GREMLIN Database
Q97W57 - Uncharacterized protein
UniProt: Q97W57 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (226)
Sequences: 489 (325)
Seq/√Len: 21.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_F204_L6.3251.00
149_A201_A4.9861.00
11_L31_S4.1971.00
9_C12_C3.5951.00
222_N232_A3.5771.00
111_E122_S2.9790.99
220_Y230_R2.7090.99
9_C13_G2.6160.98
44_K134_E2.4620.98
202_R218_E2.4620.98
137_D141_R2.1200.94
93_F97_S2.1130.94
24_C27_C2.0940.94
98_I101_D2.0260.93
219_S237_S2.0080.93
26_D218_E1.9900.92
88_V112_F1.9690.92
155_S164_K1.9510.91
6_G15_Q1.9360.91
137_D206_S1.8870.90
140_F143_K1.8500.89
38_P82_M1.8280.88
52_Q193_Y1.8100.88
92_A111_E1.7950.88
35_I114_G1.7940.88
23_L153_L1.7800.87
191_V204_L1.7540.86
184_V234_L1.7500.86
188_R206_S1.7200.85
237_S240_I1.6840.84
40_R128_S1.6770.84
43_G106_S1.6510.83
77_E198_K1.6500.83
157_G161_V1.6450.82
198_K234_L1.6380.82
12_C24_C1.6230.82
140_F145_R1.5750.80
148_E223_E1.5550.79
146_Y182_S1.5540.79
141_R238_L1.5390.78
81_K148_E1.5060.76
45_Y221_Q1.4940.76
6_G17_V1.4710.75
23_L31_S1.4510.74
128_S237_S1.4310.72
99_W102_P1.4270.72
215_E239_R1.4220.72
19_L22_S1.4160.72
73_I101_D1.4120.71
191_V195_F1.4090.71
208_I212_V1.4050.71
41_V129_L1.4040.71
138_S233_K1.3980.71
46_C49_C1.3960.71
82_M106_S1.3890.70
219_S223_E1.3840.70
6_G96_K1.3720.69
25_V39_K1.3660.69
47_K133_R1.3640.69
197_S234_L1.3430.68
9_C24_C1.3340.67
194_Y208_I1.3320.67
34_L88_V1.3260.66
195_F234_L1.3090.65
141_R146_Y1.2840.64
209_S216_V1.2550.62
153_L205_V1.2340.61
183_D221_Q1.2340.61
99_W169_F1.2320.61
197_S200_V1.2290.60
47_K227_N1.2280.60
57_K181_I1.2200.60
148_E197_S1.2200.60
12_C27_C1.2160.60
18_D22_S1.2130.59
152_Q192_D1.2130.59
45_Y191_V1.2040.59
180_N228_G1.2040.59
78_L108_A1.2020.59
141_R182_S1.1990.58
51_A92_A1.1990.58
60_R188_R1.1980.58
95_I168_F1.1940.58
50_G62_S1.1820.57
45_Y133_R1.1710.57
179_D183_D1.1680.56
179_D196_M1.1590.56
60_R183_D1.1520.55
24_C49_C1.1510.55
10_V23_L1.1390.55
161_V212_V1.1320.54
142_K145_R1.1290.54
43_G97_S1.1200.53
136_C139_C1.1180.53
141_R232_A1.1150.53
138_S201_A1.1080.52
76_R238_L1.1010.52
15_Q28_Y1.1000.52
220_Y231_E1.0950.52
42_T132_E1.0940.51
74_I108_A1.0830.51
220_Y232_A1.0820.51
27_C49_C1.0760.50
90_E235_V1.0730.50
180_N197_S1.0710.50
96_K131_M1.0660.50
135_L189_E1.0620.49
181_I214_V1.0560.49
158_K179_D1.0550.49
24_C46_C1.0550.49
141_R235_V1.0540.49
25_V119_K1.0500.49
180_N196_M1.0500.49
135_L140_F1.0460.48
