GREMLIN Database
Q97W63 - Uncharacterized protein
UniProt: Q97W63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (211)
Sequences: 1364 (797)
Seq/√Len: 54.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_V203_I4.3301.00
145_I152_A3.6141.00
174_Q203_I3.1901.00
93_D97_E2.9221.00
171_L201_C2.7991.00
194_V201_C2.7091.00
170_D200_K2.6081.00
81_Q85_A2.5991.00
145_I202_Y2.5501.00
100_K103_N2.5501.00
128_R200_K2.5041.00
194_V228_I2.4901.00
123_Y131_K2.3891.00
128_R174_Q2.3631.00
122_L178_M2.3631.00
46_E63_R2.3121.00
178_M203_I2.3001.00
94_I97_E2.2961.00
131_K143_E2.2711.00
175_V189_L2.2701.00
51_I71_A2.1971.00
82_S85_A2.1741.00
64_T68_T2.1581.00
152_A155_L2.0951.00
93_D98_D2.0761.00
72_V141_V2.0491.00
175_V228_I1.9821.00
167_L196_V1.9301.00
175_V225_L1.8991.00
122_L127_T1.8660.99
50_A58_R1.8420.99
167_L201_C1.7850.99
122_L206_V1.7610.99
47_Y72_V1.7510.99
74_I139_V1.7470.99
123_Y132_P1.7270.99
226_D230_R1.7230.99
100_K104_T1.7120.99
171_L194_V1.6980.99
168_Y229_N1.6910.99
190_S227_N1.6720.99
101_V104_T1.6590.99
103_N106_Q1.6320.99
178_M206_V1.6050.98
160_D163_I1.5650.98
218_I222_K1.5450.98
64_T70_Y1.5400.98
133_I143_E1.5380.98
70_Y133_I1.5200.98
36_I40_R1.5100.98
53_S58_R1.5060.97
114_K118_N1.4910.97
173_Q177_I1.4790.97
87_K91_I1.4680.97
102_T105_K1.4460.97
62_A141_V1.4310.97
195_I204_I1.4290.97
94_I98_D1.3950.96
68_T131_K1.3910.96
167_L171_L1.3780.96
120_S124_E1.3550.95
151_R154_L1.3510.95
171_L228_I1.3300.95
84_R92_G1.3290.95
118_N209_A1.3170.95
59_I71_A1.3100.94
166_G170_D1.3080.94
161_E164_T1.2770.94
61_P69_Y1.2770.94
43_N134_L1.2640.93
158_L174_Q1.2630.93
112_A135_V1.2610.93
113_K135_V1.2470.93
34_N137_E1.2190.92
38_I139_V1.2130.92
222_K226_D1.2090.92
174_Q177_I1.2020.91
100_K105_K1.1850.91
75_Y140_L1.1840.91
43_N141_V1.1610.90
103_N108_I1.1530.90
50_A60_Y1.1480.89
161_E165_Q1.1340.89
170_D201_C1.1310.89
30_R137_E1.1290.89
118_N206_V1.1220.88
81_Q84_R1.1210.88
41_R134_L1.1130.88
163_I199_N1.1110.88
128_R170_D1.1090.88
39_A47_Y1.0830.86
172_I175_V1.0800.86
100_K108_I1.0790.86
84_R93_D1.0730.86
70_Y141_V1.0710.86
167_L232_F1.0660.85
149_G155_L1.0630.85
231_F235_K1.0590.85
62_A70_Y1.0590.85
187_G220_L1.0490.85
116_F132_P1.0430.84
177_I181_G1.0350.84
170_D174_Q1.0240.83
104_T107_L1.0160.83
135_V138_N1.0140.82
146_G197_Y0.9860.81
60_Y157_E0.9750.80
113_K121_R0.9730.80
234_N241_P0.9720.80
61_P187_G0.9660.79
39_A132_P0.9630.79
233_E239_I0.9620.79
152_A197_Y0.9520.78
163_I167_L0.9510.78
196_V199_N0.9440.78
102_T107_L0.9320.77
106_Q109_N0.9250.76
64_T67_D0.9180.76
204_I208_Q0.9140.75
99_I108_I0.9070.75
104_T108_I0.8920.74
61_P144_F0.8880.73
206_V209_A0.8880.73
129_V143_E0.8730.72
58_R76_Y0.8670.71
62_A72_V0.8660.71
52_S206_V0.8660.71
35_L140_L0.8590.71
189_L227_N0.8570.71
101_V108_I0.8480.70
127_T174_Q0.8420.69
116_F120_S0.8370.69
96_F214_Y0.8350.69
109_N113_K0.8350.69
78_S81_Q0.8330.68
94_I122_L0.8300.68
239_I242_T0.8290.68
99_I103_N0.8290.68
75_Y207_G0.8280.68
164_T237_I0.8250.68
76_Y178_M0.8220.67
109_N138_N0.8160.67
84_R88_K0.8140.67
144_F149_G0.8120.66
145_I197_Y0.8120.66
126_G129_V0.8060.66
118_N190_S0.8040.66
33_L137_E0.8030.66
173_Q176_E0.7980.65
42_L65_F0.7960.65
44_I64_T0.7930.65
53_S138_N0.7890.64
171_L203_I0.7840.64
183_K207_G0.7840.64
31_T34_N0.7830.64
108_I192_Y0.7820.63
38_I43_N0.7780.63
48_L61_P0.7760.63
187_G223_R0.7660.62
197_Y202_Y0.7650.62
44_I74_I0.7630.62
168_Y172_I0.7620.61
160_D164_T0.7590.61
75_Y111_W0.7460.60
179_V221_L0.7450.60
184_L209_A0.7430.59
