GREMLIN Database
Q97W52 - Glucosaminyltransferase, intercellular adhesion protein A homolog, putative (IcaA)
UniProt: Q97W52 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (369)
Sequences: 9184 (6788)
Seq/√Len: 353.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_D149_R4.6711.00
61_E91_T4.2981.00
209_R213_R4.0901.00
355_L358_S3.5651.00
51_D131_A3.2921.00
135_V206_G3.0601.00
53_I84_V3.0371.00
80_K107_V2.9761.00
85_S110_R2.9371.00
93_K97_E2.8941.00
91_T94_K2.8111.00
84_V125_A2.7661.00
211_I238_I2.6921.00
150_K245_D2.6501.00
214_K236_S2.6221.00
80_K131_A2.5901.00
94_K98_S2.4881.00
156_Y241_K2.4781.00
51_D80_K2.4431.00
146_D150_K2.3661.00
255_T258_D2.3451.00
153_Q243_V2.3441.00
133_M206_G2.2841.00
54_V71_L2.2541.00
358_S361_G2.1951.00
65_K98_S2.1801.00
50_I148_L2.1801.00
133_M154_L2.1141.00
364_Q368_K2.1091.00
85_S88_T2.0781.00
96_I108_I2.0771.00
171_Q174_K2.0751.00
300_Y303_Y2.0571.00
155_D239_K2.0441.00
75_D146_D2.0331.00
49_R130_D2.0151.00
296_Q299_I2.0081.00
357_A361_G1.9741.00
151_I206_G1.9251.00
51_D129_S1.8761.00
51_D82_I1.8671.00
49_R131_A1.8571.00
332_L335_N1.8511.00
154_L206_G1.8051.00
210_D214_K1.8001.00
157_D238_I1.8001.00
65_K69_N1.7751.00
286_R289_E1.7731.00
200_A205_F1.7721.00
49_R132_E1.7661.00
48_K76_Y1.7431.00
135_V148_L1.7351.00
333_V336_G1.7321.00
354_T358_S1.7171.00
262_Q266_W1.6781.00
286_R290_G1.6651.00
97_E110_R1.6401.00
17_T21_I1.6331.00
180_N188_F1.6201.00
49_R80_K1.6101.00
292_I296_Q1.6071.00
47_N77_R1.5821.00
133_M208_K1.5811.00
328_L332_L1.5791.00
96_I99_L1.5781.00
15_F18_S1.5721.00
58_D88_T1.5671.00
275_S278_M1.5581.00
211_I233_L1.5331.00
118_K122_L1.5281.00
336_G339_I1.5231.00
214_K238_I1.5231.00
332_L336_G1.5211.00
69_N99_L1.5211.00
289_E293_Y1.5011.00
276_Y279_R1.5011.00
301_P304_L1.4981.00
80_K130_D1.4951.00
65_K95_I1.4801.00
289_E296_Q1.4741.00
129_S209_R1.4541.00
126_T134_L1.4301.00
24_Q28_Y1.4251.00
125_A129_S1.4231.00
94_K97_E1.4171.00
21_I25_A1.4021.00
183_V188_F1.3771.00
327_S330_P1.3731.00
289_E292_I1.3721.00
185_N188_F1.3661.00
75_D145_K1.3651.00
158_A240_V1.3631.00
84_V121_A1.3531.00
83_I96_I1.3521.00
93_K96_I1.3461.00
178_Y181_E1.3421.00
329_I333_V1.3351.00
71_L81_V1.3281.00
176_Y179_T1.3271.00
180_N183_V1.3131.00
228_E232_R1.3071.00
330_P333_V1.3001.00
365_G368_K1.2971.00
180_N184_M1.2861.00
70_N143_V1.2721.00
52_I135_V1.2671.00
337_I340_A1.2591.00
141_A248_V1.2551.00
178_Y182_F1.2551.00
95_I98_S1.2521.00
44_K47_N1.2501.00
181_E188_F1.2371.00
295_Q299_I1.2311.00
109_I128_I1.2211.00
325_F329_I1.2171.00
97_E100_D1.2111.00
303_Y306_L1.2021.00
289_E295_Q1.1971.00
359_L362_Y1.1951.00
334_S337_I1.1941.00
293_Y299_I1.1941.00
9_L13_S1.1841.00
356_I360_I1.1841.00
134_L209_R1.1681.00
290_G299_I1.1671.00
157_D208_K1.1671.00
292_I295_Q1.1641.00
74_L148_L1.1551.00
95_I99_L1.1531.00
165_V252_A1.1491.00
218_W221_N1.1391.00
28_Y31_S1.1361.00
301_P305_L1.1351.00
184_M188_F1.1311.00
56_I64_I1.1311.00