48_I181_I1.0390.48
225_M230_R1.0220.47
13_G24_C1.0090.46
23_L57_K1.0040.45
188_R204_L0.9980.45
186_E237_S0.9850.44
27_C46_C0.9850.44
150_I218_E0.9780.44
110_I174_S0.9740.43
141_R149_A0.9710.43
88_V175_T0.9630.43
154_R192_D0.9630.43
183_D196_M0.9620.43
9_C27_C0.9440.41
218_E231_E0.9400.41
199_S219_S0.9300.41
89_D199_S0.9270.40
135_L202_R0.9260.40
37_T125_A0.9210.40
105_N110_I0.9200.40
23_L28_Y0.9160.40
7_K22_S0.9150.40
35_I119_K0.9090.39
38_P124_E0.9060.39
51_A193_Y0.8980.39
136_C154_R0.8950.38
139_C154_R0.8950.38
52_Q94_D0.8890.38
161_V186_E0.8880.38
17_V31_S0.8840.38
91_F223_E0.8830.38
51_A94_D0.8810.37
40_R145_R0.8770.37
43_G148_E0.8700.37
16_N19_L0.8670.37
101_D169_F0.8670.37
39_K80_S0.8650.36
49_C139_C0.8620.36
49_C136_C0.8620.36
106_S238_L0.8570.36
11_L23_L0.8560.36
26_D111_E0.8560.36
141_R202_R0.8510.36
17_V197_S0.8480.35
180_N238_L0.8470.35
11_L57_K0.8460.35
220_Y234_L0.8440.35
137_D201_A0.8420.35
51_A183_D0.8320.34
188_R228_G0.8310.34
188_R225_M0.8290.34
121_F153_L0.8250.34
28_Y150_I0.8240.34
15_Q89_D0.8220.34
88_V240_I0.8210.34
25_V110_I0.8160.33
83_R123_Q0.8040.33
53_W232_A0.7990.32
158_K240_I0.7980.32
201_A233_K0.7910.32
118_G179_D0.7860.32
47_K210_S0.7850.32
140_F179_D0.7800.31
44_K133_R0.7800.31
182_S196_M0.7790.31
46_C139_C0.7780.31
46_C136_C0.7780.31
144_T215_E0.7730.31
64_T101_D0.7680.31
198_K202_R0.7650.30
135_L188_R0.7650.30
19_L25_V0.7620.30
18_D89_D0.7550.30
36_E200_V0.7480.29
30_K84_I0.7460.29
137_D227_N0.7460.29
65_S78_L0.7440.29
99_W106_S0.7440.29
45_Y50_G0.7410.29
62_S227_N0.7390.29
146_Y200_V0.7360.29
78_L97_S0.7360.29
93_F107_F0.7360.29
8_F15_Q0.7350.29
64_T100_K0.7340.29
113_R122_S0.7330.29
36_E83_R0.7320.29
48_I240_I0.7310.29
72_D224_K0.7310.29
132_E187_G0.7280.28
12_C49_C0.7270.28
112_F191_V0.7260.28
98_I102_P0.7200.28
41_V225_M0.7170.28
105_N169_F0.7140.28
36_E114_G0.7140.28
146_Y199_S0.7070.27
183_D194_Y0.7040.27
64_T102_P0.7030.27
28_Y47_K0.7010.27
10_V134_E0.6970.27
18_D52_Q0.6970.27
24_C136_C0.6960.27
24_C139_C0.6960.27
28_Y122_S0.6950.27
93_F105_N0.6950.27
60_R234_L0.6940.27
113_R120_S0.6900.26
31_S176_S0.6870.26
73_I165_K0.6850.26
25_V141_R0.6840.26
11_L153_L0.6840.26
23_L54_I0.6830.26
153_L183_D0.6820.26
217_N237_S0.6820.26
26_D29_V0.6810.26
143_K202_R0.6790.26
42_T56_G0.6790.26
90_E174_S0.6790.26
126_V188_R0.6750.26
198_K217_N0.6730.25
224_K227_N0.6730.25
137_D188_R0.6720.25
60_R209_S0.6680.25
28_Y120_S0.6680.25
97_S101_D0.6670.25
