GREMLIN Database
Q97W53 - Type II secretion system protein, virB homolog (GspE-3)
UniProt: Q97W53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (229)
Sequences: 241 (198)
Seq/√Len: 13.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_L211_N2.7910.95
212_I274_P2.7630.95
116_V258_G2.5980.93
165_Y250_S2.5500.92
270_F280_K2.3610.88
73_E205_Y2.2640.86
200_V212_I2.2370.85
242_L280_K2.2370.85
94_Y187_E2.2320.85
53_V59_V2.2110.85
73_E199_Y2.1980.84
248_S273_R2.1920.84
135_E168_L2.1770.84
194_L235_D2.0900.81
51_Y60_P2.0870.81
77_P178_T2.0570.80
140_R232_E2.0440.79
241_M247_K1.9880.78
174_Y178_T1.9850.77
94_Y202_H1.9710.77
187_E202_H1.9510.76
165_Y169_R1.9490.76
243_S267_A1.9010.74
267_A276_I1.8840.73
191_V279_I1.8640.73
59_V241_M1.8560.72
165_Y188_D1.8280.71
138_K215_T1.7990.70
189_I212_I1.7830.69
191_V281_I1.7680.68
105_I162_V1.6900.65
50_D180_L1.6560.63
206_E247_K1.6470.63
79_P188_D1.6290.62
257_D266_V1.5940.60
177_L237_L1.5680.59
188_D250_S1.5640.59
180_L212_I1.5640.59
169_R250_S1.5590.58
93_K208_I1.5570.58
77_P81_V1.5550.58
40_L208_I1.5390.57
190_S270_F1.5380.57
270_F275_K1.5350.57
82_F97_L1.5320.57
192_P279_I1.5290.57
188_D243_S1.5220.56
250_S273_R1.5170.56
142_G175_N1.5150.56
205_Y275_K1.5050.56
112_F140_R1.5040.56
247_K267_A1.5030.55
268_A280_K1.4950.55
190_S207_Y1.4920.55
173_G246_G1.4900.55
257_D267_A1.4790.54
251_V273_R1.4640.53
257_D269_T1.4630.53
98_E165_Y1.4540.53
207_Y267_A1.4430.52
245_T274_P1.4320.52
72_I85_F1.4180.51
190_S271_S1.4030.50
55_I58_L1.3970.50
98_E188_D1.3930.50
43_E46_T1.3820.49
238_V279_I1.3640.48
43_E47_I1.3590.48
181_V237_L1.3570.48
191_V238_V1.3540.48
133_I136_L1.3220.46
76_L262_N1.3160.46
51_Y56_L1.3060.45
95_V177_L1.3030.45
45_T48_V1.3010.45
257_D280_K1.2950.45
264_D267_A1.2880.44
239_L271_S1.2830.44
278_S283_L1.2820.44
120_L161_R1.2760.44
259_M271_S1.2650.43
176_V214_F1.2570.43
192_P207_Y1.2560.43
108_I159_N1.2510.42
159_N241_M1.2500.42
238_V249_I1.2480.42
99_P263_G1.2470.42
113_I170_N1.2280.41
190_S250_S1.2200.41
191_V234_L1.2130.40
244_T257_D1.1880.39
190_S281_I1.1850.39
130_A133_I1.1760.39
186_I200_V1.1740.38
99_P243_S1.1730.38
66_N155_V1.1720.38
259_M267_A1.1680.38
37_V41_P1.1580.38
165_Y190_S1.1550.38
57_N60_P1.1510.37
261_P282_N1.1450.37
249_I255_I1.1310.36
51_Y57_N1.1210.36
122_S280_K1.1150.36
201_Y243_S1.0950.35
208_I277_T1.0880.34
243_S271_S1.0870.34
193_G202_H1.0870.34
250_S259_M1.0860.34
243_S248_S1.0770.34
40_L50_D1.0740.34
99_P165_Y1.0720.34
193_G234_L1.0650.33
36_P39_P1.0640.33
76_L182_A1.0450.32
