GREMLIN Database
KHSE - Homoserine kinase
UniProt: Q97W70 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (268)
Sequences: 6493 (4837)
Seq/√Len: 295.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_E59_K3.7831.00
36_C80_K3.5581.00
116_S119_D3.3231.00
8_A99_S3.1891.00
44_N80_K2.9751.00
270_T279_I2.9611.00
137_P155_S2.9541.00
32_T84_I2.9001.00
7_R30_F2.8581.00
104_V120_L2.5581.00
232_E246_K2.5081.00
5_R34_E2.4771.00
35_I106_A2.4481.00
172_L265_S2.2681.00
38_E80_K2.2291.00
46_I82_R2.2181.00
236_L243_P2.1861.00
58_N67_V2.1861.00
185_K189_E2.1441.00
121_V145_F2.0831.00
187_A230_I2.0811.00
272_K275_D2.0791.00
38_E41_N2.0031.00
34_E82_R1.9871.00
174_T179_H1.9601.00
69_I113_L1.9541.00
273_M277_N1.9481.00
226_L256_G1.8721.00
108_N114_N1.8701.00
242_Y266_I1.8671.00
170_I269_L1.8581.00
171_L270_T1.8471.00
34_E84_I1.8261.00
108_N115_L1.8201.00
68_K123_Y1.7891.00
24_I148_V1.7821.00
169_D273_M1.7211.00
218_E221_L1.7161.00
63_T67_V1.7021.00
68_K134_S1.7011.00
72_E119_D1.6751.00
36_C82_R1.6741.00
21_I151_V1.6541.00
190_M238_L1.6461.00
6_A106_A1.6331.00
67_V70_M1.6331.00
72_E123_Y1.6221.00
243_P247_E1.6171.00
67_V71_E1.5941.00
69_I104_V1.5931.00
32_T86_G1.5741.00
182_E187_A1.5651.00
68_K72_E1.5601.00
7_R32_T1.5061.00
119_D122_R1.4871.00
247_E251_K1.4781.00
72_E134_S1.4741.00
246_K266_I1.4701.00
183_K186_K1.4681.00
42_L80_K1.4661.00
5_R32_T1.4391.00
186_K189_E1.4301.00
43_N63_T1.4301.00
241_Y244_K1.4091.00
182_E235_R1.4071.00
90_G181_E1.4061.00
69_I111_F1.4061.00
171_L276_E1.3961.00
248_V252_Y1.3931.00
62_A103_A1.3891.00
33_V103_A1.3751.00
6_A105_M1.3701.00
108_N113_L1.3651.00
35_I81_V1.3621.00
44_N82_R1.3541.00
271_D275_D1.3511.00
47_V50_N1.3501.00
62_A83_V1.3411.00
73_I113_L1.3241.00
249_A268_V1.3231.00
38_E78_S1.3131.00
242_Y259_V1.3051.00
174_T265_S1.2991.00
190_M193_K1.2881.00
257_A268_V1.2791.00
232_E236_L1.2781.00
54_P59_K1.2711.00
33_V102_A1.2671.00
27_T30_F1.2641.00
66_I70_M1.2611.00
223_R256_G1.2591.00
107_F111_F1.2501.00
25_A148_V1.2461.00
258_C267_L1.2351.00
172_L267_L1.2301.00
8_A102_A1.2221.00
40_K78_S1.2021.00
23_S151_V1.1881.00
38_E42_L1.1781.00
249_A254_A1.1651.00
81_V103_A1.1651.00
14_N207_I1.1591.00
173_F245_I1.1471.00
73_I115_L1.1471.00
17_S191_V1.1451.00
11_S143_S1.1341.00
236_L242_Y1.1251.00
171_L279_I1.1251.00
180_I241_Y1.1211.00
280_V284_T1.1141.00
19_F137_P1.1111.00
66_I81_V1.1071.00
213_G222_I1.1041.00
103_A107_F1.1031.00
212_L215_I1.0921.00
236_L246_K1.0901.00
25_A147_G1.0881.00
33_V62_A1.0841.00
68_K71_E1.0821.00
115_L123_Y1.0771.00
169_D276_E1.0721.00
117_K145_F1.0681.00
69_I73_I1.0681.00
6_A109_N1.0661.00
37_V77_A1.0631.00
61_S100_A1.0571.00
91_L174_T1.0561.00
104_V124_A1.0501.00
12_S24_I1.0461.00
220_E271_D1.0461.00
61_S135_P1.0461.00
29_F93_L1.0331.00
187_A235_R1.0321.00
209_S225_G1.0311.00
90_G264_P1.0301.00
101_A144_V1.0171.00
186_K238_L1.0161.00
