KHSE - SULSO - GREMLIN Contacts

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KHSE - Homoserine kinase

UniProt:	Q97W70	Sequences: MECKRARAYSSSANLGSGFDILSIAHTAFFDTVEICVENKNLNNIIVESNSKIPLEPNKNSATYPIVKIMEEIGIKASLKVRVIKGIPEGLGLGSSGASAAAAVMAFNNLFNLNLSKEDLVRYAMYGEIASSGSPHPDNVAASVFGGVVSVVSVSPVKVVEIPINYSFDILLFTPLNVHIEEKTKKAREMVPKTVTLSDYINNSRYISSLLLGFIKGERELIRLGLNDKIVEKARLPLFPYYPKIKEVAIKYDAIGACVSGAGPSILVLTDKMTDENKIVEEGTKTCNEFNVECKVIKAKIAGGVGIEGRD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (268)
Sequences:	6493 (4837)
Seq/√Len:	295.5

ECOLI - KHSE ISPE
BACSU - KHSE ISPE
HALSA - KHSE Q9HQI6
SULSO - KHSE Q980I6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_E	59_K	3.783	1.00
36_C	80_K	3.558	1.00
116_S	119_D	3.323	1.00
8_A	99_S	3.189	1.00
44_N	80_K	2.975	1.00
270_T	279_I	2.961	1.00
137_P	155_S	2.954	1.00
32_T	84_I	2.900	1.00
7_R	30_F	2.858	1.00
104_V	120_L	2.558	1.00
232_E	246_K	2.508	1.00
5_R	34_E	2.477	1.00
35_I	106_A	2.448	1.00
172_L	265_S	2.268	1.00
38_E	80_K	2.229	1.00
46_I	82_R	2.218	1.00
236_L	243_P	2.186	1.00
58_N	67_V	2.186	1.00
185_K	189_E	2.144	1.00
121_V	145_F	2.083	1.00
187_A	230_I	2.081	1.00
272_K	275_D	2.079	1.00
38_E	41_N	2.003	1.00
34_E	82_R	1.987	1.00
174_T	179_H	1.960	1.00
69_I	113_L	1.954	1.00
273_M	277_N	1.948	1.00
226_L	256_G	1.872	1.00
108_N	114_N	1.870	1.00
242_Y	266_I	1.867	1.00
170_I	269_L	1.858	1.00
171_L	270_T	1.847	1.00
34_E	84_I	1.826	1.00
108_N	115_L	1.820	1.00
68_K	123_Y	1.789	1.00
24_I	148_V	1.782	1.00
169_D	273_M	1.721	1.00
218_E	221_L	1.716	1.00
63_T	67_V	1.702	1.00
68_K	134_S	1.701	1.00
72_E	119_D	1.675	1.00
36_C	82_R	1.674	1.00
21_I	151_V	1.654	1.00
190_M	238_L	1.646	1.00
6_A	106_A	1.633	1.00
67_V	70_M	1.633	1.00
72_E	123_Y	1.622	1.00
243_P	247_E	1.617	1.00
67_V	71_E	1.594	1.00
69_I	104_V	1.593	1.00
32_T	86_G	1.574	1.00
182_E	187_A	1.565	1.00
68_K	72_E	1.560	1.00
7_R	32_T	1.506	1.00
119_D	122_R	1.487	1.00
247_E	251_K	1.478	1.00
72_E	134_S	1.474	1.00
246_K	266_I	1.470	1.00
183_K	186_K	1.468	1.00
42_L	80_K	1.466	1.00
5_R	32_T	1.439	1.00
186_K	189_E	1.430	1.00
43_N	63_T	1.430	1.00
241_Y	244_K	1.409	1.00
182_E	235_R	1.407	1.00
90_G	181_E	1.406	1.00
69_I	111_F	1.406	1.00
171_L	276_E	1.396	1.00
248_V	252_Y	1.393	1.00
62_A	103_A	1.389	1.00
33_V	103_A	1.375	1.00
6_A	105_M	1.370	1.00
108_N	113_L	1.365	1.00
35_I	81_V	1.362	1.00
44_N	82_R	1.354	1.00
271_D	275_D	1.351	1.00
47_V	50_N	1.350	1.00
62_A	83_V	1.341	1.00
73_I	113_L	1.324	1.00
249_A	268_V	1.323	1.00
38_E	78_S	1.313	1.00
242_Y	259_V	1.305	1.00
174_T	265_S	1.299	1.00
190_M	193_K	1.288	1.00
