GREMLIN Database
Q97W66 - Uncharacterized protein
UniProt: Q97W66 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (273)
Sequences: 176 (114)
Seq/√Len: 6.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_I258_L4.8320.99
9_G13_D4.1990.97
10_G13_D4.1990.97
196_G262_K3.7930.94
203_Y248_V3.3780.90
125_I164_Y2.8130.78
158_K274_K2.5980.72
225_I248_V2.5190.70
146_P176_D2.5120.70
39_E223_S2.4520.68
4_F9_G2.3880.66
4_F13_D2.3880.66
4_F10_G2.3880.66
120_E153_L2.3870.66
283_K287_N2.3680.65
154_A270_Y2.3500.64
281_D284_K2.3100.63
8_I134_V2.2860.62
267_S270_Y2.2710.61
9_G12_G2.1860.58
116_F191_I2.1450.57
7_G18_I2.1200.56
264_A270_Y2.1190.56
178_E221_E2.0020.51
232_G235_G1.9540.50
179_L273_V1.9320.49
135_L153_L1.9300.49
12_G17_A1.9200.48
132_G222_A1.8920.47
148_I179_L1.8860.47
111_S272_L1.8620.46
147_L282_A1.8590.46
195_N269_L1.7980.44
7_G13_D1.7960.44
7_G10_G1.7960.44
122_I253_A1.7710.43
151_I282_A1.7310.41
151_I273_V1.6760.39
34_G260_P1.6730.39
184_F263_I1.6680.39
46_I279_I1.6140.37
179_L239_I1.5980.36
25_R115_E1.5960.36
248_V254_V1.5900.36
159_L209_N1.5790.36
132_G221_E1.5390.34
101_C270_Y1.5230.34
150_F267_S1.5190.34
74_A126_V1.4860.33
168_L246_V1.4510.31
278_S281_D1.4430.31
132_G178_E1.4180.30
176_D222_A1.4180.30
62_N115_E1.4070.30
284_K288_E1.4060.30
177_G222_A1.4040.30
16_S41_Y1.4030.30
17_A252_S1.3990.30
175_S196_G1.3950.30
40_R273_V1.3910.29
12_G15_V1.3880.29
122_I164_Y1.3830.29
110_Y158_K1.3580.28
69_N128_V1.3440.28
209_N213_R1.3350.28
64_G109_L1.3330.28
7_G250_P1.3290.28
115_E119_K1.3260.27
113_L117_V1.3140.27
24_L29_Y1.3060.27
119_K265_E1.2980.27
71_D284_K1.2980.27
28_G191_I1.2930.26
248_V256_F1.2860.26
76_R278_S1.2810.26
243_T259_D1.2760.26
116_F120_E1.2750.26
120_E205_R1.2680.26
130_A256_F1.2670.26
12_G38_W1.2660.26
26_K188_I1.2500.25
7_G11_G1.2480.25
225_I252_S1.2400.25
7_G12_G1.2360.25
15_V228_D1.2360.25
121_K159_L1.2320.25
109_L125_I1.2320.25
65_L168_L1.2320.25
66_Y121_K1.2320.25
147_L270_Y1.2020.24
59_V72_T1.1980.24
106_V276_S1.1950.24
160_E274_K1.1940.24
40_R282_A1.1890.24
213_R231_K1.1870.23
143_L176_D1.1840.23
35_S220_T1.1810.23
173_S248_V1.1770.23
125_I142_T1.1710.23
190_E266_T1.1700.23
64_G280_D1.1680.23
127_G156_L1.1640.23
118_N265_E1.1630.23
201_K278_S1.1470.22
47_P278_S1.1450.22
45_P240_R1.1400.22
114_K265_E1.1330.22
195_N263_I1.1310.22
38_W178_E1.1270.22
62_N78_N1.1260.22
43_E278_S1.1230.22
249_T252_S1.1210.22
68_V281_D1.1180.22
77_G242_G1.1130.21
180_Q281_D1.1030.21
125_I159_L1.0990.21
28_G122_I1.0950.21
180_Q276_S1.0920.21
35_S79_R1.0910.21
134_V153_L1.0810.21
107_I277_I1.0790.21
8_I219_T1.0770.21
178_E222_A1.0770.21
40_R147_L1.0740.21
98_Y109_L1.0700.20
105_G276_S1.0700.20
108_G276_S1.0690.20
40_R47_P1.0690.20
24_L125_I1.0650.20
65_L119_K1.0650.20
134_V227_F1.0640.20
105_G108_G1.0560.20
197_L208_A1.0540.20
15_V273_V1.0500.20
131_G149_D1.0490.20
129_D133_D1.0490.20
133_D149_D1.0490.20
129_D149_D1.0490.20
