GREMLIN Database
Q97W50 - Uncharacterized protein
UniProt: Q97W50 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (162)
Sequences: 1506 (1052)
Seq/√Len: 82.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_D103_K4.0611.00
74_L98_E3.5511.00
107_L111_D3.2141.00
93_V107_L2.6441.00
37_E134_R2.6031.00
143_D147_S2.5841.00
90_D94_E2.5601.00
38_A65_A2.5371.00
7_L70_A2.4601.00
30_T33_S2.4461.00
8_E37_E2.1821.00
7_L40_I2.1811.00
109_L120_A2.1291.00
103_K107_L2.1251.00
108_E114_T2.1211.00
59_E63_L2.1081.00
6_L74_L2.0571.00
155_K158_S1.9951.00
41_L123_S1.9751.00
112_L121_K1.9731.00
42_A65_A1.7911.00
71_G96_F1.7841.00
127_S131_Q1.7461.00
61_S65_A1.7081.00
96_F100_G1.6901.00
42_A123_S1.6251.00
18_W135_Y1.6181.00
43_Y63_L1.5981.00
158_S161_P1.5941.00
21_N24_P1.5911.00
55_E115_N1.5841.00
38_A123_S1.5751.00
39_S66_L1.5591.00
59_E62_A1.5361.00
112_L117_A1.4770.99
57_N60_H1.4740.99
61_S116_E1.4700.99
30_T127_S1.4680.99
87_N91_A1.4670.99
4_E41_L1.4440.99
35_S38_A1.4390.99
65_A120_A1.4380.99
46_A58_P1.4240.99
58_P62_A1.4170.99
149_Y153_I1.4090.99
82_A91_A1.4030.99
10_A31_V1.3900.99
162_L166_R1.3710.99
142_V146_I1.3670.99
142_V145_I1.3650.99
131_Q135_Y1.3520.99
6_L9_G1.3360.99
151_E154_D1.3320.99
163_N167_E1.3200.99
37_E127_S1.3100.98
142_V147_S1.2990.98
10_A35_S1.2880.98
67_F105_L1.2770.98
104_E107_L1.2700.98
7_L66_L1.2650.98
93_V97_D1.2450.98
42_A61_S1.2370.98
54_I115_N1.2070.97
143_D146_I1.2010.97
137_R140_F1.1680.97
88_K121_K1.1560.97
85_R88_K1.1440.96
164_Q167_E1.1410.96
17_G135_Y1.1120.96
60_H116_E1.1100.96
33_S127_S1.1020.95
16_T79_P1.0970.95
141_N144_E1.0970.95
20_Q131_Q1.0820.95
57_N116_E1.0700.95
11_K131_Q1.0590.94
64_I114_T1.0580.94
105_L108_E1.0500.94
79_P82_A1.0470.94
43_Y106_F1.0430.94
115_N119_V1.0310.93
50_K54_I1.0200.93
97_D107_L1.0060.93
92_E95_A1.0040.93
56_I61_S1.0030.93
92_E99_L0.9980.92
56_I119_V0.9960.92
149_Y152_E0.9880.92
89_R93_V0.9690.91
50_K55_E0.9650.91
43_Y67_F0.9640.91
144_E148_S0.9580.91
45_L61_S0.9520.90
74_L99_L0.9500.90
18_W26_A0.9430.90
35_S39_S0.9210.89
65_A109_L0.9140.89
151_E163_N0.9120.88
18_W131_Q0.9060.88
64_I117_A0.9000.88
132_G135_Y0.8910.87
8_E134_R0.8910.87
84_S87_N0.8790.87
67_F70_A0.8740.86
166_R169_V0.8730.86
14_V26_A0.8650.86
158_S165_I0.8630.86
98_E101_I0.8630.86
150_A153_I0.8540.85
64_I108_E0.8500.85
25_S33_S0.8500.85
135_Y139_G0.8430.84
108_E113_N0.8340.84
13_L31_V0.8240.83
43_Y62_A0.8240.83
141_N145_I0.8190.82
49_L119_V0.8110.82
112_L125_R0.8080.82
115_N118_K0.8080.82
46_A59_E0.7990.81
109_L121_K0.7930.80
4_E81_W0.7910.80
142_V149_Y0.7900.80
119_V123_S0.7840.80
122_L158_S0.7820.79
40_I67_F0.7820.79
93_V103_K0.7770.79
58_P61_S0.7770.79