257_A	268_V	1.279	1.00
232_E	236_L	1.278	1.00
54_P	59_K	1.271	1.00
33_V	102_A	1.267	1.00
27_T	30_F	1.264	1.00
66_I	70_M	1.261	1.00
223_R	256_G	1.259	1.00
107_F	111_F	1.250	1.00
25_A	148_V	1.246	1.00
258_C	267_L	1.235	1.00
172_L	267_L	1.230	1.00
8_A	102_A	1.222	1.00
40_K	78_S	1.202	1.00
23_S	151_V	1.188	1.00
38_E	42_L	1.178	1.00
249_A	254_A	1.165	1.00
81_V	103_A	1.165	1.00
14_N	207_I	1.159	1.00
173_F	245_I	1.147	1.00
73_I	115_L	1.147	1.00
17_S	191_V	1.145	1.00
11_S	143_S	1.134	1.00
236_L	242_Y	1.125	1.00
171_L	279_I	1.125	1.00
180_I	241_Y	1.121	1.00
280_V	284_T	1.114	1.00
19_F	137_P	1.111	1.00
66_I	81_V	1.107	1.00
213_G	222_I	1.104	1.00
103_A	107_F	1.103	1.00
212_L	215_I	1.092	1.00
236_L	246_K	1.090	1.00
25_A	147_G	1.088	1.00
33_V	62_A	1.084	1.00
68_K	71_E	1.082	1.00
115_L	123_Y	1.077	1.00
169_D	276_E	1.072	1.00
117_K	145_F	1.068	1.00
69_I	73_I	1.068	1.00
6_A	109_N	1.066	1.00
37_V	77_A	1.063	1.00
61_S	100_A	1.057	1.00
91_L	174_T	1.056	1.00
104_V	124_A	1.050	1.00
12_S	24_I	1.046	1.00
220_E	271_D	1.046	1.00
61_S	135_P	1.046	1.00
29_F	93_L	1.033	1.00
187_A	235_R	1.032	1.00
209_S	225_G	1.031	1.00
90_G	264_P	1.030	1.00
101_A	144_V	1.017	1.00
186_K	238_L	1.016	1.00
87_I	93_L	1.012	1.00
10_S	87_I	1.012	1.00
70_M	111_F	1.009	1.00
108_N	116_S	1.008	1.00
151_V	159_V	1.008	1.00
125_M	155_S	1.002	1.00
31_D	87_I	0.996	1.00
260_S	265_S	0.994	1.00
41_N	78_S	0.990	1.00
106_A	110_L	0.987	1.00
277_N	280_V	0.987	1.00
108_N	120_L	0.983	1.00
46_I	80_K	0.979	1.00
220_E	224_L	0.979	1.00
230_I	235_R	0.973	1.00
108_N	117_K	0.973	1.00
191_V	195_V	0.971	1.00
26_H	30_F	0.963	1.00
26_H	172_L	0.958	1.00
186_K	190_M	0.957	1.00
25_A	146_G	0.957	1.00
252_Y	282_E	0.954	1.00
244_K	247_E	0.954	1.00
248_V	286_T	0.952	1.00
182_E	262_A	0.951	1.00
149_V	159_V	0.947	1.00
250_I	257_A	0.943	1.00
98_A	143_S	0.943	1.00
10_S	26_H	0.942	1.00
117_K	121_V	0.936	1.00
11_S	142_A	0.935	1.00
246_K	250_I	0.935	1.00
158_K	161_E	0.934	1.00
31_D	85_K	0.932	1.00
226_L	258_C	0.925	1.00
246_K	257_A	0.922	1.00
35_I	103_A	0.918	1.00
213_G	221_L	0.910	1.00
171_L	280_V	0.905	1.00
16_G	227_N	0.901	1.00
58_N	63_T	0.896	1.00
46_I	84_I	0.888	1.00
180_I	239_F	0.886	1.00
79_L	107_F	0.885	1.00
14_N	17_S	0.881	1.00
124_A	140_V	0.879	1.00
12_S	170_I	0.877	1.00
244_K	248_V	0.872	1.00
281_E	285_K	0.869	1.00
270_T	276_E	0.865	1.00
118_E	122_R	0.861	1.00
249_A	257_A	0.860	1.00
79_L	111_F	0.856	1.00
90_G	265_S	0.850	1.00
87_I	98_A	0.849	1.00
70_M	77_A	0.842	1.00
23_S	142_A	0.835	1.00
248_V	251_K	0.832	1.00
121_V	124_A	0.822	1.00
66_I	107_F	0.817	1.00
30_F	87_I	0.816	1.00
