GREMLIN Database
SSB - Single-stranded DNA binding protein Ssb
UniProt: Q97W73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (129)
Sequences: 663 (510)
Seq/√Len: 44.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_I74_A4.3741.00
98_E105_S3.4321.00
29_Q37_R3.2991.00
17_V85_L3.1341.00
108_P112_P2.8541.00
41_E52_K2.7691.00
19_V44_V2.7611.00
77_T84_Q2.6151.00
22_L45_G2.5261.00
87_A91_T2.3221.00
38_T61_G2.3101.00
29_Q38_T2.1851.00
105_S109_E2.1401.00
129_G132_Y1.9420.99
20_R68_V1.9290.99
68_V111_T1.9040.99
4_K7_N1.8750.99
35_G123_R1.7700.98
107_I110_N1.7080.98
40_S110_N1.6860.98
53_L71_I1.6590.97
28_R39_I1.5860.97
121_G124_G1.5350.96
111_T115_P1.4990.95
97_S110_N1.4950.95
43_I50_R1.4510.94
132_Y135_R1.4200.94
67_Q108_P1.4180.94
26_E119_R1.4150.94
74_A85_L1.4080.93
8_L20_R1.4010.93
25_S43_I1.3590.92
35_G38_T1.2700.89
21_V37_R1.2670.89
19_V53_L1.2440.88
71_I91_T1.2260.87
97_S104_S1.2230.87
16_N70_K1.2090.87
5_V19_V1.2030.86
31_Q39_I1.1880.86
27_A60_A1.1810.85
54_T57_G1.1730.85
48_T126_R1.1610.84
37_R79_F1.1440.84
99_D103_E1.1330.83
41_E86_N1.1200.82
44_V53_L1.1190.82
21_V67_Q1.1150.82
96_A112_P1.1110.82
21_V59_H1.1110.82
75_W78_A1.0820.80
125_F128_G1.0810.80
16_N72_E1.0760.80
47_E106_Q1.0720.79
78_A84_Q1.0700.79
45_G120_G1.0640.79
4_K103_E1.0620.79
21_V126_R1.0580.78
32_T73_N1.0400.77
4_K47_E1.0320.77
7_N10_P1.0240.76
125_F132_Y1.0190.76
93_I130_R1.0010.74
78_A83_V0.9930.74
119_R135_R0.9820.73
39_I54_T0.9780.73
17_V25_S0.9690.72
129_G135_R0.9520.71
39_I110_N0.9460.70
16_N110_N0.9400.70
75_W97_S0.9380.69
68_V97_S0.9350.69
74_A87_A0.9350.69
51_V85_L0.9310.69
21_V66_G0.9300.69
35_G87_A0.9210.68
130_R134_R0.9170.68
32_T41_E0.9120.67
52_K123_R0.9090.67
19_V104_S0.9080.67
35_G47_E0.8890.65
26_E59_H0.8870.65
4_K8_L0.8660.63
15_V113_T0.8660.63
15_V81_G0.8650.63
15_V61_G0.8630.63
16_N40_S0.8610.63
103_E112_P0.8480.62
113_T116_Q0.8180.59
40_S60_A0.8180.59
31_Q35_G0.8170.59
10_P93_I0.8120.58
93_I133_G0.8090.58
130_R135_R0.8040.57
73_N90_K0.7990.57
26_E127_G0.7910.56
69_V93_I0.7890.56
5_V47_E0.7860.56
118_M121_G0.7780.55
25_S41_E0.7770.55
13_E134_R0.7680.54
52_K83_V0.7680.54
49_G58_K0.7650.54
27_A61_G0.7640.54
42_A53_L0.7620.53
8_L83_V0.7560.53
68_V96_A0.7500.52
97_S107_I0.7480.52
76_T85_L0.7370.51
11_N47_E0.7360.51
59_H87_A0.7350.51
87_A106_Q0.7330.51
12_M123_R0.7320.51
19_V63_I0.7280.50
106_Q133_G0.7270.50
16_N84_Q0.7270.50
104_S107_I0.7240.50
18_T70_K0.7230.50
86_N109_E0.7190.49
129_G134_R0.7140.49
102_P106_Q0.7120.49
39_I78_A0.7120.49
42_A128_G0.7110.48
37_R52_K0.7100.48
13_E83_V0.7080.48
131_R135_R0.7010.48
103_E106_Q0.6990.47
129_G133_G0.6990.47
8_L135_R0.6940.47
27_A40_S0.6890.46
16_N79_F0.6880.46
55_L116_Q0.6740.45
14_S20_R0.6740.45
102_P125_F0.6690.44
60_A73_N0.6650.44
21_V108_P0.6650.44
21_V125_F0.6630.44
34_N86_N0.6610.44
31_Q36_V0.6590.43
20_R110_N0.6590.43
57_G115_P0.6460.42
8_L51_V0.6460.42
70_K107_I0.6430.42
67_Q80_K0.6360.41
71_I93_I0.6330.41
127_G132_Y0.6290.41
18_T110_N0.6260.40
58_K89_S0.6240.40
20_R39_I0.6240.40
6_G51_V0.6230.40
67_Q95_E0.6200.40
23_E43_I0.6190.40
114_A120_G0.6180.40
22_L35_G0.6050.38
127_G133_G0.6010.38
8_L15_V0.6000.38
67_Q115_P0.5960.38
48_T74_A0.5900.37
27_A95_E0.5870.37
72_E110_N0.5850.37
21_V24_A0.5840.36
21_V134_R0.5840.36
113_T131_R0.5840.36
97_S115_P0.5820.36
25_S28_R0.5790.36
47_E134_R0.5770.36
47_E135_R0.5760.36
123_R127_G0.5730.35
44_V122_G0.5690.35
68_V84_Q0.5670.35
37_R118_M0.5660.35
14_S55_L0.5630.35
53_L135_R0.5580.34
31_Q90_K0.5570.34
22_L109_E0.5550.34
72_E78_A0.5500.33
42_A51_V0.5430.33
126_R129_G0.5420.33
21_V63_I0.5420.33
63_I95_E0.5400.33
9_K83_V0.5330.32
32_T38_T0.5300.32
83_V90_K0.5250.31
26_E117_Q0.5240.31
55_L112_P0.5230.31
23_E45_G0.5220.31
69_V125_F0.5220.31
32_T55_L0.5170.31
110_N115_P0.5170.31
97_S108_P0.5110.30
73_N102_P0.5060.30
22_L66_G0.5010.29
72_E81_G0.5010.29
116_Q121_G0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gnxC 1 0.9662 99.9 0.336 Contact Map
1jmcA 1 0.7635 99.9 0.41 Contact Map
1o7iA 1 0.777 99.7 0.533 Contact Map
1wjjA 1 0.8176 99.6 0.572 Contact Map
3dm3A 4 0.6419 99.6 0.591 Contact Map
2k75A 1 0.7095 99.5 0.594 Contact Map
2kbnA 1 0.7095 99.4 0.631 Contact Map
2k50A 1 0.6757 99.4 0.632 Contact Map
1ynxA 1 0.6824 99.2 0.664 Contact Map
3e0eA 1 0.6014 99.2 0.669 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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