GREMLIN Database
Q97W60 - Uncharacterized protein
UniProt: Q97W60 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 421 (406)
Sequences: 7265 (4225)
Seq/√Len: 209.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
254_D301_A3.6281.00
254_D304_N3.6211.00
135_I169_A3.5001.00
255_D268_D3.4381.00
173_I213_D3.4071.00
313_R358_S3.2221.00
369_R405_D3.1541.00
231_D276_E3.1401.00
271_K311_E3.1341.00
367_T405_D3.1091.00
256_R301_A3.0011.00
235_E280_K2.8491.00
343_K347_I2.6911.00
306_L351_L2.6611.00
372_T393_I2.6211.00
206_K209_D2.5691.00
310_K354_D2.5061.00
367_T407_K2.4671.00
256_R260_L2.4641.00
307_L311_E2.4391.00
205_N239_N2.3251.00
169_A180_I2.2991.00
271_K312_L2.2571.00
369_R386_M2.2511.00
8_T18_T2.2441.00
277_I284_V2.2421.00
246_I284_V2.2411.00
340_I343_K2.2061.00
167_N170_R2.1941.00
178_R214_F2.1801.00
324_I335_Q2.1491.00
102_R105_D2.1341.00
169_A207_V2.1341.00
244_K386_M2.0801.00
235_E239_N2.0641.00
310_K351_L2.0371.00
272_E275_S2.0281.00
302_F347_I2.0161.00
238_R280_K2.0121.00
170_R174_Q2.0051.00
208_A240_P2.0031.00
208_A241_K2.0001.00
307_L310_K1.9851.00
3_N31_N1.9821.00
199_S232_D1.9821.00
337_P340_I1.9641.00
321_M345_I1.9621.00
299_E340_I1.9611.00
399_E402_K1.9171.00
267_V304_N1.8961.00
369_R403_W1.8941.00
306_L347_I1.8431.00
267_V271_K1.8361.00
173_I210_I1.8231.00
162_L206_K1.8061.00
250_V308_L1.8051.00
275_S311_E1.8041.00
275_S279_H1.8021.00
35_N38_N1.7961.00
303_N307_L1.7871.00
252_S305_T1.7871.00
364_V411_A1.7841.00
357_L361_L1.7831.00
370_V383_G1.7741.00
28_E108_K1.7701.00
199_S202_D1.7631.00
269_E272_E1.7561.00
338_D341_K1.7461.00
324_I331_A1.7431.00
83_A87_S1.6701.00
313_R355_L1.6621.00
266_T269_E1.6471.00
303_N347_I1.6441.00
214_F369_R1.6321.00
144_N156_K1.6311.00
208_A236_A1.6041.00
359_I362_D1.6031.00
268_D272_E1.6011.00
267_V307_L1.6011.00
372_T404_Y1.5921.00
255_D267_V1.5911.00
298_D301_A1.5831.00
363_Y368_S1.5731.00
6_V18_T1.5601.00
205_N236_A1.5401.00
4_I32_F1.5331.00
244_K283_F1.5111.00
257_V260_L1.5021.00
301_A304_N1.4861.00
315_E359_I1.4851.00
299_E303_N1.4761.00
205_N232_D1.4621.00
48_A153_A1.4511.00
160_Y168_A1.4471.00
234_I277_I1.4411.00
78_S95_I1.4361.00
43_I72_V1.4271.00
146_S262_N1.4271.00
72_V94_L1.4261.00
246_I277_I1.4231.00
21_M74_A1.4181.00
231_D235_E1.4031.00
146_S294_H1.3911.00
267_V308_L1.3881.00
167_N171_D1.3881.00
406_V418_G1.3741.00
66_T69_K1.3741.00
180_I213_D1.3681.00
304_N307_L1.3651.00
260_L333_M1.3561.00
161_P164_E1.3281.00
391_V408_I1.3271.00
384_R390_P1.3261.00
204_V242_V1.3251.00
201_V236_A1.3201.00
237_I242_V1.3121.00
48_A54_E1.3101.00