190_S241_M1.0410.32
120_L180_L1.0400.32
138_K149_K1.0210.31
205_Y245_T1.0180.31
74_L79_P1.0170.31
194_L255_I1.0150.31
173_G189_I1.0150.31
210_T246_G1.0140.31
181_V244_T1.0120.31
146_I259_M1.0090.31
136_L198_V1.0090.31
90_G256_Q1.0080.31
73_E212_I1.0000.30
182_A255_I0.9990.30
130_A189_I0.9940.30
53_V56_L0.9890.30
241_M246_G0.9890.30
99_P264_D0.9890.30
169_R188_D0.9890.30
240_R258_G0.9840.30
116_V163_T0.9830.30
239_L250_S0.9760.29
191_V273_R0.9710.29
39_P45_T0.9690.29
70_N87_E0.9610.29
206_E238_V0.9520.28
98_E169_R0.9480.28
110_N249_I0.9480.28
71_N201_Y0.9450.28
103_E130_A0.9330.27
166_Y169_R0.9280.27
76_L95_V0.9250.27
36_P41_P0.9240.27
182_A244_T0.9200.27
133_I212_I0.9070.26
62_D189_I0.9060.26
274_P282_N0.9030.26
57_N92_Y0.8980.26
39_P274_P0.8960.26
54_N97_L0.8950.26
94_Y99_P0.8920.26
243_S259_M0.8900.26
148_E153_I0.8900.26
252_A266_V0.8890.26
160_A252_A0.8870.26
51_Y259_M0.8840.25
39_P44_V0.8840.25
178_T243_S0.8830.25
182_A274_P0.8820.25
183_D254_P0.8770.25
183_D265_R0.8770.25
254_P265_R0.8770.25
211_N269_T0.8760.25
95_V215_T0.8750.25
199_Y242_L0.8740.25
180_L277_T0.8660.25
165_Y281_I0.8650.25
56_L60_P0.8650.25
74_L188_D0.8630.25
90_G148_E0.8620.25
249_I268_A0.8560.24
102_N130_A0.8550.24
252_A281_I0.8510.24
146_I194_L0.8420.24
172_F257_D0.8400.24
53_V58_L0.8330.23
191_V237_L0.8290.23
102_N105_I0.8280.23
98_E250_S0.8270.23
50_D104_M0.8270.23
198_V274_P0.8240.23
184_K277_T0.8230.23
113_I161_R0.8230.23
54_N100_P0.8210.23
77_P273_R0.8210.23
180_L251_V0.8170.23
96_L179_P0.8170.23
57_N159_N0.8130.23
195_N215_T0.8120.23
103_E133_I0.8100.23
180_L186_I0.8090.23
241_M255_I0.8040.22
247_K258_G0.7940.22
127_L144_K0.7900.22
147_Q155_V0.7900.22
47_I76_L0.7830.22
144_K232_E0.7810.22
79_P250_S0.7730.21
196_N277_T0.7720.21
129_L212_I0.7690.21
46_T50_D0.7650.21
54_N155_V0.7570.21
93_K115_E0.7550.21
123_K177_L0.7540.21
125_P174_Y0.7520.21
119_E163_T0.7500.20
96_L233_L0.7460.20
71_N82_F0.7440.20
67_L100_P0.7410.20
64_K203_R0.7390.20
79_P193_G0.7370.20
242_L269_T0.7360.20
86_D258_G0.7320.20
258_G283_L0.7280.20
51_Y189_I0.7270.20
104_M199_Y0.7260.20
75_I117_E0.7260.20
42_E46_T0.7260.20
248_S275_K0.7250.20
133_I205_Y0.7200.19
243_S270_F0.7170.19
88_R144_K0.7150.19
234_L281_I0.7110.19
255_I275_K0.7080.19
194_L200_V0.7070.19
176_V270_F0.7000.19
145_I175_N0.6980.19
146_I199_Y0.6980.19
95_V208_I0.6950.19
94_Y261_P0.6920.19
177_L261_P0.6910.19
77_P149_K0.6860.18
50_D60_P0.6790.18
66_N167_L0.6790.18
112_F214_F0.6750.18
161_R177_L0.6750.18
72_I140_R0.6750.18
63_I68_T0.6720.18
