Q97W55 - SULSO - GREMLIN Contacts

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Q97W55 - Uncharacterized protein

UniProt:	Q97W55	Sequences: MVTNLPAEAKAKWLKVMDAKTPEEKFQALQEFLKEVPKHKGTENLVYWAKRRMAELREEMEVRKSKKSGGFSLFVEKEGAGQAILIGDMLLRSFIMRKLTNVKQEFNELPVPGMVKYEDVQIQLVNPPKSLPLSKTIGLIRNADEVIIAINNKEDLSLIKSLLEDNNILLRKPKGRVVIERTRYGISGIRVVNLGKLIGIDEKVVRDYIESFGIKSAIVKIIGEVTLDDIEKSMFEAVSYKPTVVISKDRFDTGELPMLTIDQIDKLPKHLFDMLEVIRVYTKEPGEEPTKDPLILKKGSTVLDVARKLHSSLAENFRYARVWGKSVKFQGQKVGPSHILEDRDIVEIHVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	351 (265)
Sequences:	959 (643)
Seq/√Len:	39.5

ECOLI - YCHF
HALSA - Y1111
SULSO - Q97W55

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
158_L	162_L	4.499	1.00
304_D	314_A	4.210	1.00
326_S	329_F	4.169	1.00
118_E	121_Q	3.952	1.00
326_S	331_G	3.869	1.00
340_L	346_V	3.094	1.00
155_D	158_L	2.953	1.00
276_E	298_K	2.768	1.00
158_L	161_S	2.609	1.00
325_K	329_F	2.497	1.00
84_I	143_A	2.477	1.00
156_L	162_L	2.407	1.00
164_E	170_L	2.392	1.00
297_K	300_S	2.382	1.00
155_D	162_L	2.361	1.00
156_L	160_K	2.345	1.00
164_E	172_K	2.341	1.00
172_K	229_D	2.294	1.00
294_L	305_V	2.227	0.99
328_K	331_G	2.203	0.99
209_I	213_G	2.176	0.99
302_V	346_V	2.175	0.99
324_G	328_K	2.167	0.99
324_G	331_G	2.159	0.99
156_L	161_S	2.152	0.99
115_V	124_L	2.063	0.99
301_T	339_I	1.967	0.99
146_V	241_K	1.925	0.98
327_V	331_G	1.922	0.98
83_A	122_I	1.903	0.98
98_K	264_I	1.900	0.98
296_L	305_V	1.831	0.98
169_L	175_G	1.830	0.98
215_K	218_I	1.805	0.98
256_L	260_T	1.801	0.98
249_D	252_D	1.770	0.97
322_V	346_V	1.755	0.97
180_E	185_G	1.730	0.97
168_I	175_G	1.706	0.97
296_L	308_K	1.699	0.97
159_I	162_L	1.674	0.96
177_V	225_V	1.655	0.96
278_I	298_K	1.630	0.96
257_P	261_I	1.628	0.96
168_I	177_V	1.627	0.96
324_G	329_F	1.613	0.95
117_Y	269_K	1.597	0.95
124_L	264_I	1.579	0.95
226_T	229_D	1.566	0.95
81_G	122_I	1.556	0.94
164_E	169_L	1.549	0.94
189_I	192_V	1.534	0.94
169_L	172_K	1.521	0.94
230_I	234_M	1.514	0.94
307_R	314_A	1.506	0.93
225_V	229_D	1.504	0.93
203_K	206_R	1.480	0.93
296_L	300_S	1.480	0.93
106_F	134_S	1.471	0.93
323_W	331_G	1.456	0.92
270_H	274_M	1.432	0.92
171_R	174_K	1.428	0.91
106_F	131_L	1.406	0.91
325_K	331_G	1.403	0.91
129_K	134_S	1.388	0.90
287_E	312_S	1.382	0.90
253_T	257_P	1.380	0.90
257_P	262_D	1.376	0.90
327_V	330_Q	1.368	0.90
81_G	271_L	1.368	0.90
147_I	271_L	1.368	0.90
317_F	348_I	1.359	0.89
319_Y	323_W	1.351	0.89
171_R	175_G	1.350	0.89
193_N	196_K	1.332	0.88
326_S	338_H	1.330	0.88
298_K	341_E	1.329	0.88
322_V	340_L	1.328	0.88
162_L	165_D	1.319	0.88
326_S	330_Q	1.300	0.87
249_D	256_L	1.299	0.87
265_D	268_P	1.297	0.87
