GREMLIN Database
Q97W55 - Uncharacterized protein
UniProt: Q97W55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 351 (265)
Sequences: 959 (643)
Seq/√Len: 39.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_L162_L4.4991.00
304_D314_A4.2101.00
326_S329_F4.1691.00
118_E121_Q3.9521.00
326_S331_G3.8691.00
340_L346_V3.0941.00
155_D158_L2.9531.00
276_E298_K2.7681.00
158_L161_S2.6091.00
325_K329_F2.4971.00
84_I143_A2.4771.00
156_L162_L2.4071.00
164_E170_L2.3921.00
297_K300_S2.3821.00
155_D162_L2.3611.00
156_L160_K2.3451.00
164_E172_K2.3411.00
172_K229_D2.2941.00
294_L305_V2.2270.99
328_K331_G2.2030.99
209_I213_G2.1760.99
302_V346_V2.1750.99
324_G328_K2.1670.99
324_G331_G2.1590.99
156_L161_S2.1520.99
115_V124_L2.0630.99
301_T339_I1.9670.99
146_V241_K1.9250.98
327_V331_G1.9220.98
83_A122_I1.9030.98
98_K264_I1.9000.98
296_L305_V1.8310.98
169_L175_G1.8300.98
215_K218_I1.8050.98
256_L260_T1.8010.98
249_D252_D1.7700.97
322_V346_V1.7550.97
180_E185_G1.7300.97
168_I175_G1.7060.97
296_L308_K1.6990.97
159_I162_L1.6740.96
177_V225_V1.6550.96
278_I298_K1.6300.96
257_P261_I1.6280.96
168_I177_V1.6270.96
324_G329_F1.6130.95
117_Y269_K1.5970.95
124_L264_I1.5790.95
226_T229_D1.5660.95
81_G122_I1.5560.94
164_E169_L1.5490.94
189_I192_V1.5340.94
169_L172_K1.5210.94
230_I234_M1.5140.94
307_R314_A1.5060.93
225_V229_D1.5040.93
203_K206_R1.4800.93
296_L300_S1.4800.93
106_F134_S1.4710.93
323_W331_G1.4560.92
270_H274_M1.4320.92
171_R174_K1.4280.91
106_F131_L1.4060.91
325_K331_G1.4030.91
129_K134_S1.3880.90
287_E312_S1.3820.90
253_T257_P1.3800.90
257_P262_D1.3760.90
327_V330_Q1.3680.90
81_G271_L1.3680.90
147_I271_L1.3680.90
317_F348_I1.3590.89
319_Y323_W1.3510.89
171_R175_G1.3500.89
193_N196_K1.3320.88
326_S338_H1.3300.88
298_K341_E1.3290.88
322_V340_L1.3280.88
162_L165_D1.3190.88
326_S330_Q1.3000.87
249_D256_L1.2990.87
265_D268_P1.2970.87
198_I224_E1.2900.87
155_D160_K1.2890.87
283_K291_K1.2710.86
325_K341_E1.2630.85
250_R256_L1.2610.85
305_V340_L1.2590.85
302_V340_L1.2570.85
194_L197_L1.2490.85
138_G142_N1.2440.85
168_I173_P1.2370.84
165_D170_L1.2340.84
81_G275_L1.2320.84
217_A221_I1.2210.83
162_L171_R1.2100.83
239_S242_P1.1960.82
161_S174_K1.1850.81
234_M237_A1.1750.81
127_P130_S1.1700.81
218_I221_I1.1670.80
298_K311_S1.1560.80
321_R331_G1.1520.80
300_S304_D1.1490.79
250_R258_M1.1430.79
240_Y247_S1.1370.79
242_P247_S1.1360.79
167_N185_G1.1240.78
205_V209_I1.1190.78
319_Y333_K1.1180.78
323_W347_E1.1150.77
221_I224_E1.0980.76
302_V318_R1.0940.76
126_N129_K1.0930.76
162_L174_K1.0860.75
314_A336_P1.0840.75
159_I165_D1.0660.74
195_G198_I1.0600.74
167_N172_K1.0600.74
241_K247_S1.0540.73
312_S315_E1.0540.73
242_P245_V1.0440.72
272_F281_Y1.0420.72
249_D254_G1.0300.71
188_G197_L1.0240.71
155_D161_S1.0150.70
83_A145_E1.0080.70
82_Q347_E1.0040.69
209_I212_F0.9990.69
179_I182_T0.9990.69
93_S108_E0.9940.69
95_I267_L0.9930.69
322_V333_K0.9890.68
84_I336_P0.9810.68
