GREMLIN Database
Q97W69 - O-succinylhomoserine (Thiol)-lyase (Cystathionine gamma-synthase) (MetB)
UniProt: Q97W69 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 376 (370)
Sequences: 10560 (5891)
Seq/√Len: 306.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_K179_E3.3501.00
86_S113_E3.1541.00
60_A205_A3.0441.00
124_E158_E2.9961.00
259_E274_S2.9631.00
59_N179_E2.9091.00
369_D373_S2.8401.00
4_A360_D2.8071.00
252_E256_E2.6701.00
265_V297_N2.6421.00
86_S128_S2.5781.00
313_I324_S2.4691.00
54_I203_L2.4381.00
150_A283_K2.4091.00
339_L343_K2.3771.00
266_K295_E2.3441.00
150_A154_K2.3261.00
278_Y282_R2.2701.00
133_V164_I2.2611.00
257_F365_I2.2401.00
6_R56_E2.2401.00
174_N248_N2.1391.00
257_F369_D2.1361.00
245_D249_R2.1351.00
299_G302_S2.0581.00
153_S163_L1.9841.00
147_I152_L1.9551.00
119_N122_I1.9381.00
226_D229_A1.9341.00
48_L52_K1.9261.00
120_N151_E1.9201.00
111_N128_S1.8901.00
295_E350_S1.8791.00
189_A201_A1.8741.00
4_A241_K1.8731.00
157_K183_D1.8591.00
254_I365_I1.8411.00
50_L233_T1.8271.00
328_H331_T1.8101.00
246_V249_R1.8091.00
85_N132_D1.8071.00
165_V182_A1.7991.00
192_F290_G1.7841.00
154_K158_E1.7731.00
113_E128_S1.7411.00
247_I290_G1.7081.00
63_G205_A1.6901.00
82_K107_N1.6801.00
342_R349_D1.6781.00
361_V365_I1.6741.00
157_K163_L1.6721.00
3_D173_I1.6721.00
253_Q361_V1.6701.00
250_N361_V1.6581.00
121_N124_E1.6491.00
295_E348_T1.6261.00
339_L349_D1.6251.00
253_Q365_I1.6231.00
47_V230_A1.6171.00
60_A178_L1.5991.00
66_F75_T1.5921.00
256_E273_K1.5911.00
86_S111_N1.5911.00
58_E187_H1.5821.00
120_N155_V1.5741.00
37_Y43_S1.5721.00
89_V101_F1.5701.00
253_Q256_E1.5641.00
134_I152_L1.5581.00
310_L326_I1.5501.00
163_L182_A1.5281.00
115_S126_A1.5251.00
300_Q304_L1.5181.00
176_K286_K1.5101.00
305_K309_S1.5091.00
296_V306_V1.4881.00
134_I156_A1.4751.00
253_Q362_N1.4711.00
33_E36_K1.4491.00
338_S341_E1.4411.00
201_A225_L1.4361.00
265_V350_S1.4251.00
257_F261_H1.4251.00
254_I356_V1.4241.00
124_E159_Q1.4241.00
169_F319_L1.4151.00
86_S131_Y1.4141.00
151_E154_K1.4061.00
189_A233_T1.4051.00
25_Q228_H1.4031.00
300_Q349_D1.4021.00
55_V63_G1.4011.00
311_K370_R1.4011.00
50_L65_A1.4011.00
150_A284_V1.4011.00
76_T164_I1.3761.00
313_I368_L1.3741.00
63_G203_L1.3701.00
189_A203_L1.3671.00
127_K134_I1.3601.00
32_P36_K1.3571.00
37_Y48_L1.3541.00
73_I135_F1.3401.00
265_V295_E1.3351.00
273_K278_Y1.3301.00
127_K161_S1.3291.00
261_H369_D1.3221.00
21_T49_E1.3211.00
225_L230_A1.3141.00
242_I358_I1.3131.00
86_S130_R1.3131.00
153_S157_K1.3021.00
121_N125_K1.2981.00
82_K85_N1.2971.00
136_V149_V1.2881.00
50_L203_L1.2871.00
178_L207_Y1.2861.00
254_I368_L1.2831.00
61_E208_S1.2801.00
244_M247_I1.2781.00
148_D151_E1.2711.00
136_V163_L1.2691.00
89_V93_M1.2631.00
127_K155_V1.2551.00
111_N130_R1.2531.00
77_A133_V1.2491.00
175_Q180_L1.2481.00
81_L87_V1.2451.00
66_F204_A1.2411.00
206_G211_L1.2401.00
282_R288_F1.2241.00
250_N358_I1.2201.00
326_I352_L1.2141.00
313_I364_L1.2061.00
102_T114_A1.2061.00