91_T95_I1.1301.00
16_F20_W1.1241.00
18_S22_L1.1241.00
354_T357_A1.1211.00
14_S17_T1.1121.00
357_A360_I1.1111.00
294_S297_W1.1101.00
178_Y184_M1.1091.00
314_Q318_N1.1071.00
345_K349_K1.1031.00
313_I317_L1.1011.00
59_E139_A1.0981.00
66_E69_N1.0911.00
82_I107_V1.0871.00
79_Y148_L1.0851.00
73_G145_K1.0831.00
80_K129_S1.0821.00
85_S93_K1.0801.00
134_L212_L1.0801.00
93_K110_R1.0761.00
289_E299_I1.0741.00
294_S298_G1.0721.00
70_N142_R1.0701.00
328_L335_N1.0691.00
20_W24_Q1.0611.00
287_G290_G1.0611.00
58_D89_E1.0591.00
47_N149_R1.0561.00
131_A209_R1.0561.00
326_T330_P1.0521.00
11_F15_F1.0491.00
176_Y180_N1.0481.00
259_L263_I1.0481.00
331_I336_G1.0451.00
147_F204_A1.0441.00
178_Y188_F1.0431.00
14_S18_S1.0431.00
124_F128_I1.0421.00
13_S17_T1.0411.00
302_L305_L1.0351.00
323_Y327_S1.0321.00
323_Y326_T1.0221.00
181_E184_M1.0121.00
159_V243_V1.0121.00
89_E92_F1.0101.00
305_L309_I1.0091.00
324_V327_S1.0081.00
51_D209_R1.0081.00
311_I314_Q1.0031.00
350_S353_V0.9961.00
64_I83_I0.9941.00
112_P115_K0.9881.00
71_L143_V0.9871.00
111_R120_G0.9851.00
290_G296_Q0.9831.00
358_S362_Y0.9801.00
144_E249_Y0.9791.00
277_S280_L0.9791.00
67_L71_L0.9791.00
143_V147_F0.9781.00
137_L143_V0.9771.00
123_N127_N0.9731.00
313_I316_I0.9691.00
17_T24_Q0.9611.00
224_A269_G0.9611.00
185_N189_K0.9611.00
184_M187_L0.9591.00
177_S184_M0.9561.00
210_D213_R0.9561.00
179_T186_A0.9561.00
28_Y32_N0.9531.00
331_I334_S0.9531.00
124_F127_N0.9511.00
109_I124_F0.9501.00
163_L203_S0.9491.00
330_P334_S0.9481.00
292_I299_I0.9471.00
269_G272_E0.9471.00
113_E116_G0.9461.00
331_I335_N0.9411.00
318_N321_Y0.9411.00
64_I68_I0.9411.00
183_V187_L0.9381.00
286_R296_Q0.9371.00
322_F325_F0.9331.00
123_N126_T0.9321.00
303_Y307_F0.9311.00
355_L361_G0.9301.00
304_L307_F0.9291.00
61_E92_F0.9271.00
336_G340_A0.9271.00
178_Y185_N0.9271.00
315_F318_N0.9251.00
354_T360_I0.9211.00
325_F336_G0.9191.00
215_I233_L0.9171.00
32_N35_I0.9171.00
179_T184_M0.9151.00
157_D211_I0.9131.00
331_I338_Y0.9121.00
25_A29_K0.9121.00
122_L136_Y0.9111.00
177_S185_N0.9091.00
21_I24_Q0.9081.00
176_Y188_F0.9071.00
111_R124_F0.9061.00
176_Y183_V0.9061.00
290_G294_S0.9051.00
23_L31_S0.9021.00
259_L262_Q0.8981.00
43_D46_S0.8981.00
76_Y79_Y0.8971.00
179_T188_F0.8941.00
158_A200_A0.8911.00
96_I100_D0.8881.00
335_N338_Y0.8881.00
167_D170_T0.8881.00
86_D111_R0.8881.00
151_I161_F0.8861.00
68_I99_L0.8811.00
290_G293_Y0.8781.00
329_I332_L0.8771.00
179_T183_V0.8671.00
178_Y186_A0.8661.00
250_T253_P0.8651.00
182_F188_F0.8641.00
295_Q298_G0.8631.00
158_A233_L0.8611.00
12_I16_F0.8611.00
56_I92_F0.8611.00
204_A248_V0.8601.00
290_G298_G0.8591.00
157_D233_L0.8551.00
179_T182_F0.8551.00
11_F18_S0.8541.00
284_G289_E0.8531.00
52_I74_L0.8501.00
363_I367_F0.8491.00
105_N111_R0.8481.00
355_L360_I0.8461.00
182_F186_A0.8431.00
64_I92_F0.8421.00
17_T20_W0.8381.00
177_S180_N0.8381.00
122_L218_W0.8371.00
15_F19_L0.8361.00
151_I159_V0.8361.00
177_S181_E0.8351.00
