GREMLIN Database
Q97W64 - Uncharacterized protein
UniProt: Q97W64 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (167)
Sequences: 381 (229)
Seq/√Len: 17.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_L31_I4.7841.00
111_T159_Y4.5501.00
21_G25_Q3.9321.00
16_V59_I3.4491.00
8_V63_G3.1750.99
115_I142_A2.9120.99
119_T123_I2.9080.99
105_I125_I2.7070.98
20_I33_Y2.6620.97
80_T110_K2.4510.96
77_D112_K2.2500.93
86_L104_I2.1110.90
36_R40_F2.0580.89
49_Q162_L1.9760.87
140_Q144_K1.9600.87
23_L55_A1.9540.87
87_K104_I1.9440.86
8_V16_V1.9120.85
165_A168_D1.9110.85
64_L127_G1.8150.82
82_D143_K1.7950.81
96_T99_R1.7530.80
104_I125_I1.7280.79
154_E157_S1.7220.79
116_Q149_L1.6970.77
64_L129_Y1.6050.73
111_T114_I1.6000.73
13_L38_K1.4640.66
11_E126_Y1.4560.66
87_K130_I1.4500.65
136_Y140_Q1.3970.62
27_T55_A1.3940.62
8_V13_L1.3900.62
15_V62_I1.3810.61
74_L159_Y1.3790.61
59_I110_K1.3780.61
114_I118_Y1.3690.61
67_D125_I1.3630.60
67_D70_S1.3560.60
9_E63_G1.3500.60
104_I146_I1.2930.56
72_F110_K1.2880.56
70_S73_R1.2830.56
28_D46_G1.2820.56
59_I132_V1.2700.55
104_I130_I1.2650.55
35_E38_K1.2510.54
78_E160_K1.2420.53
132_V142_A1.2220.52
27_T75_L1.2080.51
18_K69_Q1.2050.51
87_K128_H1.2020.51
83_V131_G1.2020.51
70_S122_D1.1980.50
59_I104_I1.1900.50
118_Y166_E1.1830.50
32_I142_A1.1820.49
113_R125_I1.1810.49
83_V146_I1.1710.49
15_V126_Y1.1680.49
30_K43_L1.1650.48
119_T169_L1.1610.48
136_Y166_E1.1570.48
22_K32_I1.1200.46
104_I149_L1.1190.46
58_V75_L1.1130.45
69_Q110_K1.1030.45
39_T169_L1.1010.45
10_D13_L1.1010.45
82_D144_K1.0970.44
12_K15_V1.0970.44
17_K112_K1.0920.44
28_D47_Q1.0900.44
40_F74_L1.0870.44
130_I146_I1.0850.44
17_K20_I1.0810.43
89_L146_I1.0780.43
102_G107_E1.0600.42
68_E112_K1.0380.41
148_L161_F1.0310.40
25_Q75_L1.0200.40
90_I100_V1.0150.39
89_L150_I1.0090.39
17_K35_E1.0050.39
105_I113_R1.0020.39
144_K161_F1.0000.39
112_K153_K0.9980.38
121_V132_V0.9930.38
45_K118_Y0.9790.37
31_I47_Q0.9740.37
18_K139_V0.9550.36
19_V146_I0.9530.36
70_S124_S0.9520.36
23_L58_V0.9360.35
68_E105_I0.9360.35
80_T139_V0.9320.35
7_T137_D0.9300.35
87_K93_N0.9300.35
33_Y144_K0.9270.34
154_E160_K0.9180.34
108_N159_Y0.9150.34
35_E63_G0.9110.34
114_I159_Y0.9090.33
101_K126_Y0.9000.33
20_I72_F0.8960.33
106_G109_G0.8950.33
110_K166_E0.8920.33
13_L33_Y0.8890.32
58_V89_L0.8840.32
33_Y156_S0.8830.32
48_N69_Q0.8780.32
127_G138_Q0.8760.32
104_I141_I0.8720.31
17_K38_K0.8640.31
17_K125_I0.8630.31
20_I107_E0.8600.31
143_K153_K0.8510.30
57_S86_L0.8440.30
52_T58_V0.8290.29
18_K21_G0.8290.29
12_K117_E0.8270.29
74_L146_I0.8220.29
53_L157_S0.8210.29
8_V25_Q0.8190.29
108_N125_I0.8150.29
29_T120_G0.8070.28
18_K169_L0.8020.28
33_Y80_T0.8000.28
87_K91_G0.7990.28
38_K68_E0.7970.28
126_Y131_G0.7940.28
42_I130_I0.7890.27
