Q97W66 - SULSO - GREMLIN Contacts

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Q97W66 - Uncharacterized protein

UniProt:	Q97W66	Sequences: MKAFVFGIGGGGDVVSAIVAYNYLRKLGYDVLLGSVVWERYVEDPIPGPICFDNIRNGVLVNQGLYKVNRDTYAIRGNRRVVPQLVRAVRALNLGEAYGICNKDGVIGLYSSLKEFVNKEKIDLIVGVDAGGDVLAKGCEETLGSPLIDFISLASLVKLEEDGYNVMLGVIGSGSDGELQYDYFLKRISEIASLNGLLDIKGYDRETANLVGRILNEVTTEASKIPFDAFKGLYGEITIRNGTRKVLVTPISAVMFFLDPIKIAETSPLYSLVKDSISIDDAKKNLNEVGIYTEYNFEEDLYNEFGLNASHASAYDVDRIRVEGKRKLGGVKIKC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	335 (273)
Sequences:	176 (114)
Seq/√Len:	6.9

SULSO - Q97W66

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
188_I	258_L	4.832	0.99
9_G	13_D	4.199	0.97
10_G	13_D	4.199	0.97
196_G	262_K	3.793	0.94
203_Y	248_V	3.378	0.90
125_I	164_Y	2.813	0.78
158_K	274_K	2.598	0.72
225_I	248_V	2.519	0.70
146_P	176_D	2.512	0.70
39_E	223_S	2.452	0.68
4_F	9_G	2.388	0.66
4_F	13_D	2.388	0.66
4_F	10_G	2.388	0.66
120_E	153_L	2.387	0.66
283_K	287_N	2.368	0.65
154_A	270_Y	2.350	0.64
281_D	284_K	2.310	0.63
8_I	134_V	2.286	0.62
267_S	270_Y	2.271	0.61
9_G	12_G	2.186	0.58
116_F	191_I	2.145	0.57
7_G	18_I	2.120	0.56
264_A	270_Y	2.119	0.56
178_E	221_E	2.002	0.51
232_G	235_G	1.954	0.50
179_L	273_V	1.932	0.49
135_L	153_L	1.930	0.49
12_G	17_A	1.920	0.48
132_G	222_A	1.892	0.47
148_I	179_L	1.886	0.47
111_S	272_L	1.862	0.46
147_L	282_A	1.859	0.46
195_N	269_L	1.798	0.44
7_G	13_D	1.796	0.44
7_G	10_G	1.796	0.44
122_I	253_A	1.771	0.43
151_I	282_A	1.731	0.41
151_I	273_V	1.676	0.39
34_G	260_P	1.673	0.39
184_F	263_I	1.668	0.39
46_I	279_I	1.614	0.37
179_L	239_I	1.598	0.36
25_R	115_E	1.596	0.36
248_V	254_V	1.590	0.36
159_L	209_N	1.579	0.36
132_G	221_E	1.539	0.34
101_C	270_Y	1.523	0.34
150_F	267_S	1.519	0.34
74_A	126_V	1.486	0.33
168_L	246_V	1.451	0.31
278_S	281_D	1.443	0.31
132_G	178_E	1.418	0.30
176_D	222_A	1.418	0.30
62_N	115_E	1.407	0.30
284_K	288_E	1.406	0.30
177_G	222_A	1.404	0.30
16_S	41_Y	1.403	0.30
17_A	252_S	1.399	0.30
175_S	196_G	1.395	0.30
40_R	273_V	1.391	0.29
12_G	15_V	1.388	0.29
122_I	164_Y	1.383	0.29
110_Y	158_K	1.358	0.28
69_N	128_V	1.344	0.28
209_N	213_R	1.335	0.28
64_G	109_L	1.333	0.28
7_G	250_P	1.329	0.28
115_E	119_K	1.326	0.27
113_L	117_V	1.314	0.27
24_L	29_Y	1.306	0.27
119_K	265_E	1.298	0.27
71_D	284_K	1.298	0.27
28_G	191_I	1.293	0.26
248_V	256_F	1.286	0.26
76_R	278_S	1.281	0.26
243_T	259_D	1.276	0.26
116_F	120_E	1.275	0.26
120_E	205_R	1.268	0.26
130_A	256_F	1.267	0.26
12_G	38_W	1.266	0.26
26_K	188_I	1.250	0.25
7_G	11_G	1.248	0.25
225_I	252_S	1.240	0.25
7_G	12_G	1.236	0.25
15_V	228_D	1.236	0.25
121_K	159_L	1.232	0.25