191_V205_V0.9790.68
89_M93_S0.9760.67
95_I149_A0.9740.67
172_K175_G0.9700.67
321_R347_E0.9610.66
162_L167_N0.9580.66
80_A96_M0.9560.66
95_I99_L0.9470.65
239_S243_T0.9460.65
214_I217_A0.9440.65
160_K163_L0.9380.64
234_M240_Y0.9350.64
253_T256_L0.9320.64
243_T246_I0.9270.63
252_D257_P0.9270.63
115_V268_P0.9210.63
305_V346_V0.9200.63
279_R293_P0.9150.62
210_E213_G0.9110.62
237_A248_K0.9090.62
169_L173_P0.9090.62
179_I185_G0.9070.62
304_D307_R0.9050.61
122_I271_L0.9050.61
117_Y268_P0.9050.61
168_I171_R0.9020.61
303_L314_A0.9010.61
167_N175_G0.9000.61
273_D298_K0.8970.61
240_Y244_V0.8970.61
303_L307_R0.8970.61
171_R182_T0.8960.61
162_L169_L0.8950.60
106_F133_L0.8940.60
174_K182_T0.8880.60
249_D253_T0.8870.60
168_I172_K0.8870.60
158_L163_L0.8830.59
206_R210_E0.8790.59
240_Y246_I0.8720.58
188_G198_I0.8710.58
278_I296_L0.8650.58
240_Y243_T0.8630.58
231_E235_F0.8630.58
278_I301_T0.8620.58
97_R252_D0.8600.57
242_P246_I0.8520.57
218_I222_I0.8500.56
141_R239_S0.8470.56
294_L336_P0.8450.56
170_L185_G0.8450.56
131_L134_S0.8450.56
97_R313_L0.8400.56
213_G217_A0.8370.55
252_D260_T0.8350.55
240_Y245_V0.8340.55
215_K221_I0.8170.54
189_I194_L0.8090.53
329_F332_Q0.8070.53
270_H273_D0.7990.52
129_K133_L0.7950.52
238_V247_S0.7930.51
83_A107_N0.7930.51
249_D257_P0.7910.51
255_E260_T0.7880.51
149_A294_L0.7840.51
171_R177_V0.7830.50
214_I219_V0.7800.50
83_A271_L0.7770.50
90_L93_S0.7760.50
189_I198_I0.7750.50
190_R196_K0.7750.50
122_I278_I0.7720.49
240_Y248_K0.7720.49
165_D171_R0.7700.49
135_K142_N0.7660.49
313_L316_N0.7630.49
331_G347_E0.7620.49
311_S326_S0.7600.48
321_R333_K0.7590.48
241_K245_V0.7590.48
213_G216_S0.7580.48
201_D215_K0.7550.48
216_S219_V0.7530.48
90_L134_S0.7530.48
228_D232_K0.7500.47
101_N137_I0.7420.47
214_I221_I0.7410.47
244_V257_P0.7400.47
106_F109_L0.7390.46
250_R262_D0.7370.46
100_T342_D0.7350.46
89_M108_E0.7350.46
158_L165_D0.7350.46
231_E234_M0.7340.46
113_G263_Q0.7310.46
156_L171_R0.7290.46
280_V285_P0.7250.45
98_K115_V0.7230.45
307_R315_E0.7210.45
94_F142_N0.7150.44
166_N169_L0.7130.44
254_G259_L0.7100.44
170_L174_K0.7100.44
281_Y343_R0.7090.44
324_G327_V0.7080.44
181_R185_G0.7060.43
208_Y227_L0.7060.43
229_D232_K0.7050.43
251_F254_G0.7020.43
89_M284_E0.7010.43
246_I251_F0.7010.43
325_K328_K0.7010.43
294_L318_R0.7000.43
165_D168_I0.6990.43
209_I219_V0.6960.43
284_E292_D0.6950.42
228_D235_F0.6920.42
284_E287_E0.6910.42
188_G191_V0.6880.42
248_K259_L0.6830.41
234_M246_I0.6820.41
254_G258_M0.6810.41
258_M262_D0.6800.41
84_I284_E0.6790.41
182_T185_G0.6790.41
232_K238_V0.6790.41
84_I305_V0.6730.41
329_F333_K0.6720.40
251_F256_L0.6710.40
250_R254_G0.6710.40
313_L348_I0.6690.40
239_S245_V0.6690.40
134_S137_I0.6690.40
93_S109_L0.6680.40
150_I223_G0.6680.40
82_Q107_N0.6680.40
221_I225_V0.6620.40
188_G192_V0.6590.39
174_K183_R0.6560.39
241_K244_V0.6550.39
253_T261_I0.6540.39
214_I218_I0.6540.39
161_S165_D0.6520.39
256_L261_I0.6510.39
