GREMLIN Database
Q97W61 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-4)
UniProt: Q97W61 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (377)
Sequences: 15182 (8312)
Seq/√Len: 428.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_Q190_R3.4531.00
179_E329_R3.3511.00
4_S262_E3.3011.00
264_A268_L3.2881.00
108_A111_I2.9331.00
185_Y226_L2.8581.00
3_E263_K2.7791.00
37_E40_R2.7791.00
96_V359_I2.7781.00
262_E266_K2.6951.00
193_K197_N2.6761.00
180_L241_L2.6451.00
186_Q189_L2.6331.00
264_A267_E2.6011.00
362_L374_G2.5151.00
10_A360_V2.3861.00
103_I259_L2.3511.00
35_I112_V2.3441.00
6_Y265_A2.3391.00
300_L304_L2.3291.00
196_V222_A2.3031.00
11_V41_R2.2951.00
300_L389_A2.2821.00
38_A258_V2.2041.00
201_K215_N2.1991.00
208_K213_V2.1181.00
110_I260_V2.1051.00
274_A363_L2.1041.00
176_S179_E2.0971.00
99_A111_I2.0801.00
278_G304_L2.0371.00
366_L371_G1.9931.00
31_G54_M1.9921.00
313_Y340_V1.9901.00
45_E48_K1.9851.00
195_T220_I1.9611.00
8_A260_V1.9381.00
33_I207_I1.9271.00
103_I261_S1.9201.00
306_T373_R1.9201.00
219_G249_Q1.8851.00
4_S275_R1.8781.00
275_R391_E1.8751.00
273_I367_S1.8651.00
178_K182_E1.8581.00
186_Q335_Y1.8421.00
192_H220_I1.8181.00
328_N335_Y1.7901.00
255_A356_A1.7781.00
169_V175_I1.7681.00
48_K268_L1.7671.00
278_G300_L1.7641.00
201_K216_T1.7511.00
312_D371_G1.7371.00
21_A214_I1.7341.00
109_D261_S1.7031.00
229_L245_G1.6941.00
195_T204_I1.6911.00
260_V264_A1.6851.00
298_K302_S1.6731.00
260_V265_A1.6541.00
195_T216_T1.6451.00
308_I314_F1.6441.00
192_H196_V1.6401.00
172_S288_R1.6361.00
365_V369_M1.6261.00
328_N338_L1.6211.00
228_K231_S1.6091.00
199_Y341_F1.6071.00
163_G236_F1.6061.00
297_I377_S1.6021.00
341_F365_V1.6011.00
306_T311_F1.5991.00
185_Y189_L1.5991.00
33_I205_V1.5991.00
54_M114_G1.5971.00
101_Q107_D1.5931.00
109_D264_A1.5921.00
83_F98_T1.5851.00
102_M108_A1.5801.00
261_S264_A1.5761.00
202_S367_S1.5721.00
257_L356_A1.5711.00
311_F314_F1.5701.00
37_E205_V1.5631.00
29_D73_S1.5481.00
38_A42_A1.5451.00
295_F298_K1.5311.00
31_G70_C1.5271.00
311_F389_A1.5191.00
99_A259_L1.5111.00
9_S42_A1.5071.00
182_E226_L1.5031.00
182_E186_Q1.5021.00
118_N121_Q1.4991.00
36_R40_R1.4901.00
313_Y365_V1.4771.00
189_L223_D1.4381.00
277_L391_E1.4301.00
35_I70_C1.4251.00
199_Y365_V1.4241.00
365_V368_K1.4211.00
3_E261_S1.4171.00
306_T389_A1.4111.00
110_I264_A1.3991.00
6_Y275_R1.3981.00
359_I390_I1.3971.00
189_L193_K1.3971.00