87_I93_L1.0121.00
10_S87_I1.0121.00
70_M111_F1.0091.00
108_N116_S1.0081.00
151_V159_V1.0081.00
125_M155_S1.0021.00
31_D87_I0.9961.00
260_S265_S0.9941.00
41_N78_S0.9901.00
106_A110_L0.9871.00
277_N280_V0.9871.00
108_N120_L0.9831.00
46_I80_K0.9791.00
220_E224_L0.9791.00
230_I235_R0.9731.00
108_N117_K0.9731.00
191_V195_V0.9711.00
26_H30_F0.9631.00
26_H172_L0.9581.00
186_K190_M0.9571.00
25_A146_G0.9571.00
252_Y282_E0.9541.00
244_K247_E0.9541.00
248_V286_T0.9521.00
182_E262_A0.9511.00
149_V159_V0.9471.00
250_I257_A0.9431.00
98_A143_S0.9431.00
10_S26_H0.9421.00
117_K121_V0.9361.00
11_S142_A0.9351.00
246_K250_I0.9351.00
158_K161_E0.9341.00
31_D85_K0.9321.00
226_L258_C0.9251.00
246_K257_A0.9221.00
35_I103_A0.9181.00
213_G221_L0.9101.00
171_L280_V0.9051.00
16_G227_N0.9011.00
58_N63_T0.8961.00
46_I84_I0.8881.00
180_I239_F0.8861.00
79_L107_F0.8851.00
14_N17_S0.8811.00
124_A140_V0.8791.00
12_S170_I0.8771.00
244_K248_V0.8721.00
281_E285_K0.8691.00
270_T276_E0.8651.00
118_E122_R0.8611.00
249_A257_A0.8601.00
79_L111_F0.8561.00
90_G265_S0.8501.00
87_I98_A0.8491.00
70_M77_A0.8421.00
23_S142_A0.8351.00
248_V251_K0.8321.00
121_V124_A0.8221.00
66_I107_F0.8171.00
30_F87_I0.8161.00
8_A143_S0.8151.00
115_L120_L0.8131.00
255_I271_D0.8101.00
104_V123_Y0.8071.00
109_N113_L0.8071.00
199_D229_K0.8031.00
154_V159_V0.7980.99
118_E145_F0.7960.99
45_I48_E0.7960.99
9_Y146_G0.7950.99
121_V125_M0.7880.99
190_M237_P0.7850.99
115_L119_D0.7850.99
121_V144_V0.7850.99
26_H29_F0.7830.99
174_T181_E0.7810.99
154_V157_V0.7790.99
223_R226_L0.7770.99
65_P68_K0.7770.99
268_V279_I0.7760.99
69_I107_F0.7740.99
71_E134_S0.7740.99
45_I60_N0.7730.99
281_E284_T0.7700.99
25_A142_A0.7680.99
66_I78_S0.7670.99
282_E286_T0.7640.99
239_F259_V0.7640.99
105_M144_V0.7630.99
250_I256_G0.7630.99
94_G143_S0.7610.99
53_I89_E0.7590.99
248_V283_G0.7540.99
252_Y279_I0.7510.99
241_Y245_I0.7490.99
125_M157_V0.7470.99
254_A268_V0.7460.99
206_Y209_S0.7450.99
282_E285_K0.7430.99
9_Y25_A0.7380.99
63_T81_V0.7360.99
230_I262_A0.7310.99
250_I254_A0.7300.99
69_I123_Y0.7280.99
283_G287_C0.7250.99
142_A151_V0.7240.99
25_A143_S0.7240.99
182_E264_P0.7210.99
12_S267_L0.7210.99
41_N70_M0.7200.99
103_A106_A0.7190.99
65_P104_V0.7160.99
213_G225_G0.7150.99
254_A270_T0.7140.99
9_Y30_F0.7080.99
150_S211_L0.7070.99
278_K282_E0.6990.99
284_T287_C0.6980.99
277_N281_E0.6970.99
253_D256_G0.6950.99
182_E239_F0.6930.99
43_N78_S0.6920.99
66_I103_A0.6910.99
275_D278_K0.6900.99
279_I282_E0.6880.99
257_A266_I0.6860.98
38_E44_N0.6860.98
169_D272_K0.6860.98
66_I79_L0.6810.98
6_A102_A0.6790.98
207_I210_L0.6770.98
124_A144_V0.6720.98
6_A33_V0.6680.98
72_E122_R0.6670.98
43_N47_V0.6660.98
51_S55_L0.6650.98
10_S31_D0.6650.98
142_A188_R0.6650.98
19_F155_S0.6640.98
97_G143_S0.6640.98
175_P180_I0.6610.98
223_R255_I0.6590.98
152_V158_K0.6590.98
14_N210_L0.6570.98