109_L	125_I	1.232	0.25
65_L	168_L	1.232	0.25
66_Y	121_K	1.232	0.25
147_L	270_Y	1.202	0.24
59_V	72_T	1.198	0.24
106_V	276_S	1.195	0.24
160_E	274_K	1.194	0.24
40_R	282_A	1.189	0.24
213_R	231_K	1.187	0.23
143_L	176_D	1.184	0.23
35_S	220_T	1.181	0.23
173_S	248_V	1.177	0.23
125_I	142_T	1.171	0.23
190_E	266_T	1.170	0.23
64_G	280_D	1.168	0.23
127_G	156_L	1.164	0.23
118_N	265_E	1.163	0.23
201_K	278_S	1.147	0.22
47_P	278_S	1.145	0.22
45_P	240_R	1.140	0.22
114_K	265_E	1.133	0.22
195_N	263_I	1.131	0.22
38_W	178_E	1.127	0.22
62_N	78_N	1.126	0.22
43_E	278_S	1.123	0.22
249_T	252_S	1.121	0.22
68_V	281_D	1.118	0.22
77_G	242_G	1.113	0.21
180_Q	281_D	1.103	0.21
125_I	159_L	1.099	0.21
28_G	122_I	1.095	0.21
180_Q	276_S	1.092	0.21
35_S	79_R	1.091	0.21
134_V	153_L	1.081	0.21
107_I	277_I	1.079	0.21
8_I	219_T	1.077	0.21
178_E	222_A	1.077	0.21
40_R	147_L	1.074	0.21
98_Y	109_L	1.070	0.20
105_G	276_S	1.070	0.20
108_G	276_S	1.069	0.20
40_R	47_P	1.069	0.20
24_L	125_I	1.065	0.20
65_L	119_K	1.065	0.20
134_V	227_F	1.064	0.20
105_G	108_G	1.056	0.20
197_L	208_A	1.054	0.20
15_V	273_V	1.050	0.20
131_G	149_D	1.049	0.20
129_D	133_D	1.049	0.20
133_D	149_D	1.049	0.20
129_D	149_D	1.049	0.20
59_V	70_R	1.047	0.20
5_V	76_R	1.044	0.20
136_A	178_E	1.039	0.20
155_S	220_T	1.033	0.20
65_L	217_E	1.020	0.19
21_Y	26_K	1.019	0.19
86_V	172_G	1.018	0.19
154_A	197_L	1.014	0.19
246_V	269_L	1.013	0.19
143_L	146_P	1.010	0.19
74_A	253_A	1.010	0.19
32_L	168_L	1.001	0.19
11_G	17_A	0.995	0.19
146_P	222_A	0.994	0.19
36_V	130_A	0.991	0.19
89_V	227_F	0.991	0.19
191_I	227_F	0.988	0.18
40_R	267_S	0.982	0.18
182_D	192_A	0.981	0.18
38_W	132_G	0.972	0.18
19_V	187_R	0.971	0.18
4_F	18_I	0.955	0.18
118_N	165_N	0.954	0.18
40_R	261_I	0.947	0.18
28_G	241_N	0.946	0.18
78_N	242_G	0.935	0.17
220_T	293_T	0.933	0.17
277_I	281_D	0.932	0.17
89_V	279_I	0.924	0.17
97_A	184_F	0.923	0.17
97_A	263_I	0.906	0.17
4_F	199_D	0.905	0.17
90_R	166_V	0.898	0.16
98_Y	114_K	0.895	0.16
185_L	247_L	0.893	0.16
165_N	262_K	0.893	0.16
26_K	217_E	0.893	0.16
229_A	235_G	0.892	0.16
229_A	232_G	0.892	0.16
68_V	218_V	0.890	0.16
224_K	227_F	0.888	0.16
87_R	242_G	0.884	0.16
45_P	147_L	0.882	0.16
116_F	259_D	0.878	0.16
27_L	157_V	0.875	0.16
144_G	292_Y	0.875	0.16
103_K	116_F	0.874	0.16
132_G	145_S	0.872	0.16
29_Y	245_K	0.871	0.16
3_A	114_K	0.871	0.16
13_D	17_A	0.866	0.16
9_G	17_A	0.866	0.16
10_G	17_A	0.866	0.16
29_Y	34_G	0.855	0.16
267_S	282_A	0.848	0.15
99_G	112_S	0.846	0.15
44_D	47_P	0.846	0.15
46_I	233_L	0.843	0.15
38_W	145_S	0.839	0.15
106_V	243_T	0.838	0.15
97_A	273_V	0.837	0.15
40_R	44_D	0.834	0.15
141_E	203_Y	0.834	0.15
146_P	219_T	0.833	0.15