171_D175_S1.2971.00
346_Q350_K1.2861.00
380_S394_R1.2831.00
144_N152_L1.2771.00
65_N71_L1.2771.00
166_V206_K1.2751.00
309_M348_A1.2721.00
202_D232_D1.2661.00
160_Y164_E1.2661.00
290_I309_M1.2661.00
285_N387_N1.2591.00
342_K346_Q1.2521.00
313_R359_I1.2521.00
236_A242_V1.2521.00
260_L301_A1.2351.00
319_L345_I1.2221.00
363_Y366_S1.2171.00
361_L364_V1.2161.00
283_F366_S1.2151.00
300_E304_N1.2151.00
202_D206_K1.2121.00
321_M342_K1.2071.00
166_V170_R1.2021.00
260_L296_G1.2011.00
281_I284_V1.1961.00
408_I416_L1.1951.00
99_S102_R1.1931.00
410_E417_R1.1911.00
79_S96_G1.1911.00
398_V402_K1.1831.00
46_T73_V1.1821.00
208_A242_V1.1801.00
260_L294_H1.1791.00
299_E347_I1.1761.00
171_D174_Q1.1751.00
351_L355_L1.1721.00
329_R332_S1.1701.00
61_I73_V1.1691.00
149_I153_A1.1631.00
338_D342_K1.1601.00
3_N38_N1.1561.00
207_V216_I1.1461.00
55_E59_Q1.1451.00
352_Y355_L1.1421.00
44_L64_L1.1401.00
262_N329_R1.1321.00
272_E276_E1.1271.00
292_V302_F1.1261.00
321_M338_D1.1251.00
350_K354_D1.1201.00
335_Q341_K1.1191.00
303_N306_L1.1111.00
211_D241_K1.1101.00
51_L55_E1.1101.00
214_F241_K1.1081.00
276_E279_H1.1061.00
216_I241_K1.1061.00
273_L276_E1.0991.00
368_S408_I1.0971.00
7_E60_R1.0921.00
309_M317_I1.0781.00
160_Y165_I1.0631.00
94_L110_E1.0621.00
237_I281_I1.0611.00
255_D266_T1.0611.00
173_I214_F1.0581.00
191_G194_L1.0551.00
6_V43_I1.0511.00
274_I286_I1.0491.00
142_A156_K1.0491.00
313_R362_D1.0481.00
290_I317_I1.0471.00
381_V398_V1.0461.00
368_S385_L1.0451.00
198_I206_K1.0321.00
288_T314_F1.0311.00
173_I212_G1.0291.00
300_E303_N1.0281.00
162_L166_V1.0271.00
187_T218_I1.0271.00
319_L349_N1.0261.00
381_V395_S1.0251.00
25_L107_V1.0221.00
238_R281_I1.0211.00
133_A172_A1.0201.00
361_L411_A1.0121.00
46_T57_M1.0101.00
274_I312_L1.0061.00
278_R313_R1.0061.00
149_I152_L1.0041.00
354_D358_S1.0031.00
234_I280_K0.9991.00
80_A153_A0.9991.00
255_D304_N0.9961.00
146_S329_R0.9931.00
376_G379_G0.9931.00
94_L106_I0.9891.00
364_V410_E0.9851.00
288_T317_I0.9831.00
81_E84_T0.9811.00
42_I64_L0.9811.00
135_I165_I0.9791.00
237_I246_I0.9771.00
164_E167_N0.9751.00
317_I352_Y0.9731.00
6_V22_M0.9661.00
198_I202_D0.9651.00
276_E280_K0.9641.00
351_L354_D0.9631.00
283_F362_D0.9611.00
254_D257_V0.9581.00
375_L381_V0.9551.00
5_Y36_P0.9541.00
234_I281_I0.9500.99
357_L411_A0.9470.99
306_L310_K0.9470.99
302_F348_A0.9460.99
138_A157_L0.9460.99
232_D235_E0.9400.99
363_Y387_N0.9360.99
360_H389_I0.9330.99
4_I30_Y0.9290.99
245_F388_Y0.9270.99
68_S93_S0.9260.99
195_G198_I0.9220.99
163_R167_N0.9200.99
172_A177_A0.9190.99
292_V345_I0.9170.99
208_A216_I0.9160.99
