V232_Y1.1321.00
288_V292_L1.1311.00
292_L296_L1.1301.00
178_E214_S1.1281.00
65_K70_L1.1251.00
230_K234_M1.1231.00
285_F289_A1.1221.00
247_K253_V1.1151.00
300_I303_M1.1111.00
126_S130_E1.1041.00
252_K255_S1.1031.00
277_I284_D1.1021.00
67_F72_T1.1011.00
12_K15_E1.0971.00
267_T271_L1.0891.00
258_A261_N1.0881.00
247_K251_L1.0841.00
285_F288_V1.0791.00
337_L341_R1.0791.00
266_A270_D1.0781.00
277_I288_V1.0751.00
55_A148_I1.0731.00
308_E312_N1.0701.00
240_I248_G1.0641.00
273_V276_Y1.0621.00
226_N229_L1.0611.00
65_K72_T1.0591.00
231_L235_L1.0581.00
248_G251_L1.0581.00
263_R271_L1.0541.00
96_R100_D1.0521.00
263_R268_E1.0521.00
278_A281_E1.0461.00
246_R253_V1.0411.00
224_V236_E1.0381.00
311_N315_E1.0371.00
77_P80_L1.0331.00
279_P282_I1.0321.00
225_K236_E1.0301.00
269_E273_V1.0291.00
216_L223_G1.0231.00
339_A342_D1.0221.00
264_L270_D1.0211.00
267_T275_K1.0201.00
249_K253_V1.0191.00
179_E183_Q1.0141.00
268_E271_L1.0051.00
318_K322_A1.0021.00
59_A107_I1.0001.00
228_L235_L0.9981.00
18_M60_E0.9981.00
109_F150_A0.9921.00
268_E275_K0.9861.00
30_V33_L0.9831.00
303_M306_L0.9791.00
312_N315_E0.9791.00
178_E213_Y0.9781.00
253_V257_H0.9771.00
250_V254_V0.9761.00
297_K301_K0.9741.00
79_E83_A0.9731.00
331_I335_R0.9701.00
298_T301_K0.9701.00
270_D273_V0.9701.00
232_Y235_L0.9651.00
273_V277_I0.9631.00
292_L300_I0.9631.00
229_L233_A0.9611.00
286_E289_A0.9571.00
262_S268_E0.9521.00
298_T302_Y0.9511.00
75_T83_A0.9511.00
228_L237_E0.9501.00
65_K71_L0.9481.00
293_S296_L0.9471.00
311_N314_K0.9441.00
277_I283_D0.9431.00
213_Y216_L0.9431.00
343_R346_A0.9411.00
69_Y72_T0.9411.00
260_L267_T0.9381.00
281_E292_L0.9351.00
343_R347_L0.9341.00
246_R249_K0.9321.00
280_R283_D0.9321.00
321_E324_N0.9311.00
217_S220_D0.9291.00
31_I58_A0.9241.00
274_L277_I0.9231.00
297_K303_M0.9221.00
107_I110_L0.9201.00
299_P303_M0.9191.00
310_Y337_L0.9121.00
212_L215_Y0.9111.00
178_E182_K0.9101.00
258_A264_L0.9041.00
336_S340_T0.8991.00
304_K308_E0.8961.00
277_I282_I0.8961.00
79_E82_G0.8911.00
65_K68_M0.8851.00
198_A201_E0.8821.00
267_T270_D0.8781.00
313_I337_L0.8771.00
122_N125_L0.8741.00
275_K279_P0.8721.00
228_L231_L0.8711.00
244_D253_V0.8701.00
316_A319_Y0.8681.00
90_K93_Q0.8611.00
307_N310_Y0.8561.00
296_L303_M0.8461.00
66_F69_Y0.8431.00
271_L281_E0.8411.00
63_N66_F0.8401.00
319_Y323_A0.8381.00
320_V324_N0.8371.00
256_A259_I0.8331.00
29_K32_T0.8291.00
97_I102_L0.8251.00
331_I334_I0.8201.00
109_F112_E0.8151.00