59_V70_R1.0470.20
5_V76_R1.0440.20
136_A178_E1.0390.20
155_S220_T1.0330.20
65_L217_E1.0200.19
21_Y26_K1.0190.19
86_V172_G1.0180.19
154_A197_L1.0140.19
246_V269_L1.0130.19
143_L146_P1.0100.19
74_A253_A1.0100.19
32_L168_L1.0010.19
11_G17_A0.9950.19
146_P222_A0.9940.19
36_V130_A0.9910.19
89_V227_F0.9910.19
191_I227_F0.9880.18
40_R267_S0.9820.18
182_D192_A0.9810.18
38_W132_G0.9720.18
19_V187_R0.9710.18
4_F18_I0.9550.18
118_N165_N0.9540.18
40_R261_I0.9470.18
28_G241_N0.9460.18
78_N242_G0.9350.17
220_T293_T0.9330.17
277_I281_D0.9320.17
89_V279_I0.9240.17
97_A184_F0.9230.17
97_A263_I0.9060.17
4_F199_D0.9050.17
90_R166_V0.8980.16
98_Y114_K0.8950.16
185_L247_L0.8930.16
165_N262_K0.8930.16
26_K217_E0.8930.16
229_A235_G0.8920.16
229_A232_G0.8920.16
68_V218_V0.8900.16
224_K227_F0.8880.16
87_R242_G0.8840.16
45_P147_L0.8820.16
116_F259_D0.8780.16
27_L157_V0.8750.16
144_G292_Y0.8750.16
103_K116_F0.8740.16
132_G145_S0.8720.16
29_Y245_K0.8710.16
3_A114_K0.8710.16
13_D17_A0.8660.16
9_G17_A0.8660.16
10_G17_A0.8660.16
29_Y34_G0.8550.16
267_S282_A0.8480.15
99_G112_S0.8460.15
44_D47_P0.8460.15
46_I233_L0.8430.15
38_W145_S0.8390.15
106_V243_T0.8380.15
97_A273_V0.8370.15
40_R44_D0.8340.15
141_E203_Y0.8340.15
146_P219_T0.8330.15
30_D281_D0.8290.15
45_P287_N0.8280.15
146_P177_G0.8220.15
101_C263_I0.8210.15
253_A281_D0.8200.15
113_L241_N0.8190.15
200_I204_D0.8190.15
28_G152_S0.8160.15
258_L284_K0.8160.15
128_V204_D0.8100.15
116_F208_A0.8090.15
63_Q108_G0.7980.14
4_F11_G0.7970.14
220_T228_D0.7950.14
134_V168_L0.7940.14
168_L263_I0.7940.14
132_G136_A0.7910.14
12_G222_A0.7820.14
125_I166_V0.7800.14
108_G145_S0.7760.14
34_G226_P0.7740.14
95_G168_L0.7740.14
152_S172_G0.7680.14
67_K166_V0.7610.14
274_K277_I0.7570.14
124_L166_V0.7550.14
41_Y155_S0.7550.14
181_Y251_I0.7540.14
23_Y188_I0.7510.14
68_V253_A0.7480.14
106_V242_G0.7480.14
44_D132_G0.7450.14
119_K284_K0.7440.14
26_K254_V0.7420.13
146_P178_E0.7390.13
102_N228_D0.7380.13
7_G82_V0.7360.13
223_S283_K0.7340.13
122_I258_L0.7310.13
188_I253_A0.7220.13
19_V152_S0.7220.13
165_N201_K0.7200.13
29_Y253_A0.7200.13
110_Y274_K0.7200.13
191_I251_I0.7190.13
35_S38_W0.7190.13
180_Q183_Y0.7170.13
38_W221_E0.7160.13
101_C204_D0.7150.13
276_S281_D0.7120.13
124_L263_I0.7120.13
134_V280_D0.7120.13
64_G283_K0.7120.13
118_N164_Y0.7100.13
45_P134_V0.7090.13
129_D232_G0.7050.13
129_D235_G0.7050.13
131_G232_G0.7050.13
131_G235_G0.7050.13
133_D235_G0.7050.13
133_D232_G0.7050.13
149_D232_G0.7050.13
149_D235_G0.7050.13
176_D240_R0.7040.13
185_L229_A0.7030.13
205_R281_D0.7030.13
12_G178_E0.7020.13
3_A209_N0.7010.13
70_R184_F0.7010.13
96_E203_Y0.6990.13
96_E212_G0.6940.13
90_R217_E0.6930.13
34_G293_T0.6910.13
30_D111_S0.6910.13
185_L250_P0.6880.13
175_S283_K0.6880.13
40_R196_G0.6870.13
59_V265_E0.6870.13
59_V71_D0.6850.12
40_R223_S0.6850.12
3_A121_K0.6850.12
130_A148_I0.6820.12
38_W222_A0.6820.12
147_L178_E0.6810.12
88_A127_G0.6800.12