30_D	281_D	0.829	0.15
45_P	287_N	0.828	0.15
146_P	177_G	0.822	0.15
101_C	263_I	0.821	0.15
253_A	281_D	0.820	0.15
113_L	241_N	0.819	0.15
200_I	204_D	0.819	0.15
28_G	152_S	0.816	0.15
258_L	284_K	0.816	0.15
128_V	204_D	0.810	0.15
116_F	208_A	0.809	0.15
63_Q	108_G	0.798	0.14
4_F	11_G	0.797	0.14
220_T	228_D	0.795	0.14
134_V	168_L	0.794	0.14
168_L	263_I	0.794	0.14
132_G	136_A	0.791	0.14
12_G	222_A	0.782	0.14
125_I	166_V	0.780	0.14
108_G	145_S	0.776	0.14
34_G	226_P	0.774	0.14
95_G	168_L	0.774	0.14
152_S	172_G	0.768	0.14
67_K	166_V	0.761	0.14
274_K	277_I	0.757	0.14
124_L	166_V	0.755	0.14
41_Y	155_S	0.755	0.14
181_Y	251_I	0.754	0.14
23_Y	188_I	0.751	0.14
68_V	253_A	0.748	0.14
106_V	242_G	0.748	0.14
44_D	132_G	0.745	0.14
119_K	284_K	0.744	0.14
26_K	254_V	0.742	0.13
146_P	178_E	0.739	0.13
102_N	228_D	0.738	0.13
7_G	82_V	0.736	0.13
223_S	283_K	0.734	0.13
122_I	258_L	0.731	0.13
188_I	253_A	0.722	0.13
19_V	152_S	0.722	0.13
165_N	201_K	0.720	0.13
29_Y	253_A	0.720	0.13
110_Y	274_K	0.720	0.13
191_I	251_I	0.719	0.13
35_S	38_W	0.719	0.13
180_Q	183_Y	0.717	0.13
38_W	221_E	0.716	0.13
101_C	204_D	0.715	0.13
276_S	281_D	0.712	0.13
124_L	263_I	0.712	0.13
134_V	280_D	0.712	0.13
64_G	283_K	0.712	0.13
118_N	164_Y	0.710	0.13
45_P	134_V	0.709	0.13
129_D	232_G	0.705	0.13
129_D	235_G	0.705	0.13
131_G	232_G	0.705	0.13
131_G	235_G	0.705	0.13
133_D	235_G	0.705	0.13
133_D	232_G	0.705	0.13
149_D	232_G	0.705	0.13
149_D	235_G	0.705	0.13
176_D	240_R	0.704	0.13
185_L	229_A	0.703	0.13
205_R	281_D	0.703	0.13
12_G	178_E	0.702	0.13
3_A	209_N	0.701	0.13
70_R	184_F	0.701	0.13
96_E	203_Y	0.699	0.13
96_E	212_G	0.694	0.13
90_R	217_E	0.693	0.13
34_G	293_T	0.691	0.13
30_D	111_S	0.691	0.13
185_L	250_P	0.688	0.13
175_S	283_K	0.688	0.13
40_R	196_G	0.687	0.13
59_V	265_E	0.687	0.13
59_V	71_D	0.685	0.12
40_R	223_S	0.685	0.12
3_A	121_K	0.685	0.12
130_A	148_I	0.682	0.12
38_W	222_A	0.682	0.12
147_L	178_E	0.681	0.12
88_A	127_G	0.680	0.12
86_V	211_V	0.678	0.12
68_V	269_L	0.676	0.12
191_I	255_M	0.675	0.12
85_L	220_T	0.673	0.12
273_V	282_A	0.671	0.12
81_V	252_S	0.670	0.12
44_D	187_R	0.668	0.12
118_N	236_E	0.667	0.12
38_W	244_R	0.666	0.12
157_V	166_V	0.666	0.12
74_A	77_G	0.658	0.12
150_F	282_A	0.658	0.12
130_A	173_S	0.658	0.12
189_S	241_N	0.655	0.12
73_Y	125_I	0.650	0.12
191_I	196_G	0.648	0.12
33_L	264_A	0.645	0.12
154_A	176_D	0.643	0.12
274_K	280_D	0.636	0.12
39_E	77_G	0.636	0.12
7_G	80_R	0.631	0.12
201_K	209_N	0.629	0.12
9_G	129_D	0.626	0.12
9_G	149_D	0.626	0.12
9_G	131_G	0.626	0.12
10_G	149_D	0.626	0.12
13_D	133_D	0.626	0.12
10_G	129_D	0.626	0.12
10_G	133_D	0.626	0.12
10_G	131_G	0.626	0.12
13_D	129_D	0.626	0.12