221_L224_L0.6570.98
175_P264_P0.6510.98
145_F149_V0.6510.98
121_V141_A0.6500.98
93_L172_L0.6500.98
33_V98_A0.6480.98
195_V200_Y0.6460.98
75_I111_F0.6400.98
70_M78_S0.6400.98
23_S188_R0.6390.98
174_T264_P0.6350.97
45_I53_I0.6350.97
66_I111_F0.6340.97
270_T275_D0.6320.97
273_M276_E0.6310.97
152_V160_V0.6310.97
41_N79_L0.6310.97
125_M137_P0.6280.97
173_F283_G0.6270.97
235_R238_L0.6260.97
182_E238_L0.6250.97
22_L207_I0.6230.97
98_A146_G0.6230.97
212_L216_K0.6210.97
26_H170_I0.6200.97
35_I79_L0.6190.97
33_V83_V0.6190.97
118_E121_V0.6180.97
268_V283_G0.6170.97
8_A98_A0.6160.97
16_G229_K0.6150.97
91_L265_S0.6130.97
233_K243_P0.6130.97
238_L241_Y0.6110.97
245_I266_I0.6100.97
22_L162_I0.6090.97
211_L215_I0.6080.97
202_N229_K0.6080.97
204_S207_I0.6060.97
210_L213_G0.6050.97
173_F287_C0.6040.97
62_A99_S0.6020.97
89_E181_E0.5990.96
196_T199_D0.5980.96
10_S98_A0.5940.96
111_F114_N0.5920.96
202_N206_Y0.5890.96
109_N112_N0.5880.96
65_P103_A0.5880.96
69_I108_N0.5830.96
254_A257_A0.5820.96
105_M117_K0.5800.96
245_I287_C0.5780.96
31_D99_S0.5780.96
223_R250_I0.5740.95
210_L222_I0.5740.95
90_G174_T0.5740.95
9_Y98_A0.5710.95
135_P140_V0.5700.95
123_Y135_P0.5700.95
60_N83_V0.5680.95
235_R239_F0.5680.95
201_I204_S0.5650.95
20_D136_H0.5630.95
222_I256_G0.5620.95
62_A65_P0.5610.95
200_Y230_I0.5610.95
69_I115_L0.5600.95
20_D188_R0.5600.95
108_N112_N0.5600.95
235_R242_Y0.5560.95
105_M109_N0.5520.94
89_E260_S0.5510.94
13_A20_D0.5500.94
232_E258_C0.5480.94
65_P135_P0.5480.94
37_V41_N0.5480.94
163_P215_I0.5460.94
278_K281_E0.5460.94
24_I164_I0.5440.94
69_I114_N0.5440.94
64_Y68_K0.5430.94
37_V110_L0.5410.94
85_K99_S0.5400.94
283_G286_T0.5350.93
70_M75_I0.5350.93
26_H267_L0.5340.93
280_V289_E0.5320.93
71_E74_G0.5320.93
195_V230_I0.5320.93
17_S210_L0.5300.93
125_M141_A0.5300.93
65_P140_V0.5290.93
221_L225_G0.5270.93
251_K254_A0.5250.93
274_T278_K0.5200.93
101_A124_A0.5200.93
12_S172_L0.5190.92
35_I110_L0.5190.92
97_G142_A0.5170.92
43_N83_V0.5170.92
244_K289_E0.5150.92
42_L47_V0.5150.92
73_I108_N0.5150.92
11_S136_H0.5140.92
171_L268_V0.5140.92
45_I83_V0.5110.92
240_P244_K0.5100.92
203_N206_Y0.5100.92
219_R255_I0.5100.92
13_A136_H0.5090.92
89_E264_P0.5090.92
145_F159_V0.5090.92
285_K289_E0.5060.91
48_E84_I0.5060.91
187_A190_M0.5060.91
52_K56_E0.5050.91
69_I103_A0.5030.91
87_I95_S0.5010.91
103_A110_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p52A 2 0.9807 100 0.268 Contact Map
1h72C 2 0.9389 100 0.305 Contact Map
4rpfA 2 0.9807 100 0.308 Contact Map
3pyfA 1 0.9196 100 0.319 Contact Map
3hulA 4 0.881 100 0.327 Contact Map
2hfsA 1 0.9421 100 0.384 Contact Map
1uekA 1 0.8296 100 0.39 Contact Map
4hacA 2 0.9228 100 0.395 Contact Map
2v8pA 1 0.8328 100 0.397 Contact Map
4n3oA 2 0.9196 100 0.404 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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