13_L30_T0.7760.79
60_H64_I0.7760.79
158_S162_L0.7730.79
145_I148_S0.7630.78
64_I67_F0.7540.77
155_K168_L0.7470.76
9_G12_N0.7450.76
161_P166_R0.7440.76
50_K116_E0.7350.75
50_K56_I0.7320.75
61_S120_A0.7310.75
38_A85_R0.7310.75
41_L127_S0.7300.75
87_N90_D0.7240.74
21_N144_E0.7210.74
88_K135_Y0.7200.74
132_G140_F0.7090.72
162_L169_V0.7090.72
106_F110_K0.7080.72
14_V18_W0.7040.72
64_I116_E0.7010.72
122_L155_K0.6900.70
15_R29_E0.6890.70
14_V25_S0.6860.70
41_L126_L0.6780.69
20_Q125_R0.6740.69
95_A98_E0.6720.68
17_G128_T0.6640.67
68_H72_E0.6630.67
71_G75_L0.6590.67
12_N21_N0.6590.67
159_I168_L0.6590.67
22_G130_L0.6520.66
121_K125_R0.6410.65
64_I105_L0.6400.65
12_N30_T0.6370.64
146_I149_Y0.6350.64
86_I89_R0.6340.64
152_E155_K0.6290.63
38_A41_L0.6270.63
3_L95_A0.6220.62
153_I156_L0.6200.62
18_W31_V0.6200.62
2_K111_D0.6160.62
17_G31_V0.6130.61
42_A62_A0.6120.61
88_K109_L0.6110.61
157_L161_P0.6060.60
18_W22_G0.6060.60
84_S88_K0.6050.60
18_W29_E0.6040.60
135_Y138_I0.6030.60
144_E147_S0.6010.60
2_K168_L0.6000.60
12_N20_Q0.5980.59
150_A166_R0.5980.59
95_A106_F0.5940.59
11_K32_A0.5940.59
42_A119_V0.5920.59
78_L91_A0.5880.58
99_L102_G0.5880.58
20_Q130_L0.5860.58
16_T26_A0.5860.58
33_S106_F0.5850.58
12_N134_R0.5840.58
85_R121_K0.5790.57
159_I166_R0.5780.57
73_T99_L0.5760.57
71_G95_A0.5700.56
17_G26_A0.5680.55
48_E58_P0.5670.55
80_K121_K0.5660.55
8_E31_V0.5660.55
143_D148_S0.5630.55
128_T132_G0.5610.55
67_F100_G0.5590.54
78_L81_W0.5580.54
35_S69_D0.5560.54
118_K159_I0.5560.54
40_I66_L0.5520.53
36_F40_I0.5490.53
33_S36_F0.5480.53
93_V102_G0.5450.52
17_G131_Q0.5430.52
69_D72_E0.5420.52
148_S151_E0.5420.52
126_L161_P0.5370.51
79_P127_S0.5360.51
91_A98_E0.5360.51
17_G50_K0.5340.51
5_R134_R0.5330.51
58_P63_L0.5320.51
75_L81_W0.5320.51
6_L98_E0.5320.51
81_W128_T0.5310.51
62_A65_A0.5230.50
18_W138_I0.5200.49
98_E102_G0.5190.49
159_I165_I0.5170.49
19_M71_G0.5160.49
111_D114_T0.5160.49
79_P125_R0.5130.48
144_E149_Y0.5120.48
5_R130_L0.5110.48
36_F66_L0.5090.48
60_H160_E0.5070.47
22_G134_R0.5070.47
89_R112_L0.5060.47
133_L137_R0.5060.47
43_Y66_L0.5050.47
63_L67_F0.5040.47
91_A94_E0.5030.47
17_G79_P0.5030.47
64_I109_L0.5010.47
155_K161_P0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xx7A 5 0.9286 100 0.268 Contact Map
4l1jA 2 0.9341 100 0.277 Contact Map
1ynbA 5 0.8626 100 0.285 Contact Map
3kh1A 2 0.9396 100 0.339 Contact Map
2cqzA 5 0.9341 100 0.354 Contact Map
3mzoA 5 0.978 100 0.414 Contact Map
2paqA 5 0.8846 100 0.438 Contact Map
2gz4A 2 0.9121 100 0.476 Contact Map
3dtoA 2 0.8242 97.5 0.848 Contact Map
3b57A 2 0.8462 97.4 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0069 seconds.