198_I	224_E	1.290	0.87
155_D	160_K	1.289	0.87
283_K	291_K	1.271	0.86
325_K	341_E	1.263	0.85
250_R	256_L	1.261	0.85
305_V	340_L	1.259	0.85
302_V	340_L	1.257	0.85
194_L	197_L	1.249	0.85
138_G	142_N	1.244	0.85
168_I	173_P	1.237	0.84
165_D	170_L	1.234	0.84
81_G	275_L	1.232	0.84
217_A	221_I	1.221	0.83
162_L	171_R	1.210	0.83
239_S	242_P	1.196	0.82
161_S	174_K	1.185	0.81
234_M	237_A	1.175	0.81
127_P	130_S	1.170	0.81
218_I	221_I	1.167	0.80
298_K	311_S	1.156	0.80
321_R	331_G	1.152	0.80
300_S	304_D	1.149	0.79
250_R	258_M	1.143	0.79
240_Y	247_S	1.137	0.79
242_P	247_S	1.136	0.79
167_N	185_G	1.124	0.78
205_V	209_I	1.119	0.78
319_Y	333_K	1.118	0.78
323_W	347_E	1.115	0.77
221_I	224_E	1.098	0.76
302_V	318_R	1.094	0.76
126_N	129_K	1.093	0.76
162_L	174_K	1.086	0.75
314_A	336_P	1.084	0.75
159_I	165_D	1.066	0.74
195_G	198_I	1.060	0.74
167_N	172_K	1.060	0.74
241_K	247_S	1.054	0.73
312_S	315_E	1.054	0.73
242_P	245_V	1.044	0.72
272_F	281_Y	1.042	0.72
249_D	254_G	1.030	0.71
188_G	197_L	1.024	0.71
155_D	161_S	1.015	0.70
83_A	145_E	1.008	0.70
82_Q	347_E	1.004	0.69
209_I	212_F	0.999	0.69
179_I	182_T	0.999	0.69
93_S	108_E	0.994	0.69
95_I	267_L	0.993	0.69
322_V	333_K	0.989	0.68
84_I	336_P	0.981	0.68
191_V	205_V	0.979	0.68
89_M	93_S	0.976	0.67
95_I	149_A	0.974	0.67
172_K	175_G	0.970	0.67
321_R	347_E	0.961	0.66
162_L	167_N	0.958	0.66
80_A	96_M	0.956	0.66
95_I	99_L	0.947	0.65
239_S	243_T	0.946	0.65
214_I	217_A	0.944	0.65
160_K	163_L	0.938	0.64
234_M	240_Y	0.935	0.64
253_T	256_L	0.932	0.64
243_T	246_I	0.927	0.63
252_D	257_P	0.927	0.63
115_V	268_P	0.921	0.63
305_V	346_V	0.920	0.63
279_R	293_P	0.915	0.62
210_E	213_G	0.911	0.62
237_A	248_K	0.909	0.62
169_L	173_P	0.909	0.62
179_I	185_G	0.907	0.62
304_D	307_R	0.905	0.61
122_I	271_L	0.905	0.61
117_Y	268_P	0.905	0.61
168_I	171_R	0.902	0.61
303_L	314_A	0.901	0.61
167_N	175_G	0.900	0.61
273_D	298_K	0.897	0.61
240_Y	244_V	0.897	0.61
303_L	307_R	0.897	0.61
171_R	182_T	0.896	0.61
162_L	169_L	0.895	0.60
106_F	133_L	0.894	0.60
174_K	182_T	0.888	0.60
249_D	253_T	0.887	0.60
168_I	172_K	0.887	0.60
158_L	163_L	0.883	0.59
206_R	210_E	0.879	0.59
240_Y	246_I	0.872	0.58
188_G	198_I	0.871	0.58
278_I	296_L	0.865	0.58
240_Y	243_T	0.863	0.58
231_E	235_F	0.863	0.58
278_I	301_T	0.862	0.58
97_R	252_D	0.860	0.57
242_P	246_I	0.852	0.57
218_I	222_I	0.850	0.56
141_R	239_S	0.847	0.56
294_L	336_P	0.845	0.56
170_L	185_G	0.845	0.56
131_L	134_S	0.845	0.56
97_R	313_L	0.840	0.56
213_G	217_A	0.837	0.55
252_D	260_T	0.835	0.55
240_Y	245_V	0.834	0.55
215_K	221_I	0.817	0.54
189_I	194_L	0.809	0.53
329_F	332_Q	0.807	0.53
270_H	273_D	0.799	0.52
129_K	133_L	0.795	0.52
