GREMLIN Database
Q97W49 - Phosphomethylpyrimidine kinase (ThiD-2)
UniProt: Q97W49 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 456 (373)
Sequences: 440 (343)
Seq/√Len: 17.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_L46_G6.8721.00
39_F228_A5.4471.00
44_I228_A5.2381.00
49_A76_I4.3051.00
39_F44_I4.2781.00
24_L54_T4.1901.00
65_T68_N3.6831.00
90_I113_A3.6791.00
24_L50_I3.4541.00
142_V236_L3.3080.99
119_A123_T3.2110.99
52_A66_V3.1650.99
142_V181_I3.0420.99
58_T258_G2.9640.99
160_K163_D2.9600.99
112_V230_Y2.8020.98
151_S158_I2.7900.98
63_D74_K2.7860.98
18_G39_F2.7850.98
129_I132_Y2.7720.98
58_T260_G2.7090.98
90_I111_L2.6570.97
110_F141_K2.5110.96
53_I67_V2.4900.96
39_F46_G2.4770.96
107_N139_K2.4700.96
27_G54_T2.3770.95
197_C202_L2.3610.95
172_R180_V2.3190.94
20_S48_F2.3150.94
226_L240_F2.2770.93
113_A140_V2.1700.92
165_V202_L2.1330.91
53_I71_F2.1030.90
370_N373_Y2.0770.90
88_V224_T2.0510.89
300_I304_Q2.0400.89
33_E48_F2.0110.88
282_E290_A1.9450.86
92_M125_L1.9300.86
42_L229_E1.9250.86
207_Y248_Q1.9150.86
28_N34_T1.8830.85
17_V86_E1.8740.84
215_T251_I1.8600.84
235_D238_L1.8430.83
181_I222_F1.8300.83
280_V290_A1.8010.82
73_K104_E1.7890.81
151_S167_V1.7790.81
26_T54_T1.7440.80
52_A118_Y1.7340.79
137_L171_L1.7220.79
244_R248_Q1.7180.78
215_T262_G1.7150.78
100_Q135_I1.7120.78
18_G44_I1.6930.77
168_C251_I1.6860.77
32_G36_L1.6850.77
24_L33_E1.6770.77
156_V170_K1.6500.76
62_K78_T1.6430.75
212_A262_G1.6340.75
61_I220_S1.6080.74
205_I240_F1.5890.73
181_I205_I1.5760.72
230_Y233_I1.5600.71
77_E105_L1.5330.70
350_H354_M1.5320.70
17_V47_V1.5270.70
179_Y236_L1.5270.70
360_L364_D1.5110.69
350_H353_R1.5080.69
80_L85_V1.4800.67
20_S39_F1.4760.67
214_D262_G1.4720.67
146_N149_E1.4530.66
88_V111_L1.4480.65
17_V83_F1.4460.65
305_S321_D1.4450.65
302_E306_N1.4280.64
57_S223_A1.4230.64
324_T347_N1.4190.64
287_A290_A1.4160.64
349_T353_R1.4140.63
159_E163_D1.4090.63
111_L224_T1.4040.63
54_T83_F1.3850.62
24_L27_G1.3610.60
133_K153_I1.3600.60
95_T254_G1.3500.60
52_A94_Y1.3370.59
50_I54_T1.3210.58
68_N154_S1.3200.58
59_K259_K1.3140.58
386_Y389_I1.2930.56
21_I102_V1.2920.56
286_F290_A1.2900.56
214_D261_I1.2870.56
104_E171_L1.2870.56
350_H370_N1.2850.56
76_I105_L1.2450.53
171_L232_K1.2410.53
214_D254_G1.2390.53
327_G331_R1.2340.53
286_F289_F1.2340.53
321_D327_G1.2120.51
20_S36_L1.2110.51
137_L172_R1.2100.51
25_D30_A1.1840.50
198_N264_V1.1830.50
49_A75_Q1.1790.49
82_D258_G1.1790.49
158_I167_V1.1730.49
20_S50_I1.1530.48
299_L331_R1.1500.48
371_I379_E1.1490.48
28_N93_I1.1430.47
33_E223_A1.1420.47
37_R57_S1.1390.47
289_F293_N1.1340.47
265_N271_M1.1330.47
29_G35_D1.1320.47
61_I93_I1.1280.46
165_V204_K1.1270.46
77_E171_L1.1250.46
377_I380_S1.1180.46
22_A36_L1.1040.45
351_T377_I1.1030.45
132_Y138_P1.1010.45
383_R387_E1.1000.45
145_P149_E1.0990.45
301_P306_N1.0940.44
33_E49_A1.0910.44
111_L155_G1.0880.44
100_Q136_I1.0860.44
230_Y236_L1.0800.43
57_S258_G1.0800.43