199_V233_T1.2051.00
153_S182_A1.1981.00
164_I186_V1.1911.00
259_E272_L1.1911.00
312_L364_L1.1861.00
71_G223_T1.1861.00
354_L368_L1.1841.00
30_H314_I1.1801.00
254_I364_L1.1761.00
293_S351_L1.1761.00
251_A255_A1.1741.00
150_A180_L1.1731.00
54_I205_A1.1721.00
75_T223_T1.1701.00
241_K245_D1.1701.00
255_A272_L1.1621.00
144_L270_P1.1621.00
271_G288_F1.1611.00
248_N287_G1.1601.00
189_A193_L1.1591.00
279_D282_R1.1551.00
101_F112_V1.1451.00
278_Y288_F1.1411.00
123_I152_L1.1401.00
162_I210_Y1.1351.00
246_V250_N1.1311.00
277_D280_I1.1301.00
194_A199_V1.1291.00
7_A241_K1.1261.00
88_L126_A1.1211.00
156_A163_L1.1201.00
322_V358_I1.1191.00
208_S212_N1.1191.00
193_L237_I1.1111.00
91_R145_R1.1021.00
249_R253_Q1.0981.00
154_K157_K1.0981.00
198_D235_R1.0901.00
64_I215_D1.0841.00
256_E259_E1.0821.00
199_V229_A1.0731.00
19_I314_I1.0711.00
35_E308_K1.0561.00
54_I193_L1.0561.00
242_I246_V1.0531.00
122_I125_K1.0521.00
62_M208_S1.0511.00
201_A233_T1.0491.00
134_I161_S1.0491.00
281_A288_F1.0471.00
365_I369_D1.0471.00
74_S78_L1.0471.00
48_L51_A1.0471.00
124_E155_V1.0451.00
53_K234_L1.0431.00
144_L292_L1.0411.00
341_E344_I1.0371.00
212_N215_D1.0361.00
254_I361_V1.0221.00
174_N287_G1.0211.00
212_N216_Q1.0171.00
186_V204_A1.0121.00
279_D283_K1.0111.00
127_K159_Q1.0091.00
170_S285_L1.0081.00
53_K237_I1.0061.00
75_T217_M1.0021.00
74_S100_F1.0001.00
278_Y281_A1.0001.00
42_E219_R0.9921.00
255_A267_V0.9871.00
102_T106_K0.9821.00
35_E304_L0.9801.00
81_L85_N0.9751.00
136_V165_V0.9751.00
248_N252_E0.9731.00
228_H232_L0.9711.00
268_Y295_E0.9701.00
64_I211_L0.9701.00
118_G277_D0.9671.00
306_V352_L0.9611.00
62_M215_D0.9611.00
366_E369_D0.9611.00
306_V368_L0.9581.00
73_I186_V0.9571.00
77_A81_L0.9531.00
275_H278_Y0.9491.00
197_N321_G0.9491.00
194_A233_T0.9481.00
76_T184_I0.9481.00
301_E305_K0.9451.00
149_V182_A0.9431.00
117_P123_I0.9421.00
33_E308_K0.9421.00
178_L185_V0.9411.00
306_V326_I0.9411.00
294_F354_L0.9381.00
76_T204_A0.9381.00
68_S200_I0.9361.00
47_V225_L0.9361.00
89_V114_A0.9361.00
70_M73_I0.9331.00
113_E126_A0.9331.00
136_V147_I0.9321.00
98_Y102_T0.9311.00
172_P187_H0.9301.00
169_F291_V0.9301.00
257_F372_L0.9301.00
17_G32_P0.9301.00
149_V153_S0.9291.00
66_F218_R0.9281.00
184_I206_G0.9271.00
241_K246_V0.9221.00
59_N176_K0.9201.00
8_V358_I0.9141.00
367_D370_R0.9121.00
61_E206_G0.9121.00
330_A342_R0.9101.00
135_F164_I0.9091.00
62_M211_L0.9051.00
173_I245_D0.8861.00
65_A203_L0.8821.00
92_D145_R0.8821.00
149_V175_Q0.8801.00
302_S350_S0.8801.00
313_I354_L0.8791.00
204_A214_I0.8781.00
254_I354_L0.8781.00
251_A269_Y0.8771.00
263_K297_N0.8741.00
77_A101_F0.8731.00
256_E272_L0.8711.00
40_S47_V0.8701.00
258_L294_F0.8691.00
263_K372_L0.8671.00
34_G308_K0.8671.00
89_V112_V0.8661.00
190_S200_I0.8661.00
304_L308_K0.8651.00
23_I228_H0.8641.00
120_N124_E0.8621.00
238_K323_N0.8611.00
116_Y122_I0.8591.00
47_V65_A0.8541.00
299_G350_S0.8521.00
307_M326_I0.8471.00
252_E287_G0.8451.00
88_L115_S0.8371.00