8_A	143_S	0.815	1.00
115_L	120_L	0.813	1.00
255_I	271_D	0.810	1.00
104_V	123_Y	0.807	1.00
109_N	113_L	0.807	1.00
199_D	229_K	0.803	1.00
154_V	159_V	0.798	0.99
118_E	145_F	0.796	0.99
45_I	48_E	0.796	0.99
9_Y	146_G	0.795	0.99
121_V	125_M	0.788	0.99
190_M	237_P	0.785	0.99
115_L	119_D	0.785	0.99
121_V	144_V	0.785	0.99
26_H	29_F	0.783	0.99
174_T	181_E	0.781	0.99
154_V	157_V	0.779	0.99
223_R	226_L	0.777	0.99
65_P	68_K	0.777	0.99
268_V	279_I	0.776	0.99
69_I	107_F	0.774	0.99
71_E	134_S	0.774	0.99
45_I	60_N	0.773	0.99
281_E	284_T	0.770	0.99
25_A	142_A	0.768	0.99
66_I	78_S	0.767	0.99
282_E	286_T	0.764	0.99
239_F	259_V	0.764	0.99
105_M	144_V	0.763	0.99
250_I	256_G	0.763	0.99
94_G	143_S	0.761	0.99
53_I	89_E	0.759	0.99
248_V	283_G	0.754	0.99
252_Y	279_I	0.751	0.99
241_Y	245_I	0.749	0.99
125_M	157_V	0.747	0.99
254_A	268_V	0.746	0.99
206_Y	209_S	0.745	0.99
282_E	285_K	0.743	0.99
9_Y	25_A	0.738	0.99
63_T	81_V	0.736	0.99
230_I	262_A	0.731	0.99
250_I	254_A	0.730	0.99
69_I	123_Y	0.728	0.99
283_G	287_C	0.725	0.99
142_A	151_V	0.724	0.99
25_A	143_S	0.724	0.99
182_E	264_P	0.721	0.99
12_S	267_L	0.721	0.99
41_N	70_M	0.720	0.99
103_A	106_A	0.719	0.99
65_P	104_V	0.716	0.99
213_G	225_G	0.715	0.99
254_A	270_T	0.714	0.99
9_Y	30_F	0.708	0.99
150_S	211_L	0.707	0.99
278_K	282_E	0.699	0.99
284_T	287_C	0.698	0.99
277_N	281_E	0.697	0.99
253_D	256_G	0.695	0.99
182_E	239_F	0.693	0.99
43_N	78_S	0.692	0.99
66_I	103_A	0.691	0.99
275_D	278_K	0.690	0.99
279_I	282_E	0.688	0.99
257_A	266_I	0.686	0.98
38_E	44_N	0.686	0.98
169_D	272_K	0.686	0.98
66_I	79_L	0.681	0.98
6_A	102_A	0.679	0.98
207_I	210_L	0.677	0.98
124_A	144_V	0.672	0.98
6_A	33_V	0.668	0.98
72_E	122_R	0.667	0.98
43_N	47_V	0.666	0.98
51_S	55_L	0.665	0.98
10_S	31_D	0.665	0.98
142_A	188_R	0.665	0.98
19_F	155_S	0.664	0.98
97_G	143_S	0.664	0.98
175_P	180_I	0.661	0.98
223_R	255_I	0.659	0.98
152_V	158_K	0.659	0.98
14_N	210_L	0.657	0.98
221_L	224_L	0.657	0.98
175_P	264_P	0.651	0.98
145_F	149_V	0.651	0.98
121_V	141_A	0.650	0.98
93_L	172_L	0.650	0.98
33_V	98_A	0.648	0.98
195_V	200_Y	0.646	0.98
75_I	111_F	0.640	0.98
70_M	78_S	0.640	0.98
23_S	188_R	0.639	0.98
174_T	264_P	0.635	0.97
45_I	53_I	0.635	0.97
66_I	111_F	0.634	0.97
270_T	275_D	0.632	0.97
273_M	276_E	0.631	0.97
152_V	160_V	0.631	0.97
41_N	79_L	0.631	0.97
125_M	137_P	0.628	0.97
173_F	283_G	0.627	0.97
235_R	238_L	0.626	0.97
182_E	238_L	0.625	0.97
22_L	207_I	0.623	0.97
98_A	146_G	0.623	0.97
212_L	216_K	0.621	0.97
26_H	170_I	0.620	0.97
35_I	79_L	0.619	0.97
33_V	83_V	0.619	0.97
118_E	121_V	0.618	0.97
268_V	283_G	0.617	0.97