371_I375_D1.0790.43
25_D35_D1.0780.43
20_S221_V1.0720.43
124_P152_A1.0690.43
40_E310_S1.0680.43
17_V84_K1.0660.43
58_T82_D1.0630.42
32_G50_I1.0590.42
32_G46_G1.0580.42
62_K81_E1.0480.41
161_E165_V1.0470.41
94_Y117_L1.0440.41
169_K259_K1.0400.41
37_R246_F1.0380.41
224_T227_T1.0310.40
348_P351_T1.0260.40
142_V276_K1.0240.40
26_T55_A1.0220.40
25_D29_G1.0210.40
30_A61_I1.0190.40
196_M205_I1.0160.40
61_I324_T1.0130.39
300_I305_S1.0060.39
41_V168_C0.9960.38
48_F172_R0.9880.38
249_T269_E0.9860.38
23_G30_A0.9840.38
34_T61_I0.9820.38
161_E193_F0.9810.38
133_K138_P0.9780.37
302_E327_G0.9740.37
133_K171_L0.9740.37
99_F132_Y0.9730.37
86_E221_V0.9720.37
305_S328_R0.9720.37
191_Y206_G0.9720.37
302_E328_R0.9660.37
168_C171_L0.9660.37
82_D260_G0.9640.37
118_Y266_V0.9630.37
299_L328_R0.9620.36
142_V226_L0.9620.36
73_K101_V0.9610.36
101_V104_E0.9600.36
22_A220_S0.9580.36
23_G51_T0.9580.36
168_C198_N0.9570.36
172_R199_D0.9570.36
19_M47_V0.9560.36
33_E75_Q0.9560.36
142_V270_I0.9540.36
308_A355_L0.9510.36
20_S32_G0.9490.36
76_I106_L0.9450.36
18_G231_I0.9440.35
39_F140_V0.9400.35
301_P329_I0.9370.35
42_L242_K0.9320.35
120_K261_I0.9300.35
234_R245_D0.9250.34
229_E234_R0.9250.34
122_G125_L0.9210.34
75_Q79_L0.9150.34
73_K108_D0.9150.34
147_I158_I0.9100.34
86_E110_F0.9060.33
23_G35_D0.9040.33
306_N329_I0.9000.33
69_P205_I0.8980.33
183_K262_G0.8950.33
37_R58_T0.8930.33
72_L98_Q0.8920.33
72_L111_L0.8890.32
290_A296_F0.8870.32
90_I343_V0.8840.32
81_E250_S0.8820.32
240_F243_A0.8820.32
129_I138_P0.8810.32
302_E370_N0.8810.32
45_H266_V0.8770.32
302_E310_S0.8760.32
27_G83_F0.8740.32
125_L260_G0.8730.32
33_E36_L0.8720.32
383_R389_I0.8720.32
112_V142_V0.8720.32
22_A30_A0.8690.31
28_N61_I0.8690.31
183_K218_T0.8680.31
69_P101_V0.8660.31
87_A209_R0.8650.31
181_I196_M0.8630.31
82_D125_L0.8620.31
255_L264_V0.8620.31
166_I170_K0.8570.31
355_L365_S0.8550.31
301_P346_G0.8530.31
324_T328_R0.8510.30
299_L327_G0.8490.30
124_P257_I0.8450.30
49_A102_V0.8430.30
18_G237_K0.8420.30
299_L305_S0.8410.30
310_S313_P0.8390.30
75_Q258_G0.8370.30
50_I237_K0.8370.30
129_I133_K0.8360.30
283_M286_F0.8360.30
147_I167_V0.8350.30
23_G29_G0.8350.30
85_V113_A0.8350.30
64_I142_V0.8340.30
26_T150_A0.8330.30
49_A284_R0.8210.29
302_E329_I0.8210.29
22_A186_H0.8200.29
323_A345_F0.8190.29
299_L302_E0.8190.29
19_M196_M0.8190.29
61_I121_D0.8110.28
22_A118_Y0.8080.28
181_I226_L0.8070.28
248_Q269_E0.8060.28
21_I51_T0.8050.28
177_I180_V0.8040.28
153_I182_I0.8000.28
181_I265_N0.7980.28
108_D226_L0.7970.28
372_R375_D0.7970.28
120_K192_S0.7960.28
72_L139_K0.7950.28
321_D328_R0.7950.28
119_A129_I0.7940.28
142_V227_T0.7930.28
65_T225_A0.7930.28
83_F86_E0.7920.27
130_E134_K0.7910.27
32_G243_A0.7910.27
301_P350_H0.7910.27
58_T215_T0.7900.27
48_F80_L0.7890.27
72_L143_I0.7860.27
97_E357_S0.7840.27
289_F296_F0.7840.27
30_A35_D0.7820.27
146_N220_S0.7810.27
50_I326_R0.7810.27
141_K196_M0.7800.27
168_C182_I0.7780.27
198_N203_Y0.7760.27