281_A285_L0.8371.00
21_T234_L0.8361.00
4_A246_V0.8331.00
362_N366_E0.8321.00
135_F186_V0.8301.00
309_S371_A0.8291.00
156_A161_S0.8281.00
139_I175_Q0.8281.00
261_H372_L0.8271.00
136_V152_L0.8231.00
152_L163_L0.8231.00
133_V162_I0.8231.00
146_V277_D0.8191.00
189_A225_L0.8171.00
74_S221_L0.8161.00
173_I244_M0.8151.00
13_D16_T0.8111.00
149_V180_L0.8101.00
241_K360_D0.8101.00
3_D176_K0.8091.00
252_E269_Y0.8071.00
81_L133_V0.8041.00
266_K350_S0.8011.00
184_I210_Y0.7981.00
261_H373_S0.7981.00
155_V159_Q0.7951.00
313_I326_I0.7951.00
61_E207_Y0.7931.00
184_I204_A0.7921.00
208_S211_L0.7901.00
175_Q284_V0.7891.00
5_T312_L0.7871.00
107_N213_V0.7800.99
146_V280_I0.7800.99
87_V101_F0.7800.99
62_M206_G0.7790.99
87_V133_V0.7770.99
301_E304_L0.7750.99
253_Q257_F0.7750.99
81_L110_V0.7710.99
10_E13_D0.7710.99
193_L233_T0.7670.99
18_A24_Y0.7660.99
292_L354_L0.7630.99
23_I231_Y0.7620.99
252_E259_E0.7610.99
339_L342_R0.7570.99
299_G303_A0.7570.99
250_N254_I0.7560.99
3_D6_R0.7540.99
250_N356_V0.7500.99
66_F71_G0.7480.99
80_L210_Y0.7470.99
106_K111_N0.7450.99
183_D207_Y0.7430.99
187_H205_A0.7430.99
362_N365_I0.7420.99
302_S305_K0.7420.99
256_E260_G0.7410.99
117_P147_I0.7410.99
103_D216_Q0.7400.99
10_E14_D0.7400.99
175_Q285_L0.7370.99
249_R361_V0.7370.99
139_I284_V0.7370.99
174_N244_M0.7360.99
64_I214_I0.7360.99
97_S135_F0.7330.99
268_Y275_H0.7310.99
76_T186_V0.7290.99
257_F368_L0.7290.99
82_K132_D0.7290.99
307_M352_L0.7270.99
324_S354_L0.7270.99
313_I356_V0.7270.99
225_L233_T0.7260.99
140_T145_R0.7180.99
120_N123_I0.7170.99
25_Q199_V0.7150.99
50_L189_A0.7140.99
115_S122_I0.7100.99
67_S223_T0.7090.99
183_D209_K0.7080.99
140_T143_L0.7060.99
148_D283_K0.7040.99
38_R42_E0.7020.99
174_N286_K0.7010.99
146_V281_A0.6990.99
157_K161_S0.6990.99
263_K302_S0.6990.99
50_L193_L0.6980.99
54_I65_A0.6980.99
228_H231_Y0.6960.99
85_N130_R0.6940.99
180_L284_V0.6930.99
88_L131_Y0.6920.99
79_A214_I0.6920.99
20_T231_Y0.6910.99
167_A177_P0.6900.99
58_E185_V0.6870.99
248_N290_G0.6860.99
232_L235_R0.6860.99
167_A187_H0.6840.99
306_V310_L0.6820.99
193_L240_L0.6790.99
43_S48_L0.6790.99
11_D52_K0.6790.99
264_V294_F0.6780.99
65_A225_L0.6760.99
167_A170_S0.6760.99
145_R277_D0.6740.98
75_T204_A0.6710.98
87_V112_V0.6650.98
269_Y292_L0.6630.98
122_I126_A0.6620.98
151_E155_V0.6610.98
81_L132_D0.6590.98
3_D7_A0.6590.98
54_I189_A0.6560.98
139_I285_L0.6540.98
138_N167_A0.6530.98
113_E130_R0.6530.98
252_E271_G0.6510.98
366_E370_R0.6500.98
124_E151_E0.6450.98
305_K308_K0.6450.98
263_K373_S0.6450.98
254_I257_F0.6440.98
330_A349_D0.6430.98
86_S129_K0.6420.98
98_Y114_A0.6420.98
80_L164_I0.6410.98
294_F352_L0.6410.98
264_V372_L0.6390.98
118_G145_R0.6380.98
248_N288_F0.6350.98
16_T24_Y0.6330.98
52_K56_E0.6330.98
192_F291_V0.6320.98
78_L108_W0.6320.98
66_F223_T0.6320.98
134_I157_K0.6300.98
343_K348_T0.6300.98
125_K129_K0.6290.98
149_V163_L0.6280.98
306_V372_L0.6280.98
101_F135_F0.6270.98
119_N125_K0.6260.98
146_V275_H0.6260.98
