GREMLIN Database
IF2B - Translation initiation factor 2 subunit beta
UniProt: Q97W59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (124)
Sequences: 618 (370)
Seq/√Len: 33.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_I99_F5.2021.00
64_Y98_R4.9711.00
27_T112_L4.5411.00
38_I80_E3.2161.00
47_F62_M3.2121.00
47_F61_C3.0331.00
115_I128_L2.7731.00
116_L125_I2.6791.00
66_L73_G2.4240.99
31_P53_R2.1260.99
33_M93_N1.9270.97
55_R128_L1.8700.97
31_P49_E1.8620.97
36_L43_I1.7260.95
105_E112_L1.7160.95
56_R114_T1.7150.95
94_T103_Y1.6980.94
44_I50_Y1.6890.94
43_I80_E1.6050.93
56_R104_V1.5910.92
70_A103_Y1.5500.91
54_I100_L1.5490.91
21_K64_Y1.5070.90
126_V133_Q1.4940.90
125_I136_V1.4780.89
107_S134_T1.4360.88
118_K121_K1.4030.86
77_D122_S1.3890.86
101_K110_K1.3830.85
32_N97_E1.3270.83
72_P84_Q1.3060.82
116_L136_V1.3030.82
28_Q112_L1.2550.79
51_C83_I1.2520.79
47_F75_V1.2360.78
67_K71_A1.1840.75
33_M50_Y1.1820.75
20_E52_D1.1810.75
110_K126_V1.1790.75
101_K125_I1.1550.73
104_V116_L1.1510.73
122_S132_A1.1480.73
50_Y55_R1.1450.73
127_C130_C1.1390.72
18_L21_K1.1350.72
48_A92_I1.1240.71
64_Y90_Q1.1190.71
100_L105_E1.1050.70
91_V94_T1.1020.70
75_V83_I1.0960.69
52_D117_K1.0870.69
23_R26_G1.0520.66
33_M99_F1.0420.65
108_T121_K1.0420.65
25_E111_S1.0170.63
94_T98_R1.0030.62
36_L84_Q0.9990.62
36_L45_R0.9980.62
65_L92_I0.9720.60
78_K116_L0.9700.60
55_R115_I0.9620.59
27_T113_D0.9530.58
60_I71_A0.9480.58
81_L111_S0.9350.57
116_L135_P0.9300.56
34_I45_R0.9230.56
119_E133_Q0.9200.56
31_P129_A0.9200.56
97_E105_E0.9190.56
77_D101_K0.9140.55
63_K84_Q0.9040.54
115_I126_V0.8950.54
21_K58_D0.8900.53
88_S121_K0.8800.52
61_C104_V0.8780.52
35_I92_I0.8760.52
35_I89_S0.8750.52
22_G33_M0.8710.52
51_C62_M0.8590.51
74_N83_I0.8420.49
31_P131_G0.8400.49
47_F107_S0.8340.48
27_T131_G0.8330.48
72_P129_A0.8310.48
83_I107_S0.8250.48
70_A82_V0.8240.48
112_L131_G0.8190.47
49_E93_N0.8110.47
66_L83_I0.8090.46
47_F103_Y0.7890.45
28_Q54_I0.7880.45
28_Q100_L0.7850.44
44_I103_Y0.7710.43
85_G106_C0.7710.43
94_T121_K0.7670.43
47_F118_K0.7650.43
40_N133_Q0.7640.43
121_K134_T0.7590.42
51_C61_C0.7480.41
15_Y22_G0.7480.41
16_S21_K0.7460.41
120_K124_Y0.7440.41
40_N43_I0.7410.41
97_E101_K0.7410.41
86_K121_K0.7400.41
121_K132_A0.7370.40
122_S135_P0.7310.40
74_N81_L0.7070.38
76_D93_N0.6990.37
50_Y75_V0.6960.37
44_I135_P0.6950.37
40_N116_L0.6910.37
125_I135_P0.6870.36
51_C84_Q0.6840.36
81_L103_Y0.6830.36
70_A80_E0.6820.36
71_A85_G0.6820.36
17_K29_S0.6810.36
83_I92_I0.6810.36
24_K76_D0.6740.35
132_A135_P0.6710.35
73_G118_K0.6710.35
23_R29_S0.6680.35
23_R28_Q0.6620.35
44_I67_K0.6610.35
22_G103_Y0.6580.34
54_I96_M0.6470.33
33_M135_P0.6470.33
19_P131_G0.6430.33
38_I108_T0.6400.33
76_D82_V0.6360.33
29_S100_L0.6310.32
76_D80_E0.6280.32
121_K124_Y0.6250.32
67_K132_A0.6190.31
112_L129_A0.6160.31
66_L84_Q0.6140.31
26_G113_D0.6110.31
59_K75_V0.6050.30
14_L31_P0.6020.30
76_D116_L0.6010.30
81_L99_F0.5980.30
64_Y99_F0.5970.30
63_K129_A0.5960.30
79_G110_K0.5940.30
69_L90_Q0.5930.30
68_E95_L0.5900.29
17_K137_K0.5890.29
47_F66_L0.5870.29
77_D136_V0.5860.29
59_K134_T0.5820.29
103_Y122_S0.5810.29
53_R66_L0.5790.29
38_I43_I0.5760.28
44_I102_A0.5720.28
90_Q122_S0.5710.28
44_I65_L0.5690.28
110_K120_K0.5650.28
93_N110_K0.5650.28
82_V86_K0.5630.28
65_L87_F0.5610.27
42_T79_G0.5570.27
39_G112_L0.5550.27
17_K23_R0.5530.27
80_E99_F0.5490.27
63_K75_V0.5470.26
89_S93_N0.5430.26
36_L119_E0.5420.26
78_K101_K0.5420.26
57_E82_V0.5380.26
19_P129_A0.5360.26
65_L105_E0.5350.26
63_K117_K0.5340.26
35_I69_L0.5300.25
34_I74_N0.5270.25
38_I70_A0.5180.25
37_N65_L0.5170.25
30_L79_G0.5110.24
51_C54_I0.5100.24
39_G71_A0.5080.24
30_L97_E0.5040.24
30_L64_Y0.5030.24
32_N93_N0.5010.24
107_S132_A0.5010.24
55_R126_V0.5010.24
37_N86_K0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cw2K 1 0.9928 100 0.035 Contact Map
2d74B 1 0.9712 100 0.062 Contact Map
3j81l 1 0.1223 100 0.075 Contact Map
1neeA 1 0.9712 100 0.082 Contact Map
2g2kA 1 0.9137 100 0.195 Contact Map
2e9hA 1 0.964 100 0.202 Contact Map
1k8bA 1 0.3741 99.7 0.639 Contact Map
1k81A 1 0.259 99.2 0.744 Contact Map
4bpeF 1 0.5755 79.1 0.912 Contact Map
2js4A 1 0.295 75.8 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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