36_R145_A0.7840.27
28_D169_L0.7790.27
81_L169_L0.7780.27
42_I143_K0.7710.26
153_K156_S0.7670.26
36_R127_G0.7670.26
29_T118_Y0.7630.26
81_L130_I0.7600.26
48_N112_K0.7540.26
86_L101_K0.7500.25
132_V139_V0.7490.25
130_I150_I0.7370.25
120_G138_Q0.7370.25
23_L167_K0.7350.25
32_I88_A0.7330.25
113_R136_Y0.7310.25
70_S112_K0.7270.24
43_L170_I0.7230.24
162_L166_E0.7230.24
12_K16_V0.7200.24
32_I130_I0.7200.24
23_L93_N0.7200.24
77_D122_D0.7150.24
26_F136_Y0.7140.24
127_G162_L0.7110.24
16_V71_A0.7090.24
48_N162_L0.7040.23
20_I167_K0.6990.23
76_S139_V0.6970.23
142_A146_I0.6950.23
96_T150_I0.6910.23
8_V11_E0.6900.23
5_F29_T0.6830.22
103_R106_G0.6820.22
8_V69_Q0.6820.22
106_G152_G0.6820.22
82_D156_S0.6790.22
109_G152_G0.6760.22
29_T55_A0.6750.22
61_A66_F0.6750.22
42_I51_E0.6630.22
5_F41_N0.6610.22
128_H146_I0.6600.22
91_G130_I0.6560.21
55_A69_Q0.6540.21
105_I118_Y0.6510.21
100_V150_I0.6510.21
32_I40_F0.6500.21
71_A112_K0.6460.21
78_E142_A0.6450.21
15_V22_K0.6450.21
54_K135_P0.6430.21
41_N117_E0.6420.21
23_L42_I0.6360.21
23_L87_K0.6300.20
89_L147_E0.6270.20
156_S160_K0.6250.20
46_G51_E0.6200.20
52_T59_I0.6170.20
16_V104_I0.6140.20
80_T153_K0.6100.20
33_Y162_L0.6070.19
51_E110_K0.6050.19
60_R98_R0.6040.19
57_S85_D0.6040.19
8_V169_L0.6030.19
12_K48_N0.6010.19
57_S100_V0.6000.19
103_R134_G0.5950.19
28_D119_T0.5940.19
47_Q108_N0.5920.19
143_K148_L0.5900.19
147_E168_D0.5900.19
43_L133_L0.5880.19
67_D77_D0.5850.19
34_D44_P0.5730.18
46_G79_Y0.5700.18
62_I68_E0.5690.18
82_D88_A0.5670.18
124_S131_G0.5650.18
51_E162_L0.5650.18
85_D129_Y0.5540.17
6_I56_V0.5540.17
25_Q91_G0.5520.17
45_K91_G0.5510.17
14_E17_K0.5510.17
33_Y118_Y0.5480.17
103_R109_G0.5480.17
9_E16_V0.5470.17
29_T58_V0.5460.17
11_E115_I0.5410.17
162_L170_I0.5370.17
34_D58_V0.5360.17
40_F63_G0.5360.17
24_E83_V0.5330.17
73_R84_I0.5280.17
37_T88_A0.5270.17
67_D124_S0.5250.16
25_Q60_R0.5240.16
84_I137_D0.5180.16
76_S131_G0.5170.16
67_D149_L0.5160.16
6_I148_L0.5150.16
77_D130_I0.5140.16
96_T128_H0.5140.16
10_D160_K0.5120.16
23_L71_A0.5100.16
144_K170_I0.5100.16
20_I81_L0.5050.16
52_T166_E0.5050.16
78_E115_I0.5040.16
41_N76_S0.5040.16
92_S96_T0.5040.16
19_V83_V0.5040.16
16_V40_F0.5010.16
85_D128_H0.5010.16
26_F164_K0.5000.16
21_G72_F0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qmfD 1 0.8942 100 0.37 Contact Map
2e3uA 1 0.8466 100 0.461 Contact Map
1tuaA 1 0.9524 100 0.507 Contact Map
1j4wA 1 0.6508 99.1 0.815 Contact Map
2anrA 1 0.7037 99.1 0.816 Contact Map
3krmA 3 0.7196 99.1 0.818 Contact Map
2jvzA 1 0.746 99.1 0.818 Contact Map
2jzxA 1 0.7354 99 0.825 Contact Map
2qndA 2 0.6455 98.6 0.847 Contact Map
1k1gA 1 0.5132 98.2 0.863 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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