38_V273_K0.7740.27
39_F252_E0.7730.27
19_M88_V0.7720.27
117_L137_L0.7700.26
308_A324_T0.7700.26
162_S211_Q0.7680.26
27_G38_V0.7660.26
72_L138_P0.7610.26
200_E205_I0.7600.26
207_Y244_R0.7570.26
182_I384_I0.7540.26
142_V147_I0.7520.26
163_D265_N0.7510.26
25_D31_G0.7500.25
299_L321_D0.7490.25
225_A243_A0.7480.25
42_L223_A0.7480.25
214_D256_N0.7470.25
42_L226_L0.7450.25
321_D329_I0.7450.25
85_V355_L0.7430.25
75_Q126_I0.7430.25
35_D89_K0.7420.25
302_E331_R0.7390.25
279_A283_M0.7380.25
328_R331_R0.7380.25
159_E211_Q0.7370.25
282_E292_N0.7360.25
41_V225_A0.7360.25
216_H219_G0.7350.25
111_L118_Y0.7340.25
306_N350_H0.7340.25
287_A293_N0.7330.25
72_L101_V0.7330.25
137_L150_A0.7320.25
163_D374_D0.7310.25
324_T327_G0.7300.25
79_L85_V0.7270.24
293_N296_F0.7270.24
113_A168_C0.7240.24
55_A58_T0.7240.24
121_D186_H0.7230.24
279_A290_A0.7220.24
127_R169_K0.7180.24
31_G35_D0.7170.24
22_A218_T0.7170.24
40_E45_H0.7170.24
53_I154_S0.7150.24
218_T263_P0.7140.24
117_L152_A0.7130.24
122_G185_G0.7120.24
93_I102_V0.7120.24
18_G86_E0.7110.24
303_V350_H0.7050.23
57_S260_G0.7020.23
72_L176_N0.7010.23
332_R340_G0.6990.23
55_A118_Y0.6940.23
196_M240_F0.6910.23
138_P176_N0.6900.23
361_K370_N0.6890.23
60_G303_V0.6890.23
117_L132_Y0.6890.23
373_Y377_I0.6890.23
172_R197_C0.6880.23
181_I266_V0.6880.23
21_I387_E0.6870.23
115_P145_P0.6840.23
184_G194_D0.6800.22
345_F361_K0.6800.22
107_N157_K0.6770.22
168_C197_C0.6770.22
55_A71_F0.6760.22
60_G260_G0.6760.22
328_R350_H0.6760.22
230_Y239_A0.6750.22
196_M231_I0.6750.22
250_S380_S0.6750.22
16_P244_R0.6740.22
348_P370_N0.6740.22
28_N116_V0.6730.22
158_I163_D0.6720.22
322_I356_L0.6710.22
248_Q254_G0.6690.22
103_N175_Y0.6690.22
283_M287_A0.6690.22
126_I132_Y0.6680.22
195_Y233_I0.6670.22
154_S171_L0.6640.22
40_E230_Y0.6640.22
280_V283_M0.6630.22
302_E350_H0.6620.22
142_V384_I0.6600.22
38_V225_A0.6590.22
364_D372_R0.6590.22
183_K222_F0.6570.21
117_L143_I0.6570.21
18_G339_V0.6550.21
288_D294_D0.6530.21
146_N183_K0.6530.21
162_S165_V0.6510.21
164_V325_F0.6510.21
20_S46_G0.6500.21
150_A352_A0.6500.21
23_G31_G0.6480.21
200_E242_K0.6480.21
65_T71_F0.6440.21
201_G228_A0.6430.21
118_Y121_D0.6410.21
287_A291_E0.6410.21
170_K290_A0.6400.21
165_V169_K0.6390.21
121_D263_P0.6380.21
341_H364_D0.6370.21
322_I326_R0.6330.20
153_I172_R0.6330.20
356_L359_I0.6330.20
72_L151_S0.6300.20
24_L83_F0.6280.20
284_R289_F0.6280.20
149_E183_K0.6270.20
54_T150_A0.6250.20
70_E175_Y0.6240.20
382_K385_G0.6240.20
140_V143_I0.6230.20
164_V195_Y0.6210.20
324_T348_P0.6210.20
376_K379_E0.6200.20
161_E307_L0.6200.20
133_K147_I0.6190.20
16_P46_G0.6190.20
55_A226_L0.6180.20
22_A117_L0.6180.20
30_A220_S0.6160.20
96_K138_P0.6140.20
116_V184_G0.6130.20
329_I348_P0.6120.20
97_E200_E0.6120.20
300_I321_D0.6120.20
171_L202_L0.6120.20
363_K368_L0.6100.20
99_F226_L0.6100.20
102_V389_I0.6090.20
36_L55_A0.6040.19
66_V80_L0.6020.19
203_Y241_R0.5980.19
34_T38_V0.5980.19
81_E239_A0.5980.19
16_P36_L0.5970.19