344_I347_L0.8081.00
43_L173_A0.8051.00
209_L213_Y0.8021.00
286_E290_A0.8021.00
10_P13_F0.8011.00
229_L236_E0.7991.00
241_H254_V0.7981.00
123_A127_L0.7981.00
211_K214_S0.7971.00
300_I304_K0.7971.00
264_L271_L0.7921.00
231_L236_E0.7881.00
333_L336_S0.7881.00
152_N155_P0.7871.00
149_S167_L0.7841.00
288_V299_P0.7811.00
257_H261_N0.7811.00
302_Y310_Y0.7811.00
282_I285_F0.7781.00
24_R27_E0.7761.00
113_I148_I0.7761.00
125_L129_N0.7751.00
306_L309_I0.7680.99
254_V260_L0.7670.99
65_K69_Y0.7660.99
102_L127_L0.7660.99
338_R342_D0.7650.99
254_V257_H0.7570.99
278_A285_F0.7550.99
249_K254_V0.7550.99
303_M310_Y0.7530.99
281_E288_V0.7520.99
243_S246_R0.7480.99
316_A328_P0.7450.99
227_K231_L0.7450.99
227_K236_E0.7420.99
316_A320_V0.7420.99
265_K271_L0.7400.99
310_Y313_I0.7400.99
262_S265_K0.7370.99
247_K252_K0.7340.99
215_Y219_V0.7340.99
313_I316_A0.7320.99
72_T78_A0.7320.99
278_A288_V0.7300.99
247_K289_A0.7290.99
78_A82_G0.7280.99
113_I158_P0.7260.99
282_I296_L0.7260.99
69_Y73_K0.7240.99
278_A282_I0.7230.99
317_A320_V0.7200.99
120_I125_L0.7190.99
242_L252_K0.7190.99
66_F76_E0.7140.99
281_E295_E0.7100.99
248_G253_V0.7090.99
70_L74_Y0.7090.99
181_W188_T0.7080.99
187_A191_I0.7080.99
341_R348_G0.7050.99
305_E308_E0.7040.99
333_L338_R0.7020.99
185_L188_T0.7010.99
334_I337_L0.7010.99
267_T272_I0.7000.99
121_L131_R0.6980.99
71_L74_Y0.6960.99
262_S272_I0.6940.99
258_A262_S0.6920.99
216_L219_V0.6910.99
251_L256_A0.6900.99
243_S255_S0.6900.99
183_Q186_D0.6880.99
338_R341_R0.6870.99
251_L257_H0.6860.99
70_L79_E0.6810.99
254_V258_A0.6790.99
325_E328_P0.6790.99
331_I337_L0.6790.99
322_A326_S0.6780.99
63_N69_Y0.6760.99
92_G96_R0.6750.99
205_N212_L0.6740.99
265_K272_I0.6710.99
289_A292_L0.6690.99
209_L212_L0.6690.99
296_L306_L0.6680.99
72_T79_E0.6610.98
224_V235_L0.6600.98
313_I336_S0.6600.98
71_L76_E0.6590.98
30_V35_L0.6570.98
320_V325_E0.6550.98
31_I171_H0.6540.98
259_I262_S0.6540.98
31_I54_L0.6530.98
243_S250_V0.6490.98
208_H216_L0.6490.98
345_V350_E0.6490.98
326_S330_L0.6480.98
66_F72_T0.6440.98
252_K256_A0.6430.98
228_L233_A0.6420.98
74_Y78_A0.6400.98
242_L248_G0.6390.98
335_R339_A0.6390.98
123_A129_N0.6340.98
305_E310_Y0.6340.98
309_I313_I0.6340.98
295_E303_M0.6330.98
59_A66_F0.6330.98
188_T191_I0.6300.98
342_D347_L0.6300.98
52_S111_D0.6300.98
253_V260_L0.6290.98
295_E299_P0.6270.98
321_E330_L0.6230.98
247_K256_A0.6230.98
265_K268_E0.6220.98
288_V298_T0.6210.98
301_K305_E0.6210.98