326_T329_I0.8321.00
262_Q265_R0.8311.00
293_Y297_W0.8301.00
326_T333_V0.8301.00
344_P348_Y0.8291.00
176_Y184_M0.8281.00
92_F96_I0.8241.00
141_A250_T0.8241.00
328_L336_G0.8201.00
294_S299_I0.8191.00
309_I312_S0.8191.00
31_S34_N0.8191.00
69_N73_G0.8151.00
343_K347_D0.8071.00
21_I28_Y0.8041.00
18_S25_A0.8031.00
328_L333_V0.7991.00
52_I79_Y0.7961.00
20_W27_Y0.7911.00
312_S316_I0.7911.00
72_S103_P0.7871.00
332_L338_Y0.7861.00
14_S25_A0.7851.00
235_L279_R0.7851.00
291_F294_S0.7841.00
290_G297_W0.7821.00
18_S21_I0.7781.00
324_V330_P0.7761.00
333_V337_I0.7751.00
331_I339_I0.7741.00
93_K100_D0.7721.00
293_Y296_Q0.7721.00
119_A123_N0.7701.00
13_S20_W0.7691.00
90_E94_K0.7621.00
269_G273_L0.7591.00
109_I125_A0.7591.00
132_E210_D0.7571.00
90_E95_I0.7561.00
179_T187_L0.7541.00
292_I298_G0.7531.00
190_A194_L0.7521.00
343_K346_G0.7521.00
268_Y272_E0.7481.00
33_Q37_Q0.7481.00
99_L103_P0.7471.00
32_N36_I0.7461.00
181_E189_K0.7461.00
25_A28_Y0.7371.00
19_L23_L0.7361.00
300_Y304_L0.7361.00
160_A163_L0.7351.00
69_N102_L0.7351.00
333_V340_A0.7341.00
14_S21_I0.7331.00
311_I318_N0.7331.00
88_T92_F0.7321.00
208_K238_I0.7311.00
305_L308_L0.7301.00
176_Y181_E0.7301.00
325_F332_L0.7290.99
67_L137_L0.7290.99
52_I148_L0.7290.99
327_S331_I0.7240.99
82_I125_A0.7220.99
71_L137_L0.7210.99
289_E294_S0.7200.99
308_L311_I0.7190.99
182_F185_N0.7190.99
144_E247_T0.7180.99
33_Q36_I0.7170.99
177_S183_V0.7130.99
337_I341_L0.7080.99
354_T362_Y0.7070.99
225_E273_L0.7060.99
22_L25_A0.7060.99
307_F311_I0.7050.99
160_A200_A0.7050.99
288_I294_S0.7020.99
285_I289_E0.7020.99
22_L26_F0.6990.99
343_K348_Y0.6960.99
334_S338_Y0.6930.99
304_L308_L0.6910.99
354_T361_G0.6900.99
225_E269_G0.6890.99
135_V147_F0.6880.99
308_L315_F0.6880.99
24_Q32_N0.6880.99
56_I139_A0.6870.99
329_I337_I0.6870.99
287_G292_I0.6860.99
234_A240_V0.6840.99
346_G349_K0.6840.99
23_L27_Y0.6800.99
329_I339_I0.6800.99
288_I299_I0.6770.99
342_I349_K0.6760.99
336_G341_L0.6750.99
263_I266_W0.6740.99
335_N340_A0.6710.99
153_Q241_K0.6710.99
177_S182_F0.6700.99
289_E297_W0.6670.99
20_W32_N0.6660.99
373_W378_K0.6660.99
286_R299_I0.6660.99
53_I125_A0.6640.99
344_P347_D0.6610.99
285_I290_G0.6600.99
61_E95_I0.6570.99
146_D149_R0.6570.99
107_V111_R0.6510.99
327_S333_V0.6490.99
322_F326_T0.6480.99
186_A189_K0.6440.99
373_W377_P0.6420.99
72_S105_N0.6410.99
67_L72_S0.6390.99
329_I336_G0.6380.99
70_N74_L0.6380.99
305_L312_S0.6370.99
300_Y308_L0.6310.99
314_Q317_L0.6310.99
19_L22_L0.6310.99
181_E186_A0.6290.99
335_N339_I0.6280.99
107_V110_R0.6260.98
142_R166_R0.6230.98
82_I129_S0.6230.98
126_T129_S0.6230.98
39_S42_N0.6210.98
24_Q27_Y0.6200.98
92_F95_I0.6190.98
11_F21_I0.6190.98
97_E101_K0.6150.98
327_S335_N0.6150.98
303_Y310_I0.6140.98
29_K32_N0.6120.98
179_T263_I0.6110.98
25_A32_N0.6110.98
219_K222_S0.6100.98
330_P338_Y0.6090.98
19_L25_A0.6080.98
13_S21_I0.6080.98
148_L206_G0.6080.98
156_Y159_V0.6080.98
135_V151_I0.6070.98