8_A	98_A	0.616	0.97
16_G	229_K	0.615	0.97
91_L	265_S	0.613	0.97
233_K	243_P	0.613	0.97
238_L	241_Y	0.611	0.97
245_I	266_I	0.610	0.97
22_L	162_I	0.609	0.97
211_L	215_I	0.608	0.97
202_N	229_K	0.608	0.97
204_S	207_I	0.606	0.97
210_L	213_G	0.605	0.97
173_F	287_C	0.604	0.97
62_A	99_S	0.602	0.97
89_E	181_E	0.599	0.96
196_T	199_D	0.598	0.96
10_S	98_A	0.594	0.96
111_F	114_N	0.592	0.96
202_N	206_Y	0.589	0.96
109_N	112_N	0.588	0.96
65_P	103_A	0.588	0.96
69_I	108_N	0.583	0.96
254_A	257_A	0.582	0.96
105_M	117_K	0.580	0.96
245_I	287_C	0.578	0.96
31_D	99_S	0.578	0.96
223_R	250_I	0.574	0.95
210_L	222_I	0.574	0.95
90_G	174_T	0.574	0.95
9_Y	98_A	0.571	0.95
135_P	140_V	0.570	0.95
123_Y	135_P	0.570	0.95
60_N	83_V	0.568	0.95
235_R	239_F	0.568	0.95
201_I	204_S	0.565	0.95
20_D	136_H	0.563	0.95
222_I	256_G	0.562	0.95
62_A	65_P	0.561	0.95
200_Y	230_I	0.561	0.95
69_I	115_L	0.560	0.95
20_D	188_R	0.560	0.95
108_N	112_N	0.560	0.95
235_R	242_Y	0.556	0.95
105_M	109_N	0.552	0.94
89_E	260_S	0.551	0.94
13_A	20_D	0.550	0.94
232_E	258_C	0.548	0.94
65_P	135_P	0.548	0.94
37_V	41_N	0.548	0.94
163_P	215_I	0.546	0.94
278_K	281_E	0.546	0.94
24_I	164_I	0.544	0.94
69_I	114_N	0.544	0.94
64_Y	68_K	0.543	0.94
37_V	110_L	0.541	0.94
85_K	99_S	0.540	0.94
283_G	286_T	0.535	0.93
70_M	75_I	0.535	0.93
26_H	267_L	0.534	0.93
280_V	289_E	0.532	0.93
71_E	74_G	0.532	0.93
195_V	230_I	0.532	0.93
17_S	210_L	0.530	0.93
125_M	141_A	0.530	0.93
65_P	140_V	0.529	0.93
221_L	225_G	0.527	0.93
251_K	254_A	0.525	0.93
274_T	278_K	0.520	0.93
101_A	124_A	0.520	0.93
12_S	172_L	0.519	0.92
35_I	110_L	0.519	0.92
97_G	142_A	0.517	0.92
43_N	83_V	0.517	0.92
244_K	289_E	0.515	0.92
42_L	47_V	0.515	0.92
73_I	108_N	0.515	0.92
11_S	136_H	0.514	0.92
171_L	268_V	0.514	0.92
45_I	83_V	0.511	0.92
240_P	244_K	0.510	0.92
203_N	206_Y	0.510	0.92
219_R	255_I	0.510	0.92
13_A	136_H	0.509	0.92
89_E	264_P	0.509	0.92
145_F	159_V	0.509	0.92
285_K	289_E	0.506	0.91
48_E	84_I	0.506	0.91
187_A	190_M	0.506	0.91
52_K	56_E	0.505	0.91
69_I	103_A	0.503	0.91
87_I	95_S	0.501	0.91
103_A	110_L	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4p52A	2	0.9807	100	0.268	Contact Map
1h72C	2	0.9389	100	0.305	Contact Map
4rpfA	2	0.9807	100	0.308	Contact Map
3pyfA	1	0.9196	100	0.319	Contact Map
3hulA	4	0.881	100	0.327	Contact Map
2hfsA	1	0.9421	100	0.384	Contact Map
1uekA	1	0.8296	100	0.39	Contact Map
4hacA	2	0.9228	100	0.395	Contact Map
2v8pA	1	0.8328	100	0.397	Contact Map
4n3oA	2	0.9196	100	0.404	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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