46_G224_T0.5970.19
275_M278_E0.5970.19
21_I126_I0.5950.19
48_F221_V0.5940.19
52_A252_E0.5930.19
78_T81_E0.5920.19
183_K186_H0.5910.19
93_I121_D0.5890.19
305_S327_G0.5890.19
369_M373_Y0.5890.19
44_I98_Q0.5880.19
348_P368_L0.5870.19
164_V221_V0.5860.19
30_A146_N0.5860.19
194_D244_R0.5850.19
26_T50_I0.5830.19
230_Y251_I0.5830.19
205_I226_L0.5820.19
40_E267_S0.5820.19
79_L95_T0.5820.19
36_L39_F0.5820.19
264_V306_N0.5800.18
120_K266_V0.5770.18
114_D145_P0.5770.18
171_L181_I0.5750.18
303_V328_R0.5740.18
212_A251_I0.5740.18
119_A319_L0.5730.18
335_K354_M0.5720.18
300_I348_P0.5700.18
61_I123_T0.5700.18
47_V79_L0.5650.18
98_Q194_D0.5650.18
373_Y376_K0.5650.18
145_P183_K0.5640.18
305_S331_R0.5640.18
88_V94_Y0.5620.18
55_A82_D0.5610.18
56_Q89_K0.5610.18
34_T93_I0.5600.18
384_I387_E0.5600.18
135_I160_K0.5590.18
100_Q131_E0.5580.18
21_I283_M0.5570.18
36_L48_F0.5540.17
45_H128_D0.5520.17
326_R343_V0.5520.17
68_N279_A0.5520.17
36_L50_I0.5510.17
184_G216_H0.5490.17
93_I116_V0.5490.17
161_E195_Y0.5480.17
303_V306_N0.5480.17
125_L180_V0.5480.17
48_F199_D0.5470.17
330_I340_G0.5470.17
383_R388_T0.5460.17
69_P72_L0.5450.17
230_Y245_D0.5450.17
21_I374_D0.5440.17
95_T226_L0.5430.17
155_G169_K0.5430.17
169_K353_R0.5400.17
154_S180_V0.5380.17
98_Q267_S0.5380.17
329_I350_H0.5370.17
24_L97_E0.5360.17
38_V83_F0.5350.17
112_V159_E0.5350.17
214_D218_T0.5340.17
95_T267_S0.5340.17
41_V339_V0.5340.17
92_M260_G0.5330.17
251_I254_G0.5330.17
29_G56_Q0.5320.17
172_R264_V0.5320.17
149_E220_S0.5320.17
21_I70_E0.5310.17
72_L121_D0.5300.17
53_I76_I0.5290.17
181_I240_F0.5280.17
162_S203_Y0.5280.17
340_G343_V0.5270.17
370_N374_D0.5270.17
269_E273_K0.5260.17
112_V143_I0.5260.17
308_A319_L0.5260.17
22_A145_P0.5250.16
308_A367_C0.5240.16
137_L267_S0.5230.16
129_I172_R0.5230.16
60_G123_T0.5230.16
85_V162_S0.5220.16
127_R223_A0.5210.16
21_I36_L0.5210.16
42_L231_I0.5210.16
250_S311_I0.5210.16
66_V94_Y0.5180.16
238_L241_R0.5170.16
126_I260_G0.5160.16
221_V263_P0.5160.16
242_K245_D0.5160.16
302_E372_R0.5150.16
47_V83_F0.5130.16
80_L105_L0.5120.16
99_F126_I0.5120.16
333_W348_P0.5120.16
162_S290_A0.5120.16
100_Q134_K0.5110.16
240_F292_N0.5110.16
20_S33_E0.5100.16
180_V243_A0.5090.16
97_E238_L0.5070.16
199_D223_A0.5070.16
376_K380_S0.5050.16
22_A29_G0.5040.16
356_L379_E0.5040.16
137_L177_I0.5040.16
187_S207_Y0.5030.16
286_F291_E0.5010.16
142_V240_F0.5010.16
80_L223_A0.5000.16
382_K388_T0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rm5A 2 0.9583 100 0.612 Contact Map
2i5bA 2 0.5746 100 0.652 Contact Map
1ub0A 2 0.5285 100 0.681 Contact Map
4yl5A 2 0.4825 100 0.682 Contact Map
1jxhA 2 0.5241 100 0.686 Contact Map
4c5kA 2 0.5877 100 0.692 Contact Map
3h74A 2 0.5877 100 0.698 Contact Map
3mbhA 5 0.6009 100 0.708 Contact Map
2ddmA 2 0.5768 100 0.708 Contact Map
2pb9A 3 0.3882 100 0.715 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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