52_S192_Y0.7430.59
95_R114_K0.7430.59
47_Y62_A0.7430.59
102_T108_I0.7370.59
58_R79_T0.7350.59
44_I102_T0.7340.59
105_K140_L0.7340.59
201_C228_I0.7340.59
44_I216_D0.7320.58
114_K184_L0.7290.58
161_E238_N0.7250.58
121_R184_L0.7220.57
223_R227_N0.7180.57
172_I181_G0.7170.57
44_I72_V0.7160.57
185_I212_I0.7150.57
33_L109_N0.7110.56
163_I166_G0.7100.56
92_G95_R0.7080.56
191_E228_I0.7060.56
32_Y36_I0.7050.55
103_N154_L0.7020.55
92_G111_W0.6990.55
105_K136_F0.6990.55
81_Q88_K0.6940.54
122_L207_G0.6890.54
99_I140_L0.6850.53
218_I230_R0.6780.53
160_D165_Q0.6730.52
174_Q189_L0.6720.52
133_I192_Y0.6620.51
172_I225_L0.6620.51
187_G212_I0.6610.51
90_T96_F0.6610.51
216_D219_T0.6600.51
59_I132_P0.6600.51
38_I141_V0.6560.50
79_T84_R0.6500.50
114_K191_E0.6460.49
175_V226_D0.6450.49
157_E231_F0.6440.49
222_K233_E0.6390.48
125_A132_P0.6380.48
108_I138_N0.6370.48
145_I177_I0.6350.48
194_V216_D0.6340.48
181_G241_P0.6330.48
123_Y143_E0.6300.47
46_E67_D0.6300.47
225_L229_N0.6290.47
169_E173_Q0.6290.47
127_T189_L0.6250.47
103_N107_L0.6240.47
110_T167_L0.6240.47
79_T85_A0.6210.46
35_L74_I0.6190.46
185_I219_T0.6190.46
168_Y238_N0.6180.46
57_A121_R0.6180.46
35_L221_L0.6180.46
165_Q238_N0.6160.46
99_I106_Q0.6130.46
171_L174_Q0.6130.46
111_W152_A0.6100.45
76_Y138_N0.6100.45
172_I229_N0.6090.45
122_L129_V0.6090.45
87_K99_I0.6070.45
55_K188_D0.6070.45
143_E198_D0.6050.45
177_I239_I0.6040.45
151_R206_V0.6040.45
154_L203_I0.6020.44
111_W118_N0.6020.44
38_I46_E0.6000.44
166_G199_N0.5950.44
168_Y185_I0.5950.44
119_L139_V0.5940.44
79_T138_N0.5940.44
113_K138_N0.5940.44
62_A119_L0.5930.44
61_P76_Y0.5920.43
121_R211_P0.5910.43
94_I207_G0.5880.43
92_G114_K0.5860.43
101_V105_K0.5840.43
66_D185_I0.5760.42
100_K106_Q0.5750.42
190_S206_V0.5740.42
153_P158_L0.5730.41
122_L217_A0.5720.41
127_T182_A0.5710.41
32_Y35_L0.5690.41
56_E188_D0.5680.41
203_I239_I0.5670.41
60_Y84_R0.5660.41
45_K181_G0.5650.41
188_D193_N0.5650.41
35_L171_L0.5640.40
187_G240_R0.5610.40
43_N112_A0.5590.40
74_I209_A0.5580.40
92_G215_E0.5570.40
133_I141_V0.5570.40
111_W146_G0.5540.39
58_R213_D0.5530.39
238_N242_T0.5530.39
108_I111_W0.5530.39
205_D224_D0.5520.39
171_L226_D0.5520.39
185_I236_G0.5480.39
126_G170_D0.5480.39
146_G201_C0.5470.39
173_Q219_T0.5420.38
80_A84_R0.5400.38
72_V134_L0.5390.38
82_S88_K0.5370.38
183_K212_I0.5350.38
193_N205_D0.5340.37
127_T221_L0.5340.37
45_K64_T0.5340.37
89_Y96_F0.5340.37
190_S221_L0.5320.37
35_L72_V0.5320.37
177_I233_E0.5280.37
40_R156_K0.5240.36
122_L208_Q0.5230.36
47_Y81_Q0.5230.36
89_Y95_R0.5200.36
167_L197_Y0.5190.36
122_L171_L0.5180.36
118_N184_L0.5160.36
101_V179_V0.5140.35
168_Y220_L0.5130.35
42_L148_N0.5130.35
191_E231_F0.5130.35
146_G153_P0.5120.35
188_D204_I0.5110.35
151_R195_I0.5110.35
57_A238_N0.5100.35
135_V140_L0.5050.35
107_L135_V0.5040.34
227_N230_R0.5030.34
38_I164_T0.5030.34
151_R157_E0.5020.34
158_L164_T0.5010.34
230_R234_N0.5010.34
51_I144_F0.5000.34
169_E226_D0.5000.34
85_A211_P0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zthA 1 0.9331 100 0.58 Contact Map
1zarA 1 0.8701 100 0.583 Contact Map
4gyiA 1 0.9449 100 0.599 Contact Map
4otpA 1 0.7638 100 0.633 Contact Map
4pedA 1 0.9646 99.6 0.806 Contact Map
2zmdA 2 0.6811 99.6 0.815 Contact Map
4ww7A 1 0.6929 99.4 0.833 Contact Map
4bvuA 1 0.6299 99.4 0.838 Contact Map
4h05A 1 0.7244 99.4 0.839 Contact Map
2y7jA 3 0.7402 99.4 0.839 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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