34_V256_A1.3961.00
34_V254_A1.3831.00
22_L214_I1.3801.00
280_S299_K1.3541.00
301_L308_I1.3431.00
125_A147_T1.3411.00
97_I388_I1.3411.00
372_T391_E1.3341.00
78_F285_E1.3271.00
37_E41_R1.3191.00
314_F375_I1.3081.00
334_P337_R1.2991.00
66_I116_T1.2891.00
299_K302_S1.2861.00
199_Y368_K1.2821.00
179_E182_E1.2811.00
311_F373_R1.2761.00
25_L33_I1.2701.00
263_K267_E1.2511.00
9_S38_A1.2511.00
56_N59_R1.2391.00
192_H223_D1.2361.00
50_D108_A1.2351.00
298_K330_Y1.2341.00
97_I279_Y1.2321.00
11_V205_V1.2321.00
15_I353_A1.2281.00
340_V365_V1.2281.00
32_S73_S1.2271.00
177_R243_T1.2221.00
280_S300_L1.2221.00
5_V259_L1.2181.00
202_S368_K1.2171.00
363_L367_S1.2171.00
375_I389_A1.2151.00
49_I110_I1.2151.00
96_V257_L1.2061.00
90_S386_T1.1981.00
360_V364_N1.1931.00
112_V258_V1.1891.00
296_A387_A1.1691.00
54_M256_A1.1621.00
297_I375_I1.1611.00
19_G132_W1.1531.00
15_I347_L1.1401.00
175_I180_L1.1351.00
90_S380_H1.1301.00
282_V295_F1.1221.00
307_D310_H1.1221.00
304_L389_A1.1181.00
48_K264_A1.1151.00
203_E361_T1.1141.00
50_D109_D1.1061.00
183_V324_N1.1051.00
6_Y262_E1.1011.00
167_D240_G1.0981.00
226_L230_S1.0871.00
202_S364_N1.0851.00
291_E294_I1.0851.00
33_I37_E1.0841.00
163_G235_A1.0831.00
192_H222_A1.0811.00
373_R391_E1.0801.00
10_A364_N1.0791.00
107_D303_K1.0781.00
99_A113_A1.0781.00
104_K107_D1.0761.00
93_M359_I1.0701.00
284_I291_E1.0681.00
53_I111_I1.0651.00
168_M172_S1.0621.00
276_I388_I1.0591.00
6_Y260_V1.0561.00
14_P214_I1.0541.00
312_D337_R1.0511.00
55_G91_S1.0501.00
94_I98_T1.0481.00
183_V325_V1.0471.00
52_A71_A1.0401.00
3_E109_D1.0381.00
175_I325_V1.0371.00
35_I76_I1.0311.00
282_V299_K1.0301.00
288_R291_E1.0271.00
277_L373_R1.0271.00
39_L76_I1.0231.00
130_I134_V1.0211.00
96_V259_L1.0121.00
278_G303_K1.0061.00
313_Y369_M1.0011.00
101_Q105_S0.9991.00
308_I311_F0.9981.00
312_D366_L0.9941.00
173_H291_E0.9931.00
371_G374_G0.9911.00
185_Y229_L0.9901.00
340_V369_M0.9871.00
224_T229_L0.9831.00
10_A363_L0.9791.00
362_L376_A0.9741.00
232_L245_G0.9721.00
7_I390_I0.9721.00
9_S41_R0.9701.00
48_K267_E0.9671.00
11_V37_E0.9661.00
294_I298_K0.9631.00
32_S36_R0.9611.00
186_Q336_D0.9541.00
341_F368_K0.9541.00
357_R361_T0.9491.00
26_S29_D0.9461.00
189_L192_H0.9401.00
167_D171_K0.9381.00
172_S287_W0.9361.00
313_Y362_L0.9351.00
333_I338_L0.9351.00
34_V37_E0.9311.00
273_I363_L0.9311.00
225_S228_K0.9251.00
255_A353_A0.9241.00
185_Y223_D0.9231.00