88_R147_Q0.6710.18
96_L236_Q0.6700.18
91_I113_I0.6680.18
67_L72_I0.6670.18
190_S267_A0.6640.18
252_A280_K0.6620.18
178_T251_V0.6620.18
81_V273_R0.6580.17
36_P156_L0.6550.17
128_D231_E0.6540.17
165_Y271_S0.6540.17
181_V200_V0.6530.17
255_I258_G0.6510.17
139_K168_L0.6500.17
67_L88_R0.6490.17
259_M270_F0.6490.17
249_I256_Q0.6480.17
159_N167_L0.6470.17
116_V235_D0.6450.17
63_I241_M0.6450.17
101_V107_N0.6410.17
250_S277_T0.6410.17
117_E176_V0.6380.17
75_I171_M0.6370.17
96_L130_A0.6360.17
165_Y270_F0.6340.17
185_N203_R0.6280.17
100_P177_L0.6280.17
239_L256_Q0.6260.17
79_P205_Y0.6170.16
173_G280_K0.6150.16
132_I153_I0.6120.16
188_D281_I0.6100.16
255_I276_I0.6100.16
141_S200_V0.6080.16
98_E273_R0.6080.16
259_M262_N0.6080.16
131_K141_S0.6040.16
179_P213_I0.6020.16
213_I233_L0.6000.16
105_I243_S0.5990.16
55_I235_D0.5980.16
199_Y255_I0.5980.16
146_I274_P0.5980.16
190_S247_K0.5910.16
248_S271_S0.5860.15
250_S271_S0.5830.15
116_V196_N0.5820.15
190_S239_L0.5820.15
148_E255_I0.5820.15
237_L250_S0.5810.15
72_I249_I0.5790.15
80_H83_I0.5790.15
173_G178_T0.5780.15
99_P271_S0.5770.15
243_S264_D0.5760.15
171_M243_S0.5760.15
254_P278_S0.5740.15
265_R278_S0.5740.15
183_D278_S0.5740.15
75_I82_F0.5730.15
111_I115_E0.5630.15
158_T164_L0.5620.15
192_P275_K0.5610.15
262_N267_A0.5600.15
52_E90_G0.5530.15
184_K249_I0.5530.15
136_L235_D0.5510.14
269_T280_K0.5470.14
41_P44_V0.5460.14
107_N111_I0.5460.14
108_I191_V0.5430.14
137_D178_T0.5420.14
45_T212_I0.5370.14
169_R190_S0.5370.14
42_E135_E0.5360.14
185_N269_T0.5350.14
86_D192_P0.5290.14
114_E155_V0.5280.14
44_V114_E0.5260.14
119_E267_A0.5260.14
101_V281_I0.5240.14
68_T213_I0.5240.14
110_N180_L0.5230.14
96_L144_K0.5230.14
111_I134_F0.5220.14
48_V172_F0.5220.14
92_Y198_V0.5190.14
62_D232_E0.5170.14
62_D198_V0.5140.14
99_P187_E0.5110.13
242_L282_N0.5100.13
120_L138_K0.5090.13
239_L243_S0.5040.13
75_I79_P0.5040.13
87_E114_E0.5030.13
60_P172_F0.5030.13
187_E261_P0.5010.13
139_K208_I0.5000.13
177_L200_V0.5000.13
44_V62_D0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oap1 3 0.7668 100 0.572 Contact Map
4ihqA 3 0.7703 100 0.586 Contact Map
2gzaA 3 0.3781 99.7 0.807 Contact Map
2pt7A 3 0.4276 97.7 0.912 Contact Map
2ewvA 3 0.3392 96.4 0.926 Contact Map
3jvvA 3 0.3286 94.9 0.934 Contact Map
4chmA 1 0.1802 25.9 0.966 Contact Map
1owfA 1 0.159 16.3 0.969 Contact Map
1lyqA 1 0.1378 15.4 0.97 Contact Map
2akkA 1 0.1095 15.1 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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