77_E134_E0.6630.25
85_D212_V0.6600.25
10_V137_D0.6590.25
116_V122_S0.6590.25
55_R121_F0.6590.25
91_F122_S0.6550.25
202_R220_Y0.6520.24
36_E50_G0.6510.24
18_D94_D0.6500.24
43_G151_V0.6470.24
88_V127_I0.6460.24
79_G193_Y0.6450.24
194_Y232_A0.6440.24
113_R161_V0.6410.24
13_G27_C0.6400.24
137_D209_S0.6380.24
49_C154_R0.6370.24
133_R143_K0.6360.24
59_I112_F0.6330.23
137_D153_L0.6320.23
150_I183_D0.6300.23
12_C46_C0.6250.23
149_A216_V0.6240.23
102_P169_F0.6240.23
203_K238_L0.6220.23
40_R130_E0.6190.23
44_K132_E0.6180.23
17_V202_R0.6160.23
79_G106_S0.6160.23
141_R144_T0.6140.23
52_Q146_Y0.6060.22
114_G189_E0.6050.22
194_Y239_R0.6040.22
152_Q190_G0.6030.22
7_K16_N0.6030.22
6_G21_D0.6000.22
220_Y228_G0.6000.22
39_K114_G0.5960.22
118_G129_L0.5960.22
90_E93_F0.5900.21
147_Y193_Y0.5890.21
64_T79_G0.5870.21
25_V29_V0.5830.21
221_Q237_S0.5810.21
33_K61_T0.5780.21
118_G145_R0.5780.21
92_A174_S0.5780.21
184_V236_I0.5780.21
155_S158_K0.5760.21
98_I173_F0.5720.21
161_V221_Q0.5720.21
189_E210_S0.5720.21
51_A80_S0.5690.21
38_P117_R0.5690.21
140_F188_R0.5660.20
43_G128_S0.5640.20
120_S208_I0.5630.20
144_T239_R0.5590.20
27_C139_C0.5590.20
27_C136_C0.5590.20
91_F133_R0.5580.20
16_N44_K0.5530.20
63_A88_V0.5520.20
157_G221_Q0.5510.20
48_I144_T0.5510.20
46_C154_R0.5510.20
62_S117_R0.5490.20
96_K173_F0.5460.20
80_S168_F0.5420.19
135_L143_K0.5400.19
119_K188_R0.5380.19
195_F212_V0.5370.19
7_K10_V0.5360.19
176_S219_S0.5350.19
212_V240_I0.5350.19
217_N240_I0.5310.19
38_P214_V0.5310.19
73_I170_E0.5290.19
115_K120_S0.5260.19
81_K202_R0.5250.19
209_S218_E0.5240.19
38_P83_R0.5220.19
182_S191_V0.5200.18
143_K146_Y0.5160.18
31_S211_I0.5160.18
146_Y179_D0.5160.18
93_F162_D0.5150.18
96_K124_E0.5140.18
47_K177_I0.5130.18
60_R208_I0.5130.18
132_E205_V0.5110.18
215_E238_L0.5110.18
150_I236_I0.5080.18
94_D116_V0.5080.18
101_D105_N0.5070.18
50_G54_I0.5040.18
7_K48_I0.5040.18
156_K189_E0.5020.18
10_V22_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3na7A 1 0.2292 90.7 0.925 Contact Map
1vq8Z 1 0.2167 89.8 0.926 Contact Map
4iloA 3 0.2208 84.1 0.932 Contact Map
3cc2Z 1 0.2167 82.9 0.933 Contact Map
3ga8A 1 0.2792 79.6 0.935 Contact Map
3zf7o 1 0.2583 79.4 0.936 Contact Map
4ujrc 1 0.2583 78.1 0.936 Contact Map
4w20p 1 0.2583 77.2 0.937 Contact Map
4a17Y 1 0.3042 76 0.937 Contact Map
2fiyA 1 0.4 75.1 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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