278_G389_A0.9231.00
173_H330_Y0.9211.00
76_I80_I0.9201.00
262_E275_R0.9181.00
170_A322_V0.9101.00
311_F375_I0.9091.00
39_L44_V0.9071.00
299_K303_K0.9061.00
4_S104_K0.9031.00
314_F333_I0.9011.00
56_N62_H0.8971.00
191_A220_I0.8961.00
377_S380_H0.8951.00
195_T201_K0.8931.00
178_K230_S0.8901.00
373_R389_A0.8901.00
144_L147_T0.8811.00
358_I376_A0.8781.00
297_I331_L0.8721.00
53_I99_A0.8721.00
291_E330_Y0.8691.00
15_I251_S0.8671.00
53_I95_S0.8671.00
13_T34_V0.8661.00
72_I78_F0.8661.00
16_G218_E0.8631.00
169_V291_E0.8611.00
169_V326_L0.8601.00
255_A360_V0.8591.00
100_S276_I0.8591.00
142_I147_T0.8591.00
38_A112_V0.8581.00
359_I388_I0.8581.00
17_K219_G0.8541.00
197_N368_K0.8541.00
291_E326_L0.8531.00
260_V270_I0.8531.00
276_I279_Y0.8521.00
8_A270_I0.8501.00
13_T30_L0.8481.00
14_P33_I0.8431.00
232_L243_T0.8391.00
284_I292_A0.8381.00
48_K110_I0.8371.00
87_M94_I0.8371.00
13_T33_I0.8361.00
233_P244_A0.8351.00
181_D246_N0.8311.00
380_H386_T0.8311.00
193_K199_Y0.8311.00
10_A257_L0.8311.00
53_I83_F0.8291.00
370_H374_G0.8271.00
321_A345_I0.8271.00
100_S104_K0.8251.00
168_M171_K0.8221.00
195_T222_A0.8221.00
113_A257_L0.8191.00
5_V261_S0.8091.00
263_K266_K0.8061.00
324_N328_N0.8061.00
133_G136_M0.8061.00
5_V100_S0.8001.00
154_T159_Y0.7971.00
316_N377_S0.7971.00
262_E265_A0.7941.00
328_N333_I0.7941.00
363_L390_I0.7941.00
52_A80_I0.7931.00
39_L49_I0.7921.00
271_E367_S0.7841.00
190_R193_K0.7841.00
50_D299_K0.7811.00
15_I357_R0.7791.00
178_K226_L0.7791.00
49_I112_V0.7781.00
27_P116_T0.7781.00
166_A322_V0.7771.00
141_N145_I0.7761.00
344_A354_S0.7741.00
142_I146_D0.7741.00
190_R335_Y0.7691.00
297_I387_A0.7691.00
284_I295_F0.7691.00
25_L29_D0.7681.00
341_F369_M0.7671.00
179_E325_V0.7651.00
107_D279_Y0.7631.00
298_K331_L0.7621.00
120_S252_D0.7601.00
98_T101_Q0.7581.00
95_S356_A0.7571.00
51_M102_M0.7551.00
134_V142_I0.7471.00
294_I330_Y0.7451.00
5_V104_K0.7451.00
246_N321_A0.7451.00
112_V256_A0.7391.00
97_I386_T0.7391.00
185_Y224_T0.7391.00
191_A195_T0.7371.00
224_T228_K0.7371.00
38_A256_A0.7351.00
306_T310_H0.7351.00
131_R135_K0.7331.00
193_K196_V0.7271.00
34_V38_A0.7261.00
56_N66_I0.7251.00
98_T102_M0.7251.00
380_H384_G0.7241.00
380_H385_S0.7231.00
101_Q104_K0.7191.00
273_I364_N0.7131.00
76_I112_V0.7111.00
143_E147_T0.7101.00
102_M107_D0.7091.00
316_N327_I0.7091.00
227_D231_S0.7081.00
21_A218_E0.7081.00
54_M67_A0.7071.00
142_I145_I0.7041.00
