GREMLIN Database
IPYR - Inorganic pyrophosphatase
UniProt: Q97W51 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (161)
Sequences: 2299 (1152)
Seq/√Len: 90.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_V104_A4.1151.00
153_G157_E3.1821.00
160_E164_K3.1341.00
155_V159_K2.6901.00
91_Y153_G2.5431.00
12_E83_E2.5221.00
61_E98_E2.5051.00
163_K167_E2.4621.00
15_V68_V2.4251.00
125_E129_N2.3851.00
119_D154_S2.3791.00
76_L80_T2.3401.00
132_V136_E2.2851.00
137_H140_E2.1401.00
8_K11_D2.1151.00
66_L165_A1.9721.00
17_I70_V1.9291.00
11_D159_K1.9261.00
119_D155_V1.9241.00
25_I38_V1.9181.00
85_R118_N1.9121.00
89_M153_G1.9101.00
93_R150_S1.9091.00
61_E168_R1.9031.00
12_E107_R1.8131.00
83_E107_R1.8101.00
91_Y100_A1.7691.00
154_S157_E1.7631.00
118_N122_D1.7591.00
87_I117_I1.7091.00
129_N132_V1.6771.00
164_K168_R1.6621.00
100_A161_R1.6501.00
76_L82_I1.5941.00
9_A166_I1.5831.00
13_I86_P1.5791.00
77_M80_T1.5661.00
13_I68_V1.4991.00
55_I162_I1.4631.00
167_E170_K1.4570.99
159_K163_K1.4420.99
89_M161_R1.4400.99
160_E163_K1.4240.99
133_H137_H1.4240.99
13_I84_A1.4130.99
14_N37_K1.3810.99
15_V84_A1.3700.99
29_Y54_F1.3630.99
86_P102_V1.3510.99
86_P162_I1.3380.99
30_D33_E1.3150.99
133_H140_E1.3150.99
13_I55_I1.3150.99
60_E165_A1.2620.99
82_I106_P1.2480.98
35_I81_V1.2440.98
8_K12_E1.2290.98
89_M158_A1.2000.98
120_V123_L1.1950.98
157_E160_E1.1780.98
93_R97_G1.1650.98
142_E145_K1.1580.97
25_I51_N1.1510.97
91_Y150_S1.1450.97
132_V151_G1.1320.97
29_Y33_E1.1240.97
93_R98_E1.1170.97
57_E169_K1.1050.97
91_Y157_E1.1040.97
116_N125_E1.0980.96
50_F69_L1.0900.96
14_N83_E1.0780.96
103_I128_R1.0750.96
156_A159_K1.0680.96
46_M137_H1.0570.96
161_R164_K1.0480.95
43_Y112_P1.0420.95
156_A160_E1.0350.95
84_A104_A1.0290.95
121_K154_S1.0280.95
14_N56_P1.0210.95
93_R148_K1.0150.94
89_M100_A1.0060.94
30_D37_K1.0050.94
36_I78_P1.0040.94
102_V162_I1.0020.94
37_K83_E1.0010.94
126_A130_K0.9960.94
40_R142_E0.9950.94
89_M102_V0.9870.94
166_I170_K0.9830.94
29_Y36_I0.9810.93
60_E161_R0.9670.93
103_I120_V0.9280.91
55_I66_L0.9260.91
52_Y139_K0.9210.91
28_E52_Y0.9210.91
28_E139_K0.9100.91
60_E98_E0.9060.90
60_E168_R0.9000.90
46_M133_H0.8990.90
113_S127_I0.8780.89
25_I77_M0.8770.89
121_K128_R0.8750.89
52_Y101_K0.8680.88
161_R165_A0.8670.88
106_P110_T0.8640.88
21_M72_G0.8630.88
51_N76_L0.8470.87
103_I123_L0.8350.86
132_V149_I0.8270.86
41_V72_G0.8160.85
113_S117_I0.8150.85
64_D94_D0.8090.85
44_T133_H0.8030.84
57_E166_I0.7940.84
119_D156_A0.7870.83
64_D67_D0.7850.83
132_V152_W0.7840.83
38_V41_V0.7790.82
73_N113_S0.7760.82
71_L123_L0.7760.82
52_Y94_D0.7720.82
90_I149_I0.7660.81
42_L134_F0.7650.81
115_S160_E0.7610.81
154_S160_E0.7610.81
27_Y39_D0.7550.80