145_E293_P0.6460.38
115_V264_I0.6380.37
172_K177_V0.6360.37
281_Y347_E0.6360.37
296_L304_D0.6340.37
303_L336_P0.6330.37
245_V248_K0.6330.37
86_I219_V0.6320.37
225_V230_I0.6320.37
89_M128_P0.6310.37
159_I163_L0.6310.37
189_I196_K0.6310.37
278_I315_E0.6290.37
299_G330_Q0.6290.37
238_V245_V0.6260.36
91_L126_N0.6240.36
94_F158_L0.6230.36
107_N268_P0.6230.36
99_L256_L0.6230.36
217_A224_E0.6220.36
148_I243_T0.6210.36
84_I111_V0.6210.36
182_T218_I0.6200.36
93_S129_K0.6190.36
203_K210_E0.6170.36
276_E337_S0.6140.35
223_G229_D0.6100.35
102_V114_M0.6040.35
114_M246_I0.6030.35
173_P177_V0.6010.34
160_K171_R0.6010.34
100_T332_Q0.6000.34
177_V185_G0.5990.34
185_G188_G0.5980.34
302_V307_R0.5970.34
191_V194_L0.5960.34
160_K178_V0.5930.34
86_I336_P0.5900.33
188_G205_V0.5880.33
94_F113_G0.5870.33
217_A223_G0.5850.33
193_N198_I0.5830.33
105_E137_I0.5810.33
175_G179_I0.5800.33
335_G342_D0.5770.32
233_S237_A0.5770.32
198_I212_F0.5770.32
251_F258_M0.5730.32
215_K222_I0.5720.32
217_A227_L0.5710.32
202_E205_V0.5700.32
140_I153_K0.5700.32
234_M247_S0.5700.32
156_L166_N0.5670.32
156_L165_D0.5660.32
137_I141_R0.5650.31
158_L195_G0.5610.31
178_V218_I0.5600.31
167_N177_V0.5590.31
213_G221_I0.5590.31
200_I204_V0.5570.31
231_E236_E0.5560.31
93_S106_F0.5550.31
249_D255_E0.5540.31
297_K308_K0.5520.30
280_V318_R0.5510.30
147_I242_P0.5510.30
176_R179_I0.5500.30
312_S316_N0.5500.30
238_V241_K0.5460.30
124_L340_L0.5450.30
252_D256_L0.5440.30
241_K246_I0.5430.30
209_I234_M0.5400.30
86_I140_I0.5400.30
335_G344_D0.5370.29
169_L177_V0.5370.29
278_I300_S0.5360.29
207_D213_G0.5360.29
88_D94_F0.5350.29
164_E182_T0.5340.29
228_D234_M0.5320.29
189_I197_L0.5310.29
287_E293_P0.5310.29
178_V181_R0.5290.29
268_P340_L0.5280.29
82_Q331_G0.5280.29
276_E315_E0.5270.29
252_D259_L0.5260.29
180_E183_R0.5260.29
171_R185_G0.5250.28
170_L177_V0.5250.28
153_K318_R0.5230.28
135_K282_T0.5230.28
146_V282_T0.5220.28
329_F338_H0.5220.28
298_K339_I0.5200.28
213_G218_I0.5180.28
203_K207_D0.5170.28
170_L175_G0.5150.28
217_A222_I0.5150.28
167_N171_R0.5150.28
274_M287_E0.5130.28
153_K305_V0.5110.27
160_K173_P0.5110.27
179_I219_V0.5100.27
156_L168_I0.5100.27
90_L129_K0.5100.27
268_P274_M0.5090.27
250_R259_L0.5090.27
176_R181_R0.5070.27
84_I294_L0.5050.27
245_V252_D0.5040.27
162_L170_L0.5040.27
309_L330_Q0.5040.27
254_G260_T0.5030.27
215_K220_K0.5030.27
297_K304_D0.5000.27
180_E184_Y0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a9aA 1 0.9402 100 0.494 Contact Map
1jalA 1 0.7607 100 0.559 Contact Map
2dbyA 1 0.7635 100 0.563 Contact Map
1ni3A 1 0.7806 100 0.573 Contact Map
1wxqA 1 0.6952 100 0.586 Contact Map
2ohfA 1 0.7236 100 0.63 Contact Map
2ekiA 1 0.2422 100 0.767 Contact Map
3geeA 2 0.7094 99.7 0.84 Contact Map
3gehA 2 0.735 99.7 0.842 Contact Map
1xzpA 4 0.7664 99.7 0.844 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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