309_N337_R0.7031.00
39_L46_P0.7031.00
309_N332_G0.7001.00
13_T207_I0.7001.00
87_M281_W0.6961.00
109_D303_K0.6961.00
33_I36_R0.6951.00
308_I333_I0.6941.00
93_M388_I0.6921.00
185_Y225_S0.6881.00
50_D111_I0.6861.00
51_M281_W0.6851.00
3_E104_K0.6841.00
36_R46_P0.6831.00
85_V98_T0.6831.00
31_G114_G0.6831.00
370_H373_R0.6821.00
53_I98_T0.6811.00
196_V216_T0.6811.00
301_L306_T0.6761.00
42_A258_V0.6751.00
366_L374_G0.6751.00
126_I144_L0.6721.00
297_I316_N0.6711.00
277_L304_L0.6701.00
5_V103_I0.6681.00
198_G201_K0.6671.00
29_D32_S0.6661.00
300_L375_I0.6651.00
131_R134_V0.6631.00
102_M111_I0.6621.00
378_I381_G0.6610.99
224_T245_G0.6610.99
143_E146_D0.6600.99
26_S121_Q0.6590.99
185_Y228_K0.6580.99
376_A380_H0.6580.99
175_I329_R0.6580.99
11_V34_V0.6580.99
192_H221_R0.6570.99
242_H247_S0.6570.99
36_R75_G0.6550.99
277_L306_T0.6510.99
281_W386_T0.6510.99
39_L43_N0.6500.99
326_L330_Y0.6490.99
188_H219_G0.6490.99
175_I179_E0.6490.99
7_I259_L0.6480.99
234_P240_G0.6470.99
181_D226_L0.6470.99
93_M376_A0.6470.99
161_V164_Q0.6450.99
109_D267_E0.6450.99
312_D373_R0.6440.99
257_L360_V0.6440.99
110_I268_L0.6430.99
191_A346_A0.6420.99
188_H192_H0.6360.99
11_V38_A0.6350.99
160_K164_Q0.6340.99
57_V351_I0.6330.99
188_H220_I0.6320.99
47_G79_E0.6310.99
83_F94_I0.6310.99
297_I308_I0.6290.99
70_C74_A0.6280.99
259_L276_I0.6260.99
99_A108_A0.6260.99
285_E288_R0.6260.99
166_A242_H0.6240.99
354_S358_I0.6230.99
46_P77_P0.6230.99
35_I74_A0.6220.99
65_D384_G0.6210.99
39_L42_A0.6190.99
164_Q168_M0.6190.99
25_L121_Q0.6170.99
51_M87_M0.6160.99
235_A244_A0.6150.99
81_D281_W0.6150.99
7_I363_L0.6140.99
54_M70_C0.6120.99
141_N146_D0.6110.99
71_A82_G0.6110.99
28_V73_S0.6100.99
96_V356_A0.6100.99
71_A76_I0.6090.99
32_S74_A0.6080.99
165_E289_F0.6070.99
169_V173_H0.6050.99
96_V113_A0.6050.99
324_N338_L0.6030.99
376_A379_C0.6010.99
219_G251_S0.6010.99
9_S273_I0.6010.99
206_E213_V0.6000.99
191_A347_L0.5990.99
119_M351_I0.5980.99
272_P275_R0.5980.99
160_K287_W0.5950.99
188_H345_I0.5890.99
206_E215_N0.5870.99
8_A264_A0.5870.99
24_N121_Q0.5860.99
28_V62_H0.5860.99
19_G120_S0.5860.99
269_K272_P0.5830.99
173_H326_L0.5820.99
298_K332_G0.5820.99
216_T222_A0.5820.99
30_L207_I0.5810.99
35_I256_A0.5810.99
173_H288_R0.5790.99
199_Y369_M0.5790.99
347_L357_R0.5780.99
6_Y261_S0.5780.99
130_I133_G0.5770.99
35_I39_L0.5750.99
223_D228_K0.5750.99
359_I376_A0.5750.99