17_I82_I0.7470.80
51_N77_M0.7410.79
90_I152_W0.7250.78
71_L127_I0.7240.77
127_I131_I0.7230.77
88_G120_V0.7220.77
60_E100_A0.7180.77
50_F131_I0.7180.77
112_P115_S0.7170.77
31_E169_K0.7170.77
94_D101_K0.7120.76
36_I77_M0.7120.76
35_I56_P0.7110.76
19_I28_E0.7110.76
28_E94_D0.7070.76
94_D99_D0.7050.76
90_I131_I0.6970.75
50_F71_L0.6940.74
87_I123_L0.6910.74
47_V74_Y0.6890.74
128_R152_W0.6780.73
41_V51_N0.6750.72
101_K139_K0.6690.72
27_Y78_P0.6620.71
43_Y111_D0.6570.70
24_N130_K0.6560.70
25_I75_S0.6560.70
62_D67_D0.6560.70
60_E66_L0.6550.70
162_I166_I0.6550.70
52_Y99_D0.6550.70
22_G126_A0.6450.69
73_N111_D0.6390.68
87_I119_D0.6370.68
94_D139_K0.6370.68
38_V51_N0.6340.68
36_I79_G0.6310.67
24_N41_V0.6280.67
66_L96_E0.6270.67
40_R45_S0.6240.66
30_D34_D0.6230.66
11_D163_K0.6230.66
157_E161_R0.6170.66
121_K125_E0.6160.65
164_K167_E0.6120.65
117_I124_P0.6080.64
126_A129_N0.6080.64
120_V128_R0.6060.64
136_E149_I0.6050.64
20_P77_M0.6030.64
141_L145_K0.6010.64
22_G74_Y0.6000.63
74_Y112_P0.5990.63
24_N51_N0.5970.63
16_F135_F0.5930.63
157_E164_K0.5920.62
123_L128_R0.5920.62
13_I107_R0.5890.62
86_P159_K0.5860.62
41_V44_T0.5850.61
28_E101_K0.5850.61
55_I84_A0.5840.61
92_M139_K0.5840.61
15_V70_V0.5830.61
28_E39_D0.5820.61
70_V84_A0.5800.61
70_V82_I0.5790.61
72_G76_L0.5760.60
103_I152_W0.5720.60
59_L63_G0.5670.59
83_E110_T0.5660.59
55_I68_V0.5660.59
51_N72_G0.5650.59
69_L135_F0.5610.58
91_Y98_E0.5600.58
19_I101_K0.5590.58
16_F56_P0.5580.58
31_E165_A0.5570.58
107_R110_T0.5550.57
122_D128_R0.5550.57
92_M95_E0.5520.57
125_E128_R0.5510.57
112_P126_A0.5510.57
55_I102_V0.5480.57
9_A13_I0.5460.56
15_V104_A0.5450.56
28_E99_D0.5450.56
9_A12_E0.5400.55
85_R105_V0.5400.55
30_D39_D0.5380.55
85_R115_S0.5370.55
58_T162_I0.5350.55
156_A163_K0.5330.54
76_L84_A0.5320.54
42_L45_S0.5290.54
127_I130_K0.5290.54
75_S130_K0.5290.54
9_A162_I0.5280.54
19_I139_K0.5270.54
13_I159_K0.5260.54
19_I52_Y0.5240.53
155_V158_A0.5230.53
102_V158_A0.5230.53
66_L161_R0.5180.52
95_E149_I0.5160.52
12_E159_K0.5160.52
19_I99_D0.5120.52
117_I123_L0.5120.52
19_I29_Y0.5090.51
58_T65_P0.5080.51
38_V82_I0.5060.51
160_E167_E0.5010.50
113_S116_N0.5010.50
30_D69_L0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q46A 5 0.9767 100 0.068 Contact Map
2prdA 5 0.9826 100 0.069 Contact Map
1qezA 5 0.9826 100 0.074 Contact Map
2au7A 5 1 100 0.076 Contact Map
4lugA 3 0.9826 100 0.079 Contact Map
3fq3A 6 0.9884 100 0.079 Contact Map
3ld3A 5 0.9884 100 0.082 Contact Map
3gvfA 5 0.9942 100 0.082 Contact Map
3tr4A 5 0.9884 100 0.083 Contact Map
2bqxA 5 0.9651 100 0.084 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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