9_G	133_D	0.626	0.12
13_D	131_G	0.626	0.12
13_D	149_D	0.626	0.12
133_D	140_E	0.623	0.11
131_G	140_E	0.623	0.11
140_E	149_D	0.623	0.11
129_D	140_E	0.623	0.11
132_G	176_D	0.619	0.11
90_R	95_G	0.619	0.11
132_G	177_G	0.618	0.11
40_R	176_D	0.616	0.11
125_I	188_I	0.614	0.11
30_D	207_T	0.610	0.11
70_R	193_S	0.610	0.11
129_D	174_G	0.609	0.11
133_D	174_G	0.609	0.11
149_D	174_G	0.609	0.11
131_G	174_G	0.609	0.11
147_L	150_F	0.604	0.11
59_V	258_L	0.604	0.11
242_G	260_P	0.603	0.11
108_G	214_I	0.603	0.11
118_N	125_I	0.603	0.11
107_I	231_K	0.603	0.11
81_V	113_L	0.601	0.11
236_E	292_Y	0.600	0.11
14_V	17_A	0.599	0.11
220_T	260_P	0.598	0.11
57_N	100_I	0.597	0.11
107_I	157_V	0.597	0.11
67_K	119_K	0.595	0.11
211_V	216_N	0.595	0.11
39_E	145_S	0.594	0.11
125_I	246_V	0.594	0.11
44_D	147_L	0.593	0.11
47_P	147_L	0.592	0.11
157_V	189_S	0.589	0.11
90_R	260_P	0.586	0.11
214_I	265_E	0.584	0.11
23_Y	150_F	0.582	0.11
118_N	121_K	0.581	0.11
127_G	139_C	0.578	0.11
76_R	118_N	0.576	0.11
62_N	256_F	0.575	0.11
19_V	181_Y	0.572	0.11
87_R	153_L	0.571	0.11
155_S	245_K	0.568	0.11
38_W	202_G	0.566	0.11
229_A	268_P	0.565	0.11
72_T	266_T	0.564	0.11
74_A	218_V	0.559	0.11
117_V	288_E	0.559	0.11
41_Y	154_A	0.557	0.11
74_A	183_Y	0.557	0.11
157_V	165_N	0.554	0.10
38_W	44_D	0.552	0.10
193_S	288_E	0.551	0.10
154_A	267_S	0.551	0.10
5_V	28_G	0.549	0.10
67_K	209_N	0.548	0.10
82_V	263_I	0.547	0.10
17_A	251_I	0.547	0.10
110_Y	223_S	0.546	0.10
220_T	246_V	0.545	0.10
137_K	190_E	0.544	0.10
83_P	221_E	0.544	0.10
202_G	246_V	0.541	0.10
123_D	264_A	0.540	0.10
39_E	136_A	0.538	0.10
118_N	284_K	0.538	0.10
98_Y	229_A	0.536	0.10
187_R	221_E	0.536	0.10
127_G	252_S	0.533	0.10
33_L	251_I	0.530	0.10
32_L	151_I	0.530	0.10
142_T	252_S	0.528	0.10
182_D	280_D	0.525	0.10
36_V	220_T	0.525	0.10
37_V	155_S	0.524	0.10
11_G	174_G	0.524	0.10
46_I	67_K	0.523	0.10
188_I	263_I	0.520	0.10
105_G	273_V	0.520	0.10
122_I	223_S	0.511	0.10
30_D	61_V	0.511	0.10
160_E	281_D	0.508	0.10
179_L	222_A	0.506	0.10
34_G	230_F	0.506	0.10
121_K	285_N	0.505	0.10
95_G	179_L	0.504	0.10
179_L	183_Y	0.500	0.10
65_L	120_E	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2p6pA	2	0.9015	74.8	0.963	Contact Map
3h4tA	1	0.791	67.6	0.965	Contact Map
3ic5A	1	0.3313	67.1	0.965	Contact Map
4cjxA	2	0.3134	63.9	0.966	Contact Map
3rscA	1	0.9343	61.3	0.966	Contact Map
3p2oA	2	0.3045	61.2	0.966	Contact Map
3otiA	2	0.9075	57.7	0.967	Contact Map
4a5oA	2	0.2985	55.4	0.968	Contact Map
3ia7A	2	0.9194	54.8	0.968	Contact Map
2c2xA	2	0.3313	54.6	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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