238_V	247_S	0.793	0.51
83_A	107_N	0.793	0.51
249_D	257_P	0.791	0.51
255_E	260_T	0.788	0.51
149_A	294_L	0.784	0.51
171_R	177_V	0.783	0.50
214_I	219_V	0.780	0.50
83_A	271_L	0.777	0.50
90_L	93_S	0.776	0.50
189_I	198_I	0.775	0.50
190_R	196_K	0.775	0.50
122_I	278_I	0.772	0.49
240_Y	248_K	0.772	0.49
165_D	171_R	0.770	0.49
135_K	142_N	0.766	0.49
313_L	316_N	0.763	0.49
331_G	347_E	0.762	0.49
311_S	326_S	0.760	0.48
321_R	333_K	0.759	0.48
241_K	245_V	0.759	0.48
213_G	216_S	0.758	0.48
201_D	215_K	0.755	0.48
216_S	219_V	0.753	0.48
90_L	134_S	0.753	0.48
228_D	232_K	0.750	0.47
101_N	137_I	0.742	0.47
214_I	221_I	0.741	0.47
244_V	257_P	0.740	0.47
106_F	109_L	0.739	0.46
250_R	262_D	0.737	0.46
100_T	342_D	0.735	0.46
89_M	108_E	0.735	0.46
158_L	165_D	0.735	0.46
231_E	234_M	0.734	0.46
113_G	263_Q	0.731	0.46
156_L	171_R	0.729	0.46
280_V	285_P	0.725	0.45
98_K	115_V	0.723	0.45
307_R	315_E	0.721	0.45
94_F	142_N	0.715	0.44
166_N	169_L	0.713	0.44
254_G	259_L	0.710	0.44
170_L	174_K	0.710	0.44
281_Y	343_R	0.709	0.44
324_G	327_V	0.708	0.44
181_R	185_G	0.706	0.43
208_Y	227_L	0.706	0.43
229_D	232_K	0.705	0.43
251_F	254_G	0.702	0.43
89_M	284_E	0.701	0.43
246_I	251_F	0.701	0.43
325_K	328_K	0.701	0.43
294_L	318_R	0.700	0.43
165_D	168_I	0.699	0.43
209_I	219_V	0.696	0.43
284_E	292_D	0.695	0.42
228_D	235_F	0.692	0.42
284_E	287_E	0.691	0.42
188_G	191_V	0.688	0.42
248_K	259_L	0.683	0.41
234_M	246_I	0.682	0.41
254_G	258_M	0.681	0.41
258_M	262_D	0.680	0.41
84_I	284_E	0.679	0.41
182_T	185_G	0.679	0.41
232_K	238_V	0.679	0.41
84_I	305_V	0.673	0.41
329_F	333_K	0.672	0.40
251_F	256_L	0.671	0.40
250_R	254_G	0.671	0.40
313_L	348_I	0.669	0.40
239_S	245_V	0.669	0.40
134_S	137_I	0.669	0.40
93_S	109_L	0.668	0.40
150_I	223_G	0.668	0.40
82_Q	107_N	0.668	0.40
221_I	225_V	0.662	0.40
188_G	192_V	0.659	0.39
174_K	183_R	0.656	0.39
241_K	244_V	0.655	0.39
253_T	261_I	0.654	0.39
214_I	218_I	0.654	0.39
161_S	165_D	0.652	0.39
256_L	261_I	0.651	0.39
145_E	293_P	0.646	0.38
115_V	264_I	0.638	0.37
172_K	177_V	0.636	0.37
281_Y	347_E	0.636	0.37
296_L	304_D	0.634	0.37
303_L	336_P	0.633	0.37
245_V	248_K	0.633	0.37
86_I	219_V	0.632	0.37
225_V	230_I	0.632	0.37
89_M	128_P	0.631	0.37
159_I	163_L	0.631	0.37
189_I	196_K	0.631	0.37
278_I	315_E	0.629	0.37
299_G	330_Q	0.629	0.37
238_V	245_V	0.626	0.36
91_L	126_N	0.624	0.36
94_F	158_L	0.623	0.36
107_N	268_P	0.623	0.36
99_L	256_L	0.623	0.36
217_A	224_E	0.622	0.36
148_I	243_T	0.621	0.36
84_I	111_V	0.621	0.36
182_T	218_I	0.620	0.36
93_S	129_K	0.619	0.36
203_K	210_E	0.617	0.36
276_E	337_S	0.614	0.35
223_G	229_D	0.610	0.35
102_V	114_M	0.604	0.35
114_M	246_I	0.603	0.35