332_L339_I0.6040.98
342_I348_Y0.6040.98
48_K132_E0.6040.98
31_S35_I0.6020.98
98_S102_L0.6010.98
291_F298_G0.6000.98
344_P349_K0.6000.98
286_R293_Y0.5990.98
230_G240_V0.5980.98
327_S336_G0.5970.98
225_E228_E0.5960.98
332_L340_A0.5950.98
275_S280_L0.5930.98
20_W28_Y0.5930.98
181_E185_N0.5920.98
354_T359_L0.5890.98
111_R115_K0.5890.98
177_S188_F0.5880.98
180_N187_L0.5860.98
292_I297_W0.5850.98
10_L21_I0.5850.98
300_Y307_F0.5840.98
257_T261_N0.5820.98
364_Q367_F0.5800.98
327_S338_Y0.5790.97
259_L266_W0.5790.97
375_V378_K0.5790.97
284_G288_I0.5780.97
333_V339_I0.5780.97
306_L310_I0.5780.97
141_A203_S0.5780.97
177_S186_A0.5780.97
291_F295_Q0.5770.97
163_L250_T0.5760.97
28_Y35_I0.5760.97
67_L70_N0.5750.97
49_R78_F0.5740.97
11_F14_S0.5740.97
93_K108_I0.5740.97
30_V33_Q0.5720.97
47_N76_Y0.5710.97
57_K89_E0.5690.97
23_L32_N0.5670.97
58_D90_E0.5670.97
103_P106_F0.5670.97
167_D171_Q0.5670.97
276_Y281_F0.5660.97
27_Y30_V0.5660.97
81_V106_F0.5650.97
176_Y187_L0.5650.97
167_D174_K0.5650.97
304_L311_I0.5640.97
13_S16_F0.5640.97
293_Y298_G0.5630.97
68_I96_I0.5630.97
93_K99_L0.5630.97
331_I340_A0.5620.97
286_R292_I0.5610.97
180_N185_N0.5600.97
147_F151_I0.5600.97
310_I314_Q0.5540.97
13_S22_L0.5540.97
170_T173_Q0.5530.97
327_S334_S0.5510.97
72_S106_F0.5510.97
14_S19_L0.5510.97
233_L238_I0.5510.97
351_G358_S0.5500.97
330_P339_I0.5500.97
334_S339_I0.5500.97
170_T174_K0.5500.97
33_Q38_F0.5490.97
309_I313_I0.5480.97
136_Y200_A0.5470.96
191_R197_I0.5460.96
303_Y311_I0.5460.96
166_R251_L0.5450.96
57_K114_N0.5430.96
288_I292_I0.5430.96
57_K87_D0.5420.96
162_R242_Y0.5400.96
24_Q31_S0.5400.96
126_T136_Y0.5380.96
54_V67_L0.5380.96
211_I214_K0.5370.96
53_I129_S0.5370.96
98_S101_K0.5360.96
20_W25_A0.5360.96
308_L312_S0.5330.96
219_K232_R0.5330.96
225_E231_I0.5320.96
108_I111_R0.5320.96
31_S37_Q0.5320.96
100_D106_F0.5320.96
202_G265_R0.5310.96
151_I246_I0.5310.96
261_N374_K0.5310.96
302_L306_L0.5310.96
85_S140_E0.5310.96
48_K131_A0.5300.96
68_I83_I0.5300.96
300_Y311_I0.5280.96
258_D377_P0.5270.96
314_Q320_N0.5250.96
223_V269_G0.5250.96
160_A165_V0.5230.95
355_L362_Y0.5210.95
74_L143_V0.5200.95
175_I178_Y0.5190.95
24_Q33_Q0.5190.95
11_F22_L0.5170.95
199_F227_L0.5150.95
82_I109_I0.5150.95
248_V253_P0.5110.95
107_V128_I0.5080.95
48_K133_M0.5080.95
27_Y31_S0.5080.95
313_I318_N0.5070.95
21_I26_F0.5070.95
305_L311_I0.5060.95
287_G296_Q0.5030.94
115_K120_G0.5020.94
19_L29_K0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.9953 100 0.375 Contact Map
2z86A 2 0.6667 100 0.592 Contact Map
3bcvA 2 0.4155 100 0.609 Contact Map
1qg8A 1 0.493 100 0.614 Contact Map
1xhbA 1 0.8568 100 0.63 Contact Map
2bo4A 4 0.7488 100 0.631 Contact Map
3l7iA 4 0.0845 100 0.634 Contact Map
2d7iA 1 0.8709 100 0.635 Contact Map
3ckjA 2 0.6315 100 0.648 Contact Map
5ajoA 1 0.7793 100 0.651 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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