331_I336_S0.6210.98
259_I263_R0.6140.97
281_E291_L0.6140.97
337_L347_L0.6140.97
125_L130_E0.6120.97
259_I267_T0.6090.97
335_R338_R0.6040.97
262_S271_L0.6030.97
93_Q96_R0.6030.97
330_L333_L0.6020.97
328_P332_E0.6010.97
228_L236_E0.5980.97
299_P310_Y0.5970.97
334_I340_T0.5960.97
204_M208_H0.5960.97
337_L340_T0.5950.97
242_L246_R0.5950.97
295_E300_I0.5940.97
95_K99_K0.5940.97
221_L224_V0.5940.97
337_L344_I0.5900.97
302_Y305_E0.5870.97
317_A329_R0.5870.97
281_E299_P0.5870.97
327_D333_L0.5850.97
241_H245_R0.5850.97
288_V297_K0.5850.97
206_I210_D0.5840.97
107_I112_E0.5830.97
30_V36_L0.5770.96
227_K234_M0.5760.96
221_L228_L0.5690.96
225_K232_Y0.5670.96
297_K300_I0.5670.96
274_L292_L0.5670.96
266_A272_I0.5660.96
329_R333_L0.5650.96
305_E316_A0.5650.96
70_L76_E0.5650.96
302_Y306_L0.5620.96
282_I288_V0.5620.96
122_N126_S0.5620.96
44_I170_R0.5610.96
44_I154_V0.5570.96
266_A271_L0.5560.96
276_Y281_E0.5540.95
284_D287_K0.5540.95
310_Y317_A0.5530.95
234_M237_E0.5520.95
69_Y74_Y0.5510.95
246_R251_L0.5500.95
288_V293_S0.5490.95
298_T303_M0.5490.95
232_Y238_K0.5490.95
259_I264_L0.5490.95
215_Y218_Q0.5470.95
261_N264_L0.5440.95
239_G247_K0.5420.95
341_R347_L0.5400.95
213_Y219_V0.5400.95
66_F73_K0.5380.95
240_I249_K0.5370.95
243_S248_G0.5370.95
218_Q221_L0.5360.95
72_T77_P0.5360.95
243_S249_K0.5340.94
229_L237_E0.5330.94
288_V294_E0.5320.94
287_K290_A0.5310.94
319_Y322_A0.5310.94
223_G227_K0.5300.94
73_K76_E0.5270.94
247_K250_V0.5250.94
291_L297_K0.5240.94
265_K270_D0.5220.94
233_A237_E0.5170.93
244_D250_V0.5160.93
276_Y279_P0.5160.93
302_Y313_I0.5140.93
64_A70_L0.5130.93
178_E217_S0.5130.93
244_D252_K0.5130.93
241_H251_L0.5110.93
108_A112_E0.5100.93
186_D190_E0.5090.93
339_A346_A0.5080.93
222_S226_N0.5080.93
242_L247_K0.5080.93
303_M309_I0.5080.93
272_I276_Y0.5050.93
221_L225_K0.5020.92
263_R277_I0.5010.92
340_T344_I0.5010.92
100_D104_E0.5010.92
68_M73_K0.5000.92
60_E63_N0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rh7A 1 0.8927 100 0.395 Contact Map
3vkgA 2 0.9503 100 0.431 Contact Map
4r7yA 3 0.7225 100 0.568 Contact Map
2r44A 1 0.7906 100 0.577 Contact Map
4akgA 2 0.7906 100 0.581 Contact Map
3ja83 1 0.699 100 0.585 Contact Map
3ja82 1 0.7565 100 0.589 Contact Map
3ja84 1 0.7251 100 0.599 Contact Map
3nbxX 1 0.9476 100 0.6 Contact Map
3ja86 1 0.733 99.9 0.606 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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