173_P	177_V	0.601	0.34
160_K	171_R	0.601	0.34
100_T	332_Q	0.600	0.34
177_V	185_G	0.599	0.34
185_G	188_G	0.598	0.34
302_V	307_R	0.597	0.34
191_V	194_L	0.596	0.34
160_K	178_V	0.593	0.34
86_I	336_P	0.590	0.33
188_G	205_V	0.588	0.33
94_F	113_G	0.587	0.33
217_A	223_G	0.585	0.33
193_N	198_I	0.583	0.33
105_E	137_I	0.581	0.33
175_G	179_I	0.580	0.33
335_G	342_D	0.577	0.32
233_S	237_A	0.577	0.32
198_I	212_F	0.577	0.32
251_F	258_M	0.573	0.32
215_K	222_I	0.572	0.32
217_A	227_L	0.571	0.32
202_E	205_V	0.570	0.32
140_I	153_K	0.570	0.32
234_M	247_S	0.570	0.32
156_L	166_N	0.567	0.32
156_L	165_D	0.566	0.32
137_I	141_R	0.565	0.31
158_L	195_G	0.561	0.31
178_V	218_I	0.560	0.31
167_N	177_V	0.559	0.31
213_G	221_I	0.559	0.31
200_I	204_V	0.557	0.31
231_E	236_E	0.556	0.31
93_S	106_F	0.555	0.31
249_D	255_E	0.554	0.31
297_K	308_K	0.552	0.30
280_V	318_R	0.551	0.30
147_I	242_P	0.551	0.30
176_R	179_I	0.550	0.30
312_S	316_N	0.550	0.30
238_V	241_K	0.546	0.30
124_L	340_L	0.545	0.30
252_D	256_L	0.544	0.30
241_K	246_I	0.543	0.30
209_I	234_M	0.540	0.30
86_I	140_I	0.540	0.30
335_G	344_D	0.537	0.29
169_L	177_V	0.537	0.29
278_I	300_S	0.536	0.29
207_D	213_G	0.536	0.29
88_D	94_F	0.535	0.29
164_E	182_T	0.534	0.29
228_D	234_M	0.532	0.29
189_I	197_L	0.531	0.29
287_E	293_P	0.531	0.29
178_V	181_R	0.529	0.29
268_P	340_L	0.528	0.29
82_Q	331_G	0.528	0.29
276_E	315_E	0.527	0.29
252_D	259_L	0.526	0.29
180_E	183_R	0.526	0.29
171_R	185_G	0.525	0.28
170_L	177_V	0.525	0.28
153_K	318_R	0.523	0.28
135_K	282_T	0.523	0.28
146_V	282_T	0.522	0.28
329_F	338_H	0.522	0.28
298_K	339_I	0.520	0.28
213_G	218_I	0.518	0.28
203_K	207_D	0.517	0.28
170_L	175_G	0.515	0.28
217_A	222_I	0.515	0.28
167_N	171_R	0.515	0.28
274_M	287_E	0.513	0.28
153_K	305_V	0.511	0.27
160_K	173_P	0.511	0.27
179_I	219_V	0.510	0.27
156_L	168_I	0.510	0.27
90_L	129_K	0.510	0.27
268_P	274_M	0.509	0.27
250_R	259_L	0.509	0.27
176_R	181_R	0.507	0.27
84_I	294_L	0.505	0.27
245_V	252_D	0.504	0.27
162_L	170_L	0.504	0.27
309_L	330_Q	0.504	0.27
254_G	260_T	0.503	0.27
215_K	220_K	0.503	0.27
297_K	304_D	0.500	0.27
180_E	184_Y	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4a9aA	1	0.9402	100	0.494	Contact Map
1jalA	1	0.7607	100	0.559	Contact Map
2dbyA	1	0.7635	100	0.563	Contact Map
1ni3A	1	0.7806	100	0.573	Contact Map
1wxqA	1	0.6952	100	0.586	Contact Map
2ohfA	1	0.7236	100	0.63	Contact Map
2ekiA	1	0.2422	100	0.767	Contact Map
3geeA	2	0.7094	99.7	0.84	Contact Map
3gehA	2	0.735	99.7	0.842	Contact Map
1xzpA	4	0.7664	99.7	0.844	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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