GREMLIN Database
IF1A - Translation initiation factor 1A
UniProt: Q97W62 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 108 (93)
Sequences: 342 (180)
Seq/√Len: 18.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_A78_C4.6061.00
27_V60_M3.5441.00
25_C38_V3.2731.00
38_V48_A3.1250.99
36_L80_I2.4710.96
60_M77_R2.2530.94
48_A68_V1.9280.87
54_I66_V1.9110.87
38_V68_V1.8630.85
27_V66_V1.8500.85
40_C46_R1.8210.84
86_N98_I1.7840.83
38_V66_V1.6850.79
38_V78_C1.5900.75
67_L88_E1.5240.72
29_K37_I1.5060.71
23_T45_E1.5010.70
66_V80_I1.4670.69
59_W64_D1.4330.67
12_S15_V1.4240.66
47_L67_L1.3650.63
26_V98_I1.3540.62
18_P77_R1.3050.59
58_M88_E1.2950.59
23_T41_M1.2750.57
24_I83_K1.2640.57
30_M79_D1.2570.56
34_D75_P1.2550.56
54_I58_M1.2310.55
22_Q87_D1.2050.53
67_L94_N1.2030.53
25_C44_K1.1890.52
9_E81_L1.1740.51
58_M82_Y1.1680.51
27_V78_C1.1570.50
47_L74_Q1.1330.49
17_R95_E1.1300.48
28_K39_L1.1290.48
37_I45_E1.1160.47
13_R88_E1.0950.46
49_R71_W1.0900.46
78_C89_I1.0870.46
56_K89_I1.0790.45
80_I98_I1.0760.45
35_H62_E1.0700.45
36_L50_I1.0580.44
57_K83_K1.0510.43
31_L96_N1.0430.43
42_D46_R1.0400.43
24_I71_W1.0390.43
38_V53_K1.0280.42
60_M81_L1.0180.41
16_P22_Q1.0100.41
25_C78_C1.0050.41
25_C48_A0.9990.40
15_V24_I0.9920.40
13_R16_P0.9830.39
42_D84_Y0.9740.39
31_L41_M0.9360.36
31_L35_H0.9170.35
24_I97_I0.9030.35
43_G72_D0.8920.34
27_V36_L0.8910.34
81_L94_N0.8720.33
53_K73_F0.8650.32
56_K59_W0.8640.32
25_C75_P0.8530.32
47_L80_I0.8430.31
27_V77_R0.8400.31
29_K44_K0.8330.31
31_L47_L0.8210.30
70_I83_K0.8180.30
67_L87_D0.8100.30
13_R67_L0.8090.29
50_I74_Q0.7930.29
38_V80_I0.7920.29
33_G51_P0.7710.28
35_H74_Q0.7660.27
54_I81_L0.7640.27
19_E69_G0.7460.26
51_P71_W0.7450.26
30_M35_H0.7430.26
14_D91_R0.7380.26
35_H72_D0.7310.26
58_M86_N0.7240.25
48_A55_R0.7240.25
39_L60_M0.7220.25
47_L55_R0.6910.24
17_R20_E0.6830.23
15_V97_I0.6800.23
20_E89_I0.6800.23
65_V83_K0.6710.23
24_I90_K0.6630.22
8_Q41_M0.6610.22
30_M58_M0.6600.22
13_R98_I0.6590.22
18_P68_V0.6570.22
18_P71_W0.6510.22
34_D39_L0.6500.22
30_M56_K0.6490.22
43_G51_P0.6480.22
45_E54_I0.6460.22
54_I67_L0.6370.21
22_Q79_D0.6260.21
8_Q11_P0.6180.21
52_G59_W0.6130.20
62_E80_I0.6080.20
68_V78_C0.6070.20
11_P94_N0.6050.20
55_R85_G0.6010.20
85_G88_E0.5810.19
41_M83_K0.5790.19
34_D55_R0.5700.19
55_R86_N0.5700.19
93_V98_I0.5670.19
28_K94_N0.5670.19
12_S16_P0.5630.18
55_R73_F0.5610.18
93_V97_I0.5590.18
56_K68_V0.5590.18
12_S88_E0.5470.18
69_G72_D0.5420.18
53_K83_K0.5380.17
26_V86_N0.5370.17
48_A67_L0.5360.17
26_V65_V0.5320.17
40_C84_Y0.5310.17
61_R91_R0.5300.17
33_G56_K0.5260.17
63_G96_N0.5210.17
69_G73_F0.5200.17
54_I59_W0.5150.17
17_R23_T0.5130.17
57_K90_K0.5120.17
60_M78_C0.5110.17
26_V51_P0.5100.16
50_I59_W0.5080.16
21_G37_I0.5020.16
51_P69_G0.5010.16
55_R91_R0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kzyn 1 0.7593 100 0.323 Contact Map
3j80i 1 0.8889 100 0.324 Contact Map
4bpe0 1 0.9167 100 0.328 Contact Map
2oqkA 1 0.8611 100 0.355 Contact Map
4mnoA 1 0.8704 100 0.368 Contact Map
3wbkC 1 0.0093 100 0.37 Contact Map
1jt8A 1 0.9352 100 0.395 Contact Map
2dgyA 1 0.9444 100 0.403 Contact Map
4ql5A 4 0.6204 99.6 0.634 Contact Map
1ah9A 1 0.6481 99.6 0.635 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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