345_I349_N0.9150.99
372_T383_G0.9130.99
357_L360_H0.9130.99
299_E343_K0.9110.99
200_L233_L0.9080.99
8_T45_N0.9060.99
85_V92_A0.8990.99
60_R63_E0.8960.99
84_T87_S0.8920.99
13_L185_Q0.8860.99
350_K353_E0.8800.99
4_I26_K0.8790.99
170_R211_D0.8760.99
395_S398_V0.8730.99
4_I22_M0.8730.99
135_I180_I0.8720.99
331_A335_Q0.8710.99
9_Y57_M0.8710.99
92_A95_I0.8640.99
210_I213_D0.8640.99
143_G186_D0.8600.99
294_H333_M0.8590.99
22_M32_F0.8580.99
178_R403_W0.8570.99
109_S113_K0.8570.99
269_E273_L0.8540.99
178_R402_K0.8530.99
3_N33_V0.8500.99
54_E81_E0.8460.99
105_D109_S0.8460.99
352_Y356_A0.8450.99
374_E382_I0.8450.99
244_K281_I0.8440.99
33_V39_A0.8420.99
292_V341_K0.8400.99
30_Y41_I0.8380.99
9_Y60_R0.8370.99
44_L61_I0.8360.99
392_V415_D0.8340.99
169_A210_I0.8320.99
309_M314_F0.8320.99
412_S417_R0.8310.99
162_L190_Y0.8300.99
214_F403_W0.8280.99
170_R206_K0.8270.99
97_P100_V0.8230.99
201_V232_D0.8210.99
347_I351_L0.8210.99
159_S193_D0.8200.99
385_L388_Y0.8170.98
290_I348_A0.8150.98
375_L397_N0.8150.98
84_T88_I0.8140.98
250_V290_I0.8110.98
287_T316_R0.8100.98
314_F317_I0.8090.98
201_V230_M0.8090.98
356_A360_H0.8090.98
123_I126_R0.8080.98
205_N209_D0.8060.98
133_A177_A0.8050.98
204_V233_L0.7980.98
370_V406_V0.7980.98
308_L312_L0.7980.98
245_F287_T0.7960.98
41_I72_V0.7930.98
215_M243_Y0.7920.98
28_E105_D0.7920.98
36_P42_I0.7890.98
371_I403_W0.7880.98
353_E414_Y0.7880.98
250_V270_Y0.7870.98
257_V301_A0.7870.98
144_N262_N0.7850.98
271_K275_S0.7850.98
302_F306_L0.7840.98
157_L189_A0.7840.98
395_S399_E0.7830.98
65_N93_S0.7820.98
285_N315_E0.7820.98
355_L359_I0.7810.98
79_S82_P0.7810.98
253_G304_N0.7800.98
163_R195_G0.7800.98
131_K373_T0.7780.98
408_I418_G0.7770.98
152_L329_R0.7760.98
234_I276_E0.7730.98
372_T381_V0.7710.98
201_V233_L0.7710.98
256_R304_N0.7710.98
253_G270_Y0.7690.98
381_V396_E0.7690.98
292_V348_A0.7670.98
358_S361_L0.7660.98
142_A192_L0.7650.98
229_I273_L0.7650.98
110_E113_K0.7620.98
243_Y386_M0.7610.98
303_N310_K0.7600.98
24_L104_V0.7600.98
317_I355_L0.7590.98
135_I172_A0.7590.98
108_K112_R0.7590.98
268_D271_K0.7580.98
324_I341_K0.7580.98
310_K355_L0.7560.97
25_L43_I0.7550.97
309_M355_L0.7500.97
363_Y389_I0.7470.97
355_L358_S0.7460.97
22_M26_K0.7460.97
166_V210_I0.7440.97
306_L348_A0.7410.97
270_Y314_F0.7400.97
231_D234_I0.7390.97
218_I237_I0.7390.97
136_P139_D0.7380.97
30_Y108_K0.7380.97
305_T348_A0.7340.97
235_E238_R0.7330.97
163_R206_K0.7320.97
19_Y23_T0.7310.97
21_M103_I0.7310.97
173_I211_D0.7310.97
33_V38_N0.7300.97
336_V341_K0.7280.97
138_A184_G0.7240.97
5_Y33_V0.7230.97