86_V211_V0.6780.12
68_V269_L0.6760.12
191_I255_M0.6750.12
85_L220_T0.6730.12
273_V282_A0.6710.12
81_V252_S0.6700.12
44_D187_R0.6680.12
118_N236_E0.6670.12
38_W244_R0.6660.12
157_V166_V0.6660.12
74_A77_G0.6580.12
150_F282_A0.6580.12
130_A173_S0.6580.12
189_S241_N0.6550.12
73_Y125_I0.6500.12
191_I196_G0.6480.12
33_L264_A0.6450.12
154_A176_D0.6430.12
274_K280_D0.6360.12
39_E77_G0.6360.12
7_G80_R0.6310.12
201_K209_N0.6290.12
9_G129_D0.6260.12
9_G149_D0.6260.12
9_G131_G0.6260.12
10_G149_D0.6260.12
13_D133_D0.6260.12
10_G129_D0.6260.12
10_G133_D0.6260.12
10_G131_G0.6260.12
13_D129_D0.6260.12
9_G133_D0.6260.12
13_D131_G0.6260.12
13_D149_D0.6260.12
133_D140_E0.6230.11
131_G140_E0.6230.11
140_E149_D0.6230.11
129_D140_E0.6230.11
132_G176_D0.6190.11
90_R95_G0.6190.11
132_G177_G0.6180.11
40_R176_D0.6160.11
125_I188_I0.6140.11
30_D207_T0.6100.11
70_R193_S0.6100.11
129_D174_G0.6090.11
133_D174_G0.6090.11
149_D174_G0.6090.11
131_G174_G0.6090.11
147_L150_F0.6040.11
59_V258_L0.6040.11
242_G260_P0.6030.11
108_G214_I0.6030.11
118_N125_I0.6030.11
107_I231_K0.6030.11
81_V113_L0.6010.11
236_E292_Y0.6000.11
14_V17_A0.5990.11
220_T260_P0.5980.11
57_N100_I0.5970.11
107_I157_V0.5970.11
67_K119_K0.5950.11
211_V216_N0.5950.11
39_E145_S0.5940.11
125_I246_V0.5940.11
44_D147_L0.5930.11
47_P147_L0.5920.11
157_V189_S0.5890.11
90_R260_P0.5860.11
214_I265_E0.5840.11
23_Y150_F0.5820.11
118_N121_K0.5810.11
127_G139_C0.5780.11
76_R118_N0.5760.11
62_N256_F0.5750.11
19_V181_Y0.5720.11
87_R153_L0.5710.11
155_S245_K0.5680.11
38_W202_G0.5660.11
229_A268_P0.5650.11
72_T266_T0.5640.11
74_A218_V0.5590.11
117_V288_E0.5590.11
41_Y154_A0.5570.11
74_A183_Y0.5570.11
157_V165_N0.5540.10
38_W44_D0.5520.10
193_S288_E0.5510.10
154_A267_S0.5510.10
5_V28_G0.5490.10
67_K209_N0.5480.10
82_V263_I0.5470.10
17_A251_I0.5470.10
110_Y223_S0.5460.10
220_T246_V0.5450.10
137_K190_E0.5440.10
83_P221_E0.5440.10
202_G246_V0.5410.10
123_D264_A0.5400.10
39_E136_A0.5380.10
118_N284_K0.5380.10
98_Y229_A0.5360.10
187_R221_E0.5360.10
127_G252_S0.5330.10
33_L251_I0.5300.10
32_L151_I0.5300.10
142_T252_S0.5280.10
182_D280_D0.5250.10
36_V220_T0.5250.10
37_V155_S0.5240.10
11_G174_G0.5240.10
46_I67_K0.5230.10
188_I263_I0.5200.10
105_G273_V0.5200.10
122_I223_S0.5110.10
30_D61_V0.5110.10
160_E281_D0.5080.10
179_L222_A0.5060.10
34_G230_F0.5060.10
121_K285_N0.5050.10
95_G179_L0.5040.10
179_L183_Y0.5000.10
65_L120_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p6pA 2 0.9015 74.8 0.963 Contact Map
3h4tA 1 0.791 67.6 0.965 Contact Map
3ic5A 1 0.3313 67.1 0.965 Contact Map
4cjxA 2 0.3134 63.9 0.966 Contact Map
3rscA 1 0.9343 61.3 0.966 Contact Map
3p2oA 2 0.3045 61.2 0.966 Contact Map
3otiA 2 0.9075 57.7 0.967 Contact Map
4a5oA 2 0.2985 55.4 0.968 Contact Map
3ia7A 2 0.9194 54.8 0.968 Contact Map
2c2xA 2 0.3313 54.6 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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