268_Y293_S0.6250.98
164_I184_I0.6240.98
76_T80_L0.6240.98
306_V371_A0.6230.97
92_D140_T0.6230.97
172_P193_L0.6220.97
28_A318_T0.6220.97
25_Q231_Y0.6210.97
139_I170_S0.6190.97
68_S224_S0.6180.97
73_I97_S0.6170.97
134_I155_V0.6170.97
225_L229_A0.6160.97
67_S224_S0.6160.97
115_S123_I0.6160.97
123_I134_I0.6130.97
326_I354_L0.6130.97
26_T29_Y0.6110.97
90_H117_P0.6110.97
83_P109_G0.6110.97
6_R59_N0.6100.97
104_Y217_M0.6090.97
99_R103_D0.6060.97
49_E234_L0.6050.97
263_K296_V0.6050.97
51_A65_A0.6040.97
213_V216_Q0.6040.97
340_E344_I0.6030.97
255_A292_L0.6020.97
368_L372_L0.6020.97
50_L234_L0.6000.97
199_V236_G0.5980.97
79_A217_M0.5970.97
64_I204_A0.5970.97
280_I284_V0.5970.97
317_Q327_S0.5940.97
170_S281_A0.5920.97
309_S370_R0.5910.97
25_Q226_D0.5900.97
280_I283_K0.5900.97
271_G278_Y0.5900.97
48_L62_M0.5880.96
91_R116_Y0.5870.96
259_E275_H0.5870.96
247_I250_N0.5860.96
238_K322_V0.5860.96
187_H203_L0.5860.96
343_K349_D0.5850.96
295_E351_L0.5840.96
249_R287_G0.5810.96
55_V62_M0.5800.96
3_D241_K0.5800.96
75_T221_L0.5780.96
291_V319_L0.5770.96
127_K131_Y0.5740.96
104_Y220_T0.5730.96
296_V372_L0.5710.96
260_G369_D0.5710.96
149_V165_V0.5700.96
28_A316_A0.5700.96
19_I30_H0.5670.96
324_S364_L0.5640.96
255_A271_G0.5640.96
200_I224_S0.5630.95
51_A63_G0.5620.95
13_D18_A0.5590.95
340_E343_K0.5590.95
218_R224_S0.5570.95
310_L313_I0.5550.95
297_N302_S0.5540.95
16_T37_Y0.5530.95
88_L113_E0.5520.95
156_A159_Q0.5510.95
303_A350_S0.5510.95
265_V296_V0.5480.95
150_A179_E0.5470.95
88_L117_P0.5470.95
144_L293_S0.5450.95
64_I218_R0.5440.95
327_S332_M0.5410.94
324_S368_L0.5410.94
85_N110_V0.5410.94
316_A325_V0.5390.94
337_L341_E0.5390.94
46_T234_L0.5380.94
95_G334_H0.5360.94
128_S131_Y0.5350.94
105_L110_V0.5350.94
104_Y221_L0.5330.94
252_E272_L0.5330.94
304_L331_T0.5330.94
211_L215_D0.5320.94
155_V158_E0.5310.94
196_H235_R0.5310.94
138_N175_Q0.5310.94
9_R314_I0.5300.94
147_I280_I0.5280.94
245_D248_N0.5270.94
337_L345_V0.5260.94
91_R344_I0.5240.93
52_K55_V0.5240.93
248_N251_A0.5230.93
306_V309_S0.5230.93
209_K212_N0.5230.93
53_K56_E0.5220.93
308_K315_P0.5220.93
102_T341_E0.5210.93
173_I241_K0.5150.93
311_K367_D0.5140.93
192_F247_I0.5120.93
11_D14_D0.5110.93
300_Q331_T0.5110.93
303_A328_H0.5100.92
113_E131_Y0.5100.92
257_F361_V0.5080.92
259_E273_K0.5060.92
326_I368_L0.5060.92
269_Y288_F0.5050.92
44_N47_V0.5050.92
170_S175_Q0.5030.92
14_D24_Y0.5020.92
73_I100_F0.5000.92
88_L134_I0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ibjA 4 0.9947 100 0.387 Contact Map
1qgnA 4 0.9973 100 0.394 Contact Map
3ri6A 4 0.8803 100 0.42 Contact Map
3cogA 4 0.9973 100 0.424 Contact Map
4iy7A 4 0.9947 100 0.435 Contact Map
4kamA 4 0.9255 100 0.441 Contact Map
4itxA 4 0.9947 100 0.449 Contact Map
1e5eA 4 1 100 0.454 Contact Map
3ndnA 4 0.992 100 0.474 Contact Map
4oc9A 5 0.9894 100 0.487 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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