73_V92_A0.7200.97
58_K62_K0.7190.97
230_M233_L0.7190.97
257_V294_H0.7170.97
189_A224_E0.7170.97
18_T22_M0.7150.96
5_Y39_A0.7140.96
359_I363_Y0.7130.96
195_G199_S0.7130.96
5_Y42_I0.7060.96
60_R64_L0.7060.96
143_G189_A0.7040.96
166_V207_V0.6960.96
186_D225_Q0.6960.96
8_T15_R0.6940.96
409_T418_G0.6930.96
16_A136_P0.6920.96
202_D205_N0.6920.96
18_T45_N0.6920.96
212_G241_K0.6910.96
36_P64_L0.6880.96
246_I286_I0.6870.96
134_I181_E0.6840.95
103_I107_V0.6790.95
357_L413_F0.6780.95
372_T406_V0.6780.95
152_L327_N0.6750.95
36_P67_L0.6750.95
393_I406_V0.6740.95
23_T27_S0.6730.95
204_V208_A0.6730.95
347_I350_K0.6720.95
253_G305_T0.6710.95
349_N352_Y0.6700.95
62_K65_N0.6700.95
52_E55_E0.6690.95
224_E264_K0.6680.95
315_E389_I0.6670.95
12_A183_T0.6670.95
368_S386_M0.6660.95
162_L198_I0.6630.95
213_D241_K0.6630.95
170_R210_I0.6620.95
296_G335_Q0.6600.95
42_I67_L0.6590.94
28_E104_V0.6580.94
231_D280_K0.6580.94
362_D366_S0.6560.94
65_N91_N0.6560.94
215_M403_W0.6550.94
17_D139_D0.6540.94
189_A225_Q0.6530.94
137_V187_T0.6520.94
391_V418_G0.6520.94
143_G264_K0.6510.94
229_I233_L0.6490.94
66_T70_K0.6480.94
271_K308_L0.6470.94
353_E413_F0.6470.94
132_I181_E0.6470.94
363_Y367_T0.6430.94
26_K31_N0.6420.94
188_A249_P0.6410.94
52_E323_S0.6360.93
326_P331_A0.6350.93
211_D214_F0.6350.93
309_M352_Y0.6330.93
9_Y44_L0.6310.93
200_L218_I0.6280.93
253_G308_L0.6270.93
368_S387_N0.6260.93
380_S392_V0.6260.93
188_A221_M0.6250.93
370_V391_V0.6250.93
48_A80_A0.6240.93
376_G392_V0.6240.93
367_T418_G0.6230.93
196_G202_D0.6220.93
26_K32_F0.6220.93
305_T309_M0.6200.92
137_V203_V0.6200.92
246_I281_I0.6190.92
339_S343_K0.6190.92
303_N343_K0.6190.92
147_F265_Y0.6190.92
13_L16_A0.6180.92
385_L391_V0.6170.92
56_R59_Q0.6170.92
146_S260_L0.6150.92
173_I216_I0.6140.92
210_I241_K0.6130.92
23_T125_P0.6120.92
299_E344_R0.6110.92
256_R259_K0.6080.92
100_V104_V0.6060.92
294_H330_S0.6060.92
213_D403_W0.6040.91
167_N174_Q0.6040.91
309_M351_L0.6030.91
168_A172_A0.6030.91
135_I182_L0.5990.91
49_V149_I0.5980.91
4_I25_L0.5970.91
256_R296_G0.5970.91
24_L27_S0.5960.91
83_A86_L0.5950.91
201_V205_N0.5930.91
213_D216_I0.5900.91
65_N69_K0.5890.90
162_L202_D0.5870.90
165_I203_V0.5870.90
316_R356_A0.5860.90
409_T417_R0.5860.90
188_A225_Q0.5850.90
200_L204_V0.5840.90
253_G267_V0.5830.90
210_I214_F0.5820.90
394_R397_N0.5810.90
65_N89_A0.5800.90
59_Q62_K0.5780.90
406_V409_T0.5780.90
283_F387_N0.5770.90
359_I389_I0.5760.89
231_D273_L0.5740.89
321_M341_K0.5730.89
397_N402_K0.5720.89
20_V24_L0.5720.89
214_F240_P0.5720.89
356_A413_F0.5690.89
322_Y330_S0.5680.89