203_E364_N0.5750.99
188_H223_D0.5740.99
280_S303_K0.5730.99
104_K279_Y0.5720.99
301_L304_L0.5720.99
8_A265_A0.5710.99
93_M386_T0.5710.99
302_S307_D0.5700.99
276_I390_I0.5700.99
166_A170_A0.5690.99
325_V329_R0.5690.99
49_I76_I0.5680.98
94_I97_I0.5680.98
6_Y264_A0.5670.98
171_K239_D0.5670.98
36_R74_A0.5670.98
379_C383_G0.5660.98
181_D230_S0.5650.98
51_M108_A0.5630.98
319_A349_H0.5630.98
184_A229_L0.5610.98
312_D372_T0.5610.98
114_G256_A0.5610.98
260_V268_L0.5610.98
227_D230_S0.5600.98
353_A356_A0.5590.98
59_R84_S0.5580.98
160_K168_M0.5580.98
70_C116_T0.5570.98
58_L122_A0.5530.98
328_N334_P0.5530.98
95_S113_A0.5510.98
25_L118_N0.5510.98
273_I277_L0.5500.98
377_S381_G0.5490.98
35_I52_A0.5480.98
23_R132_W0.5480.98
11_V42_A0.5460.98
314_F377_S0.5460.98
377_S383_G0.5460.98
167_D242_H0.5460.98
297_I327_I0.5450.98
141_N147_T0.5430.98
131_R136_M0.5410.98
31_G116_T0.5400.98
94_I281_W0.5400.98
295_F299_K0.5390.98
226_L229_L0.5370.98
132_W135_K0.5370.98
14_P204_I0.5350.98
122_A147_T0.5350.98
297_I301_L0.5350.98
367_S370_H0.5340.98
323_N327_I0.5330.98
132_W136_M0.5310.98
44_V258_V0.5300.98
173_H329_R0.5300.98
192_H195_T0.5300.98
184_A321_A0.5290.98
57_V88_V0.5290.98
50_D80_I0.5290.98
170_A241_L0.5270.98
182_E335_Y0.5270.98
61_G125_A0.5270.98
322_V326_L0.5270.98
169_V322_V0.5260.98
145_I150_Y0.5260.98
141_N144_L0.5250.97
329_R332_G0.5250.97
102_M105_S0.5240.97
379_C382_I0.5220.97
52_A112_V0.5220.97
356_A360_V0.5220.97
374_G390_I0.5190.97
14_P215_N0.5170.97
63_G69_Q0.5160.97
53_I85_V0.5140.97
6_Y268_L0.5130.97
33_I208_K0.5130.97
94_I102_M0.5120.97
16_G22_L0.5110.97
130_I142_I0.5100.97
109_D263_K0.5100.97
316_N324_N0.5090.97
236_F240_G0.5080.97
184_A188_H0.5070.97
25_L207_I0.5050.97
16_G214_I0.5050.97
364_N368_K0.5040.97
343_G346_A0.5030.97
300_L311_F0.5030.97
127_K145_I0.5030.97
174_N329_R0.5030.97
22_L25_L0.5010.97
216_T220_I0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ulqA 4 0.9824 100 0.264 Contact Map
4n46A 4 0.9773 100 0.269 Contact Map
2wu9A 2 0.9622 100 0.272 Contact Map
2vu1A 4 0.9748 100 0.273 Contact Map
3ss6A 4 0.9748 100 0.273 Contact Map
4e1lA 4 0.9622 100 0.277 Contact Map
2ib8A 4 0.9698 100 0.285 Contact Map
4nzsA 4 0.9748 100 0.286 Contact Map
4o9aA 4 0.9748 100 0.286 Contact Map
1wdkC 2 0.9446 100 0.288 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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