173_I241_K0.5660.89
199_S230_M0.5660.89
173_I177_A0.5660.89
370_V418_G0.5640.88
393_I404_Y0.5630.88
290_I305_T0.5630.88
194_L198_I0.5620.88
235_E276_E0.5620.88
86_L95_I0.5610.88
382_I390_P0.5610.88
89_A92_A0.5610.88
361_L410_E0.5600.88
52_E56_R0.5600.88
85_V88_I0.5590.88
256_R298_D0.5590.88
256_R300_E0.5570.88
360_H411_A0.5570.88
380_S417_R0.5560.88
319_L348_A0.5550.88
247_H289_D0.5550.88
162_L203_V0.5550.88
285_N386_M0.5550.88
186_D200_L0.5530.88
64_L71_L0.5490.87
26_K29_G0.5490.87
302_F309_M0.5480.87
342_K345_I0.5480.87
407_K418_G0.5460.87
44_L57_M0.5460.87
364_V367_T0.5430.87
62_K89_A0.5420.86
7_E64_L0.5420.86
33_V36_P0.5420.86
30_Y111_E0.5420.86
184_G187_T0.5410.86
196_G199_S0.5400.86
46_T61_I0.5390.86
35_N64_L0.5390.86
381_V400_L0.5390.86
193_D197_S0.5390.86
5_Y34_E0.5390.86
129_D177_A0.5370.86
364_V408_I0.5370.86
322_Y333_M0.5370.86
143_G224_E0.5360.86
135_I160_Y0.5360.86
375_L395_S0.5360.86
292_V321_M0.5350.86
197_S202_D0.5340.86
98_Q158_R0.5340.86
340_I344_R0.5330.86
54_E80_A0.5330.86
147_F262_N0.5310.85
142_A157_L0.5300.85
319_L352_Y0.5290.85
131_K371_I0.5280.85
324_I328_T0.5270.85
236_A239_N0.5270.85
143_G153_A0.5260.85
343_K346_Q0.5250.85
5_Y35_N0.5240.85
63_E67_L0.5240.85
182_L207_V0.5230.84
309_M313_R0.5230.84
207_V213_D0.5230.84
88_I91_N0.5230.84
204_V207_V0.5220.84
221_M246_I0.5220.84
213_D369_R0.5210.84
7_E44_L0.5210.84
220_M245_F0.5210.84
178_R371_I0.5190.84
379_G394_R0.5170.84
373_T383_G0.5170.84
356_A411_A0.5150.84
386_M403_W0.5140.83
127_T175_S0.5140.83
349_N353_E0.5120.83
398_V404_Y0.5110.83
142_A189_A0.5110.83
232_D236_A0.5100.83
360_H416_L0.5100.83
8_T14_N0.5090.83
50_R320_A0.5090.83
189_A249_P0.5090.83
375_L400_L0.5060.83
389_I416_L0.5060.83
383_G404_Y0.5060.83
80_A326_P0.5050.82
104_V108_K0.5050.82
383_G393_I0.5040.82
143_G225_Q0.5040.82
215_M369_R0.5040.82
316_R388_Y0.5030.82
54_E84_T0.5030.82
73_V85_V0.5030.82
149_I327_N0.5030.82
15_R19_Y0.5030.82
381_V399_E0.5020.82
4_I18_T0.5010.82
181_E219_G0.5010.82
337_P341_K0.5010.82
146_S224_E0.5000.82
257_V295_P0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jc0A 1 0.9691 100 0.328 Contact Map
2qgqA 1 0.6318 100 0.537 Contact Map
1oltA 1 0.7482 100 0.762 Contact Map
4u0oB 1 0.6247 99.9 0.799 Contact Map
3iixA 1 0.7458 99.9 0.819 Contact Map
4wcxA 1 0.7957 99.9 0.819 Contact Map
3t7vA 1 0.7506 99.9 0.828 Contact Map
1r30A 2 0.7031 99.9 0.829 Contact Map
2yx0A 1 0.6888 99.9 0.829 Contact Map
4rtbA 2 0.8029 99.9 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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